| Compound ID |
Compound Name |
Compound Formula |
|
CP0510908
|
6-[5-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-1,5-benzoxazepin-8-yl]pyridine-2-carboxamide
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|
C22H18F3N3O2
|
1
|
| 1 |
IC50 = 340 nM
|
|
|
|
CP0504533
|
6-[1-[4-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1-benzazepin-7-yl]pyridine-2-carboxamide
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|
C23H20F3N3O
|
1
|
| 1 |
IC50 = 360 nM
|
|
|
|
CP0286809
|
(1S)-1-[6-[5-methyl-3-(trifluoromethyl)-6H-benzo[b][1,4]benzoxazepin-8-yl]pyridin-2-yl]ethane-1,2-diol
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|
C22H19F3N2O3
|
1
|
| 1 |
IC50 = 370 nM
|
|
|
|
CP0271294
|
6-[4-acetyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridine-2-carboxamide
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|
C24H21F3N4O2
|
1
|
| 1 |
IC50 = 380 nM
|
|
|
|
CP0547742
|
6-[1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-4,1-benzoxazepin-7-yl]pyridine-2-carboxamide
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|
C22H18F3N3O2
|
1
|
| 1 |
IC50 = 400 nM
|
|
|
|
CP0504535
|
(1S)-1-[6-[4-methylsulfonyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol
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|
C24H24F3N3O4S
|
1
|
| 1 |
IC50 = 470 nM
|
|
|
|
CP0488270
|
2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetonitrile
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|
C25H23F3N4O2
|
1
|
| 1 |
IC50 = 580 nM
|
|
|
|
CP0259741
|
6-[4-methyl-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridine-2-carboxamide
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|
C23H21F3N4O
|
1
|
| 1 |
IC50 = 610 nM
|
|
|
|
CP0066012
|
2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]-N-methylacetamide
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|
C26H27F3N4O3
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0066011
|
1-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]ethanone
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|
C25H24F3N3O3
|
1
|
| 1 |
IC50 = 660 nM
|
|
|
|
CP0388927
|
(1S)-1-[6-[4-(1H-imidazol-2-ylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol
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|
C27H26F3N5O2
|
1
|
| 1 |
IC50 = 670 nM
|
|
|
|
CP0325805
|
US9174999, Table 1, Compound 1
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|
C10H17N7O4
|
1
|
| 1 |
IC50 = 702 nM
|
|
|
|
CP0560835
|
6-(3-chloro-11-methyl-5,6-dihydrobenzo[b][1]benzazepin-8-yl)pyridine-2-carboxamide
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|
C21H18ClN3O
|
1
|
| 1 |
IC50 = 840 nM
|
|
|
|
CP0504532
|
6-[1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-quinolin-6-yl]pyridine-2-carboxamide
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|
C22H18F3N3O
|
1
|
| 1 |
IC50 = 910 nM
|
|
|
|
CP0066014
|
7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepine-4-carboxamide
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|
C24H23F3N4O3
|
1
|
| 1 |
IC50 = 970 nM
|
|
|
|
CP0420369
|
(1S)-1-[6-[5-methyl-8-(trifluoromethyl)-6H-benzo[b][1,4]benzoxazepin-3-yl]pyridin-2-yl]ethane-1,2-diol
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|
C22H19F3N2O3
|
1
|
| 1 |
IC50 = 1030 nM
|
|
|
|
CP0152366
|
2-[7-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-4-yl]acetamide
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|
C25H25F3N4O3
|
1
|
| 1 |
IC50 = 1050 nM
|
|
|
|
CP0283937
|
(2R,3S)-2,3-dihydroxy-3-[6-[5-methyl-3-(trifluoromethyl)-6H-benzo[b][1,4]benzoxazepin-8-yl]pyridin-2-yl]propanamide
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|
C23H20F3N3O4
|
1
|
| 1 |
IC50 = 1050 nM
|
|
|
|
CP0283936
|
(1S)-1-[6-[11-methyl-3-(trifluoromethyl)-5,6-dihydrobenzo[b][1]benzazepin-8-yl]pyridin-2-yl]ethane-1,2-diol
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|
C23H21F3N2O2
|
1
|
| 1 |
IC50 = 1080 nM
|
|
|
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CP0066013
|
(1S)-1-[6-[4-(cyclopropylmethyl)-1-[4-(trifluoromethyl)phenyl]-3,5-dihydro-2H-1,4-benzodiazepin-7-yl]pyridin-2-yl]ethane-1,2-diol
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|
C27H28F3N3O2
|
1
|
| 1 |
IC50 = 1320 nM
|
|
|
|
CP0566575
|
2-[8-[6-[(1S)-1,2-dihydroxyethyl]pyridin-2-yl]-3-(trifluoromethyl)-6H-benzo[b][1,4]benzoxazepin-5-yl]acetamide
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|
C23H20F3N3O4
|
1
|
| 1 |
IC50 = 1800 nM
|
|
|
|
CP0504534
|
6-[1-[4-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1,4-benzodiazepin-7-yl]pyridine-2-carboxamide
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|
C22H19F3N4O
|
1
|
| 1 |
IC50 = 1920 nM
|
|
|
|
CP0294578
|
6-(3-chloro-6,11-dihydro-5H-benzo[b][1]benzazepin-8-yl)pyridine-2-carboxamide
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|
C20H16ClN3O
|
1
|
| 1 |
IC50 = 1960 nM
|
|
|
|
CP0386203
|
(1S)-1-[6-[3-(trifluoromethyl)-5,6-dihydrobenzo[b][1,4]benzoxazepin-8-yl]pyridin-2-yl]ethane-1,2-diol
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|
C21H17F3N2O3
|
1
|
| 1 |
IC50 = 2570 nM
|
|
|
|
CP0369072
|
6-(11-acetyl-3-chloro-5,6-dihydrobenzo[b][1]benzazepin-8-yl)pyridine-2-carboxamide
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|
C22H18ClN3O2
|
1
|
| 1 |
IC50 = 7620 nM
|
|
|
|
CP0541000
|
6-(3-chloro-11-ethyl-5,6-dihydrobenzo[b][1]benzazepin-8-yl)pyridine-2-carboxamide
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|
C22H20ClN3O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0510907
|
6-[1-[4-(trifluoromethyl)phenyl]-2,3-dihydroindol-5-yl]pyridine-2-carboxamide
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|
C21H16F3N3O
|
1
|
| 1 |
IC50 > 20000 nM
|
|
|
