General Information of the Protein
Protein ID
PT01551
Protein Name
Casein kinase I isoform epsilon
Gene Name
CSNK1E
Sequence
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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Organism
Homo sapiens, Human
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CK1 protein kinase group
>
CK1 protein kinase CK1 family
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676).
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Uniprot ID
P49674
Ensembl ID
ENSG00000213923
HGNC ID
HGNC:2453
Subcellular Location
Cytoplasm
Nucleus
Map of Molecular Bioactivity Related to the Protein
Map of Molecular Bioactivity Related to the Protein

Protein
Cell Line
Compound

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Protein
Cell Line ID: CL000025 , HEK-293T
 Cell Line Info 
Compound ID Compound Name Compound Formula
CP0313025
 Compound Info 
4-(cyclopentylamino)-2-[(2,5-dibromo-4-methylphenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide
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C24H30Br2N6O3
  1
1
IC50 = 10900 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0130748
 Compound Info 
4-(cyclohexylamino)-2-[(2,5-dibromo-4-methylphenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamide
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C25H32Br2N6O3
  1
1
IC50 = 22100 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
Cell Line ID: CL000013 , Sf9
 Cell Line Info 
Biochemical Assays
Compound ID Compound Name Compound Formula
CP0007305
 Compound Info 
N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-9-(3-fluorophenyl)-2-morpholin-4-ylpurin-6-amine
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C23H19F3N8O
  1
1 IC50 = 260 nM
Clinical Information about the Protein
Target 1 ( Casein kinase I epsilon (CSNK1E) )
Target Type Successful Target
Disease 3 Target-related Diseases  3
1 Follicular lymphoma [ICD-11: 2A80]
2 Pancreatic cancer [ICD-11: 2C10]
3 Chronic lymphocytic leukaemia [ICD-11: 2A82.0]
Approved Drug(s) 1 Approved Drug  1
1 Umbralisib
 Drug Info 
Approved
Follicular lymphoma
Preclinical Drug(s) 2 Preclinical Drugs  2
1 IC261
 Drug Info 
Preclinical
Pancreatic cancer
2 PF-4800567
 Drug Info 
Preclinical
Chronic lymphocytic leukaemia