Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02963 , Neuromedin-B receptor
Gene Name NMBR
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P28336
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02963
 
Compound ID Compound Name Compound Formula
CP0341603
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]pentanediamide
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C57H76N14O10
 1
1
EC50 = 0.55 nM
   TI
   LI
   LO
   TS
CP0425447
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C38H47N5O2
 2
1
EC50 = 603 nM
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2
IC50 = 320 nM
   TI
   LI
   LO
   TS
CP0914282
10-butyl-11-(2-chloro-6-fluorophenyl)-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C26H30ClFN2O
 1
1
IC50 = 150 nM
   TI
   LI
   LO
   TS
CP0914497
11-(2-chloro-6-fluorophenyl)-3,3,8,10-tetramethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C23H24ClFN2O
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0947408
11-(2-chloro-6-fluorophenyl)-10-ethyl-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C24H26ClFN2O
 1
1
IC50 = 180 nM
   TI
   LI
   LO
   TS
CP0893234
3,3,8-trimethyl-11-(2-(methylthio)phenyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C23H26N2OS
 1
1
IC50 = 200 nM
   TI
   LI
   LO
   TS
CP0926231
11'-(2-chlorophenyl)-8'-methyl-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one
   Show/Hide
C24H25ClN2O
 1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
CP0916039
3,3,8-trimethyl-11-(2-(trifluoromethyl)phenyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C23H23F3N2O
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0924707
8'-methyl-11'-(2-(methylthio)phenyl)-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one
   Show/Hide
C25H28N2OS
 1
1
IC50 = 250 nM
   TI
   LI
   LO
   TS
CP0916142
11-(2-chlorophenyl)-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H23ClN2O
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0947409
11'-(2-chloro-6-fluorophenyl)-8'-methyl-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one
   Show/Hide
C24H24ClFN2O
 1
1
IC50 = 280 nM
   TI
   LI
   LO
   TS
CP0750188
11-(2-chloro-6-fluorophenyl)-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H22ClFN2O
 2
1
IC50 = 300 nM
   TI
   LI
   LO
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2
IC50 = 5500 nM
   TI
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CP0052175
(S)-2-[3-(2,6-Diisopropyl-phenyl)-ureido]-3-(1H-indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-cyclohexylmethyl)-propionamide
   Show/Hide
C37H47N5O2
 1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
CP0914279
11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-8-(trifluoromethyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H19ClF4N2O
 1
1
IC50 = 370 nM
   TI
   LI
   LO
   TS
CP0860622
11-(2-chloro-6-fluorophenyl)-3,8-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C21H20ClFN2O
 1
1
IC50 = 450 nM
   TI
   LI
   LO
   TS
CP0916040
11'-(2-fluoro-6-(trifluoromethyl)phenyl)-8'-methyl-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one
   Show/Hide
C25H24F4N2O
 1
1
IC50 = 540 nM
   TI
   LI
   LO
   TS
CP0916085
3,3,8-trimethyl-11-(2-nitrophenyl)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H23N3O3
 1
1
IC50 = 550 nM
   TI
   LI
   LO
   TS
CP0860624
8'-methyl-11'-(2-(trifluoromethyl)phenyl)-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one
   Show/Hide
C25H25F3N2O
 1
1
IC50 = 580 nM
   TI
   LI
   LO
   TS
CP0539557
3-[3-(2-Methyl-4-nitro-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C33H36N6O4
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0902956
8'-methyl-11'-(2-(trifluoromethylthio)phenyl)-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one
   Show/Hide
C25H25F3N2OS
 1
1
IC50 = 640 nM
   TI
   LI
   LO
   TS
CP0530253
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-5-methyl-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C39H49N5O2
 1
1
IC50 = 660 nM
   TI
   LI
   LO
   TS
CP0531978
3-[3-(4-Nitro-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C32H34N6O4
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0947410
11-(2-chloro-6-fluorophenyl)-3-isopropyl-8-methyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C23H24ClFN2O
 1
1
IC50 = 810 nM
   TI
   LI
   LO
   TS
CP0874223
8-chloro-11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C21H19Cl2FN2O
 1
1
IC50 = 860 nM
   TI
   LI
   LO
   TS
CP0528941
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-4,7-difluoro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C38H45F2N5O2
 1
1
IC50 = 1010 nM
   TI
   LI
   LO
   TS
CP0903070
11-(2-methoxyphenyl)-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C23H26N2O2
 1
1
IC50 = 1100 nM
   TI
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   LO
   TS
CP0374706
3-[3-(4-Trifluoromethyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C33H34F3N5O2
 1
1
IC50 = 1110 nM
   TI
   LI
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   TS
CP0893235
11-(2-fluorophenyl)-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H23FN2O
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0914280
11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-1-oxo-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepine-8-carbonitrile
   Show/Hide
C22H19ClFN3O
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0947407
11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-8-(trifluoromethoxy)-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H19ClF4N2O2
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0893236
11-(2-chloro-6-fluorophenyl)-8-methyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C20H18ClFN2O
 1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CP0415566
5-(3-{3-[(1-Pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-2,3,4,9-tetrahydro-1H-carbazol-3-yl}-ureido)-isophthalic acid diethyl ester
   Show/Hide
C38H43N5O6
 1
1
IC50 = 1850 nM
   TI
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   LO
   TS
CP0481167
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-5-trifluoromethoxy-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C39H46F3N5O3
 1
1
IC50 = 1890 nM
   TI
   LI
   LO
   TS
CP0914498
11-(2-chloro-6-fluorophenyl)-3-(4-methoxyphenyl)-8-methyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C27H24ClFN2O2
 1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CP0522676
7-Bromo-3-[3-(2,6-diisopropyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C38H46BrN5O2
 1
1
IC50 = 2140 nM
   TI
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   LO
   TS
CP0860620
11-(2-chloro-6-fluorophenyl)-8-methoxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H22ClFN2O2
 1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0376459
3-[3-(3-Acetyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C34H37N5O3
 1
1
IC50 = 2270 nM
   TI
   LI
   LO
   TS
CP0914281
11-(2,6-difluorophenyl)-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H22F2N2O
 1
1
IC50 = 2500 nM
   TI
   LI
   LO
   TS
CP0926230
11-(2-chloro-6-fluorophenyl)-3-(furan-2-yl)-8-methyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C24H20ClFN2O2
 1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS
CP0448121
3-[3-(4-Trifluoromethoxy-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C33H34F3N5O3
 1
1
IC50 = 3040 nM
   TI
   LI
   LO
   TS
CP0461250
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclopropylmethyl)-amide
   Show/Hide
C35H41N5O2
 1
1
IC50 = 3350 nM
   TI
   LI
   LO
   TS
CP0487543
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-5-trifluoromethyl-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C39H46F3N5O2
 1
1
IC50 = 3660 nM
   TI
   LI
   LO
   TS
CP0380791
3-(3-Cyclohexyl-ureido)-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C32H41N5O2
 1
1
IC50 = 3920 nM
   TI
   LI
   LO
   TS
CP0481190
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (2-methyl-2-pyridin-2-yl-propyl)-amide
   Show/Hide
C35H43N5O2
 1
1
IC50 = 4150 nM
   TI
   LI
   LO
   TS
CP0860623
11-(2-chloro-6-fluorophenyl)-3-(4-(dimethylamino)phenyl)-8-methyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C28H27ClFN3O
 1
1
IC50 = 5400 nM
   TI
   LI
   LO
   TS
CP0532729
3-[3-(2,6-Dimethyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C34H39N5O2
 1
1
IC50 = 5490 nM
   TI
   LI
   LO
   TS
CP0860621
3,3,8-trimethyl-11-phenyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C22H24N2O
 1
1
IC50 = 6900 nM
   TI
   LI
   LO
   TS
CP0521888
3-[3-(2-Methoxy-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C33H37N5O3
 1
1
IC50 = 8720 nM
   TI
   LI
   LO
   TS
CP0431072
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-5-nitro-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C38H46N6O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0481158
3-[3-(4-Nitro-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (2-pyridin-2-yl-ethyl)-amide
   Show/Hide
C27H26N6O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0496531
3-(3-Ethyl-ureido)-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C28H35N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0505939
6-[3-(2,6-Diisopropyl-phenyl)-ureido]-6-[(1-pyridin-2-yl-cyclohexylmethyl)-carbamoyl]-6,7,8,9-tetrahydro-5H-carbazole-4-carboxylic acid
   Show/Hide
C39H47N5O4
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0518238
3-[3-(4-Nitro-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1,1-dioxo-4-pyridin-2-yl-hexahydro-1lambda*6*-thiopyran-4-ylmethyl)-amide
   Show/Hide
C31H32N6O6S
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0520189
3-[3-(4-Nitro-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (2-methyl-2-pyridin-2-yl-propyl)-amide
   Show/Hide
C29H30N6O4
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0521889
3-Ureido-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (1-pyridin-2-yl-cyclohexylmethyl)-amide
   Show/Hide
C26H31N5O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0554951
3-[3-(2,6-Diisopropyl-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid [1-(4-chloro-phenyl)-cyclopropylmethyl]-amide
   Show/Hide
C36H41ClN4O2
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0457508
11-(2-chloro-6-fluorophenyl)-3,3,5,8-tetramethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C23H24ClFN2O
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0857638
11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-1-oxo-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid
   Show/Hide
C22H20ClFN2O3
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0879859
11-(2-chloro-6-fluorophenyl)-3,3-dimethyl-1-oxo-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepine-8-carboxamide
   Show/Hide
C22H21ClFN3O2
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0920425
10-(2-chloro-6-fluorophenyl)-7-methyl-2,3,9,10-tetrahydrobenzo[b]cyclopenta[e][1,4]diazepin-1(4H)-one
   Show/Hide
C19H16ClFN2O
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CP0921728
11-(2-chloro-6-fluorophenyl)-8-hydroxy-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one
   Show/Hide
C21H20ClFN2O2
 1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS