| Compound ID |
Compound Name |
Compound Formula |
|
CP0546331
|
8-oxa-2-azaspiro[4.5]decan-2-yl-[2-[(1-pyrazin-2-ylcyclobutyl)amino]pyrimidin-5-yl]methanone
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|
C21H26N6O2
|
1
|
| 1 |
IC50 = 0.04 nM
|
|
|
|
CP0579712
|
US10906888, Example 138
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|
C20H24N6O2
|
1
|
| 1 |
IC50 = 0.04 nM
|
|
|
|
CP0573882
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrazin-2-yl)propan-2-yl]amino}pyrimidin-5-yl)methanone
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|
C20H26N6O2
|
1
|
| 1 |
IC50 = 0.06 nM
|
|
|
|
CP0579711
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[2-(pyrimidin-5-yl)propan-2-yl]amino}pyrimidin-5-yl)methanone
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|
C20H26N6O2
|
1
|
| 1 |
IC50 = 0.08 nM
|
|
|
|
CP0546334
|
7-oxa-2-azaspiro[3.5]non-2-yl(2-{[2-(pyrazin-2-yl)propan-2-yl]amino}pyrimidin-5-yl)methanone
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|
C19H24N6O2
|
1
|
| 1 |
IC50 = 0.11 nM
|
|
|
|
CP0573998
|
US10906888, Example 173
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|
C21H26N6O2
|
1
|
| 1 |
IC50 = 0.12 nM
|
|
|
|
CP0579840
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[(1S)-1-(pyrazin-2-yl)ethyl]amino}pyrimidin-5-yl)methanone
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|
C19H24N6O2
|
1
|
| 1 |
IC50 = 0.24 nM
|
|
|
|
CP0549311
|
8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[1-(pyrimidin-5-yl)cyclopropyl]amino}pyrimidin-5-yl)methanone
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|
C20H24N6O2
|
1
|
| 1 |
IC50 = 0.28 nM
|
|
|
|
CP0579184
|
US10906888, Example 132
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|
C20H24N6O3
|
1
|
| 1 |
IC50 = 0.35 nM
|
|
|
|
CP0549313
|
US10906888, Example 133
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|
C20H24N6O3
|
1
|
| 1 |
IC50 = 0.43 nM
|
|
|
|
CP0579841
|
US10906888, Example 147
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|
C18H22N6O2
|
1
|
| 1 |
IC50 = 0.6 nM
|
|
|
|
CP0491745
|
US10906888, Example 149
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|
C19H24N6O2
|
1
|
| 1 |
IC50 = 0.68 nM
|
|
|
|
CP0491744
|
US10906888, Example 1
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|
C19H23N5O2
|
1
|
| 1 |
IC50 = 1.3 nM
|
|
|
|
CP0573139
|
US10906888, Example 146
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|
C19H24N6O2
|
1
|
| 1 |
IC50 = 3.12 nM
|
|
|
|
CP0573141
|
US10906888, Example 135
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|
C17H20N6O2
|
1
|
| 1 |
IC50 = 3.4 nM
|
|
|
|
CP0266746
|
3-[(2-{[1-(pyrimidin-5-yl)cyclopropyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile
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|
C19H14N6O
|
1
|
| 1 |
IC50 = 4.1 nM
|
|
|
|
CP0579710
|
3-({2-[(pyridin-3- ylmethyl)amino] pyrimidin-5- yl}carbonyl) benzonitrile
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|
C18H13N5O
|
1
|
| 1 |
IC50 = 4.4 nM
|
|
|
|
CP0229469
|
8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)amino]pyrimidin-5-yl}methanone
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|
C18H22N6O2
|
1
|
| 1 |
IC50 = 6.85 nM
|
|
|
|
CP0491746
|
US10906888, Example 185
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|
C18H22N6O2
|
1
|
| 1 |
IC50 = 7.7 nM
|
|
|
|
CP0491748
|
US10906888, Example 195
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|
C18H19N7O
|
3
|
| 1 |
IC50 = 10.4 nM
|
|
|
| 2 |
IC50 = 45 nM
|
|
|
| 3 |
Kd = 7.2 nM
|
|
|
|
CP0491747
|
[(3R)-3-methylsulfonylpiperidin-1-yl]-[2-[(1-pyrimidin-5-ylcyclopropyl)amino]pyrimidin-5-yl]methanone
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|
C18H22N6O3S
|
1
|
| 1 |
IC50 = 10.6 nM
|
|
|
|
CP0280569
|
US10906888, Example 190
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|
C17H20N6O
|
3
|
| 1 |
IC50 = 12.6 nM
|
|
|
| 2 |
IC50 = 115 nM
|
|
|
| 3 |
Kd = 20 nM
|
|
|
|
CP0567613
|
3-({2-[(1- phenylcyclopropyl) amino]pyrimidin- 5- yl}carbonyl) benzonitrile
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|
C21H16N4O
|
1
|
| 1 |
IC50 = 22 nM
|
|
|
|
CP0546333
|
US10906888, Example 150
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|
C19H24N6O2
|
1
|
| 1 |
IC50 = 27.9 nM
|
|
|
|
CP0573612
|
3-({2-[(pyrimidin- 5- ylmethyl)amino] pyrimidin-5- yl}carbonyl) benzonitrile
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|
C17H12N6O
|
1
|
| 1 |
IC50 = 33 nM
|
|
|
|
CP0491743
|
(3R)-1-[2-[(1-pyrimidin-5-ylcyclopropyl)amino]pyrimidine-5-carbonyl]piperidine-3-carbonitrile
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|
C18H19N7O
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0555300
|
(3-methylphenyl){2-[(pyridin-3-ylmethyl)amino]pyrimidin-5-yl}methanone
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|
C18H16N4O
|
1
|
| 1 |
IC50 = 52 nM
|
|
|
|
CP0579838
|
US10308615, Example 34
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|
C17H14N4O
|
1
|
| 1 |
IC50 = 53 nM
|
|
|
|
CP0573613
|
3-{[2- (benzylamino) pyrimidin-5- yl]carbonyl} benzonitrile
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|
C19H14N4O
|
1
|
| 1 |
IC50 = 80 nM
|
|
|
|
CP0571521
|
US10906888, Example 198
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|
C18H22N6O3S
|
3
|
| 1 |
IC50 = 122 nM
|
|
|
| 2 |
IC50 = 203 nM
|
|
|
| 3 |
Kd = 37 nM
|
|
|
|
CP0567317
|
US10308615, Example 100
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|
C15H12N4OS
|
1
|
| 1 |
IC50 = 160 nM
|
|
|
|
CP0546339
|
[(3S)-3-methylsulfonylpiperidin-1-yl]-[2-[(1-pyrimidin-5-ylcyclopropyl)amino]pyrimidin-5-yl]methanone
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|
C18H22N6O3S
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0551499
|
(3S)-1-[2-[(1-pyrimidin-5-ylcyclopropyl)amino]pyrimidine-5-carbonyl]piperidine-3-carbonitrile
Show/Hide
|
C18H19N7O
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
