| Compound ID |
Compound Name |
Compound Formula |
|
CP0036566
|
5-L-isoleucineangiotensin II
Show/Hide
|
C50H71N13O12
|
2
|
| 1 |
EC50 = 1.3 nM
|
|
|
| 2 |
EC50 = 6.8 nM
|
|
|
|
CP0533925
|
(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid
Show/Hide
|
C45H71N13O10
|
2
|
| 1 |
EC50 = 3.5 nM
|
|
|
| 2 |
EC50 = 6.1 nM
|
|
|
|
CP0451208
|
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
Show/Hide
|
C43H67N13O10
|
2
|
| 1 |
EC50 = 4.8 nM
|
|
|
| 2 |
EC50 = 6.6 nM
|
|
|
|
CP0887747
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-12-(3-fluoro-4-hydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-15-((R)-1-methoxyethyl)-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C42H64FN13O11
|
2
|
| 1 |
EC50 = 5 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0035923
|
(S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(diaminomethyleneamino)-2-(2-(methylamino)acetamido)pentanamido)-3-methylbutanamido)-3-(4-hydroxyphenyl)propanamido)-3-methylbutanamido)-3-(1H-imidazol-5-yl)propanoyl)pyrrolidine-5-carboxamido)propanoic acid
Show/Hide
|
C42H65N13O10
|
2
|
| 1 |
EC50 = 6 nM
|
|
|
| 2 |
EC50 = 7.5 nM
|
|
|
|
CP0868847
|
(S)-N-((S)-1-((S)-1-((S)-1-((S)-1-amino-3-(1H-imidazol-5-yl)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-5-guanidino-2-(2-(methylamino)acetamido)pentanamide
Show/Hide
|
C34H54N12O7
|
2
|
| 1 |
EC50 = 6.8 nM
|
|
|
| 2 |
EC50 = 42 nM
|
|
|
|
CP0745985
|
Angiotensin-II
Show/Hide
|
C44H67N13O12
|
2
|
| 1 |
EC50 = 7.3 nM
|
|
|
| 2 |
EC50 = 15 nM
|
|
|
|
CP0902534
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6,15-bis(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H68N16O10
|
2
|
| 1 |
EC50 = 7.4 nM
|
|
|
| 2 |
EC50 = 63 nM
|
|
|
|
CP0868848
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-12-(3-chloro-4-hydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-15-((R)-1-methoxyethyl)-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C42H64ClN13O11
|
2
|
| 1 |
EC50 = 7.9 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0902537
|
(R)-2-((S)-1-((3S,6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-3-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C44H69N13O10
|
2
|
| 1 |
EC50 = 8.2 nM
|
|
|
| 2 |
EC50 = 63 nM
|
|
|
|
CP0951397
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-15-((R)-1-methoxyethyl)-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C42H65N13O11
|
2
|
| 1 |
EC50 = 8.2 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0905465
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)pentanoic acid
Show/Hide
|
C45H71N13O10
|
2
|
| 1 |
EC50 = 9.3 nM
|
|
|
| 2 |
EC50 = 12 nM
|
|
|
|
CP0951233
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-12-(3-fluoro-4-hydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H66FN13O10
|
2
|
| 1 |
EC50 = 10 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0169597
|
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
Show/Hide
|
C43H68N14O10
|
2
|
| 1 |
EC50 = 11 nM
|
|
|
| 2 |
EC50 = 39 nM
|
|
|
|
CP0905464
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-2-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H67N13O10
|
2
|
| 1 |
EC50 = 13 nM
|
|
|
| 2 |
EC50 = 37 nM
|
|
|
|
CP0902510
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-benzyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C46H65N13O10
|
2
|
| 1 |
EC50 = 13 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0902517
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-12-(3-chloro-4-hydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H66ClN13O10
|
2
|
| 1 |
EC50 = 13 nM
|
|
|
| 2 |
EC50 = 25000 nM
|
|
|
|
CP0891301
|
(2S,3S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12,15-bis(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)-3-methylpentanoic acid
Show/Hide
|
C49H71N13O11
|
2
|
| 1 |
EC50 = 14 nM
|
|
|
| 2 |
EC50 = 32 nM
|
|
|
|
CP0868854
|
TRV-120027
Show/Hide
|
C43H67N13O10
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0905467
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-15-((R)-1-methoxyethyl)-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C42H65N13O11
|
2
|
| 1 |
EC50 = 16 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0954059
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxylic acid
Show/Hide
|
C39H60N12O9
|
2
|
| 1 |
EC50 = 17 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0897054
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12,15-bis(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C46H65N13O11
|
2
|
| 1 |
EC50 = 18 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0868841
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12,15-bis(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)-3-phenylpropanoic acid
Show/Hide
|
C52H69N13O11
|
2
|
| 1 |
EC50 = 19 nM
|
|
|
| 2 |
EC50 = 64 nM
|
|
|
|
CP0887748
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-5-sec-butyl-1-(2-(carboxymethylcarbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid
Show/Hide
|
C43H65N13O12
|
2
|
| 1 |
EC50 = 20 nM
|
|
|
| 2 |
EC50 = 160 nM
|
|
|
|
CP0905469
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-2-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C44H69N13O10
|
2
|
| 1 |
EC50 = 24 nM
|
|
|
| 2 |
EC50 = 43 nM
|
|
|
|
CP0902514
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxy-3-nitrobenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H66N14O12
|
2
|
| 1 |
EC50 = 25 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0902513
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6,15-bis(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C40H64N16O8
|
2
|
| 1 |
EC50 = 26 nM
|
|
|
| 2 |
EC50 = 27 nM
|
|
|
|
CP0905468
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-15,18-bis((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H63N15O10
|
2
|
| 1 |
EC50 = 27 nM
|
|
|
| 2 |
EC50 = 250 nM
|
|
|
|
CP0868835
|
(6S,9S,12S,15S)-15-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-ylcarbamoyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13-tetraoxo-2,5,8,11,14-pentaazaoctadecan-18-oic acid
Show/Hide
|
C39H59N13O10
|
2
|
| 1 |
EC50 = 31 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887734
|
(S)-2-((S)-1-((3S,6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-3-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H67N13O10
|
2
|
| 1 |
EC50 = 31 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0868845
|
(S)-2-((S)-1-((3S,6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-3-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C44H69N13O10
|
2
|
| 1 |
EC50 = 32 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0868840
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)-N-((S)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide
Show/Hide
|
C42H66N14O9
|
2
|
| 1 |
EC50 = 35 nM
|
|
|
| 2 |
EC50 = 200 nM
|
|
|
|
CP0902511
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12,15-bis(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C43H61N13O9
|
2
|
| 1 |
EC50 = 38 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0874454
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-12-(3,4-dihydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-15-((R)-1-methoxyethyl)-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C42H65N13O12
|
2
|
| 1 |
EC50 = 40 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0451213
|
(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid
Show/Hide
|
C42H73N13O9
|
2
|
| 1 |
EC50 = 41 nM
|
|
|
| 2 |
EC50 = 120 nM
|
|
|
|
CP0868838
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-15-propyl-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C42H65N13O10
|
2
|
| 1 |
EC50 = 50 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0874508
|
(S)-1-((6S,9S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
Show/Hide
|
C34H58N14O8
|
2
|
| 1 |
EC50 = 59 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0905463
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-12-(3,4-dihydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H67N13O11
|
2
|
| 1 |
EC50 = 63 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887736
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12,15-bis(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)-N-((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
Show/Hide
|
C49H72N14O10
|
2
|
| 1 |
EC50 = 77 nM
|
|
|
| 2 |
EC50 = 230 nM
|
|
|
|
CP0868856
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)-N-((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
Show/Hide
|
C45H72N14O9
|
2
|
| 1 |
EC50 = 79 nM
|
|
|
| 2 |
EC50 = 120 nM
|
|
|
|
CP0887738
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-12-(4-fluorobenzyl)-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H66FN13O9
|
2
|
| 1 |
EC50 = 79 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887741
|
(6S,9S,12S,15S)-15-((S)-1-((S)-2-((1S,2S)-1-carboxy-2-methylbutylcarbamoyl)pyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-ylcarbamoyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13-tetraoxo-2,5,8,11,14-pentaazaoctadecan-18-oic acid
Show/Hide
|
C45H69N13O12
|
2
|
| 1 |
EC50 = 92 nM
|
|
|
| 2 |
EC50 = 140 nM
|
|
|
|
CP0868851
|
2-((S)-1-((6S,9S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)acetic acid
Show/Hide
|
C34H57N13O9
|
2
|
| 1 |
EC50 = 96 nM
|
|
|
| 2 |
EC50 = 1900 nM
|
|
|
|
CP0902535
|
1-[3-[(3S,6S,9S,12S,15S,18S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,57S,60S)-6,27,48-tris[(2S)-butan-2-yl]-36,57-bis(3-carbamimidamidopropyl)-9,30,51-tris[(4-hydroxyphenyl)methyl]-3,24,45-tris(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,23,26,29,32,35,38,44,47,50,53,56,59-octadecaoxo-12,33,54-tri(propan-2-yl)-1,4,7,10,13,16,22,25,28,31,34,37,43,46,49,52,55,58-octadecazatetracyclo[58.3.0.018,22.039,43]trihexacontan-15-yl]propyl]guanidine
Show/Hide
|
C111H165N33O21
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
EC50 = 1900 nM
|
|
|
|
CP0902509
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-12-(3,5-dibromo-4-hydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H65Br2N13O10
|
2
|
| 1 |
EC50 = 100 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887737
|
(R)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C40H63N13O8
|
2
|
| 1 |
EC50 = 110 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0905466
|
(R)-2-((S)-1-((3R,6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-3-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C44H69N13O10
|
2
|
| 1 |
EC50 = 130 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887739
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-12-(2,6-difluoro-4-hydroxybenzyl)-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H65F2N13O10
|
2
|
| 1 |
EC50 = 160 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887744
|
(2S,5S,8S,11S,14S,17R)-2-((1H-imidazol-5-yl)methyl)-17-amino-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-5,8-bis(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaicosan-20-oic acid
Show/Hide
|
C45H63N13O11
|
2
|
| 1 |
EC50 = 180 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0902516
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)-N-((S)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide
Show/Hide
|
C43H68N14O9
|
2
|
| 1 |
EC50 = 180 nM
|
|
|
| 2 |
EC50 = 220 nM
|
|
|
|
CP0868846
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-12-benzyl-15-sec-butyl-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H67N13O9
|
2
|
| 1 |
EC50 = 200 nM
|
|
|
| 2 |
EC50 = 2700 nM
|
|
|
|
CP0887733
|
(S)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-9-isopropyl-12-(4-methoxybenzyl)-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C44H69N13O10
|
2
|
| 1 |
EC50 = 200 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0913668
|
(3S,6S,9S,12S,15S,18S,24S,27S,30S,33S,36S,39S,45S,48S,51S,54S,57S,60S)-15,36,57-tribenzyl-6,27,48-tris[(2S)-butan-2-yl]-9,30,51-tris[(4-hydroxyphenyl)methyl]-3,24,45-tris(1H-imidazol-5-ylmethyl)-12,33,54-tri(propan-2-yl)-1,4,7,10,13,16,22,25,28,31,34,37,43,46,49,52,55,58-octadecazatetracyclo[58.3.0.018,22.039,43]trihexacontane-2,5,8,11,14,17,23,26,29,32,35,38,44,47,50,53,56,59-octadecone
Show/Hide
|
C120H156N24O21
|
2
|
| 1 |
EC50 = 240 nM
|
|
|
| 2 |
EC50 = 1900 nM
|
|
|
|
CP0868852
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-(4-aminobutyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C40H64N14O8
|
2
|
| 1 |
EC50 = 260 nM
|
|
|
| 2 |
EC50 = 910 nM
|
|
|
|
CP0874476
|
(2S,5S,8S,11S,14S,17R)-2-((1H-imidazol-5-yl)methyl)-17-amino-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-5,8-bis(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid
Show/Hide
|
C44H61N13O11
|
2
|
| 1 |
EC50 = 260 nM
|
|
|
| 2 |
EC50 = 1400 nM
|
|
|
|
CP0909534
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-(4-aminobutyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H72N12O10
|
2
|
| 1 |
EC50 = 270 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0913666
|
(S)-1-((6S,9S,12S,15S,18S)-15,18-bis((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C40H59N15O8
|
2
|
| 1 |
EC50 = 270 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887735
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12,15-bis(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxylic acid
Show/Hide
|
C43H60N12O10
|
2
|
| 1 |
EC50 = 300 nM
|
|
|
| 2 |
EC50 = 440 nM
|
|
|
|
CP0913664
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-5,8-bis(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid
Show/Hide
|
C44H61N13O11
|
2
|
| 1 |
EC50 = 330 nM
|
|
|
| 2 |
EC50 = 450 nM
|
|
|
|
CP0874452
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-12,15-di-sec-butyl-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)-N-((2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
Show/Hide
|
C43H76N14O8
|
2
|
| 1 |
EC50 = 360 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0869571
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxy-2,6-dimethylbenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C45H71N13O10
|
2
|
| 1 |
EC50 = 400 nM
|
|
|
| 2 |
EC50 = 25000 nM
|
|
|
|
CP0868836
|
(S)-1-((6S,9S,12S,15R,18S)-18-((1H-imidazol-5-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-15-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C37H57N13O8
|
2
|
| 1 |
EC50 = 420 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0868849
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxy-3,5-diiodobenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H65I2N13O10
|
2
|
| 1 |
EC50 = 500 nM
|
|
|
| 2 |
EC50 = 16000 nM
|
|
|
|
CP0909536
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-1-amino-15-sec-butyl-12-(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16-tetraoxo-6-(2-(pyrrolidin-1-yl)acetamido)-2,8,11,14,17-pentaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C46H71N13O10
|
2
|
| 1 |
EC50 = 500 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0909535
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-5-benzyl-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid
Show/Hide
|
C44H61N13O10
|
2
|
| 1 |
EC50 = 530 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0947199
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-12-(4-(allyloxy)benzyl)-15-sec-butyl-6-(3-guanidinopropyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C46H71N13O10
|
2
|
| 1 |
EC50 = 630 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0955173
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-6-(4-aminobutyl)-15-sec-butyl-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H67N11O10
|
2
|
| 1 |
EC50 = 630 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0883975
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-benzyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C43H61N13O8
|
2
|
| 1 |
EC50 = 660 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887743
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-5,8-bis(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaicosan-20-oic acid
Show/Hide
|
C45H63N13O11
|
2
|
| 1 |
EC50 = 820 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0913665
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-5-benzyl-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaicosan-20-oic acid
Show/Hide
|
C45H63N13O10
|
2
|
| 1 |
EC50 = 870 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887742
|
(3S,6S,9S,12S,15S,20aS)-15-((1H-imidazol-5-yl)methyl)-3-benzyl-12-sec-butyl-9-(4-hydroxybenzyl)-6-isopropyltetradecahydropyrrolo[1,2-a][1,4,7,10,13,16]hexaazacyclooctadecine-1,4,7,10,13,16-hexaone
Show/Hide
|
C40H52N8O7
|
2
|
| 1 |
EC50 = 920 nM
|
|
|
| 2 |
EC50 = 2500 nM
|
|
|
|
CP0868855
|
(S)-2-((S)-1-((3R,6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-3-methyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C44H69N13O10
|
2
|
| 1 |
EC50 = 2100 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887745
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-5,8-bis(4-hydroxybenzyl)-11-isopropyl-17-(methylamino)-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid
Show/Hide
|
C45H63N13O11
|
2
|
| 1 |
EC50 = 2100 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0902515
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-15-sec-butyl-6-(3-guanidinopropyl)-12-(4-hydroxy-3,5-dinitrobenzyl)-9-isopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C43H65N15O14
|
2
|
| 1 |
EC50 = 2500 nM
|
|
|
| 2 |
EC50 = 4000 nM
|
|
|
|
CP0902539
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-5-benzyl-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-17-(methylamino)-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid
Show/Hide
|
C45H63N13O10
|
2
|
| 1 |
EC50 = 2800 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0913669
|
(6S,9S,12S,15S)-15-((S)-1-((S)-2-((S)-1-carboxyethylcarbamoyl)pyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-ylcarbamoyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-isopropyl-4,7,10,13-tetraoxo-2,5,8,11,14-pentaazaoctadecan-18-oic acid
Show/Hide
|
C42H63N13O12
|
2
|
| 1 |
EC50 = 3600 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0868853
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-5,8-bis(4-hydroxybenzyl)-11-isopropyl-17-(methylamino)-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaicosan-20-oic acid
Show/Hide
|
C46H65N13O11
|
2
|
| 1 |
EC50 = 3900 nM
|
|
|
| 2 |
EC50 > 10000 nM
|
|
|
|
CP0887740
|
(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-1,6-diamino-15-sec-butyl-12-(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecane)pyrrolidine-2-carboxamide
Show/Hide
|
C37H58N12O7
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
EC50 = 43000 nM
|
|
|
|
CP0887746
|
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-5-benzyl-1-((S)-2-carbamoylpyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-17-(methylamino)-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaicosan-20-oic acid
Show/Hide
|
C46H65N13O10
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
EC50 = 10000 nM
|
|
|
|
CP0944231
|
(R)-2-((S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-5-yl)methyl)-1-amino-15-sec-butyl-12-(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16-tetraoxo-6-(2-(piperidin-1-yl)acetamido)-2,8,11,14,17-pentaazanonadecane)pyrrolidine-2-carboxamido)propanoic acid
Show/Hide
|
C47H73N13O10
|
2
|
| 1 |
EC50 > 10000 nM
|
|
|
| 2 |
EC50 = 10000 nM
|
|
|
|
CP0041674
|
(S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amino}-butyric acid
Show/Hide
|
C24H29N5O3
|
1
|
| 1 |
EC50 > 10000 nM
|
|
|
