| Compound ID |
Compound Name |
Compound Formula |
|
CP0403390
|
US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzylamino)-N-(9- chloro-3,3-difluoro-3,4-dihydro- 2H-1,5-benzodioxepin-7- ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H33ClN2O4
|
1
|
| 1 |
Ki = 1.15 nM
|
|
|
|
CP0411934
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 3.29 nM
|
|
|
|
CP0422502
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H38ClN3O2
|
1
|
| 1 |
Ki = 3.68 nM
|
|
|
|
CP0429202
|
US8722896, (+/-)-2-Methyl-3-((3- acetoxy)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H35ClN2O5
|
1
|
| 1 |
Ki = 3.84 nM
|
|
|
|
CP0406923
|
US8722896, (-)-(3R)-1-(3-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0385679
|
US8722896, (+/-)-(3R)-4-(Indol-7-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-2- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 4.02 nM
|
|
|
|
CP0414108
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H40ClN3O2
|
1
|
| 1 |
Ki = 4.6 nM
|
|
|
|
CP0567086
|
US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 4.7 nM
|
|
|
|
CP0409756
|
US8722896, (-)-(3R)-1-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpiperidine- 3-carboxamide
Show/Hide
|
C31H40ClN3O2
|
1
|
| 1 |
Ki = 4.72 nM
|
|
|
|
CP0425068
|
US8722896, (+/-)-4-(Indolin-4-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H36ClN3O4
|
1
|
| 1 |
Ki = 4.8 nM
|
|
|
|
CP0411918
|
US8722896, (+/-)-4-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H35ClN2O5
|
1
|
| 1 |
Ki = 5.46 nM
|
|
|
|
CP0435225
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)- N-(9-chloro-3,3-difluoro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H32ClF2N3O3
|
1
|
| 1 |
Ki = 5.5 nM
|
|
|
|
CP0395052
|
US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 6 nM
|
|
|
|
CP0413772
|
US8722896, (+/-)-(3R)-4-(Indol-4-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 6.62 nM
|
|
|
|
CP0527454
|
US8722896, (-)-(2R)-2-Methyl-3-(indol-7- ylmethylamino)-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H34N4O3
|
1
|
| 1 |
Ki = 6.68 nM
|
|
|
|
CP0381728
|
US8722896, (+/-)-2-Methyl-3-((2- methoxybenzyl)methylamino)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O4
|
1
|
| 1 |
Ki = 7.26 nM
|
|
|
|
CP0573516
|
US8722896, (-)-(3R)-1-(4-Fluoro-2- methoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H34ClFN2O4
|
1
|
| 1 |
Ki = 7.72 nM
|
|
|
|
CP0402986
|
US8722896, (+/-)-(3R)-1-(3-acetoxybenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-3- carboxamide
Show/Hide
|
C28H35ClN2O6
|
1
|
| 1 |
Ki = 8.5 nM
|
|
|
|
CP0487018
|
US8722896, (-)-(3R)-1-(4-Fluoro-3- methoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H36ClFN2O4
|
1
|
| 1 |
Ki = 8.68 nM
|
|
|
|
CP0409766
|
US8722896, (-)-(3R)-1-(1-Methyl-indol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 8.82 nM
|
|
|
|
CP0474714
|
US8722896, (-)-(3R)-1-(N-Methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 9.08 nM
|
|
|
|
CP0385771
|
US8722896, (+/-)-(3R)-4-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylmorphoine- 2-carboxamide
Show/Hide
|
C30H38ClN3O3
|
1
|
| 1 |
Ki = 9.18 nM
|
|
|
|
CP0536418
|
US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpiperidine- 3-carboxamide
Show/Hide
|
C31H40ClN3O2
|
1
|
| 1 |
Ki = 9.42 nM
|
|
|
|
CP0538202
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H35ClN2O4
|
1
|
| 1 |
Ki = 9.42 nM
|
|
|
|
CP0422560
|
US8722896, (-)-(3R)-1-(4-Fluoro-3- methoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H34ClFN2O4
|
1
|
| 1 |
Ki = 9.66 nM
|
|
|
|
CP0470369
|
US8722896, (+/-)-(3R)-4-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylmorphoine- 2-carboxamide
Show/Hide
|
C30H38ClN3O3
|
1
|
| 1 |
Ki = 9.94 nM
|
|
|
|
CP0382564
|
US8722896, (+/-)-(3R)-2-Methyl-3-(indolin-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H36ClN3O3
|
1
|
| 1 |
Ki = 10.3 nM
|
|
|
|
CP0434730
|
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-fluoro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35FN2O4
|
1
|
| 1 |
Ki = 10.4 nM
|
|
|
|
CP0409925
|
US8722896, (-)-(3R)-1-(2-Acetoxybenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H35ClN2O5
|
1
|
| 1 |
Ki = 10.8 nM
|
|
|
|
CP0434740
|
US8722896, (-)-(3R)-1-(2,3- Dimethylbenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 11.6 nM
|
|
|
|
CP0470124
|
US8722896, (-)-(3R)-1-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C30H38ClN3O2
|
1
|
| 1 |
Ki = 11.6 nM
|
|
|
|
CP0544843
|
US8722896, (+/-)-2-Methyl-3-((3-methoxy-4- fluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H34ClFN2O4
|
1
|
| 1 |
Ki = 11.6 nM
|
|
|
|
CP0425071
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H38ClN3O2
|
1
|
| 1 |
Ki = 11.7 nM
|
|
|
|
CP0524271
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1,4- benzodioxin-5-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H35ClN2O5
|
1
|
| 1 |
Ki = 12.2 nM
|
|
|
|
CP0401174
|
US8722896, (+/-)-4-(N-methyl-indol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H36ClN3O4
|
1
|
| 1 |
Ki = 12.5 nM
|
|
|
|
CP0407215
|
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H36N2O4
|
1
|
| 1 |
Ki = 12.8 nM
|
|
|
|
CP0415779
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 12.8 nM
|
|
|
|
CP0409929
|
US8722896, (+/-)-2-Methyl-3-((2,3- dimethyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 13 nM
|
|
|
|
CP0407112
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O2
|
1
|
| 1 |
Ki = 15.4 nM
|
|
|
|
CP0409780
|
US8722896, (-)-(3R)-1-(N-methyl-indolin-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H40ClN3O3
|
1
|
| 1 |
Ki = 15.8 nM
|
|
|
|
CP0546621
|
US8722896, (+/-)-2-Methyl-3-(N-methyl-indol- 7-ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 16.5 nM
|
|
|
|
CP0407648
|
US8722896, (+/-)-4-(Indol-4-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H34ClN3O4
|
1
|
| 1 |
Ki = 17.2 nM
|
|
|
|
CP0527445
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 17.4 nM
|
|
|
|
CP0414708
|
US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 17.8 nM
|
|
|
|
CP0438210
|
US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C30H38ClN3O2
|
1
|
| 1 |
Ki = 18.5 nM
|
|
|
|
CP0473452
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H41ClN2O2
|
1
|
| 1 |
Ki = 18.7 nM
|
|
|
|
CP0409888
|
US8722896, (-)-(3R)-1-(3-Hydroxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 19.1 nM
|
|
|
|
CP0431780
|
US8722896, (+/-)-2-Methyl-3-((2- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O3
|
1
|
| 1 |
Ki = 19.6 nM
|
|
|
|
CP0549773
|
US8722896, (-)-(3R)-1-(2,3-Dimethylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 20.2 nM
|
|
|
|
CP0538643
|
US8722896, (+/-)-4-(Indolin-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H36ClN3O4
|
1
|
| 1 |
Ki = 20.4 nM
|
|
|
|
CP0550771
|
US8722896, (+/-)-2-Methyl-3-(indolin-7- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5-benzo dioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H36ClN3O3
|
1
|
| 1 |
Ki = 21.2 nM
|
|
|
|
CP0547963
|
US8722896, (+/-)-2-Methyl-3- (benzylmethylamino)-N-(9- chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O2
|
1
|
| 1 |
Ki = 21.8 nM
|
|
|
|
CP0547645
|
US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H40ClN3O2
|
1
|
| 1 |
Ki = 22 nM
|
|
|
|
CP0420479
|
US8722896, (-)-(3R)-1-(N-methyl-indolin-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpiperidine- 3-carboxamide
Show/Hide
|
C31H42ClN3O2
|
1
|
| 1 |
Ki = 22.4 nM
|
|
|
|
CP0440530
|
US8722896, (-)-(3R)-1-(3-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 23.4 nM
|
|
|
|
CP0441441
|
US8722896, (-)-(3R)-1-(3-Amino-4- fluorobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H33ClFN3O3
|
1
|
| 1 |
Ki = 24 nM
|
|
|
|
CP0406213
|
US8722896, (+/-)-4-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H36ClN3O4
|
1
|
| 1 |
Ki = 24.4 nM
|
|
|
|
CP0469307
|
US8722896, (+/-)-4-(N-methyl-indolin-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H38ClN3O4
|
1
|
| 1 |
Ki = 24.8 nM
|
|
|
|
CP0414002
|
US8722896, (-)-(3R)-1-(2,3-Dimethylbenzyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O2
|
1
|
| 1 |
Ki = 25.2 nM
|
|
|
|
CP0488978
|
US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H38ClN3O3
|
1
|
| 1 |
Ki = 26.6 nM
|
|
|
|
CP0532713
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H37ClN2O4
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0411361
|
US8722896, (-)-(3R)-1-(2-Methylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 29.2 nM
|
|
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CP0527426
|
US8722896, (-)-(3R)-1-(3-Methylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 29.4 nM
|
|
|
|
CP0414706
|
US8722896, (-)-(3R)-1-(3-Methylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O3
|
1
|
| 1 |
Ki = 29.6 nM
|
|
|
|
CP0429710
|
US8722896, (+/-)-4-(N-methyl-indolin-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C29H38ClN3O4
|
1
|
| 1 |
Ki = 30.6 nM
|
|
|
|
CP0460112
|
US8722896, (-)-(3R)-1-(N-methyl-indolin-7- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpyrrolidine- 3-carboxamide
Show/Hide
|
C30H40ClN3O2
|
1
|
| 1 |
Ki = 31.4 nM
|
|
|
|
CP0539313
|
US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H34ClN3O3
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0395039
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O2
|
1
|
| 1 |
Ki = 33.2 nM
|
|
|
|
CP0573324
|
US8722896, (+/-)-2-Methyl-3-(2,5- dimethylbenzylmethylamino)-N- (9-chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H39ClN2O2
|
1
|
| 1 |
Ki = 35.2 nM
|
|
|
|
CP0470066
|
US8722896, (-)-(3R)-1-(N-methyl-indolin-4- ylmethyl)-N-(9-chloro-2,3,4,5- tetrahydro-1-benzoxepin-7- ylmethyl)-N-isobutylpiperidine- 3-carboxamide
Show/Hide
|
C31H42ClN3O2
|
1
|
| 1 |
Ki = 36.2 nM
|
|
|
|
CP0403001
|
US8722896, (-)-(3R)-1-(2-Flurobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClFN2O3
|
1
|
| 1 |
Ki = 37.2 nM
|
|
|
|
CP0515366
|
US8722896, (+/-)-4-(2-Methylbenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C27H35ClN2O4
|
1
|
| 1 |
Ki = 37.4 nM
|
|
|
|
CP0527419
|
US8722896, (+/-)-2-Methyl-3-((2,5- dimethyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 37.4 nM
|
|
|
|
CP0438258
|
US8722896, (-)-(2R)-2-Ethyl-3-(indol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O3
|
1
|
| 1 |
Ki = 37.6 nM
|
|
|
|
CP0407056
|
US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H36ClN3O3
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0440553
|
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H38N2O4
|
1
|
| 1 |
Ki = 38.6 nM
|
|
|
|
CP0407661
|
US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 38.8 nM
|
|
|
|
CP0538191
|
US8722896, (+/-)-2-Methyl-3-(indan-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 40.4 nM
|
|
|
|
CP0550615
|
US8722896, (-)-(3R)-1-(4-Fluorobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32ClFN2O3
|
1
|
| 1 |
Ki = 40.6 nM
|
|
|
|
CP0414723
|
US8722896, (-)-(3R)-1-(7-Azaindol-4- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H33ClN4O3
|
1
|
| 1 |
Ki = 41.6 nM
|
|
|
|
CP0406434
|
US8722896, (+/-)-2-Methyl-3-((2,6- dimethyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0459954
|
US8722896, (+/-)-2-Methyl-3-((3- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H35ClN2O3
|
1
|
| 1 |
Ki = 44.2 nM
|
|
|
|
CP0384989
|
US8722896, (+/-)-2-Methyl-3-(1-((2- methoxypyridin-3- ylmethyl)amino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H34ClN3O4
|
1
|
| 1 |
Ki = 44.8 nM
|
|
|
|
CP0525107
|
US8722896, (+/-)-2-Methyl-3-(1,3- (benzodioxol-4-ylmethylamino)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H33ClN2O5
|
1
|
| 1 |
Ki = 44.8 nM
|
|
|
|
CP0414726
|
US8722896, (-)-(3R)-1-(2-Methoxy-5- methylbenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H39ClN2O4
|
1
|
| 1 |
Ki = 47.4 nM
|
|
|
|
CP0402861
|
US8722896, (-)-(3R)-1-(2,5- Dimethoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O5
|
1
|
| 1 |
Ki = 47.8 nM
|
|
|
|
CP0441446
|
US8722896, (+/-)-4-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylthiomorpholine-2- carboxamide
Show/Hide
|
C26H33ClN2O3S
|
1
|
| 1 |
Ki = 49.6 nM
|
|
|
|
CP0462699
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-4- fluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H34ClFN2O4
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0414576
|
US8722896, (+/-)-4-(2-Methoxybenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylthiomorpholine-2- carboxamide
Show/Hide
|
C27H35ClN2O4S
|
1
|
| 1 |
Ki = 50.4 nM
|
|
|
|
CP0460221
|
US8722896, (+/-)-2-Methyl-3-((2- ethyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O3
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0435220
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1,4- benzodioxin-5-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H37ClN2O5
|
1
|
| 1 |
Ki = 52 nM
|
|
|
|
CP0411921
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-5- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O4
|
1
|
| 1 |
Ki = 53.2 nM
|
|
|
|
CP0472435
|
US8722896, (+/-)-2-Methyl-3-(Indol-4- ylmethylamino)-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O2
|
1
|
| 1 |
Ki = 53.4 nM
|
|
|
|
CP0486583
|
US8722896, (-)-(3R)-1-(1-Methyl-indol-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H38ClN3O3
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0462741
|
US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H36ClN3O2
|
1
|
| 1 |
Ki = 55.8 nM
|
|
|
|
CP0512549
|
US8722896, (+/-)-2-Methyl-3-(2,3-dihydro- 1,4-benzodioxin-5- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H35ClN2O5
|
1
|
| 1 |
Ki = 58.4 nM
|
|
|
|
CP0420461
|
US8722896, (-)-(3R)-1-(Indan-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H37ClN2O3
|
1
|
| 1 |
Ki = 60.2 nM
|
|
|
|
CP0414711
|
US8722896, (-)-(3R)-1-(3-Amino-4- methoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H36ClN3O4
|
1
|
| 1 |
Ki = 61 nM
|
|
|
|
CP0560297
|
US8722896, (-)-(3R)-1-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H33ClN2O5
|
1
|
| 1 |
Ki = 61.2 nM
|
|
|
|
CP0545288
|
US8722896, (-)-(3R)-1-(3-Aminobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C27H36ClN3O3
|
1
|
| 1 |
Ki = 61.4 nM
|
|
|
|
CP0509246
|
US8722896, (+/-)-2-Methyl-3-(Indol-7- ylmethylamino)-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C28H36ClN3O2
|
1
|
| 1 |
Ki = 61.6 nM
|
|
|
|
CP0539444
|
US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(9-fluoro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
|
C25H33FN2O3
|
1
|
| 1 |
Ki = 62.4 nM
|
|
|
|
CP0481505
|
US8722896, (-)-(3R)-1-(2,5-Dimethylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 64.2 nM
|
|
|
|
CP0441451
|
US8722896, (-)-(3R)-1-(4-Fluoro-2- methoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H36ClFN2O4
|
1
|
| 1 |
Ki = 65.2 nM
|
|
|
|
CP0497787
|
US8722896, (-)-(3R)-1-(2,3-Dimethylbenzyl- N-(9-chloro-2,3,4,5-tetrahydro- 1-benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H41ClN2O2
|
1
|
| 1 |
Ki = 65.4 nM
|
|
|
|
CP0458995
|
US8722896, (-)-(3R)-1-Benzyl-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C27H35ClN2O2
|
1
|
| 1 |
Ki = 65.5 nM
|
|
|
|
CP0429303
|
US8722896, (-)-(3R)-1-(2-Isopropylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C29H39ClN2O3
|
1
|
| 1 |
Ki = 68.8 nM
|
|
|
|
CP0407173
|
US8722896, (-)-(3R)-1-((3- Dimethylamino)benzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H38ClN3O3
|
1
|
| 1 |
Ki = 71.8 nM
|
|
|
|
CP0416403
|
US8722896, (-)-(3R)-1-(2-Methoxy-3-methyl- benzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 74.5 nM
|
|
|
|
CP0429177
|
US8722896, (-)-(2R)-2-Methyl-3-(indol-4- ylmethylamino)-N-(9-fluoro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H34FN3O3
|
1
|
| 1 |
Ki = 75.4 nM
|
|
|
|
CP0523881
|
US8722896, (-)-(3R)-1-Benzyl-N-(9-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H37ClN2O2
|
1
|
| 1 |
Ki = 81 nM
|
|
|
|
CP0422404
|
US8722896, (+/-)-4-(2,5-Dimethylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 83 nM
|
|
|
|
CP0435016
|
US8722896, (-)-(3R)-1-(3-chlorobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H32Cl2N2O3
|
1
|
| 1 |
Ki = 83.6 nM
|
|
|
|
CP0380510
|
US8722896, (-)-(3R)-1-Benzyl-N-(9-fluoro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C26H33FN2O3
|
1
|
| 1 |
Ki = 84.5 nM
|
|
|
|
CP0409826
|
US8722896, (+/-)-4-(2,3-Dimethylbenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
|
C28H37ClN2O4
|
1
|
| 1 |
Ki = 86.6 nM
|
|
|
|
CP0554442
|
US8722896, (-)-(3R)-1-(N-methyl-indolin-7- ylmethyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C30H40ClN3O3
|
1
|
| 1 |
Ki = 87.3 nM
|
|
|
|
CP0403480
|
US8722896, (-)-(3R)-1-(3-Ethylbenzyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
|
C28H37ClN2O3
|
1
|
| 1 |
Ki = 88.8 nM
|
|
|
|
CP0429166
|
US8722896, (+/-)-2-Methyl-3-((3,5- diamino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H35ClN4O3
|
1
|
| 1 |
Ki = 94.4 nM
|
|
|
|
CP0407815
|
US8722896, (+/-)-2-Methyl-3-(7-Azaindol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H33ClN4O3
|
1
|
| 1 |
Ki = 95.8 nM
|
|
|
|
CP0525102
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-3- amino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C26H36ClN3O4
|
1
|
| 1 |
Ki = 96.4 nM
|
|
|
|
CP0407193
|
US8722896, (+/-)-2-Methyl-3-((2- fluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C25H32ClFN2O3
|
1
|
| 1 |
Ki = 97.8 nM
|
|
|
|
CP0441414
|
US8722896, (+/-)-2-Methyl-3-((3- dimethylamino)benzylamino)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H38ClN3O3
|
1
|
| 1 |
Ki = 98.8 nM
|
|
|
|
CP0460192
|
US8722896, (+/-)-2-Methyl-3-((2-methoxy-3- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
|
C27H37ClN2O4
|
1
|
| 1 |
Ki = 104 nM
|
|
|
|
CP0550844
|
US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (3,4-dihydro-2H-1,5-dioxepino- [2,3-b]pyridin-8-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
|
C28H36N4O3
|
1
|
| 1 |
Ki = 104 nM
|
|
|
|
CP0558361
|
US8722896, (-)-(3R)-1-(3-acetoxybenzyl)- N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7- ylmethyl)-N- isobutylpiperidine-3- carboxamide
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C29H37ClN2O5
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1
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| 1 |
Ki = 107 nM
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CP0512557
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US8722896, (-)-(3R)-1-(3-Nitro-4- fluorobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
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C26H31ClFN3O5
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1
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| 1 |
Ki = 109 nM
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CP0406691
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US8722896, (-)-(2R)-2-Ethyl-3-(2- methoxybenzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
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C27H37ClN2O4
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1
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| 1 |
Ki = 116 nM
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CP0497754
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US8722896, (-)-(3R)-1-(2-Methoxy-5-methyl- benzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
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C28H37ClN2O4
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1
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| 1 |
Ki = 117 nM
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CP0469292
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US8722896, (-)-(2R)-2-Methyl-3-((2,6- difluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
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C25H31ClF2N2O3
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1
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| 1 |
Ki = 121 nM
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CP0411377
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US8722896, (-)-(3R)-1-(3-aminobenzyl)-N- (9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
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C26H34ClN3O3
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1
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| 1 |
Ki = 133 nM
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CP0539627
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US8722896, (+/-)-2-Methyl-3-((3- hydroxy)benzylamino)-N-(9- fluoro-3,3-difluoro-3,4- dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
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C25H33FN2O4
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1
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| 1 |
Ki = 137 nM
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CP0543356
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US8722896, (-)-(2R)-2-Methyl-3-((2,4,6- trifluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
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C25H30ClF3N2O3
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1
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| 1 |
Ki = 138 nM
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CP0390286
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US8722896, (+/-)-2-Methyl-3-(indazol-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
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C26H33ClN4O3
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1
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| 1 |
Ki = 145 nM
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CP0411914
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US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)-N- (9-chloro-2,3,4,5-tetrahydro-1- benzoxepin-7-ylmethyl)-N- isobutylpiperidine-3- carboxamide
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C30H38ClN3O2
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1
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| 1 |
Ki = 147 nM
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CP0403040
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US8722896, (+/-)-2-Methyl-3-((3- amino-4-fluoro)benzylamino)- N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
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C25H33ClFN3O3
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1
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| 1 |
Ki = 151 nM
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CP0468217
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US8722896, (+/-)-4-Benzyl-N-(9-fluoro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
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C26H33FN2O4
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1
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| 1 |
Ki = 164 nM
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CP0565000
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US8722896, (-)-(3R)-1-(2,3- Dimethoxybenzyl)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
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C28H37ClN2O5
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1
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| 1 |
Ki = 173 nM
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CP0429630
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US8722896, (+/-)-2-Methyl-3-((2- isopropyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
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C28H39ClN2O3
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1
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| 1 |
Ki = 178 nM
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CP0518417
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US8722896, (+/-)-2-Methyl-3-(pyridin-2- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
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C24H32ClN3O3
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1
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| 1 |
Ki = 192 nM
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CP0427996
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US8722896, (+/-)-2-Methyl-3-((1-methyl-1H- pyrrol-2-yl)methylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
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C24H34ClN3O3
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1
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| 1 |
Ki = 194 nM
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CP0385691
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US8722896, (-)-(3R)-1-(3-Isopropylbenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C29H39ClN2O3
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1
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| 1 |
Ki = 195 nM
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CP0406951
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US8722896, (+/-)-2-Methyl-3-((3-ethyl- benzylamino)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C27H37ClN2O3
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1
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| 1 |
Ki = 197 nM
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CP0380931
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US8722896, (+/-)-1-Benzyl-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C25H33N3O3
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1
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| 1 |
Ki = 200 nM
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CP0527418
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US8722896, (+/-)-2-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- benzylpyrrolidine-3- carboxamide
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C29H31ClN2O3
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1
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| 1 |
Ki = 208 nM
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CP0413971
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US8722896, (-)-(3R)-N-(9-Chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-isobutyl-1- (pyridin-4-ylmethyl)pyrrolidine- 3-carboxamide
Show/Hide
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C25H32ClN3O3
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1
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| 1 |
Ki = 214 nM
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CP0523306
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US8722896, (+/-)-4-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpiperazine-2- carboxamide
Show/Hide
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C26H34ClN3O3
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1
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| 1 |
Ki = 216 nM
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CP0550807
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US8722896, (-)-(2R)-2-Ethyl-3- (benzylamino)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C26H35ClN2O3
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1
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| 1 |
Ki = 222 nM
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CP0417810
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US8722896, (-)-(3R)-1-Benzyl-N-(9-chloro- 3,3-difluoro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C26H31ClF2N2O3
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1
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| 1 |
Ki = 224 nM
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CP0541452
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US8722896, (-)-(3R)-1-(2-Ethyl-3- methylbenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C29H39ClN2O3
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1
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| 1 |
Ki = 226 nM
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CP0548900
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US8722896, (+/-)-2-Methyl-3-((2-ethyl-3- methyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C28H39ClN2O3
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1
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| 1 |
Ki = 226 nM
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CP0417474
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US8722896, (+/-)-2-Methyl-3-((2- amino)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C25H34ClN3O3
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1
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| 1 |
Ki = 248 nM
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CP0441458
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US8722896, (-)-(2R)-2-Methyl-3-((2,4,5- trifluoro)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C25H30ClF3N2O3
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1
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| 1 |
Ki = 258 nM
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CP0542616
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US8722896, (+/-)-4-Benzyl-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Show/Hide
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C25H33N3O4
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1
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| 1 |
Ki = 296 nM
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CP0497756
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US8722896, (+/-)-2-Methyl-3-((3- isopropyl)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C28H39ClN2O3
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1
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| 1 |
Ki = 394 nM
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CP0422503
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US8722896, (-)-(3R)-1-(2-Methoxy-5- aminobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C27H36ClN3O4
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1
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| 1 |
Ki = 442 nM
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CP0397799
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US8722896, (+/-)-2-Methyl-3-(pyridin-3- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
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C24H32ClN3O3
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1
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| 1 |
Ki = 570 nM
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CP0468181
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US8722896, (+/-)-2-Methyl-3-(Indol-7- ylmethylamino)-N-(6-chloro- 2,3,4,5-tetrahydro-1-benzoxepin- 8-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C28H36ClN3O2
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1
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| 1 |
Ki = 660 nM
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CP0533724
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US8722896, (+/-)-1-Benzyl-N-(3,4-dihydro- 2H-1,5-dioxepino-[2,3-b]pyridin- 8-ylmethyl)-N- isobutylpiperidine-3- carboxamide
Show/Hide
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C26H35N3O3
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1
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| 1 |
Ki = 708 nM
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CP0406919
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US8722896, (+/-)-2-Methyl-3-(furan-2- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C23H31ClN2O4
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1
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| 1 |
Ki = 722 nM
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CP0407672
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US8722896, (+/-)-2-Methyl-3-(benzylamino)- N-(9-chloro-3,4-dihydro-2H- 1,5-benzodioxepin-7-ylmethyl)- N-benzylpropanamide
Show/Hide
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C28H31ClN2O3
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1
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| 1 |
Ki = 992 nM
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CP0429692
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US8722896, (-)-(3R)-1-(3,5-Diaminobenzyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C26H35ClN4O3
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1
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| 1 |
Ki = 1560 nM
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CP0473450
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US8722896, (+/-)-2-Methyl-3-((3-amino-5- methoxy)benzylamino)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C26H36ClN3O4
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1
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| 1 |
Ki = 2060 nM
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CP0417809
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US8722896, (+/-)-2-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylisoxazolidin-5- carboxamide
Show/Hide
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C25H31ClN2O4
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1
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| 1 |
Ki = 2200 nM
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CP0385782
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US8722896, (-)-(3R)-1-(Indazol-4-ylmethyl)- N-(9-chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C27H33ClN4O3
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1
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| 1 |
Ki = 2480 nM
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CP0533721
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US8722896, (-)-(3R)-1-(2-Methoxy-3- aminobenzyl)-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N- isobutylpyrrolidine-3- carboxamide
Show/Hide
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C27H36ClN3O4
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1
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| 1 |
Ki = 3600 nM
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CP0402814
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US8722896, (+/-)-2-Methyl-3-(pyridin-4- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)- N-isobutylpropanamide
Show/Hide
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C24H32ClN3O3
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1
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| 1 |
Ki > 10000 nM
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CP0460195
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US8722896, (+/-)-2-Methyl-3-(pyrimidine-3- ylmethylamino)-N-(9-chloro- 3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylpropanamide
Show/Hide
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C23H31ClN4O3
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1
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| 1 |
Ki > 10000 nM
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CP0515331
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US8722896, (+/-)-N-Benzyl-N-(9-chloro-3,4- dihydro-2H-1,5-benzodioxepin- 7-ylmethyl)-N-(1,2-dimethyl) propylpyrrolidine-3- carboxamide
Show/Hide
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C27H35ClN2O3
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1
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| 1 |
Ki > 10000 nM
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