Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT04361 , Protein smoothened
Gene Name SMO
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q99835
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT04361
 
Compound ID Compound Name Compound Formula
CP0392340
N-[4-chloro-3-(5-phenyl-1H-imidazol-2-yl)phenyl]-2-[(2R)-2-methylmorpholin-4-yl]-1,6-naphthyridin-5-amine
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C28H25ClN6O
 1
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
CP0510053
(S)-6-methyl-N-(2-(thiophen-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C29H25F3N2OS
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0522191
(S)-6-methyl-N-(2-((4-methylthiazol-2-yl)methylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C29H26F3N3OS
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0507972
(S)-6-methyl-N-(2-((5-methylfuran-2-yl)methylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C30H27F3N2O2
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0402005
(S)-N-(2-(benzylamino)-2,3-dihydro-1H-inden-5-yl)-6-methyl-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C31H27F3N2O
 1
1
IC50 = 14 nM
   TI
   LI
   LO
   TS
CP0506425
(S)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C28H24F3N3OS
 1
1
IC50 = 30 nM
   TI
   LI
   LO
   TS
CP0452610
6-methyl-N-((2S)-2-(1-phenylethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C32H29F3N2O
 1
1
IC50 = 32 nM
   TI
   LI
   LO
   TS
CP0510096
6-methyl-N-((2S)-2-(2,2,2-trifluoro-1-phenylethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C32H26F6N2O
 1
1
IC50 = 55 nM
   TI
   LI
   LO
   TS
CP0187300
(S)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C30H26F3N3O
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0506426
(S)-N-(2-(4-methoxybenzylamino)-2,3-dihydro-1H-inden-5-yl)-6-methyl-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C32H29F3N2O2
 1
1
IC50 = 120 nM
   TI
   LI
   LO
   TS
CP0493906
(S)-6-methyl-N-(2-(phenylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C30H25F3N2O
 1
1
IC50 = 130 nM
   TI
   LI
   LO
   TS
CP0538074
(S)-6-methyl-N-(2-((4-methylthiazol-5-yl)methylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C29H26F3N3OS
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0510097
(S)-6-methyl-N-(2-(quinolin-3-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C34H28F3N3O
 1
1
IC50 = 210 nM
   TI
   LI
   LO
   TS
CP0522513
(S)-6-methyl-N-(2-(pyridin-4-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C30H26F3N3O
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0136263
(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b-tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
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C27H41NO2
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0372890
(S)-N-(2-(4-acetamidobenzylamino)-2,3-dihydro-1H-inden-5-yl)-6-methyl-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C33H30F3N3O2
 1
1
IC50 = 340 nM
   TI
   LI
   LO
   TS
CP0372888
(R)-6-methyl-N-(2-(thiazol-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide
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C28H24F3N3OS
 1
1
IC50 = 770 nM
   TI
   LI
   LO
   TS
CP0452609
N-[2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]-2-[4-(trifluoromethyl)phenyl]benzamide
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C29H24F3N3O
 1
1
IC50 = 790 nM
   TI
   LI
   LO
   TS
CP0421787
2-phenyl-N-[2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl]benzamide
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C28H25N3O
 1
1
IC50 = 1150 nM
   TI
   LI
   LO
   TS
CP0372887
methyl N-[5-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-2,3-dihydro-1H-inden-2-yl]carbamate
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C26H23F3N2O3
 1
1
IC50 = 2700 nM
   TI
   LI
   LO
   TS
CP0245589
(R)-methyl 5-(6-methyl-4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)-2,3-dihydro-1H-inden-2-ylcarbamate
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C26H23F3N2O3
 1
1
IC50 = 3420 nM
   TI
   LI
   LO
   TS
CP0089850
(S)-methyl 5-(6-methyl-4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)-2,3-dihydro-1H-inden-2-ylcarbamate
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C26H23F3N2O3
 1
1
IC50 = 7520 nM
   TI
   LI
   LO
   TS