Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT04975 , G-protein coupled bile acid receptor 1
Gene Name GPBAR1
Organism Mus musculus, Mouse
Protein Classification Membrane receptor
Uniprot ID Q80SS6
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT04975
 
Compound ID Compound Name Compound Formula
CP0904540
2-[3-[4-[[5-(3,4-Dimethoxy-N-methyl-anilino)-1-(4-fluorophenyl)-imidazol-2-yl]sulfanylmethyl]-3,5-difluoro-phenoxy]propyl-(2-sulfonatoethyl)amino]ethanesulfonate-diammonium
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C32H43F3N6O9S3
 1
1
EC50 = 0.3 nM
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CP0923306
3-[4-[[5-(3,4-Dimethoxy-N-methyl-anilino)-1-(4-fluorophenyl)-imidazol-2-yl]sulfanylmethyl]-3,5-difluoro-phenoxy]propane-1-sulfonate-ammonium
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C28H31F3N4O6S2
 1
1
EC50 = 0.4 nM
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CP0475160
2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-N-methylimidazol-4-amine
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C25H22F3N3O2S
 1
1
EC50 = 0.8 nM
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CP0545976
2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-3-(4-fluoro-3-methoxyphenyl)-N-methylimidazol-4-amine
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C26H24F3N3O3S
 1
1
EC50 = 0.8 nM
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CP0532039
[4-[(6-chloro-3-methyl-1-benzofuran-5-yl)oxy]pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
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C26H22ClN3O3
 1
1
EC50 = 0.92 nM
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CP0452716
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dichloro-4-methylphenoxy)pyridin-3-yl]methanone
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C24H21Cl2N3O2
 1
1
EC50 = 0.98 nM
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CP0391925
1-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentyl]-3-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]urea
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C32H43Cl2N5O5S
 1
1
EC50 = 1 nM
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CP0391954
2-[[2-[[2-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoylamino]acetyl]amino]acetyl]amino]acetic acid
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C33H40Cl2N6O6S
 1
1
EC50 = 1.995 nM
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CP0405328
5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamide
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C34H46Cl2N4O7S
 1
1
EC50 = 1.995 nM
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CP0435309
2-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methylsulfanyl]-3-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]imidazole-4-carboxamide
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C34H42Cl2N6O7S2
 1
1
EC50 = 1.995 nM
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CP0438399
5-[[(2R)-3-[[(2R)-2-[[4-carboxy-4-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoylamino]butanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]disulfanyl]-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoylamino]-5-oxopentanoic acid
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C74H90Cl4N12O16S4
 1
1
EC50 = 1.995 nM
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CP0472993
1-[4-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]butyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea
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C33H45Cl2N5O7S
 1
1
EC50 = 1.995 nM
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CP0479517
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,4,5-trichlorophenoxy)pyridin-3-yl]methanone
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C23H18Cl3N3O2
 1
1
EC50 = 2 nM
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CP0520023
3-(3-chloro-4-fluorophenyl)-2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-N-methylimidazol-4-amine
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C25H21ClF3N3O2S
 1
1
EC50 = 2 nM
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CP0487963
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,4,5-trimethylphenoxy)pyridin-3-yl]methanone
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C26H27N3O2
 1
1
EC50 = 2.1 nM
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CP0413820
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dichloro-4-ethylphenoxy)pyridin-3-yl]methanone
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C25H23Cl2N3O2
 1
1
EC50 = 2.3 nM
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CP0515670
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-[(3-methyl-1-benzofuran-5-yl)oxy]pyridin-3-yl]methanone
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C26H23N3O3
 1
1
EC50 = 2.4 nM
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CP0391955
[4-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentylcarbamoyl]piperazin-1-yl]methylphosphonic acid
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C33H45Cl2N6O5PS
 1
1
EC50 = 2.512 nM
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CP0463626
6-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenoxy]methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pyridine-3-carboxamide
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C35H41Cl2N5O8S
 1
1
EC50 = 2.512 nM
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CP0472996
5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pentanamide
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C33H44Cl2N4O7S
 1
1
EC50 = 3.162 nM
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CP0391956
3-[4-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]butyl]-1-methyl-1-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea
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C34H47Cl2N5O7S
 1
1
EC50 = 3.981 nM
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CP0392465
6-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methoxy]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pyridine-3-carboxamide
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C35H41Cl2N5O8S
 1
1
EC50 = 3.981 nM
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CP0405311
(2R,3R,4S,5R)-2-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoylamino]-3,4,5,6-tetrahydroxyhexanoic acid
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C33H42Cl2N4O8S
 1
1
EC50 = 3.981 nM
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CP0472997
1-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea
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C34H47Cl2N5O7S
 1
1
EC50 = 3.981 nM
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CP0513249
(2R)-2-[[(2R)-2-[[(2R)-2-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoylamino]propanoyl]amino]propanoyl]amino]propanoic acid
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C36H46Cl2N6O6S
 1
1
EC50 = 3.981 nM
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CP0468783
N-(3,4-dimethoxyphenyl)-2-[[4-[3-(dimethylamino)prop-1-ynyl]-2,6-difluorophenyl]methylsulfanyl]-3-(4-fluorophenyl)-N-methylimidazol-4-amine
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C30H29F3N4O2S
 1
1
EC50 = 4.1 nM
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CP0468786
3-(2,4-difluorophenyl)-2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-N-methylimidazol-4-amine
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C25H21F4N3O2S
 1
1
EC50 = 4.8 nM
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CP0539987
2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-N-methyl-3-phenylimidazol-4-amine
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C25H23F2N3O2S
 1
1
EC50 = 5.1 nM
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CP0515671
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-[(3-methyl-1,2-benzoxazol-5-yl)oxy]pyridin-3-yl]methanone
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C25H22N4O3
 1
1
EC50 = 5.5 nM
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CP0453197
ethyl 2-[[(E)-3-[5-chloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-3-methyl-1-benzofuran-2-yl]prop-2-enoyl]amino]acetate
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C33H31ClN4O6
 1
1
EC50 = 6.1 nM
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CP0260244
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dimethylphenoxy)pyridin-3-yl]methanone
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C25H25N3O2
 1
1
EC50 = 6.2 nM
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CP0405307
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(4R)-3-[[2,5-dichloro-4-(hydroxymethyl)phenyl]methyl]-1,3-thiazolidin-4-yl]methanone
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C23H25Cl2N3O2S
 1
1
EC50 = 6.31 nM
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CP0405326
3-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide
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C31H40Cl2N4O7S
 1
1
EC50 = 6.31 nM
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CP0463630
(2S)-2-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoylamino]pentanedioic acid
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C32H38Cl2N4O6S
 1
1
EC50 = 6.31 nM
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CP0463357
2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-N,5-dimethylimidazol-4-amine
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C26H24F3N3O2S
 1
1
EC50 = 7 nM
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CP0901431
(3-{4-[5-[(3,4-Dimethoxy-phenyl)-methylamino]-1-(4-fluoro-phenyl)-1H-imidazol-2-ylsulfanylmethyl]-3,5-difluoro-phenyl}-prop-2-ynyl)-trimethylammonium iodide
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C31H32F3IN4O2S
 1
1
EC50 = 7.5 nM
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CP0559261
2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-N-prop-2-enylimidazol-4-amine
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C27H24F3N3O2S
 1
1
EC50 = 7.7 nM
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CP0391957
3-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]-N-methyl-N-[(2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide
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C32H42Cl2N4O7S
 1
1
EC50 = 7.943 nM
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CP0520855
5-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methoxy]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pyridine-2-carboxamide
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C35H41Cl2N5O8S
 1
1
EC50 = 7.943 nM
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CP0901429
2-[[4-[3-(1-Aza-4-azoniabicyclo[2.2.2]octan-4-yl)propoxy]-2,6-difluoro-phenyl]methylsulfanyl]-N-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-N-methyl-imidazol-4-amine-formate
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C35H40F3N5O5S
 1
1
EC50 = 9.8 nM
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CP0389623
[4-[(6-chloro-1-benzofuran-5-yl)oxy]pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
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C25H20ClN3O3
 1
1
EC50 = 10 nM
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CP0387108
2-[carboxymethyl-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentyl]amino]acetic acid
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C31H38Cl2N4O5S
 1
1
EC50 = 10 nM
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CP0391950
5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoic acid
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C27H31Cl2N3O3S
 1
1
EC50 = 10 nM
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CP0392466
1-[4-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]butyl]-3-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]urea
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C31H41Cl2N5O5S
 1
1
EC50 = 10 nM
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CP0405318
2-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methylsulfanyl]-3-methylimidazole-4-carboxylic acid
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C28H29Cl2N5O3S2
 1
1
EC50 = 10 nM
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CP0405323
4-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methoxy]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]benzamide
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C36H42Cl2N4O8S
 1
1
EC50 = 10 nM
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CP0435307
3-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]-N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide
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C32H42Cl2N4O7S
 1
1
EC50 = 10 nM
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CP0435313
[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentylcarbamoylamino]methylphosphonic acid
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C29H38Cl2N5O5PS
 1
1
EC50 = 10 nM
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CP0438400
(2S)-2-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoylamino]-5-[methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino]-5-oxopentanoic acid
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C39H53Cl2N5O10S
 1
1
EC50 = 10 nM
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CP0463356
N-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-2-[(2-fluorophenyl)methylsulfanyl]-N-methylimidazol-4-amine
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C25H23F2N3O2S
 1
1
EC50 = 12 nM
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CP0387113
1-[4-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenoxy]butyl]-3-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]urea
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C33H45Cl2N5O8S
 1
1
EC50 = 12.59 nM
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CP0405310
2-[5-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]pentanoyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]amino]acetic acid
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C35H46Cl2N4O9S
 1
1
EC50 = 12.59 nM
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CP0453199
2-[[(E)-3-[5-chloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxycarbonyl-3-methyl-1-benzofuran-2-yl]prop-2-enoyl]amino]acetic acid
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C32H27ClN4O7
 1
1
EC50 = 13 nM
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CP0479516
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(4-methylphenoxy)pyridin-3-yl]methanone
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C24H23N3O2
 1
1
EC50 = 15 nM
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CP0387107
5-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenoxy]methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]furan-2-carboxamide
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C34H40Cl2N4O9S
 1
1
EC50 = 15.85 nM
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CP0471002
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(4R)-3-[(2,5-dichloro-4-hydroxyphenyl)methyl]-1,3-thiazolidin-4-yl]methanone
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C22H23Cl2N3O2S
 1
1
EC50 = 15.85 nM
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CP0566045
ethyl (E)-3-[5-chloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-3-methyl-1-benzofuran-2-yl]prop-2-enoate
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C31H28ClN3O5
 1
1
EC50 = 16 nM
   TI
   LI
   LO
   TS
CP0923307
(3-{4-[5-[(3,4-Dimethoxy-phenyl)-methylamino]-1-(4-fluoro-phenyl)-1H-imidazol-2-ylsulfanylmethyl]-3,5-difluoro-phenyl}-prop-2-ynyl)-trimethylammonium formate
   Show/Hide
C32H33F3N4O4S
 1
1
EC50 = 17 nM
   TI
   LI
   LO
   TS
CP0441788
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dichlorophenoxy)pyridin-3-yl]methanone
   Show/Hide
C23H19Cl2N3O2
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0400812
(E)-3-[5-chloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-3-methyl-1-benzofuran-2-yl]prop-2-enoic acid
   Show/Hide
C29H24ClN3O5
 1
1
EC50 = 18 nM
   TI
   LI
   LO
   TS
CP0474894
3-[(2,6-difluorophenyl)methylsulfanyl]-5-[(3,4-dimethoxyphenyl)methyl]-4-(4-fluorophenyl)-1,2,4-triazole
   Show/Hide
C24H20F3N3O2S
 1
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
CP0486477
methyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C27H23N3O5
 1
1
EC50 = 23.1 nM
   TI
   LI
   LO
   TS
CP0487939
[4-(2,5-dichlorophenoxy)pyridin-3-yl]-(4-ethyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C22H19Cl2N3O2
 1
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
CP0144740
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(4R)-3-[(2,5-dichlorophenyl)methyl]-1,3-thiazolidin-4-yl]methanone
   Show/Hide
C22H23Cl2N3OS
 1
1
EC50 = 25.12 nM
   TI
   LI
   LO
   TS
CP0435314
1-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pyrazole-3-carboxamide
   Show/Hide
C33H40Cl2N6O7S
 1
1
EC50 = 25.12 nM
   TI
   LI
   LO
   TS
CP0497865
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(3-methoxyphenoxy)pyridin-3-yl]methanone
   Show/Hide
C24H23N3O3
 1
1
EC50 = 26 nM
   TI
   LI
   LO
   TS
CP0400811
[4-(1-benzofuran-5-yloxy)pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C25H21N3O3
 1
1
EC50 = 28 nM
   TI
   LI
   LO
   TS
CP0441761
[4-(2-chlorophenoxy)pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C23H20ClN3O2
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0480775
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dichlorophenoxy)pyrimidin-5-yl]methanone
   Show/Hide
C22H18Cl2N4O2
 1
1
EC50 = 30 nM
   TI
   LI
   LO
   TS
CP0497864
(4-cyclobutyl-2,3-dihydroquinoxalin-1-yl)-[4-(2,5-dichlorophenoxy)pyridin-3-yl]methanone
   Show/Hide
C24H21Cl2N3O2
 1
1
EC50 = 31 nM
   TI
   LI
   LO
   TS
CP0509106
[4-(3-chlorophenoxy)pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C23H20ClN3O2
 1
1
EC50 = 31 nM
   TI
   LI
   LO
   TS
CP0405327
5-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methoxy]-1-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pyrazole-3-carboxamide
   Show/Hide
C34H42Cl2N6O8S
 1
1
EC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0463629
3-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]methoxy]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]benzamide
   Show/Hide
C36H42Cl2N4O8S
 1
1
EC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0513250
4-[[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenoxy]methyl]benzoic acid
   Show/Hide
C30H29Cl2N3O4S
 1
1
EC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0389625
ethyl 2-[6-chloro-5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-yl]acetate
   Show/Hide
C29H26ClN3O5
 1
1
EC50 = 38 nM
   TI
   LI
   LO
   TS
CP0400813
ethyl 6-chloro-5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C28H24ClN3O5
 1
1
EC50 = 39 nM
   TI
   LI
   LO
   TS
CP0520884
(2R,3S,4R,5R)-N-[3-[4-[2,5-dichloro-4-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenoxy]butylcarbamoyl-[3-[[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoyl]amino]propyl]amino]propyl]-2,3,4,5,6-pentahydroxyhexanamide
   Show/Hide
C45H67Cl2N7O15S
 1
1
EC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0515608
2-[(2,6-difluorophenyl)methylsulfanyl]-N-[(3,4-dimethoxyphenyl)methyl]-3-(4-fluorophenyl)-N-methylimidazol-4-amine
   Show/Hide
C26H24F3N3O2S
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0474941
N-(3,4-dimethoxyphenyl)-2-[(2,6-dimethylphenyl)methylsulfanyl]-3-(4-fluorophenyl)-N-methylimidazol-4-amine
   Show/Hide
C27H28FN3O2S
 1
1
EC50 = 41 nM
   TI
   LI
   LO
   TS
CP0556198
[4-(1-benzofuran-6-yloxy)pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C25H21N3O3
 1
1
EC50 = 43 nM
   TI
   LI
   LO
   TS
CP0548317
N-(4-chloro-3-methoxyphenyl)-2-[(2,6-difluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)-N-methylimidazol-4-amine
   Show/Hide
C24H19ClF3N3OS
 1
1
EC50 = 44 nM
   TI
   LI
   LO
   TS
CP0486492
ethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C28H25N3O5
 1
1
EC50 = 44 nM
   TI
   LI
   LO
   TS
CP0116346
CHEMBL3234871
   Show/Hide
C31H30F3N5O3
 1
1
EC50 = 46 nM
   TI
   LI
   LO
   TS
CP0471003
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S,4S)-1-[(2,5-dichlorophenyl)methyl]-4-fluoropyrrolidin-2-yl]methanone
   Show/Hide
C23H24Cl2FN3O
 1
1
EC50 = 50.12 nM
   TI
   LI
   LO
   TS
CP0409987
[4-(1-benzothiophen-5-yloxy)pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C25H21N3O2S
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0414624
[4-(1,3-benzothiazol-6-yloxy)pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C24H20N4O2S
 1
1
EC50 = 60 nM
   TI
   LI
   LO
   TS
CP0392468
[(4R)-3-[[5-chloro-2-(trifluoromethyl)phenyl]methyl]-1,3-thiazolidin-4-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C23H23ClF3N3OS
 1
1
EC50 = 63.1 nM
   TI
   LI
   LO
   TS
CP0471007
[(4R)-3-[[4-(5-aminopentyl)-2,5-dichlorophenyl]methyl]-1,3-thiazolidin-4-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C27H34Cl2N4OS
 1
1
EC50 = 63.1 nM
   TI
   LI
   LO
   TS
CP0413818
[4-(2,5-dichlorophenoxy)pyridin-3-yl]-(4-prop-2-enyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C23H19Cl2N3O2
 1
1
EC50 = 66 nM
   TI
   LI
   LO
   TS
CP0409997
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-(4-naphthalen-1-yloxypyridin-3-yl)methanone
   Show/Hide
C27H23N3O2
 1
1
EC50 = 66 nM
   TI
   LI
   LO
   TS
CP0453198
[4-[(2-bromo-6-chloro-3-methyl-1-benzofuran-5-yl)oxy]pyridin-3-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C26H21BrClN3O3
 1
1
EC50 = 66 nM
   TI
   LI
   LO
   TS
CP0475158
2-benzylsulfanyl-N-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-N-methylimidazol-4-amine
   Show/Hide
C25H24FN3O2S
 1
1
EC50 = 68 nM
   TI
   LI
   LO
   TS
CP0453200
[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl] 5-chloro-2-(3-ethoxy-3-oxopropyl)-3-methyl-1-benzofuran-4-carboxylate
   Show/Hide
C32H30ClN3O6
 1
1
EC50 = 72 nM
   TI
   LI
   LO
   TS
CP0479515
[4-(2,5-dichlorophenoxy)pyridin-3-yl]-(4-propyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C23H21Cl2N3O2
 1
1
EC50 = 76 nM
   TI
   LI
   LO
   TS
CP0389624
[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl] 6-chloro-3-(3-methoxy-3-oxopropyl)-1-benzofuran-5-carboxylate
   Show/Hide
C30H26ClN3O6
 1
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
CP0460507
methyl 3-[2-[(2,6-difluorophenyl)methylsulfanyl]-5-(3,4-dimethoxy-N-methylanilino)-1-(4-fluorophenyl)imidazol-4-yl]propanoate
   Show/Hide
C29H28F3N3O4S
 1
1
EC50 = 82 nM
   TI
   LI
   LO
   TS
CP0532040
ethyl 2-[3-[5-chloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-3-methyl-1-benzofuran-2-yl]propanoylamino]acetate
   Show/Hide
C33H33ClN4O6
 1
1
EC50 = 85 nM
   TI
   LI
   LO
   TS
CP0563298
2-[(2,6-difluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)-N-(3-methoxyphenyl)-N-methylimidazol-4-amine
   Show/Hide
C24H20F3N3OS
 1
1
EC50 = 91 nM
   TI
   LI
   LO
   TS
CP0390774
2-[3,5-bis(trifluoromethyl)phenyl]-2-[[4-(2,6-difluorophenyl)pyridin-3-yl]methylamino]acetonitrile
   Show/Hide
C22H13F8N3
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0391953
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S)-1-[(2,5-dichlorophenyl)methyl]pyrrolidin-2-yl]methanone
   Show/Hide
C23H25Cl2N3O
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0463627
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S,4R)-1-[(2,5-dichlorophenyl)methyl]-4-fluoropyrrolidin-2-yl]methanone
   Show/Hide
C23H24Cl2FN3O
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0472992
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S,4R)-1-[(2,5-dichlorophenyl)methyl]-4-methoxypyrrolidin-2-yl]methanone
   Show/Hide
C24H27Cl2N3O2
 1
1
EC50 = 100 nM
   TI
   LI
   LO
   TS
CP0448854
3-[5-chloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-3-methyl-1-benzofuran-2-yl]propanoic acid
   Show/Hide
C29H26ClN3O5
 1
1
EC50 = 101 nM
   TI
   LI
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   TS
CP0572971
propyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C29H27N3O5
 1
1
EC50 = 115 nM
   TI
   LI
   LO
   TS
CP0523564
5-(4-aminobutyl)-2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-N-methylimidazol-4-amine
   Show/Hide
C29H31F3N4O2S
 1
1
EC50 = 119 nM
   TI
   LI
   LO
   TS
CP0387106
[(4R)-3-[(2-chloro-5-iodophenyl)methyl]-1,3-thiazolidin-4-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C22H23ClIN3OS
 1
1
EC50 = 125.89 nM
   TI
   LI
   LO
   TS
CP0438398
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S)-1-[(2,5-dichlorophenyl)methyl]-4,4-difluoropyrrolidin-2-yl]methanone
   Show/Hide
C23H23Cl2F2N3O
 1
1
EC50 = 125.89 nM
   TI
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   LO
   TS
CP0390777
4-[[3,5-bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-5H-pyrido[3,2-f][1,4]oxazepin-3-one
   Show/Hide
C23H15F7N2O2
 1
1
EC50 = 130 nM
   TI
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   TS
CP0568212
methoxymethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C28H25N3O6
 1
1
EC50 = 137 nM
   TI
   LI
   LO
   TS
CP0540506
2-[(2,6-difluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)-N-(4-methoxyphenyl)-N-methylimidazol-4-amine
   Show/Hide
C24H20F3N3OS
 1
1
EC50 = 141 nM
   TI
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   TS
CP0527673
methylsulfanylmethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C28H25N3O5S
 1
1
EC50 = 143 nM
   TI
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   TS
CP0390779
2-[3,5-bis(trifluoromethyl)phenyl]-2-[[4-(2-fluorophenyl)pyridin-3-yl]methylamino]acetonitrile
   Show/Hide
C22H14F7N3
 1
1
EC50 = 150 nM
   TI
   LI
   LO
   TS
CP0391958
3-[4-chloro-3-[[(4R)-4-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-1,3-thiazolidin-3-yl]methyl]phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide
   Show/Hide
C31H41ClN4O7S
 1
1
EC50 = 158.49 nM
   TI
   LI
   LO
   TS
CP0548318
5-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-4-(4-fluorophenyl)-N-methyl-1,2,4-triazol-3-amine
   Show/Hide
C24H21F3N4O2S
 1
1
EC50 = 180 nM
   TI
   LI
   LO
   TS
CP0486475
ethoxymethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C29H27N3O6
 1
1
EC50 = 209 nM
   TI
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   TS
CP0486493
2-methoxyethoxymethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C30H29N3O7
 1
1
EC50 = 211 nM
   TI
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   LO
   TS
CP0400816
6-chloro-5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylic acid
   Show/Hide
C26H20ClN3O5
 1
1
EC50 = 215 nM
   TI
   LI
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   TS
CP0375371
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-N-[(4-phenylpyridin-3-yl)methyl]thiophene-3-carboxamide
   Show/Hide
C26H18F6N2OS
 1
1
EC50 = 230 nM
   TI
   LI
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   TS
CP0191847
6alpha-ethyl-23(S)-methyl-cholic acid
   Show/Hide
C27H46O5
 2
1
EC50 = 251 nM
   TI
   LI
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   TS
2
EC50 = 360 nM
   TI
   LI
   LO
   TS
CP0387109
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S,4R)-1-[(2,5-dichlorophenyl)methyl]-4-hydroxypyrrolidin-2-yl]methanone
   Show/Hide
C23H25Cl2N3O2
 1
1
EC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0952636
4-[2-[(2,6-Difluorophenyl)methylsulfanyl]-5-(3,4-dimethoxy-N-methyl-anilino)-1-(4-fluorophenyl)imidazol-4-yl]butyl-trimethylammonium-formate
   Show/Hide
C33H39F3N4O4S
 1
1
EC50 = 254 nM
   TI
   LI
   LO
   TS
CP0121522
(3R)-N-[2-(4-cyanophenyl)ethyl]-1-[6-(4-methylpiperazin-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]piperidine-3-carboxamide
   Show/Hide
C25H30F3N7O
 1
1
EC50 = 296 nM
   TI
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   TS
CP0413817
N-[[3,5-bis(trifluoromethyl)phenyl]methyl]-N-[(4-phenylpyridin-3-yl)methyl]thiophene-2-carboxamide
   Show/Hide
C26H18F6N2OS
 1
1
EC50 = 300 nM
   TI
   LI
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   TS
CP0438401
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S,4S)-1-[(2,5-dichlorophenyl)methyl]-4-methoxypyrrolidin-2-yl]methanone
   Show/Hide
C24H27Cl2N3O2
 1
1
EC50 = 316.23 nM
   TI
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   TS
CP0438404
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(3S)-4-[(2,5-dichlorophenyl)methyl]morpholin-3-yl]methanone
   Show/Hide
C23H25Cl2N3O2
 1
1
EC50 = 316.23 nM
   TI
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   TS
CP0512855
2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-N-methyl-3-[4-(trifluoromethyl)phenyl]imidazol-4-amine
   Show/Hide
C26H22F5N3O2S
 1
1
EC50 = 366 nM
   TI
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   TS
CP0411580
2-[3,5-bis(trifluoromethyl)phenyl]-2-[(4-phenylpyridin-3-yl)methylamino]acetonitrile
   Show/Hide
C22H15F6N3
 1
1
EC50 = 370 nM
   TI
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   LO
   TS
CP0560548
2,2,2-trifluoroethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C28H22F3N3O5
 1
1
EC50 = 388 nM
   TI
   LI
   LO
   TS
CP0405306
3-[2,5-dichloro-4-[[(2S)-2-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyrrolidin-1-yl]methyl]phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide
   Show/Hide
C32H42Cl2N4O7
 1
1
EC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0405314
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(4R)-3-[(2,5-dichlorophenyl)methyl]-2,2-dimethyl-1,3-thiazolidin-4-yl]methanone
   Show/Hide
C24H27Cl2N3OS
 1
1
EC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0471004
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S,4S)-1-[(2,5-dichlorophenyl)methyl]-4-hydroxypyrrolidin-2-yl]methanone
   Show/Hide
C23H25Cl2N3O2
 1
1
EC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0516892
N-(3,4-dichlorophenyl)-2-[(2,6-difluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)-N-methylimidazol-4-amine
   Show/Hide
C23H16Cl2F3N3S
 1
1
EC50 = 507 nM
   TI
   LI
   LO
   TS
CP0404068
N-[[4-(2,6-difluorophenyl)pyridin-3-yl]methyl]-3,5-bis(trifluoromethyl)benzenesulfonamide
   Show/Hide
C20H12F8N2O2S
 1
1
EC50 = 550 nM
   TI
   LI
   LO
   TS
CP0549475
acetyloxymethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C29H25N3O7
 1
1
EC50 = 561 nM
   TI
   LI
   LO
   TS
CP0391926
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S)-1-[(2,5-dichlorophenyl)methyl]azetidin-2-yl]methanone
   Show/Hide
C22H23Cl2N3O
 1
1
EC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0405320
3-[2,5-dichloro-4-[[(2S,4S)-2-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)-4-fluoropyrrolidin-1-yl]methyl]phenyl]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]propanamide
   Show/Hide
C32H41Cl2FN4O7
 1
1
EC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0438397
[(4R)-3-[(2-chloro-5-cyclopropylphenyl)methyl]-1,3-thiazolidin-4-yl]-(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)methanone
   Show/Hide
C25H28ClN3OS
 1
1
EC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0443636
N-[[4-(2-fluorophenyl)pyridin-3-yl]methyl]-3,5-bis(trifluoromethyl)benzenesulfonamide
   Show/Hide
C20H13F7N2O2S
 1
1
EC50 = 820 nM
   TI
   LI
   LO
   TS
CP0395769
N-[3,5-bis(trifluoromethyl)phenyl]sulfonyl-N-[[4-(2-fluorophenyl)pyridin-3-yl]methyl]benzamide
   Show/Hide
C27H17F7N2O3S
 1
1
EC50 = 850 nM
   TI
   LI
   LO
   TS
CP0443634
N-[3,5-bis(trifluoromethyl)phenyl]sulfonyl-N-[[4-(2-fluorophenyl)pyridin-3-yl]methyl]furan-2-carboxamide
   Show/Hide
C25H15F7N2O4S
 1
1
EC50 = 910 nM
   TI
   LI
   LO
   TS
CP0515607
2-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-N-methylimidazol-4-amine
   Show/Hide
C26H25F2N3O3S
 1
1
EC50 = 939 nM
   TI
   LI
   LO
   TS
CP0471005
(2S)-N-(2-cyclopropyloxyphenyl)-1-[(2,5-dichlorophenyl)methyl]-N-methylpyrrolidine-2-carboxamide
   Show/Hide
C22H24Cl2N2O2
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0475198
(2S)-N-(2-cyclobutyloxyphenyl)-1-[(2,5-dichlorophenyl)methyl]-N-methylpyrrolidine-2-carboxamide
   Show/Hide
C23H26Cl2N2O2
 1
1
EC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0403773
N-[3,5-bis(trifluoromethyl)phenyl]sulfonyl-N-[[4-(2-fluorophenyl)pyridin-3-yl]methyl]thiophene-3-carboxamide
   Show/Hide
C25H15F7N2O3S2
 1
1
EC50 = 1090 nM
   TI
   LI
   LO
   TS
CP0390773
N-[1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-N-[(4-phenylpyridin-3-yl)methyl]furan-2-carboxamide
   Show/Hide
C27H20F6N2O2
 1
1
EC50 = 1180 nM
   TI
   LI
   LO
   TS
CP0513248
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2R)-1-[(2,5-dichlorophenyl)methyl]pyrrolidin-2-yl]methanone
   Show/Hide
C23H25Cl2N3O
 1
1
EC50 = 1258.93 nM
   TI
   LI
   LO
   TS
CP0543366
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S)-1-[(2,5-dichlorophenyl)methyl]-2-methylpyrrolidin-2-yl]methanone
   Show/Hide
C24H27Cl2N3O
 1
1
EC50 = 1258.93 nM
   TI
   LI
   LO
   TS
CP0545857
ethoxycarbonyloxymethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C30H27N3O8
 1
1
EC50 = 1372 nM
   TI
   LI
   LO
   TS
CP0463628
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(3R)-4-[(2,5-dichlorophenyl)methyl]thiomorpholin-3-yl]methanone
   Show/Hide
C23H25Cl2N3OS
 1
1
EC50 = 1584.89 nM
   TI
   LI
   LO
   TS
CP0474895
4-ethyl-1-[[4-(trifluoromethyl)phenyl]methylsulfanyl]-[1,2,4]triazolo[4,3-a]quinazolin-5-one
   Show/Hide
C19H15F3N4OS
 1
1
EC50 = 1680 nM
   TI
   LI
   LO
   TS
CP0512815
3-[2-[(2,6-difluorophenyl)methylsulfanyl]-5-(3,4-dimethoxy-N-methylanilino)-1-(4-fluorophenyl)imidazol-4-yl]propanoic acid
   Show/Hide
C28H26F3N3O4S
 1
1
EC50 = 1935 nM
   TI
   LI
   LO
   TS
CP0460760
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2S)-1-[(2,5-dichlorophenyl)methyl]piperidin-2-yl]methanone
   Show/Hide
C24H27Cl2N3O
 1
1
EC50 = 1995.26 nM
   TI
   LI
   LO
   TS
CP0411579
1-[3,5-bis(trifluoromethyl)phenyl]-N-[[4-(2-fluorophenyl)pyridin-3-yl]methyl]ethanamine
   Show/Hide
C22H17F7N2
 1
1
EC50 = 2040 nM
   TI
   LI
   LO
   TS
CP0435308
[(2S)-1-[(2,5-dichlorophenyl)methyl]pyrrolidin-2-yl]-(3,4-dihydro-2H-quinolin-1-yl)methanone
   Show/Hide
C21H22Cl2N2O
 1
1
EC50 = 2511.89 nM
   TI
   LI
   LO
   TS
CP0444625
(1S,3aS,5aR,5bR,7aR,9R,11aR,11bR,13aR,13bR)-9-butanoyloxy-5a,5b,8,8,11a-pentamethyl-1-propan-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
   Show/Hide
C34H56O4
 1
1
EC50 = 2610 nM
   TI
   LI
   LO
   TS
CP0519723
3-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoylamino]propanoic acid
   Show/Hide
C29H28Cl2N4O5
 1
1
EC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0534667
chloromethyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C27H22ClN3O5
 1
1
EC50 = 3468 nM
   TI
   LI
   LO
   TS
CP0435311
[(2S)-1-[(2,5-dichlorophenyl)methyl]pyrrolidin-2-yl]-(2,3-dihydro-1,4-benzothiazin-4-yl)methanone
   Show/Hide
C20H20Cl2N2OS
 1
1
EC50 = 5011.87 nM
   TI
   LI
   LO
   TS
CP0519722
ethyl 2-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoylamino]acetate
   Show/Hide
C30H30Cl2N4O5
 1
1
EC50 = 5700 nM
   TI
   LI
   LO
   TS
CP0441232
2-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoyl-methylamino]acetic acid
   Show/Hide
C29H28Cl2N4O5
 1
1
EC50 = 5800 nM
   TI
   LI
   LO
   TS
CP0486476
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylate
   Show/Hide
C31H25N3O8
 1
1
EC50 = 5953 nM
   TI
   LI
   LO
   TS
CP0487680
5-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxy-1-benzofuran-3-carboxylic acid
   Show/Hide
C26H21N3O5
 1
1
EC50 = 6052 nM
   TI
   LI
   LO
   TS
CP0410853
ethyl 2-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoyl-methylamino]acetate
   Show/Hide
C31H32Cl2N4O5
 1
1
EC50 = 7800 nM
   TI
   LI
   LO
   TS
CP0519721
2-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoylamino]acetic acid
   Show/Hide
C28H26Cl2N4O5
 1
1
EC50 = 8000 nM
   TI
   LI
   LO
   TS
CP0544869
5-[(2,6-difluorophenyl)methylsulfanyl]-N-(3,4-dimethoxyphenyl)-4-(4-fluorophenyl)-1,2,4-triazol-3-amine
   Show/Hide
C23H19F3N4O2S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0391951
(2S)-N-[2-(cyclopropylmethoxy)phenyl]-1-[(2,5-dichlorophenyl)methyl]-N-methylpyrrolidine-2-carboxamide
   Show/Hide
C23H26Cl2N2O2
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0391952
[(2S)-1-[(2,5-dichlorophenyl)methyl]pyrrolidin-2-yl]-(4-methyl-3,4-dihydro-2H-quinolin-1-yl)methanone
   Show/Hide
C22H24Cl2N2O
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0441233
ethyl 3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoate
   Show/Hide
C28H27Cl2N3O4
 1
1
EC50 = 11000 nM
   TI
   LI
   LO
   TS
CP0441231
3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]-N-[2-[2-[2-[2-[2-[2-[2-[2-[2-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]propanamide
   Show/Hide
C70H82Cl4N8O14
 1
1
EC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0499289
3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]-N-[2-[2-[2-[2-[2-[2-[2-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]propanamide
   Show/Hide
C66H74Cl4N8O12
 1
1
EC50 = 13000 nM
   TI
   LI
   LO
   TS
CP0415203
3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]-N-[2-[2-[2-[2-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoylamino]ethoxy]ethoxy]ethoxy]ethyl]propanamide
   Show/Hide
C60H62Cl4N8O9
 1
1
EC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0415204
ethyl 3-[3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoylamino]propanoate
   Show/Hide
C31H32Cl2N4O5
 1
1
EC50 = 17000 nM
   TI
   LI
   LO
   TS
CP0415205
3-[2,5-dichloro-4-[3-(4-cyclopropyl-2,3-dihydroquinoxaline-1-carbonyl)pyridin-4-yl]oxyphenyl]propanoic acid
   Show/Hide
C26H23Cl2N3O4
 1
1
EC50 = 71000 nM
   TI
   LI
   LO
   TS
CP0438405
(4-cyclopropyl-2,3-dihydroquinoxalin-1-yl)-[(2R)-1-[(2,5-dichlorophenyl)methyl]piperidin-2-yl]methanone
   Show/Hide
C24H27Cl2N3O
 1
1
EC50 > 3162.28 nM
   TI
   LI
   LO
   TS
CP0915815
N-[2-(2,6-Difluoro-benzylsulfanyl)-3-(4-fluoro-phenyl)-3H-imidazol-4-yl]-3,4-dimethoxy-benzamide
   Show/Hide
C25H20F3N3O3S
 1
1
EC50 >= 6000 nM
   TI
   LI
   LO
   TS
CP0507508
(2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethyl-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-2-methylpentanoic acid
   Show/Hide
C27H46O4
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0509585
3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl)quinolin-7-ol
   Show/Hide
C22H19BrN2OS
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0374154
3-((4-bromophenethylamino)methyl)-7-methoxy-2-(thiophen-3-yl)quinolin-6-ol
   Show/Hide
C23H21BrN2O2S
 1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0506215
3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl)quinolin-6-ol
   Show/Hide
C22H19BrN2OS
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0386163
2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C23H21BrN2OS
 1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0435365
2-(4-bromophenyl)-N-((7-methoxy-2-(pyridin-4-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C24H22BrN3O
 1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0487913
2-(4-chlorophenyl)-N-((7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C23H21ClN2OS
 1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0388571
1-(7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)-N-(4-methylbenzyl)methanamine
   Show/Hide
C23H22N2OS
 1
1
IC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0478818
2-(4-bromophenyl)-N-((2-(furan-2-yl)-7-methoxyquinolin-3-yl)methyl)ethanamine
   Show/Hide
C23H21BrN2O2
 1
1
IC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0435363
1-(4-chlorophenyl)-N-[(7-methoxy-2-thiophen-3-ylquinolin-3-yl)methyl]methanamine
   Show/Hide
C22H19ClN2OS
 1
1
IC50 = 4300 nM
   TI
   LI
   LO
   TS
CP0470471
2-(4-bromophenyl)-N-((7-methoxy-2-(thiophen-2-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C23H21BrN2OS
 1
1
IC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0487914
2-(4-bromophenyl)-N-((7-methoxy-2-(pyridin-3-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C24H22BrN3O
 1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
CP0057055
(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid
   Show/Hide
C24H40O5
 1
1
IC50 = 5300 nM
   TI
   LI
   LO
   TS
CP0470472
2-(4-bromophenyl)-N-((2-(furan-3-yl)-7-methoxyquinolin-3-yl)methyl)ethanamine
   Show/Hide
C23H21BrN2O2
 1
1
IC50 = 6100 nM
   TI
   LI
   LO
   TS
CP0388572
2-(4-bromophenyl)-N-((7-methoxy-2-phenylquinolin-3-yl)methyl)ethanamine
   Show/Hide
C25H23BrN2O
 1
1
IC50 = 8100 nM
   TI
   LI
   LO
   TS
CP0377218
1-(7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)-N-(4-methoxybenzyl)methanamine
   Show/Hide
C23H22N2O2S
 1
1
IC50 = 8500 nM
   TI
   LI
   LO
   TS
CP0388573
2-(4-bromophenyl)-N-((7-ethoxy-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C24H23BrN2OS
 1
1
IC50 = 9400 nM
   TI
   LI
   LO
   TS
CP0374153
N-[(7-methoxy-2-thiophen-3-ylquinolin-3-yl)methyl]-1-phenylmethanamine
   Show/Hide
C22H20N2OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0377220
3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl)quinoline-6,7-diol
   Show/Hide
C22H19BrN2O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0377251
2-(4-bromophenyl)-N-((7-methoxy-2-(oxazol-2-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C22H20BrN3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0435368
2-(4-bromophenyl)-N-((6-methoxy-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C23H21BrN2OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0469328
2-(4-bromophenyl)-N-((7-methyl-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C23H21BrN2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0470473
2-(4-bromophenyl)-N-((2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
   Show/Hide
C22H19BrN2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0472803
2-(4-bromophenyl)-N-((7-chloro-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
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C22H18BrClN2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0472805
3-((4-bromophenethylamino)methyl)-2-(thiophen-3-yl)quinoline-7-carboxylic acid
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C23H19BrN2O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0478821
3-((4-bromophenethylamino)methyl)-6-methoxy-2-(thiophen-3-yl)quinolin-7-ol
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C23H21BrN2O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0502951
2-(4-bromophenyl)-N-((7-methoxy-2-(thiazol-2-yl)quinolin-3-yl)methyl)ethanamine
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C22H20BrN3OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0502961
2-(4-bromophenyl)-N-((7-methoxy-2-(pyridin-3-yloxy)quinolin-3-yl)methyl)ethanamine
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C24H22BrN3O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0506216
2-(4-bromophenyl)-N-((2-(thiophen-3-yl)-7-(trifluoromethoxy)quinolin-3-yl)methyl)ethanamine
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C23H18BrF3N2OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0507509
2-(4-bromophenyl)-N-((6,7-dimethoxy-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
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C24H23BrN2O2S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0502960
2-(3-bromophenyl)-N-((7-methoxy-2-(thiophen-3-yl)quinolin-3-yl)methyl)ethanamine
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C23H21BrN2OS
 1
1
IC50 = 13000 nM
   TI
   LI
   LO
   TS