| Compound ID |
Compound Name |
Compound Formula |
|
CP0422527
|
US8975409, Example 38
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|
C33H37FN2O7
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0539630
|
US8975409, Example 19
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|
C30H33FN2O6
|
1
|
| 1 |
IC50 = 1.7 nM
|
|
|
|
CP0417340
|
US8975409, Example 9
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|
C32H37FN2O6
|
1
|
| 1 |
IC50 = 2.5 nM
|
|
|
|
CP0548817
|
US8975409, Example 13
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|
C34H39FN2O6
|
1
|
| 1 |
IC50 = 3 nM
|
|
|
|
CP0395995
|
US8975409, Example 9(3)
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|
C31H26F2N2O6
|
1
|
| 1 |
IC50 = 3.3 nM
|
|
|
|
CP0484486
|
N-[3-(4-fluorophenoxy)-5-(4-methylsulfonylphenoxy)phenyl]-4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxamide
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|
C31H28F2N2O6S
|
1
|
| 1 |
IC50 = 4.6 nM
|
|
|
|
CP0375037
|
N-[3-(4-carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(2-ethylbutyl)-4-hydroxypiperidine-1-carboxamide
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|
C31H36FN3O5
|
1
|
| 1 |
IC50 = 4.8 nM
|
|
|
|
CP0486509
|
US8975409, Example 15(6)
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|
C36H44FN3O6
|
1
|
| 1 |
IC50 = 5 nM
|
|
|
|
CP0436276
|
N-[3-(4-fluorophenoxy)-5-(4-sulfamoylphenoxy)phenyl]-4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxamide
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|
C30H27F2N3O6S
|
1
|
| 1 |
IC50 = 5.8 nM
|
|
|
|
CP0474711
|
US8975409, Example 15(1)
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|
C33H40FN3O5
|
1
|
| 1 |
IC50 = 9.6 nM
|
|
|
|
CP0509477
|
N-[3-(4-carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(4-chlorophenyl)-4-hydroxypiperidine-1-carboxamide
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|
C31H27ClFN3O5
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0407758
|
N-[3-(4-fluorophenoxy)-5-pyridin-4-yloxyphenyl]-4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxamide
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|
C29H25F2N3O4
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0509478
|
N-[3-(4-carbamoylphenoxy)-5-(4-fluorophenoxy)phenyl]-4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxamide
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|
C31H27F2N3O5
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0494561
|
US8975409, Comparative compound B
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|
C24H31FN2O3
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0396413
|
4-(2-ethylbutyl)-N-[3-fluoro-5-(trifluoromethyl)phenyl]-4-hydroxypiperidine-1-carboxamide
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|
C19H26F4N2O2
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0484517
|
US8975409, Comparative compound A
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|
C25H30F4N2O3
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0450587
|
4-(4-bromophenyl)-N-[3-fluoro-5-(trifluoromethyl)phenyl]-4-hydroxypiperidine-1-carboxamide
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|
C19H17BrF4N2O2
|
1
|
| 1 |
IC50 = 690 nM
|
|
|
