Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01555 , Oxysterols receptor LXR-alpha
Gene Name NR1H3
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID Q13133
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01555
 
Compound ID Compound Name Compound Formula
CP0051600
2-(2-chloro-4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)phenyl)acetic acid
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C23H24ClF3N2O4
 1
1
EC50 = 170 nM
   TI
   LI
   LO
   TS
CP0099162
2-(2-oxo-1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)indolin-5-yl)acetic acid
   Show/Hide
C24H23F3N2O5
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0099161
2-(4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)phenyl)acetic acid
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C23H25F3N2O4
 1
1
EC50 = 450 nM
   TI
   LI
   LO
   TS
CP0171368
2-(1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indazol-5-yl)acetic acid
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C23H22F3N3O4
 1
1
EC50 = 480 nM
   TI
   LI
   LO
   TS
CP0154694
2-(5-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)pyrazin-2-yl)acetic acid
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C21H23F3N4O4
 1
1
EC50 = 540 nM
   TI
   LI
   LO
   TS
CP0179493
2-(1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)acetic acid
   Show/Hide
C24H23F3N2O4
 1
1
EC50 = 590 nM
   TI
   LI
   LO
   TS
CP0051604
2-(2-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)pyrimidin-5-yl)acetic acid
   Show/Hide
C21H23F3N4O4
 1
1
EC50 = 620 nM
   TI
   LI
   LO
   TS
CP0328071
3-(1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indol-5-yl)propanoic acid
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C25H25F3N2O4
 1
1
EC50 = 820 nM
   TI
   LI
   LO
   TS
CP0051591
2-(2-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)thiazol-5-yl)acetic acid
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C20H22F3N3O4S
 1
1
EC50 = 1100 nM
   TI
   LI
   LO
   TS
CP0200289
2-(2-methyl-4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)phenyl)acetic acid
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C24H27F3N2O4
 1
1
EC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0099133
1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-indole-5-carboxylic acid
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C23H21F3N2O4
 1
1
EC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0216283
2-(1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)-1H-benzo[d][1,2,3]triazol-5-yl)acetic acid
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C22H21F3N4O4
 1
1
EC50 = 2300 nM
   TI
   LI
   LO
   TS
CP0156187
2-(3-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)phenyl)acetic acid
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C23H25F3N2O4
 1
1
EC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0051589
2-oxo-1-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)indoline-5-carboxylic acid
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C23H21F3N2O5
 1
1
EC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0200285
2-(4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)-2-(trifluoromethyl)phenyl)acetic acid
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C24H24F6N2O4
 1
1
EC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0099132
2-(6-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)pyridin-3-yl)acetic acid
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C22H24F3N3O4
 1
1
EC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0079923
2-(3-chloro-4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propylthio)phenyl)acetic acid
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C22H21ClF3NO4S
 1
1
EC50 = 5900 nM
   TI
   LI
   LO
   TS
CP0190669
4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)benzoic acid
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C22H23F3N2O4
 1
1
EC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0051606
2-(4-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propylamino)phenyl)acetic acid
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C22H23F3N2O4
 1
1
EC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0394759
2-[4-({[3-(3-benzyl-8-chloroquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid
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C31H25ClN2O2
 1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CP0510893
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid
   Show/Hide
C32H23F3N2O3
 1
1
IC50 = 7 nM
   TI
   LI
   LO
   TS
CP0221684
2-{4-[({3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid
   Show/Hide
C32H25F3N2O2
 1
1
IC50 = 7.6 nM
   TI
   LI
   LO
   TS
CP0394761
2-{4-[({3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid
   Show/Hide
C31H23F3N2O2
 1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CP0394755
2-[4-({[3-(3-benzoyl-8-chloroquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid
   Show/Hide
C31H23ClN2O3
 1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CP0425193
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetamide
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C32H24F3N3O2
 1
1
IC50 = 11 nM
   TI
   LI
   LO
   TS
CP0434065
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}propanoic acid
   Show/Hide
C33H25F3N2O3
 1
1
IC50 = 15.2 nM
   TI
   LI
   LO
   TS
CP0530681
2-{4-[({3-[3-methyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid
   Show/Hide
C26H21F3N2O2
 1
1
IC50 = 16 nM
   TI
   LI
   LO
   TS
CP0431994
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}-2-methylpropanoic acid
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C34H27F3N2O3
 1
1
IC50 = 17.2 nM
   TI
   LI
   LO
   TS
CP0437270
2-[4-({[3-(3-benzoyl-8-methylquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid
   Show/Hide
C32H26N2O3
 1
1
IC50 = 18 nM
   TI
   LI
   LO
   TS
CP0431991
2-[4-({[3-(3-benzyl-8-methylquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid
   Show/Hide
C32H28N2O2
 1
1
IC50 = 21 nM
   TI
   LI
   LO
   TS
CP0436387
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}-2,2-difluoroacetic acid
   Show/Hide
C32H21F5N2O3
 1
1
IC50 = 30.2 nM
   TI
   LI
   LO
   TS
CP0394792
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}-2-hydroxyacetic acid
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C32H23F3N2O4
 1
1
IC50 = 33.6 nM
   TI
   LI
   LO
   TS
CP0434066
2-{3-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid
   Show/Hide
C32H23F3N2O3
 1
1
IC50 = 33.6 nM
   TI
   LI
   LO
   TS
CP0439549
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}ethan-1-ol
   Show/Hide
C32H25F3N2O2
 1
1
IC50 = 34 nM
   TI
   LI
   LO
   TS
CP0394791
2-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenoxy}acetic acid
   Show/Hide
C32H23F3N2O4
 1
1
IC50 = 63.9 nM
   TI
   LI
   LO
   TS
CP0510891
methyl alcohol analogue,39
   Show/Hide
C31H23F3N2O2
 1
1
IC50 = 90.5 nM
   TI
   LI
   LO
   TS
CP0434062
2-[4-({[3-(3-benzoyl-8-fluoroquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid
   Show/Hide
C31H23FN2O3
 1
1
IC50 = 104 nM
   TI
   LI
   LO
   TS
CP0434059
2-{4-[({3-[3-cyano-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid
   Show/Hide
C26H18F3N3O2
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0525916
3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]-N-benzylaniline
   Show/Hide
C30H21F3N2O
 1
1
IC50 = 241 nM
   TI
   LI
   LO
   TS
CP0394758
2-(4-{[(3-{3-[hydroxy(phenyl)methyl]-8-(trifluoromethyl)quinolin-4-yl}phenyl)amino]methyl}phenyl)acetic acid
   Show/Hide
C32H25F3N2O3
 1
1
IC50 = 384 nM
   TI
   LI
   LO
   TS
CP0425194
4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]benzoic acid
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C31H21F3N2O3
 1
1
IC50 = 420 nM
   TI
   LI
   LO
   TS
CP0436384
(5Z)-5-({4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}methylidene)-1,3-thiazolidine-2,4-dione
   Show/Hide
C34H22F3N3O3S
 1
1
IC50 = 456 nM
   TI
   LI
   LO
   TS
CP0855521
5-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl] benzylidene}-2-thioxo-1,3-thiazolidin-4-one
   Show/Hide
C34H22F3N3O2S2
 1
1
IC50 = 479 nM
   TI
   LI
   LO
   TS
CP0394756
2-[4-({[3-(3-benzoylquinolin-4-yl)phenyl]amino}methyl)phenyl]acetic acid
   Show/Hide
C31H24N2O3
 1
1
IC50 = 650 nM
   TI
   LI
   LO
   TS
CP0437268
2-{4-[({3-[3-carbamoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetic acid
   Show/Hide
C26H20F3N3O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0522252
(2E)-3-{4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}prop-2-enoic acid
   Show/Hide
C33H23F3N2O3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS