Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01922 , Toll-like receptor 9
Gene Name TLR9
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID Q9NR96
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01922
 
Compound ID Compound Name Compound Formula
CP0553498
4-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-7-(3-pyrrolidin-1-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine
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C25H36N6
 1
1
IC50 = 3.5 nM
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CP0489188
2-[4-(4-methylpiperazin-1-yl)phenyl]-7-(3-pyrrolidin-1-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine
   Show/Hide
C24H34N6
 1
1
IC50 = 3.9 nM
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CP0379727
6,7-dimethoxy-2-[4-(4-methylpiperazin-1-yl)phenyl]-N-(2-morpholin-4-ylethyl)quinazolin-4-amine
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C27H36N6O3
 1
1
IC50 = 4.6 nM
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CP0539214
4-[3-[2-[4-(4-methylpiperazin-1-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]propyl]morpholine
   Show/Hide
C24H34N6O
 1
1
IC50 = 8.6 nM
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CP0455911
4-[4-[2-[4-(4-methylpiperazin-1-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]butyl]morpholine
   Show/Hide
C25H36N6O
 1
1
IC50 = 11 nM
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CP0553499
4-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-7-(2-pyrrolidin-1-ylethyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine
   Show/Hide
C24H34N6
 1
1
IC50 = 11 nM
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CP0379721
2-[4-[4-[7-(3-morpholin-4-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]phenyl]piperazin-1-yl]ethanol
   Show/Hide
C25H36N6O2
 1
1
IC50 = 13 nM
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CP0351217
6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole
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C27H35N3O3
 1
1
IC50 = 15 nM
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CP0536790
4-[3-[4-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]propyl]morpholine
   Show/Hide
C25H36N6O
 1
1
IC50 = 16 nM
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CP0379725
4-[2-[4-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]ethyl]morpholine
   Show/Hide
C24H34N6O
 1
1
IC50 = 20 nM
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CP0455912
2-[4-(4-methylpiperazin-1-yl)phenyl]-N-(2-morpholin-4-ylethyl)-5,6,7,8-tetrahydroquinazolin-4-amine
   Show/Hide
C25H36N6O
 1
1
IC50 = 27 nM
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CP0511155
4-[3-[2-[4-[4-(2-methoxyethyl)piperazin-1-yl]phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]propyl]morpholine
   Show/Hide
C26H38N6O2
 1
1
IC50 = 28 nM
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CP0551498
5,6-dimethyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-N-(2-morpholin-4-ylethyl)pyrimidin-4-amine
   Show/Hide
C23H34N6O
 1
1
IC50 = 35 nM
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CP0238617
1-methyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine
   Show/Hide
C26H34N4O2
 1
1
IC50 = 37 nM
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CP0241920
4-[(dimethylamino)methyl]-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide
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C30H34N4O3
 1
1
IC50 = 48 nM
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CP0379722
4-[3-[2-[2-(4-methylpiperazin-1-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]propyl]morpholine
   Show/Hide
C24H34N6O
 1
1
IC50 = 56 nM
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CP0555193
4-[3-[2-[3-(4-methylpiperazin-1-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]propyl]morpholine
   Show/Hide
C24H34N6O
 1
1
IC50 = 56 nM
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CP0509533
1-[3-[4-[6-[3-(3-aminopyrrolidin-1-yl)propoxy]-1,3-benzoxazol-2-yl]phenoxy]propyl]pyrrolidin-3-amine
   Show/Hide
C27H37N5O3
 1
1
IC50 = 60 nM
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CP0489189
N,N-dimethyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-7-(3-pyrrolidin-1-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-amine
   Show/Hide
C26H39N7
 1
1
IC50 = 73 nM
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CP0511156
4-[2-[2-[4-(4-methylpiperazin-1-yl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]ethyl]morpholine
   Show/Hide
C23H32N6O
 1
1
IC50 = 73 nM
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CP0379724
4-chloro-2-[4-(4-methylpiperazin-1-yl)phenyl]-7-(3-pyrrolidin-1-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine
   Show/Hide
C24H33ClN6
 1
1
IC50 = 84 nM
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CP0457834
6-(3-piperidin-1-ylpropoxy)-2-[4-(3-piperidin-1-ylpropoxy)phenyl]-1,3-benzoxazole
   Show/Hide
C29H39N3O3
 1
1
IC50 = 98 nM
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CP0571764
6-(3-pyrrolidin-1-ylpropoxy)-2-[3-(1,2,3,6-tetrahydropyridin-4-yl)phenyl]-1,3-benzoxazole
   Show/Hide
C25H29N3O2
 1
1
IC50 = 99 nM
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CP0481609
5-methyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-N-(2-morpholin-4-ylethyl)pyrimidin-4-amine
   Show/Hide
C22H32N6O
 1
1
IC50 = 120 nM
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CP0498610
4-methoxy-2-[4-(4-methylpiperazin-1-yl)phenyl]-7-(3-pyrrolidin-1-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine
   Show/Hide
C25H36N6O
 1
1
IC50 = 120 nM
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CP0315415
1-benzyl-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine
   Show/Hide
C32H38N4O2
 1
1
IC50 = 130 nM
   TI
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CP0351219
2-(3-piperidin-4-ylphenyl)-6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazole
   Show/Hide
C25H31N3O2
 1
1
IC50 = 133 nM
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CP0379309
2-[4-(4-methylpiperazin-1-yl)phenyl]-N-(2-morpholin-4-ylethyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-amine
   Show/Hide
C24H34N6O2
 1
1
IC50 = 190 nM
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CP0508476
2-[4-(4-methylpiperazin-1-yl)phenyl]-N-(2-morpholin-4-ylethyl)pyrimidin-4-amine
   Show/Hide
C21H30N6O
 1
1
IC50 = 190 nM
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CP0521006
N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]piperidin-4-amine
   Show/Hide
C25H32N4O2
 1
1
IC50 = 308 nM
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CP0950854
2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperidin-4-yl)-1H-indole
   Show/Hide
C23H29N3
 1
1
IC50 = 350 nM
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CP0388427
2-[4-[2-(3,4-dimethoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
   Show/Hide
C25H33N3O2
 1
1
IC50 = 430 nM
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CP0539158
2-[4-[2-(4-methoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
   Show/Hide
C24H31N3O
 1
1
IC50 = 500 nM
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CP0543455
US10660877, Example 776
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C22H28N4
 1
1
IC50 = 570 nM
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CP0548732
4-(aminomethyl)-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide
   Show/Hide
C28H30N4O3
 1
1
IC50 = 590 nM
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CP0577540
2-[4-[2-(5-methoxypyridin-3-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
   Show/Hide
C23H30N4O
 1
1
IC50 = 630 nM
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CP0572228
2-[4-[2-(6-methoxypyridin-3-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
   Show/Hide
C23H30N4O
 1
1
IC50 = 820 nM
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CP0457142
2-phenyl-6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazole
   Show/Hide
C20H22N2O2
 1
1
IC50 = 830 nM
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CP0458597
6-(3-pyrrolidin-1-ylpropoxy)-2-[4-(trifluoromethyl)phenyl]-1,3-benzoxazole
   Show/Hide
C21H21F3N2O2
 1
1
IC50 = 1100 nM
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CP0547003
US10660877, Example 777
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C23H30N4O
 1
1
IC50 = 1500 nM
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CP0540174
2-[4-[2-(3-methoxyphenyl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
   Show/Hide
C24H31N3O
 1
1
IC50 = 1900 nM
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CP0548692
6-(3-imidazol-1-ylpropoxy)-2-phenyl-1,3-benzoxazole
   Show/Hide
C19H17N3O2
 1
1
IC50 = 2100 nM
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CP0141465
1-pentyl-4-(2-phenylmethoxyphenyl)imidazol-2-amine;hydrochloride
   Show/Hide
C21H26ClN3O
 1
1
IC50 = 2400 nM
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CP0543198
N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide
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C27H27N3O3
 1
1
IC50 = 2560 nM
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CP0572227
N-methyl-2-[4-(3-methyl-2-pyridin-3-yl-1H-indol-5-yl)piperidin-1-yl]ethanamine
   Show/Hide
C22H28N4
 1
1
IC50 = 2800 nM
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CP0543451
2-[4-[2-(6-methoxypyridin-2-yl)-3-methyl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
   Show/Hide
C23H30N4O
 1
1
IC50 = 4600 nM
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CP0571763
6-(3-imidazol-1-ylpropoxy)-2-[4-(3-imidazol-1-ylpropoxy)phenyl]-1,3-benzoxazole
   Show/Hide
C25H25N5O3
 1
1
IC50 = 5100 nM
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CP0547971
2-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-1,3-benzoxazole
   Show/Hide
C20H22N2O2
 1
1
IC50 = 7000 nM
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CP0571742
4-amino-N-[3-[6-(3-pyrrolidin-1-ylpropoxy)-1,3-benzoxazol-2-yl]phenyl]benzamide
   Show/Hide
C27H28N4O3
 1
1
IC50 = 21000 nM
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CP0566945
4-methyl-1-[4-[7-(3-morpholin-4-ylpropyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]phenyl]piperazin-2-one
   Show/Hide
C24H32N6O2
 1
1
IC50 > 1000 nM
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