(2-morpholino-5-nitrophenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone

4-(4-(2-morpholino-5-nitrobenzoyl)piperazin-1-yl)benzonitrile

(4-(4-chlorophenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

1-(3-fluoro-4-(4-(2-(methylamino)-5-nitrobenzoyl)piperazin-1-yl)phenyl)ethanone

1-(4-(4-(2-(dimethylamino)-5-nitrobenzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

(4-(4-(methylsulfonyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

(4-(3-chlorophenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

(2-morpholino-5-nitrophenyl)(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)methanone

1-(4-(4-(2-amino-5-nitrobenzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

(2-morpholino-5-nitrophenyl)(4-m-tolylpiperazin-1-yl)methanone

1-(3-fluoro-4-(4-(5-nitro-2-(piperidin-1-yl)benzoyl)piperazin-1-yl)phenyl)ethanone

3-fluoro-4-(4-(2-morpholino-5-nitrobenzoyl)piperazin-1-yl)benzonitrile

1-(3-fluoro-4-(4-(2-morpholino-5-nitrobenzoyl)piperazin-1-yl)phenyl)ethanone

1-(4-(4-(5-bromo-2-morpholinobenzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

(2-morpholino-5-nitrophenyl)(4-p-tolylpiperazin-1-yl)methanone

(4-(3-methoxyphenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

1-(4-(4-(2-(cyclohexylamino)-5-nitrobenzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

1-(3-fluoro-4-(4-(2-(isopropylamino)-5-nitrobenzoyl)piperazin-1-yl)phenyl)ethanone

1-(3-fluoro-4-(4-(2-morpholino-5-(trifluoromethyl)benzoyl)piperazin-1-yl)phenyl)ethanone

(4-(2-chlorophenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

(4-(4-methoxyphenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-phenylisoindolin-2-yl)methanone

3-(4-(4-acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzonitrile

(4-(2-methoxyphenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

(2-morpholino-5-nitrophenyl)(4-o-tolylpiperazin-1-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-(pyrrolidin-1-yl)isoindolin-2-yl)methanone

(4-(3-fluoro-4-(trifluoromethyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

(4-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methanone

1-(3-fluoro-4-(4-(3-nitrobenzoyl)piperazin-1-yl)phenyl)ethanone

(4-(2-fluoro-4-(trifluoromethyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[3-methyl-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methanone

1-(3-fluoro-4-(4-(5-(methylsulfonyl)-2-morpholinobenzoyl)piperazin-1-yl)phenyl)ethanone

1-(4-(4-(2-sec-butoxy-5-(methylsulfonyl)benzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

1-(3-fluoro-4-(4-(3'-fluoro-4-(methylsulfonyl)biphenylcarbonyl)piperazin-1-yl)phenyl)ethanone

(4-(2-fluoro-4-(methylsulfonyl)phenyl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

(2-morpholino-5-nitrophenyl)(4-(2-(trifluoromethyl)phenyl)piperazin-1-yl)methanone

1-(3-fluoro-4-(4-(2-morpholino-5-(propylsulfonyl)benzoyl)piperazin-1-yl)phenyl)ethanone

1-(4-(4-(5-amino-2-morpholinobenzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

3-(4-(4-acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

1-(3-fluoro-4-(4-(5-methyl-2-morpholinobenzoyl)piperazin-1-yl)phenyl)ethanone

2-(4-(2-morpholino-5-nitrobenzoyl)piperazin-1-yl)-5-(trifluoromethyl)benzonitrile

1-(3-fluoro-4-(4-(4-(methylsulfonyl)biphenylcarbonyl)piperazin-1-yl)phenyl)ethanone

(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)(2-morpholino-5-nitrophenyl)methanone

1-(4-(4-(5-(benzylsulfonyl)-2-morpholinobenzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

1-(3-fluoro-4-(4-(2-(isopropylthio)-5-(methylsulfonyl)benzoyl)piperazin-1-yl)phenyl)ethanone

1-(3-fluoro-4-(4-(2-isopropoxy-5-(methylsulfonyl)benzoyl)piperazin-1-yl)phenyl)ethanone

1-(4-(4-(2-(cyclopropylmethoxy)-5-(methylsulfonyl)benzoyl)piperazin-1-yl)-3-fluorophenyl)ethanone

3-(4-(4-acetyl-2-fluorophenyl)piperazine-1-carbonyl)-N-methyl-4-morpholinobenzenesulfonamide

4-(4-(2-(cyclopropylmethoxy)-5-(methylsulfonyl)benzoyl)piperazin-1-yl)-3-fluorobenzonitrile

[2-[(2S)-3,3-dimethylbutan-2-yl]oxy-5-methylsulfonylphenyl]-[4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methanone

4-[4-(2-Cyclohexyloxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-benzonitrile

4-{4-[2-(2-Dimethylamino-ethoxy)-5-methanesulfonyl-benzoyl]-piperazin-1-yl}-3-fluorobenzonitrile

[4-(4-methylphenyl)piperazin-1-yl]-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]methanone

1-[4-[4-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)benzoyl]piperazin-1-yl]phenyl]ethanone

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]methanone

3-Fluoro-4-[4-(5-methanesulfonyl-2-methoxy-benzoyl)-piperazin-1-yl]-benzonitrile

4-[4-(2-Cyclohexylmethoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-benzonitrile

4-[4-(2-Benzyloxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-benzonitrile

3-Fluoro-4-{4-[5-methanesulfonyl-2-(tetrahydro-pyran-4-yloxy)-benzoyl]-piperazin-1-yl}-benzonitrile

4-[4-(2-Cyclopentyloxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-benzonitrile

4-[4-(2-Cyclobutoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-benzonitrile

[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]methanone

3-Fluoro-4-[4-(2-hydroxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

[4-[2-fluoro-4-(trifluoromethyl)phenyl]piperazin-1-yl]-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]methanone

4-[4-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)benzoyl]piperazin-1-yl]benzonitrile

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[2-(trifluoromethyl)pyrimidin-5-yl]piperazin-1-yl]methanone

[4-(4-methylsulfonylphenyl)piperazin-1-yl]-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]methanone

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[6-(trifluoromethyl)pyridazin-3-yl]piperazin-1-yl]methanone

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]methanone

3-Fluoro-4-[4-(2-isobutoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

3-Fluoro-4-{4-[5-methanesulfonyl-2-(2,2,2-trifluoro-ethoxy)-benzoyl]-piperazin-1-yl}-benzonitrile

[4-[2-chloro-4-(trifluoromethyl)phenyl]piperazin-1-yl]-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]methanone

3-Fluoro-4-[4-(2-isopropoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

4-[4-(2-Ethoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-3-fluoro-benzonitrile

3-fluoro-4-[4-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)benzoyl]piperazin-1-yl]benzonitrile

3-Fluoro-4-[4-(5-methanesulfonyl-2-propoxy-benzoyl)-piperazin-1-yl]-benzonitrile

[4-(4-methoxyphenyl)piperazin-1-yl]-[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]methanone

[2-[(2R)-3,3-dimethylbutan-2-yl]oxy-5-methylsulfonylphenyl]-[4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methanone

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[6-(trifluoromethyl)pyridin-3-yl]piperazin-1-yl]methanone

[5-methylsulfonyl-2-(1,1,1-trifluoropropan-2-yloxy)phenyl]-[4-[5-(trifluoromethyl)pyrazin-2-yl]piperazin-1-yl]methanone

rac-4-(3-Fluoro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-[5-methanesulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)phenyl]-methanone

(2-isobutoxy-5-(methylsulfonyl)phenyl)(3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(5-(methylsulfonyl)-2-(3,3,3-trifluoropropoxy)phenyl)(3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(3',4'-difluoro-4-(methylsulfonyl)biphenyl-2-yl)(3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(S)-(4-methylisoindolin-2-yl)(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(6-(trifluoromethyl)-1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-morpholinoisoindolin-2-yl)methanone

(S)-(5-methoxyisoindolin-2-yl)(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)methanone

(S)-(4-methoxyisoindolin-2-yl)(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)methanone

(2-isopropoxy-5-(methylsulfonyl)phenyl)(5-(tetrahydro-2H-pyran-4-yl)isoindolin-2-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(5-(methylsulfonyl)-2-((S)-1,1,1-trifluoropropan-2-yloxy)phenyl)(5-(tetrahydro-2H-pyran-2-yl)isoindolin-2-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-(pyridin-4-yl)isoindolin-2-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(2-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(S)-2-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)benzoyl)isoindoline-4-carbonitrile

(5-(methylsulfonyl)-2-morpholinophenyl)(3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(4'-fluoro-4-(methylsulfonyl)biphenyl-2-yl)(5-(tetrahydro-2H-pyran-4-yl)isoindolin-2-yl)methanone

(2-(benzyloxy)-5-(methylsulfonyl)phenyl)(3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(S)-(5-(4-methylpiperazin-1-yl)isoindolin-2-yl)(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)methanone

(S)-isoindolin-2-yl(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)methanone

(5-(methylsulfonyl)-2-(3,3,3-trifluoropropoxy)phenyl)(5-(tetrahydro-2H-pyran-4-yl)isoindolin-2-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-(pyridin-2-yl)isoindolin-2-yl)methanone

(2-isopropoxy-5-(methylsulfonyl)phenyl)(3-(trifluoromethyl)-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-(tetrahydro-2H-pyran-4-yl)isoindolin-2-yl)methanone

(S)-(5-(methylsulfonyl)-2-(1,1,1-trifluoropropan-2-yloxy)phenyl)(5-(trifluoromethyl)isoindolin-2-yl)methanone