Brief Information of the Cell Line and Protein
Cell Line ID: CL000013 , Sf9
Synonyms
SF9
sf9
SF-9
Sf-9
sf-9
Sf 9
Spodoptera frugiperda clone 9
Sf clone 9
IPLB-Sf-9AE
IPLB-SF-9AE
IPLB-SF-9
IPLB-Sf-9
IPLB-Sf9
Category Spontaneously immortalized cell line
Organism
Spodoptera frugiperda (Fall armyworm)
Cellosaurus ID
CVCL_0549
Protein ID: PT00875 , Tyrosine-protein kinase Lyn
Gene Name LYN
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P07948
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000013  Protein ID: PT00875
 
Compound ID Compound Name Compound Formula
CP0495854
N-[3-[[8-[[(E)-4-(dimethylamino)but-2-enoyl]-methylamino]imidazo[1,5-a]quinoxalin-4-yl]amino]-4-methylphenyl]-3-(trifluoromethyl)benzamide
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C32H30F3N7O2
 1
1
IC50 = 1.55 nM
   TI
   LI
   LO
   TS
CP0460224
3-bromo-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
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C29H30BrN7O
 1
1
IC50 = 3.1 nM
   TI
   LI
   LO
   TS
CP0891978
(R)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide hydrochloride
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C30H32ClF3N8O
 1
1
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
CP0509438
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide
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C30H30F3N7O
 1
1
IC50 = 4.8 nM
   TI
   LI
   LO
   TS
CP0891982
(4-(((S)-3-((dimethylamino)methyl)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)phenyl)(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenylamino)methanol hydrochloride
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C31H36ClF3N8O
 1
1
IC50 = 7.6 nM
   TI
   LI
   LO
   TS
CP0485201
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide
   Show/Hide
C29H29F3N8O
 1
1
IC50 = 8.5 nM
   TI
   LI
   LO
   TS
CP0406460
(E)-4-(dimethylamino)-N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
   Show/Hide
C24H26N6O2
 1
1
IC50 = 10.9 nM
   TI
   LI
   LO
   TS
CP0433224
(E)-4-(dimethylamino)-N-[4-(5-hydroxy-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
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C24H26N6O2
 1
1
IC50 = 10.9 nM
   TI
   LI
   LO
   TS
CP0378468
(S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide
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C30H31F3N8O
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0433231
7-fluoro-8-N-methyl-4-N-(2-methylphenyl)imidazo[1,5-a]quinoxaline-4,8-diamine
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C18H16FN5
 1
1
IC50 = 19 nM
   TI
   LI
   LO
   TS
CP0433232
N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-piperidin-1-ylbut-2-ynamide
   Show/Hide
C27H28N6O2
 1
1
IC50 = 21.3 nM
   TI
   LI
   LO
   TS
CP0893327
(4-((3-(dimethylamino)azetidin-1-yl)methyl)-3-(trifluoromethyl)phenyl)(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenylamino)methanol hydrochloride
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C29H32ClF3N8O
 1
1
IC50 = 29 nM
   TI
   LI
   LO
   TS
CP0485079
3-fluoro-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide
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C29H30FN7O
 1
1
IC50 = 35 nM
   TI
   LI
   LO
   TS
CP0433210
4-N-(5-fluoro-2-methylphenyl)-8-N-methylimidazo[1,5-a]quinoxaline-4,8-diamine
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C18H16FN5
 1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
CP0525044
(E)-N-[4-(2-chloro-6-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
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C24H25ClN6O
 1
1
IC50 = 44.4 nM
   TI
   LI
   LO
   TS
CP0395331
N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-morpholin-4-ylbut-2-ynamide
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C26H26N6O3
 1
1
IC50 = 46.6 nM
   TI
   LI
   LO
   TS
CP0390478
7-fluoro-N-methyl-4-(2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-amine
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C18H15FN4O
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0459027
(E)-4-(dimethylamino)-N-[4-(2-hydroxy-6-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
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C24H26N6O2
 1
1
IC50 = 167 nM
   TI
   LI
   LO
   TS
CP0007430
IBRUTINIB
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C25H24N6O2
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0002778
4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide
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C29H31N7O
 1
1
IC50 = 220 nM
   TI
   LI
   LO
   TS
CP0440316
N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-2-(morpholin-4-ylmethyl)prop-2-enamide
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C26H28N6O3
 1
1
IC50 = 297 nM
   TI
   LI
   LO
   TS
CP0390470
(E)-4-(dimethylamino)-N-[4-(3-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H25FN6O
 1
1
IC50 = 327 nM
   TI
   LI
   LO
   TS
CP0406458
(E)-4-(dimethylamino)-N-[4-(4-hydroxy-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H26N6O2
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0075633
(E)-4-(dimethylamino)-N-[7-fluoro-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
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C24H25FN6O
 2
1
IC50 = 353 nM
   TI
   LI
   LO
   TS
2
IC50 = 624 nM
   TI
   LI
   LO
   TS
CP0496024
(E)-N-[4-(4-chloro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C24H25ClN6O
 1
1
IC50 = 378 nM
   TI
   LI
   LO
   TS
CP0433183
(E)-4-(dimethylamino)-N-[4-(3-hydroxy-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H26N6O2
 1
1
IC50 = 490 nM
   TI
   LI
   LO
   TS
CP0433233
(E)-4-(dimethylamino)-N-ethyl-N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
   Show/Hide
C26H30N6O2
 1
1
IC50 = 533 nM
   TI
   LI
   LO
   TS
CP0513524
4-(4-fluoro-2-methylphenoxy)-N-methylimidazo[1,5-a]quinoxalin-8-amine
   Show/Hide
C18H15FN4O
 1
1
IC50 = 560 nM
   TI
   LI
   LO
   TS
CP0523439
(E)-4-(dimethylamino)-N-methyl-N-[4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
   Show/Hide
C24H26N6O
 1
1
IC50 = 623 nM
   TI
   LI
   LO
   TS
CP0390612
(E)-4-(dimethylamino)-N-[4-(4-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H25FN6O
 1
1
IC50 = 716 nM
   TI
   LI
   LO
   TS
CP0390472
(E)-N-[7-chloro-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C24H25ClN6O
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0459025
(E)-4-(dimethylamino)-N-[4-(5-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H25FN6O
 1
1
IC50 = 1420 nM
   TI
   LI
   LO
   TS
CP0433228
(E)-N-[7-chloro-4-(4-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C24H24ClFN6O
 1
1
IC50 = 1590 nM
   TI
   LI
   LO
   TS
CP0525045
(E)-N-[4-(5-chloro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C24H25ClN6O
 1
1
IC50 = 1670 nM
   TI
   LI
   LO
   TS
CP0440317
(E)-N-(cyclopropylmethyl)-4-(dimethylamino)-N-[7-methoxy-4-(2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
   Show/Hide
C28H32N6O2
 1
1
IC50 = 1980 nM
   TI
   LI
   LO
   TS
CP0495995
(E)-N-[7-chloro-4-(2-chloroanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C23H22Cl2N6O
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0406459
(E)-N-[4-(2-chloroanilino)-7-fluoroimidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C23H22ClFN6O
 1
1
IC50 = 2130 nM
   TI
   LI
   LO
   TS
CP0433223
(E)-N-[4-(3-chloro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C24H25ClN6O
 1
1
IC50 = 2320 nM
   TI
   LI
   LO
   TS
CP0078281
(E)-N-[7-chloro-4-(5-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-4-(dimethylamino)-N-methylbut-2-enamide
   Show/Hide
C24H24ClFN6O
 2
1
IC50 = 3020 nM
   TI
   LI
   LO
   TS
2
IC50 = 3390 nM
   TI
   LI
   LO
   TS
CP0433227
(E)-4-(dimethylamino)-N-[7-fluoro-4-(5-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H24F2N6O
 1
1
IC50 = 3080 nM
   TI
   LI
   LO
   TS
CP0456249
(E)-4-(dimethylamino)-N-[7-fluoro-4-(4-fluoro-2-methylanilino)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H24F2N6O
 1
1
IC50 = 3450 nM
   TI
   LI
   LO
   TS
CP0456250
(E)-4-(dimethylamino)-N-[4-(4-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H24FN5O2
 1
1
IC50 = 3730 nM
   TI
   LI
   LO
   TS
CP0433186
(E)-4-(dimethylamino)-N-[7-fluoro-4-(2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H24FN5O2
 1
1
IC50 = 6020 nM
   TI
   LI
   LO
   TS
CP0433229
(E)-4-(dimethylamino)-N-[7-fluoro-4-(5-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H23F2N5O2
 1
1
IC50 = 7400 nM
   TI
   LI
   LO
   TS
CP0406463
(E)-4-(dimethylamino)-N-[7-fluoro-4-(4-fluoro-2-methylphenoxy)imidazo[1,5-a]quinoxalin-8-yl]-N-methylbut-2-enamide
   Show/Hide
C24H23F2N5O2
 1
1
IC50 = 10400 nM
   TI
   LI
   LO
   TS
CP0456251
(E)-4-(dimethylamino)-N-methyl-N-[4-(2-methylphenyl)sulfanylimidazo[1,5-a]quinoxalin-8-yl]but-2-enamide
   Show/Hide
C24H25N5OS
 1
1
IC50 = 19600 nM
   TI
   LI
   LO
   TS
CP0406461
(E)-N-(4-chloroimidazo[1,5-a]quinoxalin-8-yl)-4-(dimethylamino)-N-methylbut-2-enamide
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C17H18ClN5O
 1
1
IC50 > 50000 nM
   TI
   LI
   LO
   TS
CP0382724
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
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C49H54BF2N7O7
 1
1
Kd = 63 nM
   TI
   LI
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   TS
CP0382649
3-(2,2-difluoro-10,12-dimethyl-1-aza-3-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-3,5,7,9,11-pentaen-4-yl)-N-[2-[2-[2-[2-[[(2S,3R,4R,6R)-3-methoxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-methylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
   Show/Hide
C50H56BF2N7O7
 1
1
Kd = 116 nM
   TI
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