| Compound ID |
Compound Name |
Compound Formula |
|
CP0543269
|
4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C21H22N6O3S
|
1
|
| 1 |
IC50 = 23 nM
|
|
|
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CP0579960
|
4-[[7-(2,6-difluorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C20H18F2N6O3S
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
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CP0543268
|
4-[[7-(2-ethylphenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C22H24N6O3S
|
1
|
| 1 |
IC50 = 51 nM
|
|
|
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CP0570277
|
N-cyclopropyl-4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C24H26N6O3S
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
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CP0579959
|
4-[[5,8-dimethyl-6-oxo-7-[2-(trifluoromethyl)phenyl]-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C21H19F3N6O3S
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
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CP0578321
|
4-[[7-(2-bromophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C20H19BrN6O3S
|
1
|
| 1 |
IC50 = 57 nM
|
|
|
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CP0576787
|
N-(cyclopropylmethyl)-4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C25H28N6O3S
|
1
|
| 1 |
IC50 = 60 nM
|
|
|
|
CP0574517
|
4-[[7-(2-fluorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C20H19FN6O3S
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0578241
|
4-[[5,8-dimethyl-7-(2-methylpropyl)-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C18H24N6O3S
|
1
|
| 1 |
IC50 = 77 nM
|
|
|
|
CP0580024
|
N-(cyclopropylmethyl)-4-[[7-(2,6-difluorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C24H24F2N6O3S
|
1
|
| 1 |
IC50 = 79 nM
|
|
|
|
CP0576864
|
4-[(5,8-dimethyl-6-oxo-7-thiophen-2-yl-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C18H18N6O3S2
|
1
|
| 1 |
IC50 = 88 nM
|
|
|
|
CP0569121
|
4-[(5',8'-dimethyl-6'-oxospiro[cyclopropane-1,7'-pteridine]-2'-yl)amino]benzenesulfonamide
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|
C16H18N6O3S
|
1
|
| 1 |
IC50 = 103 nM
|
|
|
|
CP0464211
|
4-[(2,9-dimethyl-8-oxo-6-thia-2,9,12,14-tetrazatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-13-yl)amino]benzenesulfonamide
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|
C17H16N6O3S2
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0572750
|
4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]-N-methylbenzenesulfonamide
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|
C22H24N6O3S
|
1
|
| 1 |
IC50 = 104 nM
|
|
|
|
CP0574535
|
4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]-N-ethylbenzenesulfonamide
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|
C23H26N6O3S
|
1
|
| 1 |
IC50 = 119 nM
|
|
|
|
CP0576859
|
4-[[7-(2-chlorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C20H19ClN6O3S
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0579714
|
4-[(5',8'-dimethyl-6'-oxospiro[cyclopentane-1,7'-pteridine]-2'-yl)amino]benzenesulfonamide
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|
C18H22N6O3S
|
1
|
| 1 |
IC50 = 129 nM
|
|
|
|
CP0550118
|
4-[[7-(3-fluorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C20H19FN6O3S
|
1
|
| 1 |
IC50 = 134 nM
|
|
|
|
CP0578276
|
4-[(7-cyclopropyl-5,8-dimethyl-6-oxo-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C17H20N6O3S
|
1
|
| 1 |
IC50 = 136 nM
|
|
|
|
CP0578242
|
4-[(5',8'-dimethyl-6'-oxospiro[cyclobutane-1,7'-pteridine]-2'-yl)amino]benzenesulfonamide
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|
C17H20N6O3S
|
1
|
| 1 |
IC50 = 141 nM
|
|
|
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CP0575439
|
2-[4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]phenyl]-2-methylpropanenitrile
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|
C25H26N6O
|
1
|
| 1 |
IC50 = 153 nM
|
|
|
|
CP0576862
|
4-[[7-(5-fluoro-2-methylphenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C21H21FN6O3S
|
1
|
| 1 |
IC50 = 168 nM
|
|
|
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CP0579543
|
4-[[7-(2,6-difluorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-N,N-dimethylbenzenesulfonamide
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|
C22H22F2N6O3S
|
1
|
| 1 |
IC50 = 181 nM
|
|
|
|
CP0576855
|
4-[(5,8-dimethyl-6-oxo-7-propyl-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C17H22N6O3S
|
1
|
| 1 |
IC50 = 206 nM
|
|
|
|
CP0579066
|
4-[[7-(cyclopropylmethyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C18H22N6O3S
|
1
|
| 1 |
IC50 = 211 nM
|
|
|
|
CP0579715
|
4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]-N,N-dimethylbenzenesulfonamide
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|
C23H26N6O3S
|
1
|
| 1 |
IC50 = 219 nM
|
|
|
|
CP0576860
|
4-[[7-(2-methoxyphenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C21H22N6O4S
|
1
|
| 1 |
IC50 = 251 nM
|
|
|
|
CP0579958
|
4-[(5,8-dimethyl-6-oxo-7-propan-2-yl-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C17H22N6O3S
|
1
|
| 1 |
IC50 = 254 nM
|
|
|
|
CP0578802
|
1-[4-[[5,8-dimethyl-7-(2-methylphenyl)-6-oxo-7H-pteridin-2-yl]amino]phenyl]cyclopropane-1-carbonitrile
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|
C25H24N6O
|
1
|
| 1 |
IC50 = 256 nM
|
|
|
|
CP0574518
|
4-[(5',8'-dimethyl-6'-oxospiro[cyclohexane-1,7'-pteridine]-2'-yl)amino]benzenesulfonamide
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|
C19H24N6O3S
|
1
|
| 1 |
IC50 = 272 nM
|
|
|
|
CP0544910
|
4-[(5,7,8-trimethyl-6-oxo-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C15H18N6O3S
|
1
|
| 1 |
IC50 = 313 nM
|
|
|
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CP0576865
|
4-[[7-(2,6-difluorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]-N-methylbenzenesulfonamide
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|
C21H20F2N6O3S
|
1
|
| 1 |
IC50 = 318 nM
|
|
|
|
CP0577591
|
4-[(5,8-dimethyl-6-oxo-7-phenyl-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C20H20N6O3S
|
1
|
| 1 |
IC50 = 383 nM
|
|
|
|
CP0579597
|
4-[[7-(3-fluoro-2-methylphenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
Show/Hide
|
C21H21FN6O3S
|
1
|
| 1 |
IC50 = 419 nM
|
|
|
|
CP0572749
|
4-[(7-ethyl-5,8-dimethyl-6-oxo-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C16H20N6O3S
|
1
|
| 1 |
IC50 = 479 nM
|
|
|
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CP0571658
|
4-[(5,8-dimethyl-6-oxo-7H-pteridin-2-yl)amino]benzenesulfonamide
Show/Hide
|
C14H16N6O3S
|
1
|
| 1 |
IC50 = 495 nM
|
|
|
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CP0576858
|
4-[[7-(3-methoxyphenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C21H22N6O4S
|
1
|
| 1 |
IC50 = 954 nM
|
|
|
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CP0579540
|
4-[[7-(3-chlorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
Show/Hide
|
C20H19ClN6O3S
|
1
|
| 1 |
IC50 = 989 nM
|
|
|
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CP0576856
|
4-[[7-(4-fluorophenyl)-5,8-dimethyl-6-oxo-7H-pteridin-2-yl]amino]benzenesulfonamide
Show/Hide
|
C20H19FN6O3S
|
1
|
| 1 |
IC50 = 1770 nM
|
|
|
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CP0544911
|
4-[[5,8-dimethyl-6-oxo-7-[3-(trifluoromethyl)phenyl]-7H-pteridin-2-yl]amino]benzenesulfonamide
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|
C21H19F3N6O3S
|
1
|
| 1 |
IC50 = 2710 nM
|
|
|
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CP0579541
|
4-[(7-benzyl-5,8-dimethyl-6-oxo-7H-pteridin-2-yl)amino]benzenesulfonamide
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|
C21H22N6O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
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CP0382649
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C50H56BF2N7O7
|
1
|
| 1 |
Kd = 4 nM
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CP0382724
|
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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|
C49H54BF2N7O7
|
1
|
| 1 |
Kd = 7 nM
|
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