| Compound ID |
Compound Name |
Compound Formula |
|
CP0077413
|
(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
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C15H20ClN5O4
|
1
|
| 1 |
EC50 = 17.7 nM
|
|
|
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CP0381107
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4-[2-[6-[(3-chlorophenyl)methylamino]-9-[(1S,2R,3S,4R,5S)-3,4-dihydroxy-5-(methylcarbamoyl)-2-bicyclo[3.1.0]hexanyl]purin-2-yl]ethynyl]benzenesulfonic acid
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C28H25ClN6O6S
|
2
|
| 1 |
EC50 = 495 nM
|
|
|
| 2 |
Ki = 35.1 nM
|
|
|
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CP0018686
|
(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide
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|
C18H19IN6O4
|
1
|
| 1 |
Ki = 5.9 nM
|
|
|
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CP0161397
|
(1S,2R,3S,4R,5S)-4-(2-chloro-6-(2-phenylcyclopropylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C22H23ClN6O3
|
1
|
| 1 |
Ki = 6.6 nM
|
|
|
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CP0169051
|
(1S,2R,3S,4R,5S)-4-(2-chloro-6-(2,2-diphenylethylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C27H27ClN6O3
|
1
|
| 1 |
Ki = 6.83 nM
|
|
|
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CP0315311
|
(1S,2R,3S,4R,5S)-4-(6-(3-iodobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C20H20ClIN6O3
|
1
|
| 1 |
Ki = 7.32 nM
|
|
|
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CP0310622
|
(1S,2R,3S,4R,5S)-4-(6-(3-bromobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C20H20BrClN6O3
|
1
|
| 1 |
Ki = 8.79 nM
|
|
|
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CP0169052
|
(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C20H20Cl2N6O3
|
1
|
| 1 |
Ki = 15.3 nM
|
|
|
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CP0161398
|
(1S,2R,3S,4R,5S)-4-(6-(2,5-dimethoxybenzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C22H25ClN6O5
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0017043
|
(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide
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|
C18H18ClIN6O4
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0458052
|
(1S,2R,3S,4R,5S)-4-[6-[[3-[6-(2-acetamidoethylamino)-6-oxohex-1-ynyl]phenyl]methylamino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C30H35ClN8O5
|
1
|
| 1 |
Ki = 45.4 nM
|
|
|
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CP0437346
|
(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-ethynylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C22H21ClN6O3
|
1
|
| 1 |
Ki = 45.6 nM
|
|
|
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CP0162587
|
(1S,2R,3S,4R,5S)-4-(2-Chloro-6-methylamino-purin-9-yl)-2,3-dihydroxy-bicyclo[3.1.0]hexane-1-carboxylic acid methylamide
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|
C14H17ClN6O3
|
1
|
| 1 |
Ki = 55.3 nM
|
|
|
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CP0408228
|
(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-(methylthio)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C21H23ClN6O3S
|
1
|
| 1 |
Ki = 98.9 nM
|
|
|
|
CP0202457
|
(1S,2R,3S,4R,5S)-4-(6-(3-(3-hydroxyprop-1-ynyl)benzylamino)-2-chloro-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C23H23ClN6O4
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0458053
|
(1S,2R,3S,4R,5S)-4-[6-[[3-[6-(2-aminoethylamino)-6-oxohex-1-ynyl]phenyl]methylamino]-2-chloropurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C28H33ClN8O4
|
1
|
| 1 |
Ki = 151 nM
|
|
|
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CP0513682
|
(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-(2-trimethylsilylethynyl)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C25H29ClN6O3Si
|
1
|
| 1 |
Ki = 159 nM
|
|
|
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CP0156790
|
(1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-iodo-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C20H20ClIN6O3
|
1
|
| 1 |
Ki = 210 nM
|
|
|
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CP0532493
|
N-[4-(3-bromo-5-methylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
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|
C21H15BrN4OS
|
1
|
| 1 |
Ki = 252 nM
|
|
|
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CP0443565
|
(1S,2R,3S,4R,5S)-4-[2-[2-(4-aminophenyl)ethynyl]-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C28H26ClN7O3
|
1
|
| 1 |
Ki = 261 nM
|
|
|
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CP0433774
|
(1S,2R,3S,4R,5S)-4-[6-[(2,5-dimethoxyphenyl)methylamino]-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C22H25IN6O5
|
1
|
| 1 |
Ki = 293 nM
|
|
|
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CP0076892
|
(2S,3S,4R,5R)-5-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
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|
C20H21ClN6O4S
|
1
|
| 1 |
Ki = 315 nM
|
|
|
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CP0259712
|
N-[4-(3,5-dimethylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
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|
C22H18N4OS
|
1
|
| 1 |
Ki = 411 nM
|
|
|
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CP0490526
|
(1S,2R,3S,4R,5S)-4-[2-[6-(2-aminoethylamino)-6-oxohex-1-ynyl]-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C28H33ClN8O4
|
1
|
| 1 |
Ki = 546 nM
|
|
|
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CP0228686
|
(1R,2R,3S,4R,5S)-4-[6-[2-(4-hydroxy-3-methoxyphenyl)ethylamino]-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C28H27N5O4
|
1
|
| 1 |
Ki = 590 nM
|
|
|
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CP0418019
|
(1R,2R,3S,4R,5S)-4-[2-[2-(2-fluorophenyl)ethynyl]-6-[2-(4-hydroxy-3-methoxyphenyl)ethylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C28H26FN5O4
|
1
|
| 1 |
Ki = 620 nM
|
|
|
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CP0399593
|
6-[3-[[[2-chloro-9-[(1S,2R,3S,4R,5S)-3,4-dihydroxy-5-(methylcarbamoyl)-2-bicyclo[3.1.0]hexanyl]purin-6-yl]amino]methyl]phenyl]hex-5-ynoic acid
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|
C26H27ClN6O5
|
1
|
| 1 |
Ki = 703 nM
|
|
|
|
CP0532744
|
ethyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylate
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|
C21H20FN5O4S
|
1
|
| 1 |
Ki = 864 nM
|
|
|
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CP0377279
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(1R,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-[2-(4-phenylphenyl)ethynyl]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C32H26ClN5O2
|
1
|
| 1 |
Ki = 1110 nM
|
|
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CP0490527
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(1S,2R,3S,4R,5S)-4-[2-chloro-6-(methoxyamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C14H17ClN6O4
|
1
|
| 1 |
Ki = 1160 nM
|
|
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CP0436653
|
methyl 6-[6-[(3-chlorophenyl)methylamino]-9-[(1S,2R,3S,4R,5S)-3,4-dihydroxy-5-(methylcarbamoyl)-2-bicyclo[3.1.0]hexanyl]purin-2-yl]hex-5-ynoate
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|
C27H29ClN6O5
|
1
|
| 1 |
Ki = 1340 nM
|
|
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CP0440557
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(1S,2R,3S,4R,5S)-4-[6-[(3-chlorophenyl)methylamino]-2-pent-1-ynylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C25H27ClN6O3
|
1
|
| 1 |
Ki = 1390 nM
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CP0529958
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(1R,2R,3S,4R,5S)-4-[6-[2-(3,4-dihydroxyphenyl)ethylamino]-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C27H25N5O4
|
1
|
| 1 |
Ki = 1420 nM
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CP0543930
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N-[4-(3-iodo-5-methylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
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|
C21H15IN4OS
|
1
|
| 1 |
Ki = 2640 nM
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CP0418017
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(1R,2R,3S,4R,5S)-4-[2-[2-(5-bromothiophen-2-yl)ethynyl]-6-[2-(4-hydroxy-3-methoxyphenyl)ethylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C26H24BrN5O4S
|
1
|
| 1 |
Ki = 2840 nM
|
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CP0551692
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(1S,2R,3S,4R,5S)-4-[2-[2-(5-fluorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
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|
C20H19FN6O3S
|
1
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| 1 |
Ki = 3260 nM
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CP0381108
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(1R,2R,3S,4R,5S)-4-[6-(methylamino)-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diol
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|
C20H19N5O2
|
1
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| 1 |
Ki = 3800 nM
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CP0076890
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(2S,3S,4R,5R)-5-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamide
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|
C18H17ClN6O4S
|
1
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| 1 |
Ki = 4170 nM
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CP0418190
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6-[6-[(3-chlorophenyl)methylamino]-9-[(1S,2R,3S,4R,5S)-3,4-dihydroxy-5-(methylcarbamoyl)-2-bicyclo[3.1.0]hexanyl]purin-2-yl]hex-5-ynoic acid
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|
C26H27ClN6O5
|
1
|
| 1 |
Ki = 10500 nM
|
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