Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT03917 , P2X purinoceptor 7
Gene Name P2RX7
Organism Rattus norvegicus, Rat
Protein Classification Ion channel
Uniprot ID Q64663
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT03917
 
Compound ID Compound Name Compound Formula
CP0542887
N-[(2S)-2-(4-chlorophenyl)-2-morpholin-4-ylethyl]-2-pyrimidin-2-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
   Show/Hide
C21H19ClF3N5O2S
 2
1
IC50 = 2.4 nM
   TI
   LI
   LO
   TS
2
IC50 = 66 nM
   TI
   LI
   LO
   TS
CP0305061
N-[1-[(Z)-[(cyanoamino)-(2,5-dimethylanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C25H33N5O3
 1
1
IC50 = 3.162 nM
   TI
   LI
   LO
   TS
CP0064246
A-740003
   Show/Hide
C26H30N6O3
 2
1
IC50 = 4 nM
   TI
   LI
   LO
   TS
2
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0543669
AZD-9056
   Show/Hide
C24H35ClN2O2
 1
1
IC50 = 4.4 nM
   TI
   LI
   LO
   TS
CP0153595
N-[[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl]-2-phenylsulfanylpyridine-3-carboxamide
   Show/Hide
C28H32N4O2S
 1
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS
CP0447237
1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine
   Show/Hide
C19H17N5
 1
1
IC50 = 6.1 nM
   TI
   LI
   LO
   TS
CP0399814
N-[1-[(E)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(4-cyanophenyl)acetamide
   Show/Hide
C25H25N7O
 1
1
IC50 = 6.31 nM
   TI
   LI
   LO
   TS
CP0537882
2-(4-chlorophenyl)-N-[1-[[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]acetamide
   Show/Hide
C24H25ClN6O
 1
1
IC50 = 6.31 nM
   TI
   LI
   LO
   TS
CP0399824
N-[1-[(E)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(4-methylsulfanylphenyl)acetamide
   Show/Hide
C23H29N5OS
 1
1
IC50 = 7.943 nM
   TI
   LI
   LO
   TS
CP0417433
N-[2,2-dichloro-1-[[(cyanoamino)-[(2-methoxypyridin-3-yl)amino]methylidene]amino]propyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C21H24Cl2N6O4
 1
1
IC50 = 7.943 nM
   TI
   LI
   LO
   TS
CP0445443
N-[1-[(Z)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(4-methylsulfanylphenyl)acetamide
   Show/Hide
C25H28N6OS
 1
1
IC50 = 7.943 nM
   TI
   LI
   LO
   TS
CP0475892
N-[1-[[(2-chloroanilino)-(cyanoamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H28ClN5O3
 1
1
IC50 = 7.943 nM
   TI
   LI
   LO
   TS
CP0417435
4-chloro-N-[2,2-dichloro-1-[[(cyanoamino)-[(2,6-dimethoxypyridin-3-yl)amino]methylidene]amino]propyl]benzamide
   Show/Hide
C19H19Cl3N6O3
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0435266
N-[1-[[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
   Show/Hide
C26H28N6O3
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0445444
N-[1-[(Z)-[(cyanoamino)-(2,4-difluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H27F2N5O3
 1
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
CP0467308
N-[1-[(Z)-[(cyanoamino)-(2-fluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H28FN5O3
 1
1
IC50 = 12.59 nM
   TI
   LI
   LO
   TS
CP0467315
N-[1-[(Z)-[(cyanoamino)-[(2,6-dimethoxypyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C24H32N6O5
 1
1
IC50 = 12.59 nM
   TI
   LI
   LO
   TS
CP0422018
1-(2,3-dichlorophenyl)-N-[(2,3-dimethoxyphenyl)methyl]tetrazol-5-amine
   Show/Hide
C16H15Cl2N5O2
 1
1
IC50 = 18.62 nM
   TI
   LI
   LO
   TS
CP0443427
N-[1-[(Z)-[(cyanoamino)-(4-fluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H28FN5O3
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0455062
N-[1-[(Z)-[(cyanoamino)-(4-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C24H31N5O3
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0510504
N-[2,2-dichloro-1-[(Z)-[(cyanoamino)-[(2-methoxypyridin-3-yl)amino]methylidene]amino]propyl]-3,5-dimethoxybenzamide
   Show/Hide
C20H22Cl2N6O4
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0518430
N-[1-[[(5-chloro-2-fluoroanilino)-(cyanoamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H27ClFN5O3
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0523251
2-(4-chlorophenyl)-N-[1-[[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]acetamide
   Show/Hide
C22H26ClN5O
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0526152
N-[1-[(Z)-[(cyanoamino)-(2,5-difluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H27F2N5O3
 1
1
IC50 = 19.95 nM
   TI
   LI
   LO
   TS
CP0509555
1-(2,3-dichlorophenyl)-N-[(2-methylsulfonylphenyl)methyl]tetrazol-5-amine
   Show/Hide
C15H13Cl2N5O2S
 1
1
IC50 = 21.38 nM
   TI
   LI
   LO
   TS
CP0445442
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-4-phenylbutanamide
   Show/Hide
C24H31N5O
 1
1
IC50 = 25.12 nM
   TI
   LI
   LO
   TS
CP0467310
N-[1-[(Z)-[(cyanoamino)-(2-methoxyanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C24H31N5O4
 1
1
IC50 = 25.12 nM
   TI
   LI
   LO
   TS
CP0417432
N-[1-[[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-naphthalen-1-ylacetamide
   Show/Hide
C28H28N6O
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0435264
N-[1-[[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-2-(4-methylsulfanylphenyl)acetamide
   Show/Hide
C22H28N6OS
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0445445
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]hexanamide
   Show/Hide
C20H31N5O
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0467313
N-[1-[(E)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-4-(4-methoxyphenyl)butanamide
   Show/Hide
C25H33N5O2
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0467316
N-[1-[(Z)-[(cyanoamino)-(2,4,6-trifluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H26F3N5O3
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0467317
N-[1-[(Z)-[(cyanoamino)-(2,6-difluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H27F2N5O3
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0476197
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(4-methoxyphenyl)acetamide
   Show/Hide
C23H29N5O2
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0495665
N-[1-[(Z)-[(cyanoamino)-(isoquinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C26H30N6O3
 1
1
IC50 = 31.62 nM
   TI
   LI
   LO
   TS
CP0305060
2-(4-chlorophenyl)-N-[1-[(Z)-[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]acetamide
   Show/Hide
C21H25ClN6O
 1
1
IC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0417427
N-[1-[(Z)-[(cyanoamino)-(3-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C24H31N5O3
 1
1
IC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0417434
N-[1-[(Z)-[[(2-chloropyridin-3-yl)amino]-(cyanoamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C22H27ClN6O3
 1
1
IC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0467309
2-(1,3-benzodioxol-5-yl)-N-[1-[[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]acetamide
   Show/Hide
C23H27N5O3
 1
1
IC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0510497
N-[1-[(Z)-[(cyanoamino)-[(2-methoxypyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H30N6O4
 1
1
IC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0537880
N-[1-[(Z)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-4-pyridin-3-ylbutanamide
   Show/Hide
C25H29N7O
 1
1
IC50 = 39.81 nM
   TI
   LI
   LO
   TS
CP0502619
1-(2,3-dichlorophenyl)-N-(2-methylphenyl)tetrazol-5-amine
   Show/Hide
C14H11Cl2N5
 1
1
IC50 = 42.66 nM
   TI
   LI
   LO
   TS
CP0504372
1-(2,3-dichlorophenyl)-N-[(2-methylsulfanylphenyl)methyl]tetrazol-5-amine
   Show/Hide
C15H13Cl2N5S
 1
1
IC50 = 43.65 nM
   TI
   LI
   LO
   TS
CP0441357
1-(2,3-dichlorophenyl)-N-[(2-morpholin-4-ylphenyl)methyl]tetrazol-5-amine
   Show/Hide
C18H18Cl2N6O
 1
1
IC50 = 45.71 nM
   TI
   LI
   LO
   TS
CP0399812
N-[1-[[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-5-phenylpentanamide
   Show/Hide
C24H32N6O
 1
1
IC50 = 50.12 nM
   TI
   LI
   LO
   TS
CP0435265
4-chloro-N-[2,2-dichloro-1-[(Z)-[(cyanoamino)-[(2-methoxypyridin-3-yl)amino]methylidene]amino]propyl]benzamide
   Show/Hide
C18H17Cl3N6O2
 1
1
IC50 = 50.12 nM
   TI
   LI
   LO
   TS
CP0495664
2-(3,4-dimethoxyphenyl)-N-[2,2,2-trichloro-1-[(2-methylphenyl)carbamothioylamino]ethyl]acetamide
   Show/Hide
C20H22Cl3N3O3S
 1
1
IC50 = 50.12 nM
   TI
   LI
   LO
   TS
CP0526151
N-[1-[(Z)-[(cyanoamino)-(3,4-difluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H27F2N5O3
 1
1
IC50 = 50.12 nM
   TI
   LI
   LO
   TS
CP0494400
1-(2,3-dichlorophenyl)-N-[(2-methylphenyl)methyl]tetrazol-5-amine
   Show/Hide
C15H13Cl2N5
 1
1
IC50 = 50.12 nM
   TI
   LI
   LO
   TS
CP0441353
N-benzyl-1-(2,3-dichlorophenyl)tetrazol-5-amine
   Show/Hide
C14H11Cl2N5
 1
1
IC50 = 54.95 nM
   TI
   LI
   LO
   TS
CP0509276
1-(2,3-dichlorophenyl)-N-[(2-methoxyphenyl)methyl]tetrazol-5-amine
   Show/Hide
C15H13Cl2N5O
 1
1
IC50 = 56.23 nM
   TI
   LI
   LO
   TS
CP0529836
1-(2,3-dichlorophenyl)-N-[(3-fluorophenyl)methyl]tetrazol-5-amine
   Show/Hide
C14H10Cl2FN5
 1
1
IC50 = 56.23 nM
   TI
   LI
   LO
   TS
CP0460705
1-(2,3-dichlorophenyl)-N-[(1R)-2,3-dihydro-1H-inden-1-yl]tetrazol-5-amine
   Show/Hide
C16H13Cl2N5
 1
1
IC50 = 58.88 nM
   TI
   LI
   LO
   TS
CP0501763
N-(1-adamantylmethyl)-2-chloro-5-(piperidin-4-ylmethyl)benzamide
   Show/Hide
C24H33ClN2O
 1
1
IC50 = 63.1 nM
   TI
   LI
   LO
   TS
CP0445441
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,5-dimethoxyphenyl)acetamide
   Show/Hide
C24H31N5O3
 1
1
IC50 = 63.1 nM
   TI
   LI
   LO
   TS
CP0404877
5-(2,3-dichlorophenyl)-1-[(2-methylphenyl)methyl]tetrazole
   Show/Hide
C15H12Cl2N4
 1
1
IC50 = 69.18 nM
   TI
   LI
   LO
   TS
CP0459177
1-(2,3-dichlorophenyl)-N-[[2-[2-(diethylamino)ethoxy]phenyl]methyl]tetrazol-5-amine
   Show/Hide
C20H24Cl2N6O
 1
1
IC50 = 69.18 nM
   TI
   LI
   LO
   TS
CP0407519
3-[[5-[2-chloro-3-(trifluoromethyl)phenyl]tetrazol-1-yl]methyl]pyridine
   Show/Hide
C14H9ClF3N5
 1
1
IC50 = 71 nM
   TI
   LI
   LO
   TS
CP0459178
1-(2,3-dichlorophenyl)-N-[[2-(difluoromethoxy)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C15H11Cl2F2N5O
 1
1
IC50 = 72.44 nM
   TI
   LI
   LO
   TS
CP0494399
1-(2,3-dichlorophenyl)-N-[(2-fluorophenyl)methyl]tetrazol-5-amine
   Show/Hide
C14H10Cl2FN5
 1
1
IC50 = 75.86 nM
   TI
   LI
   LO
   TS
CP0467312
N-[1-[(Z)-[(cyanoamino)-(3-fluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H28FN5O3
 1
1
IC50 = 79.43 nM
   TI
   LI
   LO
   TS
CP0542885
N-[(2R)-2-(4-chlorophenyl)-2-morpholin-4-ylethyl]-2-pyrimidin-2-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
   Show/Hide
C21H19ClF3N5O2S
 1
1
IC50 = 95 nM
   TI
   LI
   LO
   TS
CP0373179
N-(1-adamantylmethyl)-2-chloro-5-[(3S)-piperidin-3-yl]oxybenzamide
   Show/Hide
C23H31ClN2O2
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0399818
N-[1-[(Z)-[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-4-(4-methoxyphenyl)butanamide
   Show/Hide
C24H32N6O2
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0399823
N-[1-[(Z)-[(cyanoamino)-(2,3-difluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H27F2N5O3
 1
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
CP0441354
1-(2,3-dichlorophenyl)-N-[[2-(dimethylamino)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C16H16Cl2N6
 1
1
IC50 = 102.33 nM
   TI
   LI
   LO
   TS
CP0476845
2-[[[1-(2,3-dichlorophenyl)tetrazol-5-yl]amino]methyl]benzonitrile
   Show/Hide
C15H10Cl2N6
 1
1
IC50 = 102.33 nM
   TI
   LI
   LO
   TS
CP0501477
N-[(2-chlorophenyl)methyl]-1-(2,3-dichlorophenyl)tetrazol-5-amine
   Show/Hide
C14H10Cl3N5
 1
1
IC50 = 104.71 nM
   TI
   LI
   LO
   TS
CP0441355
1-(2,3-dichlorophenyl)-N-[(2-ethoxyphenyl)methyl]tetrazol-5-amine
   Show/Hide
C16H15Cl2N5O
 1
1
IC50 = 107.15 nM
   TI
   LI
   LO
   TS
CP0460704
1-(2,3-dichlorophenyl)-N-[(2-propan-2-yloxyphenyl)methyl]tetrazol-5-amine
   Show/Hide
C17H17Cl2N5O
 1
1
IC50 = 114.82 nM
   TI
   LI
   LO
   TS
CP0501527
1-(2,3-dichlorophenyl)-N-[[2-(trifluoromethyl)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C15H10Cl2F3N5
 1
1
IC50 = 120.23 nM
   TI
   LI
   LO
   TS
CP0473675
4-chloro-N-[2,2-dichloro-1-[[[(2-chloropyridin-3-yl)amino]-(cyanoamino)methylidene]amino]propyl]benzamide
   Show/Hide
C17H14Cl4N6O
 1
1
IC50 = 125.89 nM
   TI
   LI
   LO
   TS
CP0501529
1-(2,3-dichlorophenyl)-N-[(4-fluorophenyl)methyl]tetrazol-5-amine
   Show/Hide
C14H10Cl2FN5
 1
1
IC50 = 125.89 nM
   TI
   LI
   LO
   TS
CP0476783
1-(2,3-dichlorophenyl)-N-[(2,5-difluorophenyl)methyl]tetrazol-5-amine
   Show/Hide
C14H9Cl2F2N5
 1
1
IC50 = 141.25 nM
   TI
   LI
   LO
   TS
CP0483451
1-(2,3-dichlorophenyl)-N-(2-phenylpropan-2-yl)tetrazol-5-amine
   Show/Hide
C16H15Cl2N5
 1
1
IC50 = 144.54 nM
   TI
   LI
   LO
   TS
CP0470271
N-(1,3-benzodioxol-4-ylmethyl)-1-(2,3-dichlorophenyl)tetrazol-5-amine
   Show/Hide
C15H11Cl2N5O2
 1
1
IC50 = 151.36 nM
   TI
   LI
   LO
   TS
CP0473673
N-[1-[(Z)-[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H30N6O3
 1
1
IC50 = 158.49 nM
   TI
   LI
   LO
   TS
CP0490672
N-[1-[(Z)-[(cyanoamino)-(quinolin-8-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C26H30N6O3
 1
1
IC50 = 158.49 nM
   TI
   LI
   LO
   TS
CP0499830
N-[(2-chloro-4-fluorophenyl)methyl]-2-(3-ethyl-5-methyl-2-phenylimidazol-4-yl)acetamide
   Show/Hide
C21H21ClFN3O
 1
1
IC50 = 158.49 nM
   TI
   LI
   LO
   TS
CP0504871
N-[(2-chloro-4-fluorophenyl)methyl]-2-[2-(2,4-difluorophenyl)-3-ethyl-5-methylimidazol-4-yl]acetamide
   Show/Hide
C21H19ClF3N3O
 1
1
IC50 = 158.49 nM
   TI
   LI
   LO
   TS
CP0459176
1-(2,3-dichlorophenyl)-N-[(3-methoxyphenyl)methyl]tetrazol-5-amine
   Show/Hide
C15H13Cl2N5O
 1
1
IC50 = 173.78 nM
   TI
   LI
   LO
   TS
CP0483450
1-(2,3-dichlorophenyl)-N-[[2-(trifluoromethoxy)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C15H10Cl2F3N5O
 1
1
IC50 = 186.21 nM
   TI
   LI
   LO
   TS
CP0467305
N-[1-[[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-2-(3-fluoro-4-methylphenyl)acetamide
   Show/Hide
C22H27FN6O
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0473672
N-[1-[[N'-[(2-chlorophenyl)methyl]-N-cyanocarbamimidoyl]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C24H30ClN5O3
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0470270
2-(2,3-dichlorophenyl)-N-[(2-methylphenyl)methyl]-1,2,4-triazol-3-amine
   Show/Hide
C16H14Cl2N4
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0504368
1-(2,3-dichlorophenyl)-N-(2,3-dihydro-1-benzofuran-3-yl)tetrazol-5-amine
   Show/Hide
C15H11Cl2N5O
 1
1
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
CP0424996
E133
   Show/Hide
C47H49N3O7S2
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0201601
3-(2,3-dichlorophenyl)-4-[(2-methylphenyl)methyl]-1,2,4-triazole
   Show/Hide
C16H13Cl2N3
 1
1
IC50 = 208.93 nM
   TI
   LI
   LO
   TS
CP0501478
1-(2,3-dichlorophenyl)-N-(2,3-dihydro-1-benzofuran-4-ylmethyl)tetrazol-5-amine
   Show/Hide
C16H13Cl2N5O
 1
1
IC50 = 218.78 nM
   TI
   LI
   LO
   TS
CP0494356
1-(2,3-dichlorophenyl)-N-[(2,3-difluorophenyl)methyl]tetrazol-5-amine
   Show/Hide
C14H9Cl2F2N5
 1
1
IC50 = 229.09 nM
   TI
   LI
   LO
   TS
CP0467678
1-(2,3-dichlorophenyl)-N-[(2,3-dimethylphenyl)methyl]tetrazol-5-amine
   Show/Hide
C16H15Cl2N5
 1
1
IC50 = 245.47 nM
   TI
   LI
   LO
   TS
CP0373175
N-(1-adamantylmethyl)-2-chloro-5-[[(1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]benzamide
   Show/Hide
C24H32ClN3O
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0498495
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-3-(4-methoxyphenyl)propanamide
   Show/Hide
C24H31N5O2
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0127922
N-[(2-chloro-4-fluorophenyl)methyl]-2-(3,5-dimethyl-2-phenylimidazol-4-yl)acetamide
   Show/Hide
C20H19ClFN3O
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0504868
N-[(2-chloro-4-fluorophenyl)methyl]-2-[2-(2,4-difluorophenyl)-3-methylimidazol-4-yl]acetamide
   Show/Hide
C19H15ClF3N3O
 1
1
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
CP0520236
BDBM199009
   Show/Hide
C16H12ClF3N2O2
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0498949
1-(2,3-dichlorophenyl)-N-[(1S)-2,3-dihydro-1H-inden-1-yl]tetrazol-5-amine
   Show/Hide
C16H13Cl2N5
 1
1
IC50 = 288.4 nM
   TI
   LI
   LO
   TS
CP0078785
A-438079
   Show/Hide
C13H9Cl2N5
 2
1
IC50 = 309.03 nM
   TI
   LI
   LO
   TS
2
IC50 = 910 nM
   TI
   LI
   LO
   TS
CP0373181
N-(1-adamantylmethyl)-2-chloro-5-piperidin-4-ylbenzamide
   Show/Hide
C23H31ClN2O
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0405263
N-(1-adamantylmethyl)-5-chloro-2-piperidin-3-yloxypyrimidine-4-carboxamide
   Show/Hide
C21H29ClN4O2
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0489285
N-(1-adamantylmethyl)-2-chloro-5-[(3R)-piperidin-3-yl]oxybenzamide
   Show/Hide
C23H31ClN2O2
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0435263
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-2-phenylacetamide
   Show/Hide
C22H27N5O
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0473674
N-[1-[(Z)-[(cyanoamino)-(3,5-difluoroanilino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide
   Show/Hide
C23H27F2N5O3
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0509085
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-3-(3,4-dimethoxyphenyl)propanamide
   Show/Hide
C25H33N5O3
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0495326
N-[(2-chloro-4-fluorophenyl)methyl]-2-[2-(2,4-difluorophenyl)-3,5-dimethylimidazol-4-yl]acetamide
   Show/Hide
C20H17ClF3N3O
 1
1
IC50 = 316.23 nM
   TI
   LI
   LO
   TS
CP0489291
N-(1-adamantylmethyl)-2-chloro-5-(piperazin-1-ylmethyl)benzamide
   Show/Hide
C23H32ClN3O
 1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0467314
N-[1-[(Z)-[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]-2,2-dimethylpropyl]-2-(4-fluorophenyl)acetamide
   Show/Hide
C21H25FN6O
 1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0493954
N-[(3-chloro-2-methylphenyl)methyl]-2-[2-(2,4-difluorophenyl)-3-ethyl-5-methylimidazol-4-yl]acetamide
   Show/Hide
C22H22ClF2N3O
 1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0503102
N-[(2-chloro-4-fluorophenyl)methyl]-2-[2-(2,4-difluorophenyl)-3-ethylimidazol-4-yl]acetamide
   Show/Hide
C20H17ClF3N3O
 1
1
IC50 = 398.11 nM
   TI
   LI
   LO
   TS
CP0441356
N-[(3-chlorophenyl)methyl]-1-(2,3-dichlorophenyl)tetrazol-5-amine
   Show/Hide
C14H10Cl3N5
 1
1
IC50 = 467.74 nM
   TI
   LI
   LO
   TS
CP0136276
2-chloro-N-[(1-hydroxycycloheptyl)methyl]-5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]benzamide
   Show/Hide
C22H29ClN4O6
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0405267
N-(1-adamantylmethyl)-2-chloro-5-(piperidin-4-ylamino)benzamide
   Show/Hide
C23H32ClN3O
 1
1
IC50 = 501.19 nM
   TI
   LI
   LO
   TS
CP0455051
2-(1-adamantyl)-N-(1H-indazol-5-yl)acetamide
   Show/Hide
C19H23N3O
 1
1
IC50 = 501.19 nM
   TI
   LI
   LO
   TS
CP0504872
N-[(2-chloro-6-methylphenyl)methyl]-2-(3-ethyl-5-methyl-2-phenylimidazol-4-yl)acetamide
   Show/Hide
C22H24ClN3O
 1
1
IC50 = 501.19 nM
   TI
   LI
   LO
   TS
CP0504356
N-[(5-chloro-2-fluorophenyl)methyl]-1-(2,3-dichlorophenyl)tetrazol-5-amine
   Show/Hide
C14H9Cl3FN5
 1
1
IC50 = 524.81 nM
   TI
   LI
   LO
   TS
CP0405265
N-(1-adamantylmethyl)-2-chloro-5-piperidin-4-yloxybenzamide
   Show/Hide
C23H31ClN2O2
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0535299
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzamide
   Show/Hide
C23H29N5O3
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0397256
N-[(3-chloro-2-methylphenyl)methyl]-2-[2-(2,4-difluorophenyl)-3,5-dimethylimidazol-4-yl]acetamide
   Show/Hide
C21H20ClF2N3O
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0397258
N-[(3-chloro-2-methylphenyl)methyl]-2-[2-(2,4-difluorophenyl)-3-methylimidazol-4-yl]acetamide
   Show/Hide
C20H18ClF2N3O
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0505144
N-[(3-chloro-2-methylphenyl)methyl]-2-(3-ethyl-5-methyl-2-phenylimidazol-4-yl)acetamide
   Show/Hide
C22H24ClN3O
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0513227
N-[(2-chloro-6-methylphenyl)methyl]-2-[2-(2,4-difluorophenyl)-3-ethyl-5-methylimidazol-4-yl]acetamide
   Show/Hide
C22H22ClF2N3O
 1
1
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
CP0392998
N-(1-adamantylmethyl)-2-chloro-4-(piperidin-1-ylmethyl)benzamide
   Show/Hide
C24H33ClN2O
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0501762
N-(1-adamantylmethyl)-3-methyl-6-piperidin-4-yloxypyridazine-4-carboxamide
   Show/Hide
C22H32N4O2
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0399826
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-3,5-dimethoxybenzamide
   Show/Hide
C23H29N5O3
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0395186
1-(2,3-dichlorophenyl)-N-[(1S)-1-phenylethyl]tetrazol-5-amine
   Show/Hide
C15H13Cl2N5
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0509275
N-[(2-chloro-3,6-difluorophenyl)methyl]-1-(2,3-dichlorophenyl)tetrazol-5-amine
   Show/Hide
C14H8Cl3F2N5
 1
1
IC50 = 794.33 nM
   TI
   LI
   LO
   TS
CP0476759
1-(2,3-dichlorophenyl)-N-[(1R)-1-phenylethyl]tetrazol-5-amine
   Show/Hide
C15H13Cl2N5
 1
1
IC50 = 831.76 nM
   TI
   LI
   LO
   TS
CP0377846
N-[(4-chlorophenyl)methyl]-1-(2,3-dichlorophenyl)tetrazol-5-amine
   Show/Hide
C14H10Cl3N5
 1
1
IC50 = 933.25 nM
   TI
   LI
   LO
   TS
CP0513987
1-(2,3-dichlorophenyl)-N-[[3-(trifluoromethoxy)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C15H10Cl2F3N5O
 1
1
IC50 = 954.99 nM
   TI
   LI
   LO
   TS
CP0467307
N-[2,2-dichloro-1-[(Z)-[(cyanoamino)-[(2-methylpyridin-3-yl)amino]methylidene]amino]propyl]-3,5-dimethoxybenzamide
   Show/Hide
C20H22Cl2N6O3
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0493955
2-[2-(2,4-difluorophenyl)-3-ethyl-5-methylimidazol-4-yl]-N-[(2,3,4-trifluorophenyl)methyl]acetamide
   Show/Hide
C21H18F5N3O
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0395185
1-(2,3-dichlorophenyl)-N-[[3-(trifluoromethyl)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C15H10Cl2F3N5
 1
1
IC50 = 1023.29 nM
   TI
   LI
   LO
   TS
CP0471385
N-(1-adamantylmethyl)-2-chloro-5-piperazin-1-ylbenzamide
   Show/Hide
C22H30ClN3O
 1
1
IC50 = 1258.93 nM
   TI
   LI
   LO
   TS
CP0552679
N-(cycloheptylmethyl)-1-(2-hydroxyethyl)indole-3-carboxamide
   Show/Hide
C19H26N2O2
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0524760
N-[(3-chloro-2-methylphenyl)methyl]-2-(3,5-dimethyl-2-phenylimidazol-4-yl)acetamide
   Show/Hide
C21H22ClN3O
 1
1
IC50 = 1584.89 nM
   TI
   LI
   LO
   TS
CP0231462
(2S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxopyrrolidine-2-carboxamide
   Show/Hide
C14H14ClF3N2O2
 1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS
CP0455054
N-[1-[(Z)-[(cyanoamino)-(2-methylanilino)methylidene]amino]-2,2-dimethylpropyl]-4-methoxybenzamide
   Show/Hide
C22H27N5O2
 1
1
IC50 = 2511.89 nM
   TI
   LI
   LO
   TS
CP0378257
N-[(2-chloro-6-methylphenyl)methyl]-2-(3,5-dimethyl-2-phenylimidazol-4-yl)acetamide
   Show/Hide
C21H22ClN3O
 1
1
IC50 = 3162.28 nM
   TI
   LI
   LO
   TS
CP0460706
N-benzyl-1-(2,3-dichlorophenyl)-N-methyltetrazol-5-amine
   Show/Hide
C15H13Cl2N5
 1
1
IC50 = 3630.78 nM
   TI
   LI
   LO
   TS
CP0397257
2-(3-ethyl-5-methyl-2-phenylimidazol-4-yl)-N-[(2,3,4-trifluorophenyl)methyl]acetamide
   Show/Hide
C21H20F3N3O
 1
1
IC50 = 3981.07 nM
   TI
   LI
   LO
   TS
CP0499829
2-(3,5-dimethyl-2-phenylimidazol-4-yl)-N-[(2,3,4-trifluorophenyl)methyl]acetamide
   Show/Hide
C20H18F3N3O
 1
1
IC50 = 5011.87 nM
   TI
   LI
   LO
   TS
CP0502311
2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide
   Show/Hide
C18H17ClF3N3O2
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0501528
1-(2,3-dichlorophenyl)-N-[[4-(trifluoromethyl)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C15H10Cl2F3N5
 1
1
IC50 = 7079.46 nM
   TI
   LI
   LO
   TS
CP0378258
2-[2-(2,4-difluorophenyl)-3,5-dimethylimidazol-4-yl]-N-[(2,3,4-trifluorophenyl)methyl]acetamide
   Show/Hide
C20H16F5N3O
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0019322
(4S)-N-[4-chloro-5-(2-hydroxyethoxy)-2-methylphenyl]-4-(4-fluorophenyl)-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide
   Show/Hide
C21H20ClFN2O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0459179
1-(2,3-dichlorophenyl)-N-[[4-(trifluoromethoxy)phenyl]methyl]tetrazol-5-amine
   Show/Hide
C15H10Cl2F3N5O
 1
1
IC50 = 15848.93 nM
   TI
   LI
   LO
   TS
CP0860727
N-(1-adamantylmethyl)-2-methyl-5-(piperazin-1-ylmethyl)thiophene-3-carboxamide
   Show/Hide
C22H33N3OS
 1
1
IC50 < 10000 nM
   TI
   LI
   LO
   TS
CP0873063
N-adamantan-1-ylmethyl-2-chloro-3-piperidin-1-ylmethyl-benzamide
   Show/Hide
C24H33ClN2O
 1
1
IC50 < 10000 nM
   TI
   LI
   LO
   TS
CP0918644
N-(1-adamantylmethyl)-2-methyl-5-(piperazin-1-ylmethyl)furan-3-carboxamide
   Show/Hide
C22H33N3O2
 1
1
IC50 < 10000 nM
   TI
   LI
   LO
   TS
CP0924831
N-adamantan-1-ylmethyl-2-chloro-6-(piperidin-4-yloxy)-benzamide
   Show/Hide
C23H31ClN2O2
 1
1
IC50 < 10000 nM
   TI
   LI
   LO
   TS
CP0145047
N-(1-adamantylmethyl)-2-methyl-5-(9-oxa-3,7-diazabicyclo[3.3.1]nonane-3-carbonyl)benzamide
   Show/Hide
C26H35N3O3
 1
1
Kd = 15.85 nM
   TI
   LI
   LO
   TS
CP0918647
N-(1-adamantylmethyl)-2-chloro-5-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-ylmethyl)benzamide
   Show/Hide
C25H34ClN3O2
 1
1
Kd = 25.12 nM
   TI
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   TS