Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02444 , Metabotropic glutamate receptor 1
Gene Name GRM1
Organism Rattus norvegicus, Rat
Protein Classification Membrane receptor
Uniprot ID P23385
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02444
 
Compound ID Compound Name Compound Formula
CP0386287
4-fluoro-N-[4-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide
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C18H10F4N2O3
 1
1
EC50 = 19 nM
   TI
   LI
   LO
   TS
CP0467608
2-fluoro-N-[5-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide
   Show/Hide
C18H10F4N2O3
 1
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
CP0398588
4-fluoro-N-[5-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide
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C18H10F4N2O3
 1
1
EC50 = 21 nM
   TI
   LI
   LO
   TS
CP0386288
4,5-difluoro-N-(5-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide
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C18H9F5N2O3
 1
1
EC50 = 25 nM
   TI
   LI
   LO
   TS
CP0452473
N-[5-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide
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C18H11F3N2O3
 1
1
EC50 = 38 nM
   TI
   LI
   LO
   TS
CP0398587
3-fluoro-N-[4-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide
   Show/Hide
C18H10F4N2O3
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0452474
2-fluoro-N-[4-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide
   Show/Hide
C18H10F4N2O3
 1
1
EC50 = 40 nM
   TI
   LI
   LO
   TS
CP0398589
2,7-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide
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C18H9F5N2O3
 1
1
EC50 = 44 nM
   TI
   LI
   LO
   TS
CP0474886
4,5-difluoro-N-(4-(trifluoromethyl)oxazol-2-yl)-9H-xanthene-9-carboxamide
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C18H9F5N2O3
 1
1
EC50 = 47 nM
   TI
   LI
   LO
   TS
CP0423477
N-(5-methyl-1,2,4-oxadiazol-3-yl)-9H-xanthene-9-carboxamide
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C17H13N3O3
 1
1
EC50 = 52 nM
   TI
   LI
   LO
   TS
CP0061426
N-[4-(trifluoromethyl)-1,3-oxazol-2-yl]-9H-xanthene-9-carboxamide
   Show/Hide
C18H11F3N2O3
 1
1
EC50 = 56 nM
   TI
   LI
   LO
   TS
CP0474887
2,7-difluoro-N-(oxazol-2-yl)-9H-xanthene-9-carboxamide
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C17H10F2N2O3
 1
1
EC50 = 124 nM
   TI
   LI
   LO
   TS
CP0396032
N-[(5R,7S)-2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]pyridine-2-carboxamide
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C20H20ClN3O2
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0396034
N-[(5R,7S)-2-(3-chlorophenyl)-1-oxa-3-azaspiro[4.5]dec-2-en-7-yl]-6-methylpyridine-2-carboxamide
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C21H22ClN3O2
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0418181
N-[(1R,3R)-3-[(3-cyanobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
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C20H20N4O2
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0447528
N-[(1R,3R)-3-[(3-chlorobenzoyl)amino]cyclohexyl]-3-fluorobenzamide
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C20H20ClFN2O2
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0450228
N-[(1R,3R)-3-[(3-chlorobenzoyl)amino]cyclohexyl]pyridine-2-carboxamide
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C19H20ClN3O2
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0060391
3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
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C16H12F5N3O
 2
1
EC50 > 10000 nM
   TI
   LI
   LO
   TS
2
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0002355
(2S)-2-aminopentanedioic acid
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C5H9NO4
 2
1
EC50 = 13870 nM
   TI
   LI
   LO
   TS
2
Ki = 340 nM
   TI
   LI
   LO
   TS
CP0391280
3-[3-[(2-cyclopentyl-1-oxo-3H-isoindol-5-yl)oxymethyl]phenyl]-4-methoxybenzoic acid
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C28H27NO5
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0397657
2-chloro-5-[3-(2-cyclopentyl-1-oxo-3H-isoindol-5-yl)phenyl]benzoic acid
   Show/Hide
C26H22ClNO3
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0397658
2-chloro-5-[3-[(2-cyclopropyl-3-oxo-1,2-benzothiazol-6-yl)oxymethyl]phenyl]benzoic acid
   Show/Hide
C24H18ClNO4S
 1
1
EC50 > 30000 nM
   TI
   LI
   LO
   TS
CP0377671
2-[4-(4-butanoyl-3-hydroxy-2-methylphenoxy)butoxy]-3-methoxybenzoic acid
   Show/Hide
C23H28O7
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0381866
N-(4,4-difluorocyclohexyl)-3,5,8,9-tetrazatricyclo[7.4.0.02,7]trideca-1,3,5,7,10,12-hexaen-6-amine
   Show/Hide
C15H15F2N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0428436
N-[(1R)-1-cyclopropylethyl]-3,5,8,9-tetrazatricyclo[7.4.0.02,7]trideca-1,3,5,7,10,12-hexaen-6-amine
   Show/Hide
C14H15N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0454861
N-(2-methylbutan-2-yl)-3,5,8,9-tetrazatricyclo[7.4.0.02,7]trideca-1,3,5,7,10,12-hexaen-6-amine
   Show/Hide
C14H17N5
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0059516
(S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid
   Show/Hide
C8H11NO4
 1
1
IC50 = 25000 nM
   TI
   LI
   LO
   TS
CP0098440
(S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid
   Show/Hide
C9H9NO5
 1
1
IC50 = 40000 nM
   TI
   LI
   LO
   TS
CP0040798
(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
   Show/Hide
C5H7N3O5
 1
1
Ki = 10 nM
   TI
   LI
   LO
   TS
CP0050732
(2S)-amino(3,5-dihydroxyphenyl)ethanoic acid
   Show/Hide
C8H9NO4
 1
1
Ki = 900 nM
   TI
   LI
   LO
   TS
CP0067543
(S)-4-(amino(carboxy)methyl)benzoic acid
   Show/Hide
C9H9NO4
 1
1
Ki = 3700 nM
   TI
   LI
   LO
   TS
CP0091883
(1R,2R)-3-((S)-Amino-carboxy-methyl)-cyclopropane-1,2-dicarboxylic acid
   Show/Hide
C7H9NO6
 1
1
Ki = 77000 nM
   TI
   LI
   LO
   TS