Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT04128 , C-C chemokine receptor type 2
Gene Name CCR2
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID P51683
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT04128
 
Compound ID Compound Name Compound Formula
CP0437369
1-ethyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C30H34F4N2O
 1
1
IC50 = 3.5 nM
   TI
   LI
   LO
   TS
CP0444505
(1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide
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C31H36F4N2O
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0428650
(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C32H38F4N2O
 1
1
IC50 = 7.5 nM
   TI
   LI
   LO
   TS
CP0425145
(1S,3R)-1-cyclopropyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C31H34F4N2O
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0425146
1-(cyclopropylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C32H36F4N2O
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0442366
(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide
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C32H36F6N2O
 1
1
IC50 = 15 nM
   TI
   LI
   LO
   TS
CP0522581
N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide
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C31H36F4N2O
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0525772
(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide
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C30H34F4N2OS
 1
1
IC50 = 17 nM
   TI
   LI
   LO
   TS
CP0428649
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-ethyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C31H34F6N2O
 1
1
IC50 = 17.5 nM
   TI
   LI
   LO
   TS
CP0437367
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C33H38F6N2O
 1
1
IC50 = 26 nM
   TI
   LI
   LO
   TS
CP0420176
(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide
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C32H36F6N2O
 1
1
IC50 = 44.3 nM
   TI
   LI
   LO
   TS
CP0535185
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-cyclopropyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C32H34F6N2O
 1
1
IC50 = 45 nM
   TI
   LI
   LO
   TS
CP0373631
(1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C29H32F4N2O
 1
1
IC50 = 57 nM
   TI
   LI
   LO
   TS
CP0427178
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(cyclopropylmethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C33H36F6N2O
 1
1
IC50 = 63.5 nM
   TI
   LI
   LO
   TS
CP0428648
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(cyclobutylmethyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C34H38F6N2O
 1
1
IC50 = 64 nM
   TI
   LI
   LO
   TS
CP0428698
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide
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C31H34F6N2OS
 1
1
IC50 = 65.5 nM
   TI
   LI
   LO
   TS
CP0522580
N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-1-(methoxymethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C30H34F4N2O2
 1
1
IC50 = 74 nM
   TI
   LI
   LO
   TS
CP0535186
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-(methoxymethyl)-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C31H34F6N2O2
 1
1
IC50 = 93 nM
   TI
   LI
   LO
   TS
CP0437368
(1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C30H32F6N2O
 1
1
IC50 = 126 nM
   TI
   LI
   LO
   TS
CP0373628
N-[[3-fluoro-5-(trifluoromethyl)phenyl]methyl]-1-hexyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C34H42F4N2O
 1
1
IC50 = 128 nM
   TI
   LI
   LO
   TS
CP0505434
(1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide
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C29H32F4N2OS
 1
1
IC50 = 193 nM
   TI
   LI
   LO
   TS
CP0433969
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1-hexyl-3-[(1S,3'R)-3'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide
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C35H42F6N2O
 1
1
IC50 = 279 nM
   TI
   LI
   LO
   TS
CP0433968
(1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide
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C30H32F6N2OS
 1
1
IC50 = 351 nM
   TI
   LI
   LO
   TS