Brief Information of the Cell Line and Protein
Cell Line ID: CL000011 , CHO
Synonyms
Chinese Hamster Ovary
CHO-ori
Category Spontaneously immortalized cell line
Organism
Cricetulus griseus (Chinese hamster)
Cellosaurus ID
CVCL_0213
Protein ID: PT01026 , Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Organism Homo sapiens, Human
Protein Classification Transporter
Uniprot ID P23975
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000011  Protein ID: PT01026
 
Compound ID Compound Name Compound Formula
CP0446388
2-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]pyridazin-3-one;hydrochloride
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C16H18Cl2FN3O2
 1
1
IC50 = 0.065 nM
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CP0419397
1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]pyridin-2-one;hydrochloride
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C17H19Cl2FN2O2
 1
1
IC50 = 0.079 nM
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CP0424796
1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-1,3-diazinan-2-one;hydrochloride
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C16H22Cl2FN3O2
 1
1
IC50 = 0.08 nM
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CP0419414
1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]piperidin-2-one;hydrochloride
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C17H23Cl2FN2O2
 1
1
IC50 = 0.1 nM
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CP0399274
1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]pyrrolidin-2-one;hydrochloride
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C16H21Cl2FN2O2
 1
1
IC50 = 0.13 nM
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CP0380158
methyl 1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-2-oxopyridine-3-carboxylate;hydrochloride
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C19H21Cl2FN2O4
 1
1
IC50 = 0.21 nM
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CP0380067
1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-3-(5-methyl-1H-1,2,4-triazol-3-yl)pyridin-2-one;hydrochloride
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C20H22Cl2FN5O2
 1
1
IC50 = 0.64 nM
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CP0424798
3-[1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-2-oxopyridin-3-yl]-4H-1,2,4-oxadiazol-5-one;hydrochloride
   Show/Hide
C19H19Cl2FN4O4
 1
1
IC50 = 1 nM
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CP0424797
1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-2-oxopyridine-3-carboxylic acid;hydrochloride
   Show/Hide
C18H19Cl2FN2O4
 1
1
IC50 = 1.1 nM
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CP0455079
1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-3-(2H-tetrazol-5-yl)pyridin-2-one;hydrochloride
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C18H19Cl2FN6O2
 1
1
IC50 = 1.4 nM
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CP0064605
3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
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C19H21N
 5
1
IC50 = 1.7 nM
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2
IC50 = 2.8 nM
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3
IC50 = 2.9 nM
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4
Ki = 2 nM
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5
Ki = 2.1 nM
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CP0380065
3-[1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-2-oxopyridin-4-yl]-4H-1,2,4-oxadiazol-5-one;hydrochloride
   Show/Hide
C19H19Cl2FN4O4
 1
1
IC50 = 1.9 nM
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CP0873467
N-(((6S,7R)-7-(4-Chloro-3-fluorophenyl)-1,4-oxazepan-6-yl)methyl)acetamide monohydrochloride
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C14H19Cl2FN2O2
 1
1
IC50 = 2.3 nM
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CP0187236
(3S)-3-methyl-1-naphthalen-2-yl-1,4-diazepan-2-one;hydrochloride
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C16H19ClN2O
 1
1
IC50 = 3.8 nM
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CP0754937
Rac-1-(3,4-dichlorophenyl)-3-ethyl-1,4-diazepan-2-one hydrochloride
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C13H17Cl3N2O
 1
1
IC50 = 7.7 nM
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CP0686869
Rac-1-(3,4-dichlorophenyl)-3-methyl-1,4-diazepan-2-one hydrochloride
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C12H15Cl3N2O
 1
1
IC50 = 8 nM
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CP0336241
4-[1-(3,4-dichlorophenyl)-2-ethylsulfanylethyl]piperidine;hydrochloride
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C15H22Cl3NS
 1
1
IC50 = 8.7 nM
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CP0686870
Rac-3-ethyl-1-(naphthalen-2-yl)-1,4-diazepan-2-one hydrochloride
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C17H21ClN2O
 1
1
IC50 = 9.2 nM
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CP0351318
4-[1-(3,4-dichlorophenyl)-2-methylsulfanylethyl]piperidine;hydrochloride
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C14H20Cl3NS
 1
1
IC50 = 9.3 nM
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CP0043371
ethyl 2-(3,4-dichlorophenyl)-2-piperidin-4-ylacetate;hydrochloride
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C15H20Cl3NO2
 1
1
IC50 = 12 nM
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CP0113559
1-(3,4-dichlorophenyl)-1,4-diazepan-2-one;hydrochloride
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C11H13Cl3N2O
 1
1
IC50 = 13 nM
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CP0087527
4-[1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine;hydrochloride
   Show/Hide
C14H20Cl3NO
 1
1
IC50 = 14 nM
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CP0686868
Rac-3-methyl-1-(naphthalen-2-yl)-1,4-diazepan-2-one hydrochloride
   Show/Hide
C16H19ClN2O
 1
1
IC50 = 14 nM
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CP0070380
4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine;hydrochloride
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C14H20Cl3NO
 1
1
IC50 = 15 nM
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CP0043462
methyl 2-(3,4-dichlorophenyl)-2-piperidin-4-ylacetate;hydrochloride
   Show/Hide
C14H18Cl3NO2
 1
1
IC50 = 18 nM
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CP0444267
4-[(1R)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine;hydrochloride
   Show/Hide
C14H20Cl3NO
 1
1
IC50 = 21 nM
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CP0043374
1-(3,4-dichlorophenyl)-1-piperidin-4-ylpentan-2-one;hydrochloride
   Show/Hide
C16H22Cl3NO
 1
1
IC50 = 22 nM
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CP0043463
4-[1-(3,4-dichlorophenyl)ethyl]piperidine;hydrochloride
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C13H18Cl3N
 1
1
IC50 = 25 nM
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CP0424799
3-[1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-6-oxopyridin-3-yl]-4H-1,2,4-oxadiazol-5-one;hydrochloride
   Show/Hide
C19H19Cl2FN4O4
 1
1
IC50 = 25 nM
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CP0149350
4-[1-(3,4-dichlorophenyl)-2-ethoxyethyl]piperidine;hydrochloride
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C15H22Cl3NO
 1
1
IC50 = 28 nM
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CP0176395
1-(3,4-dichlorophenyl)-1-piperidin-4-ylbutan-2-one;hydrochloride
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C15H20Cl3NO
 1
1
IC50 = 28 nM
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CP0106864
4-(2-methoxy-1-naphthalen-2-ylethyl)piperidine;hydrochloride
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C18H24ClNO
 1
1
IC50 = 36 nM
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CP0327222
1-(3,4-dichlorophenyl)-1-piperidin-4-ylpropan-2-one;hydrochloride
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C14H18Cl3NO
 1
1
IC50 = 44 nM
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CP0330843
4-[1-(3-chloro-4-fluorophenyl)-2-methoxyethyl]piperidine;hydrochloride
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C14H20Cl2FNO
 1
1
IC50 = 70 nM
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CP0666771
(1R,5S)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride
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C11H12Cl3N
 1
1
IC50 = 71 nM
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CP0445840
8-(3,4-dichlorophenyl)-5,8-diazaspiro[2.6]nonan-7-one;hydrochloride
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C13H15Cl3N2O
 1
1
IC50 = 82 nM
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CP0345296
4-[1-(3-chlorophenyl)-2-methoxyethyl]piperidine;hydrochloride
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C14H21Cl2NO
 1
1
IC50 = 98 nM
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CP0424795
3-[1-[[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl]-6-oxopyridin-2-yl]-4H-1,2,4-oxadiazol-5-one;hydrochloride
   Show/Hide
C19H19Cl2FN4O4
 1
1
IC50 = 100 nM
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CP0101383
2-(3,4-dichlorophenyl)-2-piperidin-4-ylethanol;hydrochloride
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C13H18Cl3NO
 1
1
IC50 = 110 nM
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CP0149347
dimethylamino 2-(3,4-dichlorophenyl)-2-piperidin-4-ylacetate;hydrochloride
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C15H21Cl3N2O2
 1
1
IC50 = 120 nM
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CP0176393
4-[1-(4-chlorophenyl)-2-methoxyethyl]piperidine;hydrochloride
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C14H21Cl2NO
 1
1
IC50 = 130 nM
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CP0847605
cis-N-(3-(4-(dimethylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
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C21H27ClN4S
 1
1
IC50 = 160 nM
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CP0139333
3-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(3,4-dichlorophenyl)propan-1-ol
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C21H23Cl2NO
 1
1
IC50 = 178 nM
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CP0075191
4-[1-(3,4-dichlorophenyl)-2-methylsulfonylethyl]piperidine;hydrochloride
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C14H20Cl3NO2S
 1
1
IC50 = 200 nM
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CP0445839
1-(3,4-dichlorophenyl)-6-methyl-1,4-diazepan-2-one;hydrochloride
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C12H15Cl3N2O
 1
1
IC50 = 260 nM
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CP0175021
4-benzyl-1-[3-(3,4-dichlorophenyl)-3-hydroxypropyl]piperidin-4-ol
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C21H25Cl2NO2
 1
1
IC50 = 265 nM
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CP0875724
(+/-)-N-(3-(4-(ethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C21H25ClN4S
 1
1
IC50 = 280 nM
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CP0111325
1-(1-benzothiophen-2-yl)-3-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)propan-1-ol
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C23H25NOS
 1
1
IC50 = 327 nM
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CP0704704
cis-N-(3-(4-(ethylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
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C21H27ClN4S
 1
1
IC50 = 380 nM
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CP0139332
1-(1-benzothiophen-3-yl)-3-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)propan-1-ol
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C23H25NOS
 1
1
IC50 = 385 nM
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CP0704838
cis-N-(3-(4-(methylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C20H25ClN4S
 1
1
IC50 = 400 nM
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CP0147595
3-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-ol
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C26H28ClNO2
 1
1
IC50 = 420 nM
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CP0504788
(1S,2S)-2-(4-benzyl-3,6-dihydro-2H-pyridin-1-yl)-1-(3,4-dichlorophenyl)propan-1-ol
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C21H23Cl2NO
 1
1
IC50 = 531 nM
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CP0445837
(3R)-3-methyl-1-naphthalen-2-yl-1,4-diazepan-2-one;hydrochloride
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C16H19ClN2O
 1
1
IC50 = 570 nM
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CP0379413
1-(3,4-dichlorophenyl)-7-methyl-1,4-diazepan-2-one;hydrochloride
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C12H15Cl3N2O
 1
1
IC50 = 660 nM
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CP0870508
trans-(+/-)-N-(3-(3-(Ethylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C21H27ClN4S
 1
1
IC50 = 760 nM
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CP0504790
4-benzyl-1-[3-(5-chloro-6-methoxynaphthalen-2-yl)-3-hydroxypropyl]piperidin-4-ol
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C26H30ClNO3
 1
1
IC50 = 800 nM
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CP0861066
trans-(+/-)-N-(3-(3-(methylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C20H25ClN4S
 1
1
IC50 = 880 nM
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CP0035807
Cocaine
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C17H21NO4
 1
1
IC50 = 900 nM
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CP0913091
(+/-)-N-(3-(4-(methylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C20H23ClN4S
 1
1
IC50 = 1300 nM
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CP0667837
cis-(+/-)-N-(3-(3-(Ethylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C21H27ClN4S
 1
1
IC50 = 1700 nM
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CP0053138
1-(3,4-dichlorophenyl)-5-methyl-1,4-diazepan-2-one;hydrochloride
   Show/Hide
C12H15Cl3N2O
 1
1
IC50 = 1700 nM
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CP0913090
trans-N-(3-(4-(methylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C20H25ClN4S
 1
1
IC50 = 2000 nM
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CP0445838
1-(3,4-dichlorophenyl)-6,6-difluoro-1,4-diazepan-2-one;hydrochloride
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C11H11Cl3F2N2O
 1
1
IC50 = 2000 nM
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CP0913093
trans-N-(3-(4-(dimethylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C21H27ClN4S
 1
1
IC50 = 2200 nM
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CP0873763
cis-(+/-)-N-(3-(3-(methylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C20H25ClN4S
 1
1
IC50 = 2400 nM
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CP0871713
trans-N-(3-(4-(ethylamino)cyclohexyl)-1H-indol-5-yl)thiophene-2-carboximidamide hydrochloride
   Show/Hide
C21H27ClN4S
 1
1
IC50 = 2800 nM
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CP0692263
1-(3,4-dichlorophenyl)-4-methyl-1,4-diazepan-2-one hydrochloride
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C12H15Cl3N2O
 1
1
IC50 = 3200 nM
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CP0387862
N'-[1-[4-(methylamino)cyclohexyl]-2,3-dihydroindol-6-yl]thiophene-2-carboximidamide
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C20H26N4S
 1
1
IC50 = 4400 nM
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CP0933737
bip-tyr-thr-ala-pro-phe
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C45H52N6O10
 1
1
IC50 = 25000 nM
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CP0449426
(2S)-2-amino-3-[4-[4-[(3S)-3-amino-4-[[(2S)-1-[[(2S,3R)-1-[(2S)-2-[[(2S,3R)-1-(carboxymethylamino)-1-oxo-3-phenylmethoxybutan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-oxobutan-2-yl]phenyl]phenyl]propanoic acid
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C50H61N7O12
 1
1
IC50 = 90000 nM
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