| Compound ID |
Compound Name |
Compound Formula |
|
CP0519815
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(2,5-difluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H18F4N8O
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0550149
|
[1-[6-[(4,5-difluoro-1H-benzimidazol-2-yl)methylamino]-9-(3-fluorophenyl)purin-2-yl]piperidin-4-yl]methanol
Show/Hide
|
C25H23F3N8O
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0550145
|
9-(3-fluorophenyl)-N-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]methyl]-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C26H30FN9O
|
1
|
| 1 |
IC50 = 54 nM
|
|
|
|
CP0550143
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(2,3-difluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H18F4N8O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0407852
|
N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H19Cl2N9O
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0547446
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-thiophen-3-ylpurin-6-amine
Show/Hide
|
C21H18F2N8OS
|
1
|
| 1 |
IC50 = 105 nM
|
|
|
|
CP0416139
|
N-(1,3-benzothiazol-2-ylmethyl)-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H20FN7OS
|
1
|
| 1 |
IC50 = 115 nM
|
|
|
|
CP0457180
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-thiophen-3-ylpurin-6-amine
Show/Hide
|
C22H21F2N9S
|
1
|
| 1 |
IC50 = 125 nM
|
|
|
|
CP0416137
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-methylphenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C24H22F2N8O
|
1
|
| 1 |
IC50 = 135 nM
|
|
|
|
CP0519818
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3,5-difluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H18F4N8O
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0450879
|
N-(1,3-benzoxazol-2-ylmethyl)-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H20FN7O2
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0013554
|
3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)-N,N-dimethylimidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C18H16FN7
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0450880
|
6-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)purine-2,6-diamine
Show/Hide
|
C19H13F3N8
|
1
|
| 1 |
IC50 = 170 nM
|
|
|
|
CP0457179
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-[2-(trifluoromethyl)phenyl]purin-6-amine
Show/Hide
|
C24H19F5N8O
|
1
|
| 1 |
IC50 = 175 nM
|
|
|
|
CP0014522
|
2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C17H13FN6S
|
1
|
| 1 |
IC50 = 180 nM
|
|
|
|
CP0014523
|
3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C16H12FN7
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0407861
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-(4-methoxypiperidin-1-yl)purin-6-amine
Show/Hide
|
C25H23F3N8O
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0416141
|
2-[[6-[(4,5-difluoro-1H-benzimidazol-2-yl)methylamino]-9-(3-fluorophenyl)purin-2-yl]amino]ethanol
Show/Hide
|
C21H17F3N8O
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0484204
|
9-(3-fluorophenyl)-N-(1H-imidazol-2-ylmethyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C19H19FN8O
|
1
|
| 1 |
IC50 = 205 nM
|
|
|
|
CP0457186
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-fluoropyridin-4-yl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C22H18F3N9O
|
1
|
| 1 |
IC50 = 245 nM
|
|
|
|
CP0457187
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-methylpyridin-4-yl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H21F2N9O
|
1
|
| 1 |
IC50 = 245 nM
|
|
|
|
CP0445947
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(2,4-difluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H18F4N8O
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0484203
|
N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H20Cl2N10
|
1
|
| 1 |
IC50 = 255 nM
|
|
|
|
CP0007305
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H19F3N8O
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0484199
|
1-[6-[(4,5-difluoro-1H-benzimidazol-2-yl)methylamino]-9-(3-fluorophenyl)purin-2-yl]piperidin-4-one
Show/Hide
|
C24H19F3N8O
|
1
|
| 1 |
IC50 = 265 nM
|
|
|
|
CP0457189
|
9-(3-fluorophenyl)-2-morpholin-4-yl-N-[(5-phenyl-1H-imidazol-2-yl)methyl]purin-6-amine
Show/Hide
|
C25H23FN8O
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0450877
|
6-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(1-methylpiperidin-4-yl)purine-2,6-diamine
Show/Hide
|
C25H24F3N9
|
1
|
| 1 |
IC50 = 305 nM
|
|
|
|
CP0457183
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-thiomorpholin-4-ylpurin-6-amine
Show/Hide
|
C23H19F3N8S
|
1
|
| 1 |
IC50 = 310 nM
|
|
|
|
CP0445942
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-4-ylpurin-6-amine
Show/Hide
|
C23H22F2N10
|
1
|
| 1 |
IC50 = 315 nM
|
|
|
|
CP0519820
|
N-[(5,6-dichloro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C23H22Cl2N10
|
1
|
| 1 |
IC50 = 320 nM
|
|
|
|
CP0521557
|
N-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C24H26N10O
|
1
|
| 1 |
IC50 = 335 nM
|
|
|
|
CP0445944
|
N-[(5,6-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H19F2N9O
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0484205
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(1,1-dioxo-1,4-thiazinan-4-yl)-9-(3-fluorophenyl)purin-6-amine
Show/Hide
|
C23H19F3N8O2S
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0450876
|
6-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(oxan-4-ylmethyl)purine-2,6-diamine
Show/Hide
|
C25H23F3N8O
|
1
|
| 1 |
IC50 = 375 nM
|
|
|
|
CP0407859
|
9-(3-fluorophenyl)-N-[[4-(4-methylpiperazin-1-yl)phenyl]methyl]-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C27H31FN8O
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0416138
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-(2-methylpyridin-4-yl)purin-6-amine
Show/Hide
|
C24H24F2N10
|
1
|
| 1 |
IC50 = 385 nM
|
|
|
|
CP0547447
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-4-ylpurin-6-amine
Show/Hide
|
C22H19F2N9O
|
1
|
| 1 |
IC50 = 385 nM
|
|
|
|
CP0445946
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(4-fluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H19F3N8O
|
1
|
| 1 |
IC50 = 395 nM
|
|
|
|
CP0457184
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H19F2N9O
|
1
|
| 1 |
IC50 = 500 nM
|
|
|
|
CP0411091
|
N-[(6-chloro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C23H23ClN10
|
1
|
| 1 |
IC50 = 630 nM
|
|
|
|
CP0416164
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-[4-(methylamino)piperidin-1-yl]purin-6-amine
Show/Hide
|
C25H24F3N9
|
1
|
| 1 |
IC50 = 655 nM
|
|
|
|
CP0484196
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(2-fluoropyridin-4-yl)-2-(4-methylpiperazin-1-yl)purin-6-amine
Show/Hide
|
C23H21F3N10
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0541134
|
N-[(5,6-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C23H22F2N10
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0550144
|
N-[(6-chloro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H20ClN9O
|
1
|
| 1 |
IC50 = 715 nM
|
|
|
|
CP0445943
|
9-(6-chloropyridin-3-yl)-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)purin-6-amine
Show/Hide
|
C23H21ClF2N10
|
1
|
| 1 |
IC50 = 860 nM
|
|
|
|
CP0550148
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-2-ylpurin-6-amine
Show/Hide
|
C23H22F2N10
|
1
|
| 1 |
IC50 = 860 nM
|
|
|
|
CP0445948
|
N-[(6-chloro-1H-benzimidazol-2-yl)methyl]-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H21ClN10
|
1
|
| 1 |
IC50 = 915 nM
|
|
|
|
CP0007377
|
2-(4-fluorophenyl)-N,N-dimethyl-3-pyridin-4-ylimidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C19H16FN5
|
1
|
| 1 |
IC50 = 920 nM
|
|
|
|
CP0450878
|
N-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C23H23N9O2
|
1
|
| 1 |
IC50 = 975 nM
|
|
|
|
CP0450874
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3,4-difluorophenyl)-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C23H18F4N8O
|
1
|
| 1 |
IC50 = 990 nM
|
|
|
|
CP0005356
|
3-(2-aminopyrimidin-4-yl)-N,N-dimethyl-2-phenylimidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C18H17N7
|
1
|
| 1 |
IC50 = 1050 nM
|
|
|
|
CP0445941
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C23H22F2N10
|
1
|
| 1 |
IC50 = 1145 nM
|
|
|
|
CP0450875
|
9-(6-chloropyridin-3-yl)-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C22H18ClF2N9O
|
1
|
| 1 |
IC50 = 1195 nM
|
|
|
|
CP0484198
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-[4-(dimethylamino)piperidin-1-yl]-9-(3-fluorophenyl)purin-6-amine
Show/Hide
|
C26H26F3N9
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0416163
|
6-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(2-morpholin-4-ylethyl)purine-2,6-diamine
Show/Hide
|
C25H24F3N9O
|
1
|
| 1 |
IC50 = 1230 nM
|
|
|
|
CP0519817
|
6-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-N-(3-morpholin-4-ylpropyl)purine-2,6-diamine
Show/Hide
|
C26H26F3N9O
|
1
|
| 1 |
IC50 = 1310 nM
|
|
|
|
CP0562566
|
N-[(6-methoxy-1H-benzimidazol-2-yl)methyl]-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C23H24N10O
|
1
|
| 1 |
IC50 = 1765 nM
|
|
|
|
CP0484197
|
N-(1H-benzimidazol-2-ylmethyl)-2-piperazin-1-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H22N10
|
1
|
| 1 |
IC50 = 1840 nM
|
|
|
|
CP0519819
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-9-pyridin-2-ylpurin-6-amine
Show/Hide
|
C22H19F2N9O
|
1
|
| 1 |
IC50 = 1905 nM
|
|
|
|
CP0541136
|
2-N-butyl-6-N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)purine-2,6-diamine
Show/Hide
|
C23H21F3N8
|
1
|
| 1 |
IC50 = 2010 nM
|
|
|
|
CP0013705
|
2-(4-fluorophenyl)-3-(1H-indazol-5-yl)-N,N-dimethylimidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C21H17FN6
|
1
|
| 1 |
IC50 = 2080 nM
|
|
|
|
CP0407857
|
N-(1H-benzimidazol-2-ylmethyl)-2-morpholin-4-yl-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C22H21N9O
|
1
|
| 1 |
IC50 = 2095 nM
|
|
|
|
CP0015297
|
8-chloro-3-(2-methylsulfanylpyrimidin-4-yl)-2-phenylimidazo[1,2-a]pyrazine
Show/Hide
|
C17H12ClN5S
|
1
|
| 1 |
IC50 = 2900 nM
|
|
|
|
CP0457188
|
N-(1H-benzimidazol-2-ylmethyl)-2-(4-methylpiperazin-1-yl)-9-pyridin-3-ylpurin-6-amine
Show/Hide
|
C23H24N10
|
1
|
| 1 |
IC50 = 2955 nM
|
|
|
|
CP0484200
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-ethyl-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C19H20F2N8O
|
1
|
| 1 |
IC50 = 6560 nM
|
|
|
|
CP0407858
|
9-(3-fluorophenyl)-2-morpholin-4-yl-N-[(4-phenyl-1,3-oxazol-2-yl)methyl]purin-6-amine
Show/Hide
|
C25H22FN7O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0445945
|
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-methyl-2-morpholin-4-ylpurin-6-amine
Show/Hide
|
C18H18F2N8O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0457181
|
9-(3-fluorophenyl)-2-morpholin-4-yl-N-[(4-phenyl-1,3-thiazol-2-yl)methyl]purin-6-amine
Show/Hide
|
C25H22FN7OS
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0005367
|
2-(4-fluorophenyl)-N,N-dimethyl-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C19H17FN6S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0013553
|
N,N-dimethyl-3-(2-methylsulfanylpyrimidin-4-yl)-2-phenylimidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C19H18N6S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0015298
|
8-chloro-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrazine
Show/Hide
|
C17H11ClFN5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0005820
|
2-(4-fluorophenyl)-N,N-dimethyl-3-pyrimidin-5-ylimidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C18H15FN6
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0011947
|
2-(4-fluorophenyl)-N,N-dimethyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C18H17FN6
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0012300
|
2-(4-fluorophenyl)-N,N-dimethyl-3-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine
Show/Hide
|
C19H16FN5
|
1
|
| 1 |
IC50 > 100000 nM
|
|
|
|
CP0012979
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3-(2-aminopyrimidin-5-yl)-2-(4-fluorophenyl)-N,N-dimethylimidazo[1,2-a]pyrazin-8-amine
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C18H16FN7
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1
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| 1 |
IC50 > 100000 nM
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