Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT04639 , NPC1-like intracellular cholesterol transporter 1
Gene Name NPC1L1
Organism Homo sapiens, Human
Protein Classification Other membrane protein
Uniprot ID Q9UHC9
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT04639
 
Compound ID Compound Name Compound Formula
CP0415847
N-[(2S)-2-[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-5,6-dihydroxy-10,13-dimethyl-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]propyl]-3,5-bis(trifluoromethyl)benzamide
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C37H50F6N2O6
 1
1
EC50 = 86 nM
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CP0481959
2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone
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C33H57NO5
 1
1
EC50 = 150 nM
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CP0555310
(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
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C33H53NO4
 1
1
EC50 = 290 nM
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CP0539719
2-[[(3S,7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone
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C33H55NO4
 1
1
EC50 = 360 nM
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CP0560924
2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-5,6-dihydroxy-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone
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C35H59NO5
 1
1
EC50 = 360 nM
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CP0415848
N-[(2S)-2-[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-5,6-dihydroxy-10,13-dimethyl-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]propyl]-2-methylpropanamide
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C32H54N2O6
 1
1
EC50 = 370 nM
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CP0494598
2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-N,N-bis(2-hydroxyethyl)acetamide
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C33H59NO6
 1
1
EC50 = 560 nM
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CP0539720
2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]acetamide
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C29H51NO4
 1
1
EC50 = 840 nM
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CP0415849
2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone
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C33H55NO4
 1
1
EC50 = 880 nM
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CP0415850
(3S,5R,6R,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-3-(2-morpholin-4-ylethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-5,6-diol
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C33H59NO4
 1
1
EC50 = 1000 nM
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CP0488271
2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-N,N-dimethylacetamide
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C31H53NO3
 1
1
EC50 = 1400 nM
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CP0488014
(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
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C27H44O3
 1
1
EC50 = 1500 nM
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CP0317964
3Beta,5Alpha,6Beta-Trihydroxycholestanol
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C27H48O3
 1
1
EC50 = 1700 nM
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CP0427399
(4R)-N,N-diethyl-4-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide
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C28H47NO2
 1
1
EC50 = 1700 nM
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CP0437353
(3S,5R,6R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,5,6-triol
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C27H48O4
 1
1
EC50 = 1700 nM
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CP0510313
(3S,5R,8S,9S,10R,13R,14S,17R)-3,5-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-one
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C27H46O3
 1
1
EC50 = 1700 nM
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CP0574219
2-[[(3S,5R,6R,8S,9S,10R,13R,14S,17R)-5,6-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-piperidin-1-ylethanone
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C34H59NO4
 1
1
EC50 = 1800 nM
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CP0574220
(3S,7R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
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C27H46O3
 1
1
EC50 = 1900 nM
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CP0101202
(1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3S)-3-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol
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C27H46O2
 1
1
EC50 = 2900 nM
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CP0252873
(4R)-4-[(1S,2R,5S,10S,11S,14R,15R)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-14-yl]-N,N-dimethylpentanamide
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C26H43NO2
 1
1
EC50 = 3100 nM
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CP0004096
(1S,2R,5S,10S,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-ol
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C27H46O2
 1
1
EC50 = 3300 nM
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CP0410637
7Beta-Hydroxycholesterol
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C27H46O2
 1
1
EC50 = 3400 nM
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CP0444211
5alpha-CHOLESTAN-3beta-OL-6-ONE
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C27H46O2
 1
1
EC50 = 3400 nM
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CP0542158
(3S,7R,8S,9S,10R,13R,14S,17R)-3-(2-hydroxyethoxy)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-7-ol
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C29H50O3
 1
1
EC50 = 3400 nM
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CP0482079
(8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
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C27H44O2
 1
1
EC50 = 4000 nM
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CP0548312
(3S,4S,5S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,4,5-triol
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C27H48O3
 1
1
EC50 = 4300 nM
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CP0574221
N,N-diethyl-2-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]acetamide
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C33H57NO3
 1
1
EC50 = 4800 nM
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CP0548313
[(3S,7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] morpholine-4-carboxylate
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C32H53NO4
 1
1
EC50 = 6100 nM
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CP0542256
3-[(2S)-2-[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-5,6-dihydroxy-10,13-dimethyl-3-(2-morpholin-4-yl-2-oxoethoxy)-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]propyl]-1,1-dimethylurea
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C31H53N3O6
 1
1
EC50 = 6800 nM
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CP0379247
7-OXOCHOLESTEROL
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C27H44O2
 1
1
EC50 = 8700 nM
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CP0482080
(6R)-6-[(3S,8S,9S,10R,13R,14S,17R)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methylheptan-2-ol
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C33H59NO2
 1
1
EC50 = 9900 nM
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CP0038783
3beta-hydroxyandrost-5-en-17-one
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C19H28O2
 1
1
EC50 > 10000 nM
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CP0574222
2-[[(3S,5R,6R,8S,9S,10R,13S,14S,17R)-17-[(2S)-1-[3,5-bis(trifluoromethyl)phenoxy]propan-2-yl]-5,6-dihydroxy-10,13-dimethyl-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-yl]oxy]-1-morpholin-4-ylethanone
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C36H49F6NO6
 1
1
EC50 > 10000 nM
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CP0498536
(2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(3-(methylsulfonamido)prop-1-ynyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
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C28H31FN2O11S
 1
1
IC50 = 7 nM
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CP0374285
(2S,3S,4S,5R,6S)-6-(4-((2S,3R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid
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C30H29F2NO9
 1
1
IC50 = 300 nM
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CP0540252
(1-(1-naphthoyl)-5-phenylpiperidin-3-yl)(spiro[indene-1,4'-piperidine]-1'-yl)methanone
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C36H34N2O2
 1
1
IC50 = 390 nM
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CP0407642
2,2,6,6-tetramethylpiperidin-4-yl 2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetate
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C37H50N4O4
 1
1
IC50 = 600 nM
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CP0509390
((2S,4S)-1-benzoyl-4-phenylpyrrolidin-2-yl)(spiro[indene-1,4'-piperidine]-1'-yl)methanone
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C31H30N2O2
 1
1
IC50 = 660 nM
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CP0520759
ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylate
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C36H46N4O5
 1
1
IC50 = 900 nM
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CP0466756
tert-butyl 4-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylate
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C35H47N5O5
 1
1
IC50 = 1000 nM
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CP0501724
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-hydroxyethyl)acetamide
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C28H36N4O4
 1
1
IC50 = 1000 nM
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CP0466765
8-(4-cyclohexylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C33H42N4O3
 1
1
IC50 = 1100 nM
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CP0527670
8-(4-cyclohexylbenzoyl)-3-(2-(4-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C34H44N4O4
 1
1
IC50 = 1100 nM
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CP0382736
2,2,6,6-tetramethylpiperidin-4-yl 2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetate
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C35H48N4O4
 1
1
IC50 = 1300 nM
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CP0393235
tert-butyl N-[[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamate
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C34H45N5O5
 1
1
IC50 = 1700 nM
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CP0407981
2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-hydroxyethyl)acetamide
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C30H38N4O4
 1
1
IC50 = 2000 nM
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CP0466755
2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-(methylsulfonamido)ethyl)acetamide
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C31H41N5O5S
 1
1
IC50 = 2100 nM
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CP0345231
8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperidin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C31H40N4O3
 1
1
IC50 = 2500 nM
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CP0437342
tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamate
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C39H53N5O5
 1
1
IC50 = 2500 nM
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CP0512844
methyl 4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butanoate
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C33H42N4O5
 1
1
IC50 = 2500 nM
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CP0522285
8-(4-tert-butylbenzoyl)-3-(2-(4-(1,3-diethyl-4-methyl-1H-pyrazol-5-yl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C39H52N6O3
 1
1
IC50 = 2500 nM
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CP0409998
8-(4-cyclohexylbenzoyl)-3-(2-(3-ethylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C35H46N4O3
 1
1
IC50 = 2600 nM
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CP0543861
8-(4-tert-butylbenzoyl)-3-(2-(4-(2-hydroxyethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
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C33H44N4O4
 1
1
IC50 = 2600 nM
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CP0409995
N-(3-aminopropyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide
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C31H41N5O3
 1
1
IC50 = 3100 nM
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CP0520758
ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-4-carboxylate
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C34H44N4O5
 1
1
IC50 = 3100 nM
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CP0520760
1-(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)piperidine-3-carboxamide
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C34H43N5O4
 1
1
IC50 = 3100 nM
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CP0543856
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(methylsulfonamidomethyl)acetamide
   Show/Hide
C28H37N5O5S
 1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CP0518389
1-(2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)-N,N-diethylpiperidine-3-carboxamide
   Show/Hide
C38H51N5O4
 1
1
IC50 = 3300 nM
   TI
   LI
   LO
   TS
CP0466757
tert-butyl 4-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperazine-1-carboxylate
   Show/Hide
C37H49N5O5
 1
1
IC50 = 3500 nM
   TI
   LI
   LO
   TS
CP0407985
8-(4-cyclohexylbenzoyl)-3-(2-(3-methylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C34H44N4O3
 1
1
IC50 = 3600 nM
   TI
   LI
   LO
   TS
CP0527667
methyl 2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetate
   Show/Hide
C31H38N4O5
 1
1
IC50 = 3700 nM
   TI
   LI
   LO
   TS
CP0379955
2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-(methylsulfonamido)propyl)acetamide
   Show/Hide
C32H43N5O5S
 1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0463772
tert-butyl N-[[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamate
   Show/Hide
C39H53N5O5
 1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0527123
N-(2-aminoethyl)-2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide
   Show/Hide
C30H39N5O3
 1
1
IC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0437341
8-(4-tert-butylbenzoyl)-3-(2-(3-ethylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C33H44N4O3
 1
1
IC50 = 3900 nM
   TI
   LI
   LO
   TS
CP0409999
8-(4-tert-butylbenzoyl)-3-(2-(4-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C32H42N4O4
 1
1
IC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0407641
ethyl 1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylate
   Show/Hide
C36H46N4O5
 1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0437339
N-(3-aminopropyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide
   Show/Hide
C29H39N5O3
 1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0512846
tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]methyl]carbamate
   Show/Hide
C37H51N5O5
 1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0527124
tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamate
   Show/Hide
C36H49N5O5
 1
1
IC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0509650
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-isobutylacetamide
   Show/Hide
C30H40N4O3
 1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0478959
tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]carbamate
   Show/Hide
C38H51N5O5
 1
1
IC50 = 4400 nM
   TI
   LI
   LO
   TS
CP0503862
tert-butyl N-[3-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamate
   Show/Hide
C34H47N5O5
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0512843
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(4-(methylsulfonamido)butyl)acetamide
   Show/Hide
C31H43N5O5S
 1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS
CP0389827
7-(2-(1-(4-cyclohexylbutyl)-3-(4-(trifluoromethylthio)phenyl)ureido)ethyl)-2-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
   Show/Hide
C30H37F3N2O5S
 1
1
IC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0527688
8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(4-(1,3,4-triethyl-1H-pyrazol-5-yl)piperidin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C40H54N6O3
 1
1
IC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0543859
tert-butyl N-[4-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]butyl]carbamate
   Show/Hide
C37H51N5O5
 1
1
IC50 = 4600 nM
   TI
   LI
   LO
   TS
CP0473039
8-(4-tert-butylbenzoyl)-3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C31H40N4O4
 1
1
IC50 = 4700 nM
   TI
   LI
   LO
   TS
CP0496739
tert-butyl N-[1-[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamate
   Show/Hide
C38H51N5O5
 1
1
IC50 = 4800 nM
   TI
   LI
   LO
   TS
CP0527669
3-(2-(4-benzoylpiperazin-1-yl)-2-oxoethyl)-8-(4-cyclohexylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C39H45N5O4
 1
1
IC50 = 4800 nM
   TI
   LI
   LO
   TS
CP0498567
8-(4-tert-butylbenzoyl)-3-(2-(4-(1,5-diethyl-4-methyl-1H-pyrazol-3-yl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C39H52N6O3
 1
1
IC50 = 5400 nM
   TI
   LI
   LO
   TS
CP0527678
tert-butyl N-[2-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamate
   Show/Hide
C35H47N5O5
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0543857
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(5-(methylsulfonamido)pentyl)acetamide
   Show/Hide
C32H45N5O5S
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0543858
tert-butyl N-[3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propyl]carbamate
   Show/Hide
C36H49N5O5
 1
1
IC50 = 6000 nM
   TI
   LI
   LO
   TS
CP0512845
8-(4-tert-butylbenzoyl)-3-(2-(2-(2-hydroxyethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C33H44N4O4
 1
1
IC50 = 6100 nM
   TI
   LI
   LO
   TS
CP0498248
8-(4-cyclohexylbenzoyl)-3-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C33H43N5O5S
 1
1
IC50 = 6300 nM
   TI
   LI
   LO
   TS
CP0523562
3-(2-(4-(3-benzyl-1-ethyl-1H-pyrazol-5-yl)piperidin-1-yl)-2-oxoethyl)-8-(4-tert-butylbenzoyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C43H52N6O3
 1
1
IC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0473038
8-(4-cyclohexylbenzoyl)-3-(2-oxo-2-(piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C32H41N5O3
 1
1
IC50 = 6500 nM
   TI
   LI
   LO
   TS
CP0528599
N-(2-aminoethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide
   Show/Hide
C28H37N5O3
 1
1
IC50 = 7000 nM
   TI
   LI
   LO
   TS
CP0505057
4-(4-(((4-tert-butylcyclohexyl)(5-(cyclopentyloxy)-1-methyl-1H-benzo[d]imidazol-2-yl)amino)methyl)phenoxy)butanoic acid
   Show/Hide
C34H47N3O4
 1
1
IC50 = 7400 nM
   TI
   LI
   LO
   TS
CP0425653
N-(5-aminopentyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide
   Show/Hide
C31H43N5O3
 1
1
IC50 = 7700 nM
   TI
   LI
   LO
   TS
CP0379957
8-(4-tert-butylbenzoyl)-3-(2-(3-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C32H42N4O4
 1
1
IC50 = 8200 nM
   TI
   LI
   LO
   TS
CP0501911
ethyl 1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidine-3-carboxylate
   Show/Hide
C34H44N4O5
 1
1
IC50 = 8200 nM
   TI
   LI
   LO
   TS
CP0379954
2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(hydroxymethyl)acetamide
   Show/Hide
C29H36N4O4
 1
1
IC50 = 8300 nM
   TI
   LI
   LO
   TS
CP0527671
tert-butyl N-[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-4-yl]carbamate
   Show/Hide
C36H49N5O5
 1
1
IC50 = 8300 nM
   TI
   LI
   LO
   TS
CP0523418
1-(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)-N,N-diethylpiperidine-3-carboxamide
   Show/Hide
C36H49N5O4
 1
1
IC50 = 8700 nM
   TI
   LI
   LO
   TS
CP0499515
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(5-hydroxypentyl)acetamide
   Show/Hide
C31H42N4O4
 1
1
IC50 = 9400 nM
   TI
   LI
   LO
   TS
CP0501910
tert-butyl N-[[1-[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]piperidin-3-yl]methyl]carbamate
   Show/Hide
C37H51N5O5
 1
1
IC50 = 9500 nM
   TI
   LI
   LO
   TS
CP0437340
2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(4-hydroxybutyl)acetamide
   Show/Hide
C32H42N4O4
 1
1
IC50 = 10300 nM
   TI
   LI
   LO
   TS
CP0503864
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-(methylsulfonamido)propyl)acetamide
   Show/Hide
C30H41N5O5S
 1
1
IC50 = 10400 nM
   TI
   LI
   LO
   TS
CP0473037
tert-butyl N-[2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]ethyl]carbamate
   Show/Hide
C33H45N5O5
 1
1
IC50 = 10900 nM
   TI
   LI
   LO
   TS
CP0466754
3-(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetamido)propanoic acid
   Show/Hide
C29H36N4O5
 1
1
IC50 = 11400 nM
   TI
   LI
   LO
   TS
CP0407986
8-(4-tert-butylbenzoyl)-3-(2-(2-(hydroxymethyl)piperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C32H42N4O4
 1
1
IC50 = 11800 nM
   TI
   LI
   LO
   TS
CP0407984
8-(4-tert-butylbenzoyl)-3-(2-(3-methylpiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C32H42N4O3
 1
1
IC50 = 12000 nM
   TI
   LI
   LO
   TS
CP0379960
8-(4-tert-butylbenzoyl)-3-(2-(3-hydroxypiperidin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C31H40N4O4
 1
1
IC50 = 12200 nM
   TI
   LI
   LO
   TS
CP0376033
methyl 3-[[2-[8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]propanoate
   Show/Hide
C32H40N4O5
 1
1
IC50 = 12900 nM
   TI
   LI
   LO
   TS
CP0532776
tert-butyl N-[5-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]pentyl]carbamate
   Show/Hide
C36H51N5O5
 1
1
IC50 = 13700 nM
   TI
   LI
   LO
   TS
CP0527122
2-(8-(4-cyclohexylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-hydroxypropyl)acetamide
   Show/Hide
C31H40N4O4
 1
1
IC50 = 14000 nM
   TI
   LI
   LO
   TS
CP0409996
8-(4-cyclohexylbenzoyl)-3-(2-oxo-2-(4-(phenylsulfonyl)piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C38H45N5O5S
 1
1
IC50 = 14200 nM
   TI
   LI
   LO
   TS
CP0425652
N-(4-aminobutyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide
   Show/Hide
C30H41N5O3
 1
1
IC50 = 14500 nM
   TI
   LI
   LO
   TS
CP0407983
8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(4-(phenylsulfonyl)piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C36H43N5O5S
 1
1
IC50 = 15000 nM
   TI
   LI
   LO
   TS
CP0499550
methyl 2-[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]acetate
   Show/Hide
C29H36N4O5
 1
1
IC50 = 16600 nM
   TI
   LI
   LO
   TS
CP0382734
1-(2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)acetyl)piperidine-3-carboxamide
   Show/Hide
C32H41N5O4
 1
1
IC50 = 16900 nM
   TI
   LI
   LO
   TS
CP0498247
8-(4-tert-butylbenzoyl)-3-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C31H41N5O5S
 1
1
IC50 = 19000 nM
   TI
   LI
   LO
   TS
CP0425651
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(4-hydroxybutyl)acetamide
   Show/Hide
C30H40N4O4
 1
1
IC50 = 19200 nM
   TI
   LI
   LO
   TS
CP0407982
8-(4-tert-butylbenzoyl)-3-(2-oxo-2-(piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
   Show/Hide
C30H39N5O3
 1
1
IC50 = 22000 nM
   TI
   LI
   LO
   TS
CP0528598
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(3-hydroxypropyl)acetamide
   Show/Hide
C29H38N4O4
 1
1
IC50 = 23600 nM
   TI
   LI
   LO
   TS
CP0503863
N-(aminomethyl)-2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetamide
   Show/Hide
C27H35N5O3
 1
1
IC50 = 26500 nM
   TI
   LI
   LO
   TS
CP0409994
2-(8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2-(methylsulfonamido)ethyl)acetamide
   Show/Hide
C29H39N5O5S
 1
1
IC50 = 49000 nM
   TI
   LI
   LO
   TS
CP0393234
tert-butyl N-[[[2-[8-(4-tert-butylbenzoyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]acetyl]amino]methyl]carbamate
   Show/Hide
C32H43N5O5
 1
1
IC50 = 59000 nM
   TI
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   LO
   TS
CP0540247
2-phenylethyl 1-[(4-tert-butylbenzoyl)sulfamoyl]spiro[2H-indole-3,4'-piperidine]-1'-carboxylate
   Show/Hide
C32H37N3O5S
 1
1
IC50 = 79000 nM
   TI
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   TS
CP0505062
benzyl 2-[2-(4-methylphenyl)ethyl]-5-[(1H-pyrazole-4-carbonylamino)methyl]piperidine-1-carboxylate
   Show/Hide
C27H32N4O3
 1
1
IC50 = 81000 nM
   TI
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   TS