Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02658 , Nuclear receptor ROR-alpha
Gene Name RORA
Organism Homo sapiens, Human
Protein Classification Transcription factor
Uniprot ID P35398
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02658
 
Compound ID Compound Name Compound Formula
CP0952843
N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)thiophene-2-sulfonamide
   Show/Hide
C13H9F6NO3S2
 1
1
EC50 = 480 nM
   TI
   LI
   LO
   TS
CP0257822
N-(2-methylpropyl)-N-[[4-(4-methylsulfonylphenyl)phenyl]methyl]-1-phenylmethanesulfonamide
   Show/Hide
C25H29NO4S2
 1
1
EC50 = 2400 nM
   TI
   LI
   LO
   TS
CP0234135
N-(2-methylpropyl)-N-[[5-(4-methylsulfonylphenyl)thiophen-2-yl]methyl]-1-phenylmethanesulfonamide
   Show/Hide
C23H27NO4S3
 1
1
EC50 = 2800 nM
   TI
   LI
   LO
   TS
CP0059785
N-[[4-[4-(methanesulfonamido)phenyl]phenyl]methyl]-N-(2-methylpropyl)-1-phenylmethanesulfonamide
   Show/Hide
C25H30N2O4S2
 1
1
EC50 = 3800 nM
   TI
   LI
   LO
   TS
CP0205289
N-[5-[[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]sulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide
   Show/Hide
C15H13F6N3O4S2
 1
1
EC50 = 4000 nM
   TI
   LI
   LO
   TS
CP0059780
N-(2-methylpropyl)-N-[[5-(3-methylsulfonylphenyl)thiophen-2-yl]methyl]-1-phenylmethanesulfonamide
   Show/Hide
C23H27NO4S3
 1
1
EC50 = 4200 nM
   TI
   LI
   LO
   TS
CP0168528
4-[4-[[benzylsulfonyl(2-methylpropyl)amino]methyl]phenyl]benzamide
   Show/Hide
C25H28N2O3S
 1
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0488049
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 = 5300 nM
   TI
   LI
   LO
   TS
CP0459435
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-(trifluoromethyl)phenanthridin-6-one
   Show/Hide
C21H16F9NO2
 1
1
IC50 = 5500 nM
   TI
   LI
   LO
   TS
CP0459436
5-butyl-9-chloro-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C20H16ClF6NO2
 1
1
IC50 = 5600 nM
   TI
   LI
   LO
   TS
CP0389304
2-(5,5-dibutylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
   Show/Hide
C23H26F6OSi
 1
1
IC50 = 6200 nM
   TI
   LI
   LO
   TS
CP0524496
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-hydroxyphenanthridin-6-one
   Show/Hide
C20H17F6NO3
 1
1
IC50 = 6400 nM
   TI
   LI
   LO
   TS
CP0380839
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C20H17F6NO2
 2
1
IC50 = 7200 nM
   TI
   LI
   LO
   TS
2
IC50 = 9800 nM
   TI
   LI
   LO
   TS
CP0481996
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-hexylphenanthridin-6-one
   Show/Hide
C22H21F6NO2
 1
1
IC50 = 7600 nM
   TI
   LI
   LO
   TS
CP0487873
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-9-methylphenanthridin-6-one
   Show/Hide
C21H19F6NO2
 1
1
IC50 = 7600 nM
   TI
   LI
   LO
   TS
CP0456138
2-(5-butyl-5-methylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
   Show/Hide
C20H20F6OSi
 1
1
IC50 = 7700 nM
   TI
   LI
   LO
   TS
CP0395912
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 = 7800 nM
   TI
   LI
   LO
   TS
CP0380838
5-butyl-2-ethylphenanthridin-6-one
   Show/Hide
C19H21NO
 1
1
IC50 = 9000 nM
   TI
   LI
   LO
   TS
CP0473976
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-10-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 = 9100 nM
   TI
   LI
   LO
   TS
CP0401199
2-(5,5-dimethylbenzo[b][1]benzosilol-2-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol
   Show/Hide
C17H14F6OSi
 1
1
IC50 = 9400 nM
   TI
   LI
   LO
   TS
CP0499213
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-(2,2,2-trifluoroethyl)phenanthridin-6-one
   Show/Hide
C18H10F9NO2
 1
1
IC50 = 9900 nM
   TI
   LI
   LO
   TS
CP0467810
5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4-methoxyphenanthridin-6-one
   Show/Hide
C21H19F6NO3
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0417384
5-butylphenanthridin-6-one
   Show/Hide
C17H17NO
 1
1
IC50 = 10200 nM
   TI
   LI
   LO
   TS
CP0459431
5-butyl-2-hexylphenanthridin-6-one
   Show/Hide
C23H29NO
 1
1
IC50 = 10300 nM
   TI
   LI
   LO
   TS
CP0488050
5-(cyclohexylmethyl)-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C23H21F6NO2
 1
1
IC50 = 10300 nM
   TI
   LI
   LO
   TS
CP0395440
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-propylphenanthridin-6-one
   Show/Hide
C19H15F6NO2
 1
1
IC50 = 10800 nM
   TI
   LI
   LO
   TS
CP0003740
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
   Show/Hide
C17H12F9NO3S
 2
1
IC50 = 11000 nM
   TI
   LI
   LO
   TS
2
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0487874
5-butyl-2-tert-butylphenanthridin-6-one
   Show/Hide
C21H25NO
 1
1
IC50 = 11800 nM
   TI
   LI
   LO
   TS
CP0467808
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-propan-2-ylphenanthridin-6-one
   Show/Hide
C19H15F6NO2
 1
1
IC50 = 12300 nM
   TI
   LI
   LO
   TS
CP0459432
5-(cyclopropylmethyl)-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C20H15F6NO2
 1
1
IC50 = 13600 nM
   TI
   LI
   LO
   TS
CP0467809
5-butyl-2-propan-2-ylphenanthridin-6-one
   Show/Hide
C20H23NO
 1
1
IC50 = 16700 nM
   TI
   LI
   LO
   TS
CP0459433
5-butyl-2-methylphenanthridin-6-one
   Show/Hide
C18H19NO
 1
1
IC50 = 17600 nM
   TI
   LI
   LO
   TS
CP0395918
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-nonylphenanthridin-6-one
   Show/Hide
C25H27F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0395919
5-ethyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6-one
   Show/Hide
C18H13F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0397540
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-methylphenanthridin-6-one
   Show/Hide
C17H11F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0459434
5-butyl-2-(hydroxymethyl)phenanthridin-6-one
   Show/Hide
C18H19NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0478004
2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5H-phenanthridin-6-one
   Show/Hide
C16H9F6NO2
 1
1
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CP0385671
N-[4-[hydroxy(dimethyl)silyl]phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
   Show/Hide
C16H18F3NO3SSi
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0390984
N-butyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamide
   Show/Hide
C18H25NO3SSi
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0396599
N-[4-[hydroxy(dimethyl)silyl]phenyl]-N-(2-phenylethyl)benzenesulfonamide
   Show/Hide
C22H25NO3SSi
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0396600
N-benzyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamide
   Show/Hide
C21H23NO3SSi
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0466299
N-ethyl-N-[4-[hydroxy(dimethyl)silyl]phenyl]benzenesulfonamide
   Show/Hide
C16H21NO3SSi
 1
1
IC50 > 30000 nM
   TI
   LI
   LO
   TS