Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01996 , Bombesin receptor subtype-3
Gene Name BRS3
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID P32247
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01996
 
Compound ID Compound Name Compound Formula
CP0341603
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxohexan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]pentanediamide
   Show/Hide
C57H76N14O10
 1
1
EC50 = 3.9 nM
   TI
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CP0102963
6-(4-tert-butylphenyl)sulfonyl-7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C25H26F3N3O2S
 1
1
EC50 = 15 nM
   TI
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CP0365995
4'-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylic acid
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C24H28N2O2
 1
1
EC50 = 25 nM
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CP0430445
6-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridin-2-amine
   Show/Hide
C22H28N4
 1
1
EC50 = 37 nM
   TI
   LI
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   TS
CP0423561
6-(4-tert-butylphenyl)sulfonyl-2-chloro-7,8-dimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H26ClN3O2S
 1
1
EC50 = 38 nM
   TI
   LI
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   TS
CP0414267
7,8-dimethyl-6-[4-(trifluoromethoxy)phenyl]sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C22H17F6N3O3S
 1
1
EC50 = 43 nM
   TI
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   TS
CP0402311
4-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)isothiazole
   Show/Hide
C20H25N3S
 1
1
EC50 = 44 nM
   TI
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   TS
CP0225161
2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridine
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C22H27N3
 1
1
EC50 = 47 nM
   TI
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CP0453510
7,8-dimethyl-6-(4-propan-2-ylphenyl)sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H24F3N3O2S
 1
1
EC50 = 49 nM
   TI
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CP0389466
6-(4-tert-butylphenyl)sulfonyl-7,8-dimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine-2-carbonitrile
   Show/Hide
C25H26N4O2S
 1
1
EC50 = 50 nM
   TI
   LI
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   TS
CP0395607
6-(4-tert-butylphenyl)sulfonyl-7-methyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H24F3N3O2S
 1
1
EC50 = 50 nM
   TI
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   LO
   TS
CP0538376
2-[4-[[7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-6-yl]sulfonyl]phenyl]-2-methylpropanenitrile
   Show/Hide
C25H23F3N4O2S
 1
1
EC50 = 60 nM
   TI
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   TS
CP0390896
5-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)isothiazole
   Show/Hide
C20H25N3S
 1
1
EC50 = 63 nM
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   TS
CP0462864
4'-(2-(4-(cyclohexylmethyl)-1H-imidazol-2-yl)ethyl)-4,5-difluorobiphenyl-2-carboxylic acid
   Show/Hide
C25H26F2N2O2
 1
1
EC50 = 63 nM
   TI
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   TS
CP0441853
6-(4-tert-butylphenyl)sulfonyl-7-chloro-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C23H21ClF3N3O2S
 1
1
EC50 = 63 nM
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CP0401480
2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-5-fluoropyridine
   Show/Hide
C22H26FN3
 1
1
EC50 = 66 nM
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CP0523686
6-[4-(2-fluoropropan-2-yl)phenyl]sulfonyl-7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H23F4N3O2S
 1
1
EC50 = 69 nM
   TI
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   TS
CP0441855
2-[6-(4-tert-butylphenyl)sulfonyl-7-fluoro-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-8-yl]propan-2-ol
   Show/Hide
C26H27F4N3O3S
 1
1
EC50 = 77 nM
   TI
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   TS
CP0441859
6-(4-tert-butylphenyl)sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-7-ol
   Show/Hide
C23H22F3N3O3S
 1
1
EC50 = 88 nM
   TI
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CP0462865
2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-6-methylpyridine
   Show/Hide
C23H29N3
 1
1
EC50 = 105 nM
   TI
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   TS
CP0376662
10-(4-tert-butylphenyl)sulfonyl-5-(trifluoromethyl)-2,4,10,16-tetrazatetracyclo[9.8.0.03,8.012,17]nonadeca-1(11),3(8),4,6,12(17),13,15,18-octaene
   Show/Hide
C26H23F3N4O2S
 1
1
EC50 = 108 nM
   TI
   LI
   LO
   TS
CP0423563
6-(4-tert-butylphenyl)sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C23H22F3N3O2S
 1
1
EC50 = 110 nM
   TI
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   TS
CP0441854
10-(4-tert-butylphenyl)sulfonyl-13-methyl-5-(trifluoromethyl)-2,4,10,12-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
   Show/Hide
C23H23F3N4O2S
 1
1
EC50 = 110 nM
   TI
   LI
   LO
   TS
CP0395609
7,8-dimethyl-2-(trifluoromethyl)-6-[5-(trifluoromethyl)thiophen-3-yl]sulfonyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C20H15F6N3O2S2
 1
1
EC50 = 123 nM
   TI
   LI
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   TS
CP0377000
3-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridine
   Show/Hide
C22H27N3
 1
1
EC50 = 131 nM
   TI
   LI
   LO
   TS
CP0423565
6-(4-tert-butylphenyl)sulfonyl-2,7,8-trimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C25H29N3O2S
 1
1
EC50 = 131 nM
   TI
   LI
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   TS
CP0402312
1-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-1H-pyrazole
   Show/Hide
C20H26N4
 1
1
EC50 = 135 nM
   TI
   LI
   LO
   TS
CP0481364
7,8-dimethyl-2-(trifluoromethyl)-6-[4-(trifluoromethyl)phenyl]sulfonyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C22H17F6N3O2S
 1
1
EC50 = 154 nM
   TI
   LI
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   TS
CP0395608
7,8-dimethyl-2-(trifluoromethyl)-6-[5-(trifluoromethyl)thiophen-2-yl]sulfonyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C20H15F6N3O2S2
 1
1
EC50 = 158 nM
   TI
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   TS
CP0390895
6-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridin-2-ol
   Show/Hide
C22H27N3O
 1
1
EC50 = 169 nM
   TI
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   TS
CP0410795
1-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)piperidine
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C22H33N3
 1
1
EC50 = 171 nM
   TI
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   TS
CP0400009
6-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)picolinonitrile
   Show/Hide
C23H26N4
 1
1
EC50 = 193 nM
   TI
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   TS
CP0377610
6-(4-tert-butylphenyl)sulfonyl-8-methyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H24F3N3O2S
 1
1
EC50 = 199 nM
   TI
   LI
   LO
   TS
CP0497670
2-(2-(6-chlorobenzo[d][1,3]dioxol-5-yl)ethyl)-6-methoxy-1H-benzo[d]imidazole
   Show/Hide
C17H15ClN2O3
 1
1
EC50 = 210 nM
   TI
   LI
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   TS
CP0423562
4-tert-butyl-2-[[7,8-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-6-yl]sulfonyl]-1,3-thiazole
   Show/Hide
C22H24F3N4O2S2+
 1
1
EC50 = 216 nM
   TI
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   TS
CP0493082
2-((6-chlorobenzo[d][1,3]dioxol-5-yloxy)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole
   Show/Hide
C16H10ClF3N2O3
 1
1
EC50 = 240 nM
   TI
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   TS
CP0441856
6-(4-tert-butylphenyl)sulfonyl-2-chloro-3-fluoro-7,8-dimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H25ClFN3O2S
 1
1
EC50 = 277 nM
   TI
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   TS
CP0417715
4-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridine
   Show/Hide
C22H27N3
 1
1
EC50 = 305 nM
   TI
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   TS
CP0395610
6-(4-tert-butylphenyl)sulfonyl-7,8-dimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H27N3O2S
 1
1
EC50 = 325 nM
   TI
   LI
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   TS
CP0493081
2-(1-(6-chlorobenzo[d][1,3]dioxol-5-yl)propan-2-yl)-6-methoxy-1H-benzo[d]imidazole
   Show/Hide
C18H17ClN2O3
 1
1
EC50 = 350 nM
   TI
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   TS
CP0455893
2-((6-chlorobenzo[d][1,3]dioxol-5-yl)methylthio)-6-methoxy-1H-benzo[d]imidazole
   Show/Hide
C16H13ClN2O3S
 1
1
EC50 = 380 nM
   TI
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   TS
CP0401489
2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-2H-tetrazole
   Show/Hide
C18H24N6
 1
1
EC50 = 422 nM
   TI
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CP0417714
2-(4-(2-(4-(cyclopentylmethyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridine
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C22H25N3
 1
1
EC50 = 425 nM
   TI
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CP0401483
2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyrazine
   Show/Hide
C21H26N4
 1
1
EC50 = 431 nM
   TI
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   TS
CP0474231
2-((6-chlorobenzo[d][1,3]dioxol-5-yloxy)methyl)-6-methoxy-1H-benzo[d]imidazole
   Show/Hide
C16H13ClN2O4
 1
1
EC50 = 510 nM
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CP0507291
4-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-1,2,3-thiadiazole
   Show/Hide
C19H24N4S
 1
1
EC50 = 538 nM
   TI
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CP0481277
7,8-dimethyl-6-(4-methylsulfonylphenyl)sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C22H20F3N3O4S2
 1
1
EC50 = 543 nM
   TI
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   TS
CP0528332
6-chloro-2-((6-chlorobenzo[d][1,3]dioxol-5-yloxy)methyl)-1H-benzo[d]imidazole
   Show/Hide
C15H10Cl2N2O3
 1
1
EC50 = 570 nM
   TI
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CP0390897
1-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-1H-1,2,4-triazole
   Show/Hide
C19H25N5
 1
1
EC50 = 570 nM
   TI
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CP0401488
1-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)-1H-1,2,3-triazole
   Show/Hide
C19H25N5
 1
1
EC50 = 641 nM
   TI
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CP0401495
3-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)picolinic acid
   Show/Hide
C23H27N3O2
 1
1
EC50 = 1263 nM
   TI
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CP0144281
2-(3,5-dimethoxybenzylthio)-6-methoxy-1H-benzo[d]imidazole
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C17H18N2O3S
 1
1
EC50 = 1600 nM
   TI
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CP0309541
5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole
   Show/Hide
C17H19N3O2S
 1
1
EC50 = 3900 nM
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   TS
CP0401496
6-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)picolinic acid
   Show/Hide
C23H27N3O2
 1
1
EC50 = 5234 nM
   TI
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CP0423564
6-(4-tert-butylphenyl)sulfonyl-9,10-dimethyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C25H26F3N3O2S
 1
1
EC50 > 10000 nM
   TI
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   TS
CP0441858
6-(4-tert-butylphenyl)sulfonyl-3-chloro-7,8-dimethyl-5,11-dihydropyrido[3,2-c][1,5]benzodiazepine
   Show/Hide
C24H26ClN3O2S
 1
1
EC50 > 10000 nM
   TI
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   TS
CP0017654
(RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1H-benzo[d]imidazole
   Show/Hide
C17H19N3O3S
 1
1
EC50 = 14000 nM
   TI
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CP0340376
6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d]imidazole
   Show/Hide
C19H16N2OS
 1
1
EC50 > 32000 nM
   TI
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   TS
CP0398619
2-(2-(6-chlorobenzo[d][1,3]dioxol-5-yl)ethyl)-6-methoxybenzo[d]thiazole
   Show/Hide
C17H14ClNO3S
 1
1
EC50 > 32000 nM
   TI
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   TS
CP0398620
6-chloro-2-((6-chlorobenzo[d][1,3]dioxol-5-yloxy)methyl)-5-methyl-1H-benzo[d]imidazole
   Show/Hide
C16H12Cl2N2O3
 1
1
EC50 > 32000 nM
   TI
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   TS
CP0422294
2-(2-(6-chlorobenzo[d][1,3]dioxol-5-yl)ethyl)-5-methoxybenzo[d]thiazole
   Show/Hide
C17H14ClNO3S
 1
1
EC50 > 32000 nM
   TI
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CP0440664
2-((6-chlorobenzo[d][1,3]dioxol-5-yloxy)methyl)-6-phenoxy-1H-benzo[d]imidazole
   Show/Hide
C21H15ClN2O4
 1
1
EC50 > 32000 nM
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CP0474232
2-(2-(6-chlorobenzo[d][1,3]dioxol-5-yl)ethyl)-6-methoxybenzo[d]oxazole
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C17H14ClNO4
 1
1
EC50 > 32000 nM
   TI
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CP0492680
2-(3,4-difluorobenzylthio)-6-methoxy-1H-benzo[d]imidazole
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C15H12F2N2OS
 1
1
EC50 > 32000 nM
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CP0526658
6-chloro-N-(6-methoxy-1H-benzo[d]imidazol-2-yl)benzo[d][1,3]dioxole-5-carboxamide
   Show/Hide
C16H12ClN3O4
 1
1
EC50 > 32000 nM
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CP0526772
3-((6-methoxy-1H-benzo[d]imidazol-2-ylthio)methyl)-1H-indazole
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C16H14N4OS
 1
1
EC50 > 32000 nM
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CP0527030
N-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-6-methoxy-1H-benzimidazol-2-amine
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C16H14ClN3O3
 1
1
EC50 > 32000 nM
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CP0532014
6-methoxy-2-(pyridin-4-ylmethylthio)-1H-benzo[d]imidazole
   Show/Hide
C14H13N3OS
 1
1
EC50 > 32000 nM
   TI
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   TS
CP0553683
2-(2-(6-chlorobenzo[d][1,3]dioxol-5-yl)ethyl)-5-methoxybenzo[d]oxazole
   Show/Hide
C17H14ClNO4
 1
1
EC50 > 32000 nM
   TI
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   TS
CP0869977
2-(2-(6-chlorobenzo[d][1,3]dioxol-5-yl)vinyl)-6-methoxy-1H-benzo[d]imidazole
   Show/Hide
C17H13ClN2O3
 1
1
EC50 > 32000 nM
   TI
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   TS