| Compound ID |
Compound Name |
Compound Formula |
|
CP0558808
|
methyl (3S,3'R,5'S)-1'-(1-benzylimidazole-4-carbonyl)-5-fluoro-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C28H29FN4O4
|
1
|
| 1 |
IC50 = 44 nM
|
|
|
|
CP0412858
|
6-benzyl-3-[3-(1,3-thiazol-5-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C24H20N4O3S
|
2
|
| 1 |
IC50 = 79 nM
|
|
|
| 2 |
IC50 = 1300 nM
|
|
|
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CP0558807
|
methyl (3S,3'R,5'S)-5-fluoro-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C22H25FN4O4
|
1
|
| 1 |
IC50 = 110 nM
|
|
|
|
CP0468071
|
6-benzyl-3-[3-(pyridin-3-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C26H22N4O3
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
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CP0462041
|
(3S,3'R,5'S)-1'-(1-benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
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|
C27H29FN4O2
|
1
|
| 1 |
IC50 = 350 nM
|
|
|
|
CP0539047
|
(3S,3'R,5'S)-3'-methyl-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
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|
C22H25N3O2
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0456407
|
methyl (3S,3'R,5'S)-5-fluoro-1'-(1H-imidazole-5-carbonyl)-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C21H23FN4O4
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0447207
|
(3S,3'R,5'S)-5-fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
Show/Hide
|
C21H25FN4O2
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0468070
|
6-benzyl-3-(3-phenylmethoxyphenyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C27H23N3O3
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0558964
|
methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C23H24FN3O4
|
1
|
| 1 |
IC50 = 910 nM
|
|
|
|
CP0558806
|
(3S,3'R,5'S)-3'-(fluoromethyl)-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
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|
C22H24FN3O2
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0493366
|
6-benzyl-3-[3-(pyridin-2-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C26H22N4O3
|
1
|
| 1 |
IC50 = 1400 nM
|
|
|
|
CP0565179
|
6-benzyl-3-[2-(3-fluoropyridin-2-yl)-3,4-dihydro-2H-chromen-7-yl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C28H23FN4O3
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0481061
|
methyl (3S,3'R,5'S)-5-fluoro-1'-(1-methylimidazole-2-carbonyl)-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C22H25FN4O4
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0558232
|
(3S,3'R,5'S)-3'-(chloromethyl)-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
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|
C22H24ClN3O2
|
1
|
| 1 |
IC50 = 2800 nM
|
|
|
|
CP0476122
|
methyl (3S,3'R,5'S)-4-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C23H24FN3O4
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0412859
|
3-[5-[(Z)-(5-imino-7-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-ylidene)methyl]furan-2-yl]benzoic acid
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|
C20H16N4O4S
|
1
|
| 1 |
IC50 = 4200 nM
|
|
|
|
CP0403312
|
methyl (3S,3'R,5'S)-7-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C23H24FN3O4
|
1
|
| 1 |
IC50 = 4300 nM
|
|
|
|
CP0436680
|
methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-1'-(1-methylpyrazole-3-carbonyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C22H25FN4O4
|
1
|
| 1 |
IC50 = 4600 nM
|
|
|
|
CP0403361
|
6-benzyl-3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C29H25FN4O3
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0469863
|
3-[5-[(Z)-(2-cyclohexyl-5-imino-7-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-ylidene)methyl]furan-2-yl]benzoic acid
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|
C23H20N4O4S
|
1
|
| 1 |
IC50 = 5300 nM
|
|
|
|
CP0436679
|
methyl (3S,3'R,5'S)-5-chloro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
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|
C23H24ClN3O4
|
1
|
| 1 |
IC50 = 8000 nM
|
|
|
|
CP0403311
|
(3S,3'R,5'S)-3'-(hydroxymethyl)-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
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|
C22H25N3O3
|
1
|
| 1 |
IC50 = 12000 nM
|
|
|
|
CP0403360
|
3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-6-(2,2,2-trifluoroethyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
Show/Hide
|
C24H20F4N4O3
|
1
|
| 1 |
IC50 = 36000 nM
|
|
|
|
CP0407822
|
6-benzyl-3-(2-phenylmethoxyphenyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C27H23N3O3
|
1
|
| 1 |
IC50 = 58000 nM
|
|
|
|
CP0463438
|
(3R,3'S,5'R)-5-fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
Show/Hide
|
C21H25FN4O2
|
1
|
| 1 |
IC50 = 84000 nM
|
|
|
|
CP0476123
|
methyl (3S,3'R,5'S)-6-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C23H24FN3O4
|
1
|
| 1 |
IC50 = 88000 nM
|
|
|
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CP0468069
|
3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-6-methyl-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dione
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|
C23H21FN4O3
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0487763
|
6-benzyl-3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-1-methyl-4H-pyrido[4,3-d]pyrimidine-2,7-dione
Show/Hide
|
C30H27FN4O3
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0403310
|
methyl (3R,3'S,5'R)-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C23H25N3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0476120
|
methyl (3S,3'R,5'S)-5'-(2-methylpropyl)-2-oxo-1'-(2-pyridin-2-ylacetyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C24H27N3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0476121
|
methyl (3S,3'R,5'S)-5'-methyl-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C20H19N3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0477034
|
(3R,3'S,5'R)-1'-(1-benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-one
Show/Hide
|
C27H29FN4O2
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0481059
|
methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-3-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C23H24FN3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0481060
|
methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-4-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C23H24FN3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0488964
|
(3S,3'R,5'S)-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxamide
Show/Hide
|
C22H24N4O3
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0488965
|
methyl (3S,3'R,5'S)-1'-benzoyl-5-fluoro-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C24H25FN2O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0513727
|
methyl (3S,3'S,5'S)-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C23H25N3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0513728
|
methyl (3S,3'R,5'R)-5'-benzyl-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C26H23N3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0558805
|
(3S,3'R,5'S)-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylic acid;hydrochloride
Show/Hide
|
C22H24ClN3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
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CP0574422
|
methyl (3S,3'R,5'S)-1-methyl-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[indole-3,2'-pyrrolidine]-3'-carboxylate
Show/Hide
|
C24H27N3O4
|
1
|
| 1 |
IC50 > 100000 nM
|
|
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