Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT02260 , Cyclin-dependent kinase 11A
Gene Name CDK11A
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID Q9UQ88
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT02260
 
Compound ID Compound Name Compound Formula
CP0011894
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C21H21Cl2N5OS
 1
1
IC50 = 170 nM
   TI
   LI
   LO
   TS
CP0494964
[4-amino-2-[4-[(4-methylpiperazin-1-yl)methyl]anilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C22H23Cl2N5OS
 1
1
IC50 = 190 nM
   TI
   LI
   LO
   TS
CP0014731
[4-amino-2-[[2-methyl-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C21H22Cl2N6OS
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0578077
[4-amino-2-[[6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C20H20Cl2N6OS
 1
1
IC50 = 230 nM
   TI
   LI
   LO
   TS
CP0576314
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,6-difluorophenyl)methanone
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C21H21F2N5OS
 1
1
IC50 = 260 nM
   TI
   LI
   LO
   TS
CP0533705
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2-chlorophenyl)methanone
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C21H22ClN5OS
 1
1
IC50 = 330 nM
   TI
   LI
   LO
   TS
CP0576988
[4-amino-2-[[3-methyl-5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C21H22Cl2N6OS
 1
1
IC50 = 470 nM
   TI
   LI
   LO
   TS
CP0576047
[4-amino-2-[[4-methyl-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C20H21Cl2N7OS
 1
1
IC50 = 580 nM
   TI
   LI
   LO
   TS
CP0572918
[4-amino-2-[[6-(2,4-dimethylpiperazin-1-yl)-2-methylpyridin-3-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C22H24Cl2N6OS
 1
1
IC50 = 620 nM
   TI
   LI
   LO
   TS
CP0543526
[4-amino-2-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C20H20Cl2N6OS
 1
1
IC50 = 700 nM
   TI
   LI
   LO
   TS
CP0564369
[4-amino-2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C22H23Cl2N5O2S
 1
1
IC50 = 710 nM
   TI
   LI
   LO
   TS
CP0494963
[4-amino-2-[2-methyl-4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C22H23Cl2N5OS
 1
1
IC50 = 800 nM
   TI
   LI
   LO
   TS
CP0571015
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-[2-fluoro-6-(trifluoromethyl)phenyl]methanone
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C22H21F4N5OS
 1
1
IC50 = 900 nM
   TI
   LI
   LO
   TS
CP0545297
[4-amino-2-[[2-methyl-6-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)pyridin-3-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C26H30Cl2N6OS
 1
1
IC50 = 1000 nM
   TI
   LI
   LO
   TS
CP0573485
[4-amino-2-[(2-methyl-6-piperazin-1-ylpyridin-3-yl)amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C20H20Cl2N6OS
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0577034
[4-amino-2-[4-(4-methylpiperazin-1-yl)sulfonylanilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C21H21Cl2N5O3S2
 1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
CP0494961
N-[5-(2,6-dichlorobenzoyl)-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-4-yl]acetamide
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C23H23Cl2N5O2S
 1
1
IC50 = 1300 nM
   TI
   LI
   LO
   TS
CP0578078
[4-amino-2-[[2-methyl-6-(4-methyl-3-propan-2-ylpiperazin-1-yl)pyridin-3-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C24H28Cl2N6OS
 1
1
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CP0494962
[4-amino-2-[3-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C21H21Cl2N5OS
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0575653
[4-[[4-amino-5-(2,6-dichlorobenzoyl)-1,3-thiazol-2-yl]amino]phenyl]-(4-methylpiperazin-1-yl)methanone
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C22H21Cl2N5O2S
 1
1
IC50 = 1600 nM
   TI
   LI
   LO
   TS
CP0533707
[4-amino-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C22H23Cl2N5O2S
 1
1
IC50 = 2100 nM
   TI
   LI
   LO
   TS
CP0494965
[4-amino-2-[[6-(4-hydroxypiperidin-1-yl)-2-methylpyridin-3-yl]amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C21H21Cl2N5O2S
 1
1
IC50 = 2200 nM
   TI
   LI
   LO
   TS
CP0545295
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(3-chloropyridin-2-yl)methanone
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C20H21ClN6OS
 1
1
IC50 = 2600 nM
   TI
   LI
   LO
   TS
CP0573484
[4-amino-2-[(2-methyl-6-morpholin-4-ylpyridin-3-yl)amino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C20H19Cl2N5O2S
 1
1
IC50 = 3400 nM
   TI
   LI
   LO
   TS
CP0533706
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,4,6-trimethylphenyl)methanone
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C24H29N5OS
 1
1
IC50 = 6100 nM
   TI
   LI
   LO
   TS
CP0494941
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-phenylmethanone
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C21H23N5OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0545296
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-[(2S,6R)-2,6-dimethylpiperidin-1-yl]methanone
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C22H32N6OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0550249
(2,6-dichlorophenyl)-[4-(methylamino)-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]methanone
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C22H23Cl2N5OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0572916
4-amino-N-(2,6-dichlorophenyl)-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazole-5-carboxamide
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C21H22Cl2N6OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0572917
[4-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,6-dichlorophenyl)methanone
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C21H19Cl3N4OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CP0578076
[4-amino-2-[4-(4-methylpiperazin-1-yl)anilino]-1,3-thiazol-5-yl]-(2,4-dichlorophenyl)methanone
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C21H21Cl2N5OS
 1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS