| Compound ID |
Compound Name |
Compound Formula |
|
CP0480207
|
US11168089, Ex. No. 15
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|
C20H10F3N7O
|
1
|
| 1 |
EC50 <= 10 nM
|
|
|
|
CP0545749
|
3-(4-amino-7-(1-methyl-1H-pyrazol-5-yl)-2-(pyridin-2-ylmethyl)-2H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-fluorobenzonitrile
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|
C22H16FN9
|
1
|
| 1 |
EC50 <= 10 nM
|
|
|
|
CP0554486
|
US11161850, Example 77
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|
C23H16F2N8O
|
1
|
| 1 |
EC50 <= 10 nM
|
|
|
|
CP0557689
|
US11168089, Ex. No. 14
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|
C19H11F3N6O
|
1
|
| 1 |
EC50 <= 10 nM
|
|
|
|
CP0559063
|
3-(4-amino-2-((3-fluoropyridin-2-yl)methyl)-7-(pyridin-4-yl)-2H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)benzonitrile
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|
C23H15FN8
|
1
|
| 1 |
EC50 <= 10 nM
|
|
|
|
CP0914644
|
3-(5-amino-2-(pyridin-3-ylmethyl)-8-(pyrimidin-4-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile
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|
C22H15N9
|
1
|
| 1 |
EC50 <= 10 nM
|
|
|
|
CP0381856
|
6-(4-{[4-(4-bromobenzyl)piperazin-1-yl]sulfonyl}phenyl)-1,3-dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C25H26BrN5O4S
|
1
|
| 1 |
IC50 = 1 nM
|
|
|
|
CP0434374
|
1-(2-methoxyethyl)-5-methyl-6-[(5-methyl-1H-imidazol-4-yl)methyl]-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
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|
C23H26N4O3S
|
1
|
| 1 |
IC50 = 2.4 nM
|
|
|
|
CP0381854
|
6-(4-(4-((5-chlorothiophen-2-yl)methyl)piperazin-1-ylsulfonyl)phenyl)-1,3-dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C23H24ClN5O4S2
|
1
|
| 1 |
IC50 = 4 nM
|
|
|
|
CP0381858
|
1,3-dimethyl-6-(4-(4-phenylpiperazin-1-ylsulfonyl)phenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C24H25N5O4S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0503366
|
4-((4-(4-(1-methyl-2,4-dioxo-3-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)phenylsulfonyl)piperazin-1-yl)methyl)benzonitrile
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|
C28H30N6O4S
|
1
|
| 1 |
IC50 = 6 nM
|
|
|
|
CP0394069
|
6-(4-(4-(2,4-difluorobenzyl)piperazin-1-ylsulfonyl)phenyl)-1,3-dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C25H25F2N5O4S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0394071
|
6-(4-(4-(3-fluorobenzyl)piperazin-1-ylsulfonyl)phenyl)-1,3-dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C25H26FN5O4S
|
1
|
| 1 |
IC50 = 7 nM
|
|
|
|
CP0559522
|
1-(2-methoxyethyl)-5-methyl-6-[(2-methyl-1H-imidazol-5-yl)methyl]-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
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|
C23H26N4O3S
|
1
|
| 1 |
IC50 = 8.8 nM
|
|
|
|
CP0509554
|
6-(4-(4-(4-fluorobenzyl)piperazin-1-ylsulfonyl)phenyl)-1,3-dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C25H26FN5O4S
|
1
|
| 1 |
IC50 = 10 nM
|
|
|
|
CP0381852
|
4-(1,3-diethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]benzenesulfonamide
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|
C28H32FN5O4S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0485278
|
4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-(pyridin-2-yl)benzenesulfonamide
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|
C19H17N5O4S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0415989
|
6-(imidazol-1-ylmethyl)-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
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|
C22H24N4O3S
|
1
|
| 1 |
IC50 = 12 nM
|
|
|
|
CP0496711
|
6-(4-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-ylsulfonyl)phenyl)-3-methyl-1-propyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C28H31N5O6S
|
1
|
| 1 |
IC50 = 13 nM
|
|
|
|
CP0386026
|
4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-(2-(pyridin-2-yl)ethyl)benzenesulfonamide
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|
C21H21N5O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0472172
|
6-[cyclopropyl(hydroxy)methyl]-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
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|
C22H26N2O4S
|
1
|
| 1 |
IC50 = 14 nM
|
|
|
|
CP0497195
|
6-(4-(4-(3-fluorobenzyl)piperazin-1-ylsulfonyl)phenyl)-1,3-diethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C27H30FN5O4S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0516276
|
N-[(5-methoxypyridin-2-yl)methyl]-4-(1-methyl-2,4-dioxo-3-propyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)benzenesulfonamide
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|
C23H25N5O5S
|
1
|
| 1 |
IC50 = 15 nM
|
|
|
|
CP0529118
|
6-(4-(4-benzylpiperazin-1-ylsulfonyl)phenyl)-1,3-dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
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|
C25H27N5O4S
|
1
|
| 1 |
IC50 = 16 nM
|
|
|
|
CP0381599
|
4-(1-methyl-2,4-dioxo-3-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-(2-(pyridin-2-yl)ethyl)benzenesulfonamide
Show/Hide
|
C23H25N5O4S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0497196
|
4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-(2-(pyridin-2-yloxy)ethyl)benzenesulfonamide
Show/Hide
|
C21H21N5O5S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0540269
|
6-(4-(4-(3-fluorobenzyl)piperazin-1-ylsulfonyl)phenyl)-3-methyl-1-propyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C27H30FN5O4S
|
1
|
| 1 |
IC50 = 17 nM
|
|
|
|
CP0394074
|
4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-(6-methoxypyridin-3-yl)benzenesulfonamide
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|
C20H19N5O5S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0433482
|
N-(1-benzylpiperidin-4-yl)-4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)benzenesulfonamide
Show/Hide
|
C30H37N5O4S
|
1
|
| 1 |
IC50 = 18 nM
|
|
|
|
CP0386027
|
4-(1,3-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-((5-methoxypyridin-2-yl)methyl)benzenesulfonamide
Show/Hide
|
C21H21N5O5S
|
1
|
| 1 |
IC50 = 20 nM
|
|
|
|
CP0509553
|
1,3-dimethyl-6-(4-(4-(pyridin-4-ylmethyl)piperazin-1-ylsulfonyl)phenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C24H26N6O4S
|
1
|
| 1 |
IC50 = 27 nM
|
|
|
|
CP0530191
|
6-[hydroxy(phenyl)methyl]-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
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|
C25H26N2O4S
|
1
|
| 1 |
IC50 = 30 nM
|
|
|
|
CP0069838
|
(4-Cyano-phenyl)-carbamic acid 4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl ester
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|
C26H26N6O4
|
5
|
| 1 |
IC50 = 32 nM
|
|
|
| 2 |
Ki = 1.9 nM
|
|
|
| 3 |
Ki = 1.97 nM
|
|
|
| 4 |
Ki = 2 nM
|
|
|
| 5 |
Ki = 10.39 nM
|
|
|
|
CP0542276
|
N,3-diethyl-N-(2-hydroxy-2-methylpropyl)-5-methyl-2,4-dioxo-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C19H26F3N3O4S
|
1
|
| 1 |
IC50 = 39 nM
|
|
|
|
CP0528201
|
N,N-diethyl-1-(2-methoxyethyl)-5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C23H29N3O4S
|
1
|
| 1 |
IC50 = 42 nM
|
|
|
|
CP0528174
|
N-(1-benzylpiperidin-4-yl)-4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)benzenesulfonamide
Show/Hide
|
C26H29N5O4S
|
1
|
| 1 |
IC50 = 43 nM
|
|
|
|
CP0472175
|
N,3-diethyl-N-(2-hydroxyethyl)-5-methyl-2,4-dioxo-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C17H22F3N3O4S
|
1
|
| 1 |
IC50 = 50 nM
|
|
|
|
CP0571928
|
5-methyl-3-(2-pyridin-3-ylethyl)-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C17H16F3N3O2S
|
1
|
| 1 |
IC50 = 55 nM
|
|
|
|
CP0550958
|
5-methyl-3-(2-phenylethyl)-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
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|
C18H17F3N2O2S
|
1
|
| 1 |
IC50 = 56 nM
|
|
|
|
CP0415983
|
3-ethyl-6-(4-hydroxypiperidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C18H22F3N3O4S
|
1
|
| 1 |
IC50 = 59 nM
|
|
|
|
CP0964764
|
4-(2-(7-amino-2-(4,5-dihydrofuran-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol
Show/Hide
|
C16H17N7O2
|
1
|
| 1 |
IC50 = 72 nM
|
|
|
|
CP0414025
|
3-[2-(2-fluorophenyl)ethyl]-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C18H16F4N2O2S
|
1
|
| 1 |
IC50 = 73 nM
|
|
|
|
CP0496712
|
4-(1,3-diethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-(2-(pyridin-2-yl)ethyl)benzenesulfonamide
Show/Hide
|
C23H25N5O4S
|
1
|
| 1 |
IC50 = 75 nM
|
|
|
|
CP0394366
|
N-(1-benzylpiperidin-4-yl)-4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-methylbenzenesulfonamide
Show/Hide
|
C27H31N5O4S
|
1
|
| 1 |
IC50 = 90 nM
|
|
|
|
CP0559523
|
N,N-diethyl-3-(2-methoxyethyl)-5-methyl-2,4-dioxo-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C18H24F3N3O4S
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0563753
|
9-(2-methoxyethyl)-11-(2-phenylethyl)-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6)-diene-10,12-dione
Show/Hide
|
C20H22N2O3S
|
1
|
| 1 |
IC50 = 97 nM
|
|
|
|
CP0409696
|
5-Ethyl-2-phenyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
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|
C14H12N6
|
1
|
| 1 |
IC50 < 100 nM
|
|
|
|
CP0099922
|
N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide
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|
C18H14FN5O
|
2
|
| 1 |
IC50 = 120 nM
|
|
|
| 2 |
Ki = 24 nM
|
|
|
|
CP0571923
|
1-(1H-imidazol-2-ylmethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C19H18N4O2S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0575389
|
2-[5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidin-1-yl]acetonitrile
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|
C17H15N3O2S
|
1
|
| 1 |
IC50 = 130 nM
|
|
|
|
CP0571924
|
1-(2-fluoroethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C17H17FN2O2S
|
1
|
| 1 |
IC50 = 135 nM
|
|
|
|
CP0555122
|
5-methyl-1-[(1-methylimidazol-2-yl)methyl]-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C20H20N4O2S
|
1
|
| 1 |
IC50 = 145 nM
|
|
|
|
CP0575961
|
6-(1-cyclopropyl-1-hydroxyethyl)-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C23H28N2O4S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0577949
|
6-(hydroxymethyl)-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C19H22N2O4S
|
1
|
| 1 |
IC50 = 150 nM
|
|
|
|
CP0472173
|
1-(2-methoxyethyl)-5-methyl-6-(1-methylimidazole-4-carbonyl)-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C23H24N4O4S
|
1
|
| 1 |
IC50 = 190 nM
|
|
|
|
CP0415979
|
3-ethyl-6-(3-hydroxyazetidine-1-carbonyl)-5-methyl-1-(3,3,3-trifluoropropyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C16H18F3N3O4S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0537965
|
1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)-6-(pyrrolidin-1-ylmethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C23H29N3O3S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0542278
|
1-(2-methoxyethyl)-5,6-dimethyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C19H22N2O3S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0563756
|
6-(3-hydroxyazetidine-1-carbonyl)-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C22H25N3O5S
|
1
|
| 1 |
IC50 = 200 nM
|
|
|
|
CP0561546
|
3-[2-(2-fluorophenyl)ethyl]-1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C18H19FN2O3S
|
1
|
| 1 |
IC50 = 210 nM
|
|
|
|
CP0542339
|
11-ethyl-9-(2-methoxyethyl)-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6)-diene-10,12-dione
Show/Hide
|
C14H18N2O3S
|
1
|
| 1 |
IC50 = 220 nM
|
|
|
|
CP0556773
|
6-(cyclopentyloxymethyl)-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C24H30N2O4S
|
1
|
| 1 |
IC50 = 250 nM
|
|
|
|
CP0547186
|
1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)-6-(pyrrolidine-1-carbonyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C23H27N3O4S
|
1
|
| 1 |
IC50 = 260 nM
|
|
|
|
CP0549195
|
1-(2-methoxyethyl)-5-methyl-3-(2-pyridin-3-ylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C17H19N3O3S
|
1
|
| 1 |
IC50 = 280 nM
|
|
|
|
CP0561545
|
1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C18H20N2O3S
|
1
|
| 1 |
IC50 = 300 nM
|
|
|
|
CP0422261
|
4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine
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|
C17H12N6O
|
2
|
| 1 |
IC50 = 321 nM
|
|
|
| 2 |
Ki = 17 nM
|
|
|
|
CP0434376
|
3-ethyl-1-(2-methoxyethyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C15H20N2O3S
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0530181
|
N-methoxy-1-(2-methoxyethyl)-N,5-dimethyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C21H25N3O5S
|
1
|
| 1 |
IC50 = 390 nM
|
|
|
|
CP0563755
|
1-(2-methoxyethyl)-5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C19H21N3O4S
|
1
|
| 1 |
IC50 = 430 nM
|
|
|
|
CP0555224
|
3-(2,2-difluoro-2-phenylethyl)-1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C18H18F2N2O3S
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0577493
|
3-ethyl-1-(2-methoxyethyl)-5,6-dimethylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C13H18N2O3S
|
1
|
| 1 |
IC50 = 440 nM
|
|
|
|
CP0572048
|
5-[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C15H12N6O2
|
2
|
| 1 |
IC50 = 479 nM
|
|
|
| 2 |
Ki = 491 nM
|
|
|
|
CP0575390
|
5-methyl-3-(2-phenylethyl)-1H-thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C15H14N2O2S
|
1
|
| 1 |
IC50 = 480 nM
|
|
|
|
CP0542340
|
1-(2-methoxyethyl)-3-(2-phenylethyl)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C21H24N2O3S
|
1
|
| 1 |
IC50 = 490 nM
|
|
|
|
CP0547187
|
6-benzyl-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C25H26N2O3S
|
1
|
| 1 |
IC50 = 540 nM
|
|
|
|
CP0520818
|
3-ethyl-1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C12H16N2O3S
|
1
|
| 1 |
IC50 = 640 nM
|
|
|
|
CP0519052
|
US8796284, 1
Show/Hide
|
C10H8BrN7
|
1
|
| 1 |
IC50 = 680 nM
|
|
|
|
CP0542275
|
1-(2-methoxyethyl)-5-methyl-6-(morpholin-4-ylmethyl)-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C23H29N3O4S
|
1
|
| 1 |
IC50 = 760 nM
|
|
|
|
CP0563757
|
6-(cyclopropanecarbonyl)-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C22H24N2O4S
|
1
|
| 1 |
IC50 = 790 nM
|
|
|
|
CP0507803
|
4-[(5-naphthalen-2-yl-4-phenylpyrimidin-2-yl)amino]cyclohexan-1-ol
Show/Hide
|
C26H25N3O
|
1
|
| 1 |
IC50 = 1000 nM
|
|
|
|
CP0555123
|
2-[[5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidin-1-yl]methyl]-1,3-benzoxazole-5-sulfonamide
Show/Hide
|
C23H20N4O5S2
|
1
|
| 1 |
IC50 = 1100 nM
|
|
|
|
CP0472174
|
6-[1-hydroxy-1-(3-methylimidazol-4-yl)ethyl]-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C24H28N4O4S
|
1
|
| 1 |
IC50 = 1200 nM
|
|
|
|
CP0571927
|
1-(1H-imidazol-5-ylmethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C19H18N4O2S
|
1
|
| 1 |
IC50 = 1300 nM
|
|
|
|
CP0552654
|
1-(2-methoxyethyl)-5-methyl-3-[(1-phenylcyclopropyl)methyl]thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C20H22N2O3S
|
1
|
| 1 |
IC50 = 1500 nM
|
|
|
|
CP0477435
|
3-(2,2-dimethylpropyl)-1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C15H22N2O3S
|
1
|
| 1 |
IC50 = 1600 nM
|
|
|
|
CP0391080
|
ethyl 1-(2-methoxyethyl)-5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxylate
Show/Hide
|
C21H24N2O5S
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0577492
|
4-[2-[5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidin-1-yl]ethyl]benzenesulfonamide
Show/Hide
|
C23H23N3O4S2
|
1
|
| 1 |
IC50 = 1700 nM
|
|
|
|
CP0556774
|
1-(2-methoxyethyl)-5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxylic acid
Show/Hide
|
C19H20N2O5S
|
1
|
| 1 |
IC50 = 2100 nM
|
|
|
|
CP0563758
|
6-benzoyl-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C25H24N2O4S
|
1
|
| 1 |
IC50 = 2300 nM
|
|
|
|
CP0471941
|
5-Butyl-2-(4-chloro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H15ClN6
|
1
|
| 1 |
IC50 = 2700 nM
|
|
|
|
CP0578884
|
6-[difluoro(phenyl)methyl]-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C25H24F2N2O3S
|
1
|
| 1 |
IC50 = 2800 nM
|
|
|
|
CP0421230
|
6-chloro-1-(2-methoxyethyl)-5-methyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C18H19ClN2O3S
|
1
|
| 1 |
IC50 = 3300 nM
|
|
|
|
CP0575962
|
5-methyl-1-[(5-methyl-1H-imidazol-4-yl)methyl]-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C20H20N4O2S
|
1
|
| 1 |
IC50 = 3400 nM
|
|
|
|
CP0434369
|
1-(2-methoxyethyl)-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C17H18N2O3S
|
1
|
| 1 |
IC50 = 4700 nM
|
|
|
|
CP0552655
|
3-(3,3-difluoroprop-2-enyl)-1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C13H14F2N2O3S
|
1
|
| 1 |
IC50 = 4900 nM
|
|
|
|
CP0564776
|
1-(2-methoxyethyl)-5-methyl-6-phenyl-3-(2-phenylethyl)thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C24H24N2O3S
|
1
|
| 1 |
IC50 = 4900 nM
|
|
|
|
CP0399728
|
5-Butyl-2-(4-fluoro-phenyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H15FN6
|
1
|
| 1 |
IC50 = 9400 nM
|
|
|
|
CP0306274
|
5-Butyl-8-(4-trifluoromethyl-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H15F3N6
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki = 6 nM
|
|
|
|
CP0337596
|
8-Biphenyl-4-yl-5-butyl-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C22H20N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0372284
|
5-Butyl-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H18N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0375149
|
5-Butyl-9-chloro-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0376682
|
2-(4-Bromo-phenyl)-5-butyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17BrN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0383677
|
5-Butyl-8-chloro-2-phenyl-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0383693
|
5-Butyl-9-chloro-2-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H16Cl2N4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0399696
|
5-Butyl-2-p-tolyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C17H18N6
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0447720
|
5-Butyl-2-(4-chloro-phenyl)-[1,2,4]triazolo[1,5-c]quinazoline
Show/Hide
|
C19H17ClN4
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0447721
|
8-Biphenyl-4-yl-5-(2-methoxy-ethyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C21H18N6O
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0488144
|
4-[8-(4-Chloro-phenyl)-3H-[1,2,4]triazolo[5,1-i]purin-5-yl]-butyric acid
Show/Hide
|
C16H13ClN6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0509127
|
4-(8-Biphenyl-4-yl-3H-[1,2,4]triazolo[5,1-i]purin-5-yl)-butyric acid
Show/Hide
|
C22H18N6O2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0380753
|
7-ethoxy-6-ethyl-3-(4-methyl-1,3-thiazol-2-yl)chromen-4-one
Show/Hide
|
C17H17NO3S
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0201120
|
8-cyclopentyl-2-(3,4-difluorophenoxy)-1-propyl-7H-purin-6-one
Show/Hide
|
C19H20F2N4O2
|
2
|
| 1 |
IC50 > 10000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0477436
|
1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C10H12N2O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0530179
|
3-[2-(1,1-dioxo-1,4-thiazinan-4-yl)ethyl]-1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C16H23N3O5S2
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0530192
|
5-amino-N,N-diethyl-1,3-dimethyl-2,4-dioxothieno[2,3-d]pyrimidine-6-carboxamide
Show/Hide
|
C13H18N4O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0547196
|
3-benzyl-1-(2-methoxyethyl)-5-methylthieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C17H18N2O3S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0563765
|
4-chloro-2-[[2-[5-methyl-2,4-dioxo-3-(2-phenylethyl)thieno[2,3-d]pyrimidin-1-yl]acetyl]amino]benzoic acid
Show/Hide
|
C24H20ClN3O5S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0574919
|
1-(2-methoxyethyl)-5-methyl-3-[2-(oxan-4-yl)ethyl]thieno[2,3-d]pyrimidine-2,4-dione
Show/Hide
|
C17H24N2O4S
|
1
|
| 1 |
IC50 > 10000 nM
|
|
|
|
CP0447991
|
2-Phenyl-5-propyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C15H14N6
|
1
|
| 1 |
IC50 > 1500 nM
|
|
|
|
CP0054097
|
2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C18H15N7O
|
2
|
| 1 |
IC50 > 2000 nM
|
|
|
| 2 |
Ki > 10000 nM
|
|
|
|
CP0488154
|
5-Butyl-2-phenyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine
Show/Hide
|
C16H16N6
|
1
|
| 1 |
IC50 > 2600 nM
|
|
|
|
CP0414421
|
N-[2-[2-[2-[6-[[2-[4-(2,2-difluoro-12-thiophen-2-yl-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-4-yl)phenoxy]acetyl]amino]hexanoylamino]ethoxy]ethoxy]ethyl]-N'-[2-(4-methoxyphenyl)-1-oxo-[1,2,4]triazolo[4,3-a]quinoxalin-4-yl]butanediamide
Show/Hide
|
C53H55BF2N10O9S
|
1
|
| 1 |
Kd < 1000 nM
|
|
|
|
CP0866586
|
(E)-5,5-difluoro-3-(4-(23-(2-(4-methoxyphenyl)-1-oxo-1,2,5a,9a-tetrahydro-[1,2,4]triazolo[4,3-a]quinoxalin-4-ylamino)-2,9,20,23-tetraoxo-13,16-dioxa-3,10,19-triazatricosyloxy)styryl)-7-(thiophen-2-yl)-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide
Show/Hide
|
C55H57BF2N10O9S
|
1
|
| 1 |
Kd < 1000 nM
|
|
|
|
CP0455585
|
N-[2-[[2-phenyl-8-[4-(3-phenylpropyl)piperazine-1-carbonyl]-7H-purin-6-yl]amino]ethyl]acetamide
Show/Hide
|
C29H34N8O2
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0048716
|
N-[2-[[2-phenyl-6-[4-(3-phenylpropyl)piperazine-1-carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethyl]acetamide
Show/Hide
|
C30H35N7O2
|
1
|
| 1 |
Ki = 0.5 nM
|
|
|
|
CP0441360
|
N-[6-(2-fluorophenyl)-5-(3-fluoropyridin-4-yl)pyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C19H14F2N4O
|
1
|
| 1 |
Ki = 0.6 nM
|
|
|
|
CP0381840
|
[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-thiophen-3-ylcarbamate
Show/Hide
|
C20H18N4O4S
|
1
|
| 1 |
Ki = 0.8 nM
|
|
|
|
CP0397979
|
8-[1-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H28F3N7O3
|
2
|
| 1 |
Ki = 0.9 nM
|
|
|
| 2 |
Ki = 1 nM
|
|
|
|
CP0428834
|
8-[1-[2-oxo-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H31F3N8O3
|
1
|
| 1 |
Ki = 0.9 nM
|
|
|
|
CP0399316
|
N-(4-bromophenyl)-2-[4-(7-hydroxy-2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetamide
Show/Hide
|
C26H27BrN4O5
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0394216
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C18H15F3N6O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0382449
|
8-(1-((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H24N8O3
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0417943
|
N-[5-(3-fluoropyridin-4-yl)-6-(furan-2-yl)pyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C18H14FN3O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0417947
|
N-[6-(furan-2-yl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C18H15N3O2
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0384230
|
7-(furan-2-yl)-6-(pyrimidin-4-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
Show/Hide
|
C15H9N5O3
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0490013
|
N-[6-(2-fluorophenyl)-5-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C19H15FN4O
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0406626
|
8-[4-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C29H30F3N5O4
|
1
|
| 1 |
Ki = 1 nM
|
|
|
|
CP0468059
|
8-[1-[2-hydroxy-2-[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]ethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H30F3N7O4
|
1
|
| 1 |
Ki = 1.2 nM
|
|
|
|
CP0413020
|
1-propyl-8-[1-[3-[4-(trifluoromethyl)phenyl]prop-2-ynyl]pyrazol-4-yl]-3,7-dihydropurine-2,6-dione
Show/Hide
|
C21H17F3N6O2
|
1
|
| 1 |
Ki = 1.3 nM
|
|
|
|
CP0308003
|
N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 1.39 nM
|
|
|
|
CP0132091
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)-N-phenylacetamide
Show/Hide
|
C25H27N5O4
|
1
|
| 1 |
Ki = 1.48 nM
|
|
|
|
CP0406633
|
8-[1-[2-oxo-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H31F3N8O3
|
2
|
| 1 |
Ki = 1.5 nM
|
|
|
| 2 |
Ki = 4 nM
|
|
|
|
CP0454790
|
1,3-dipropyl-8-[1-[3-[4-(trifluoromethyl)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C24H23F3N6O2
|
1
|
| 1 |
Ki = 1.5 nM
|
|
|
|
CP0453330
|
2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-(4-nitro-phenyl)-acetamide (0.43CH3OH)
Show/Hide
|
C25H26N6O6
|
1
|
| 1 |
Ki = 1.52 nM
|
|
|
|
CP0448663
|
8-[1-[3-(4-fluorophenyl)prop-2-ynyl]pyrazol-4-yl]-1-propyl-3,7-dihydropurine-2,6-dione
Show/Hide
|
C20H17FN6O2
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0478464
|
1-propyl-8-[1-[3-[4-(trifluoromethoxy)phenyl]prop-2-ynyl]pyrazol-4-yl]-3,7-dihydropurine-2,6-dione
Show/Hide
|
C21H17F3N6O3
|
1
|
| 1 |
Ki = 1.6 nM
|
|
|
|
CP0374370
|
[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-(1,2-oxazol-3-yl)carbamate
Show/Hide
|
C23H25N5O5
|
1
|
| 1 |
Ki = 1.7 nM
|
|
|
|
CP0397333
|
2-[4-(1,3-Diethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-p-tolyl-acetamide
Show/Hide
|
C24H25N5O4
|
1
|
| 1 |
Ki = 1.78 nM
|
|
|
|
CP0413108
|
8-[1-[2-[4-(3-chloro-4-fluorophenyl)piperazin-1-yl]-2-oxoethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H30ClFN8O3
|
1
|
| 1 |
Ki = 1.8 nM
|
|
|
|
CP0447762
|
3-[3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoic acid
Show/Hide
|
C24H24N6O4
|
2
|
| 1 |
Ki = 1.8 nM
|
|
|
| 2 |
Ki = 5.3 nM
|
|
|
|
CP0173506
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)-N-p-tolylacetamide
Show/Hide
|
C26H29N5O4
|
1
|
| 1 |
Ki = 1.88 nM
|
|
|
|
CP0381843
|
[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-(4-fluorophenyl)carbamate
Show/Hide
|
C26H27FN4O4
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0373086
|
8-(1-benzylpyrazol-4-yl)-1-ethyl-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C18H18N6O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0382872
|
N-[6-(2-fluorophenyl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C20H16FN3O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0400423
|
N-[6-(3-fluorophenyl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C20H16FN3O
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0469200
|
N-[5-(3-fluoropyridin-4-yl)-6-(1,3-oxazol-5-yl)pyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C16H12FN5O2
|
1
|
| 1 |
Ki = 2 nM
|
|
|
|
CP0154687
|
N-benzyl-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C26H29N5O4
|
1
|
| 1 |
Ki = 2.04 nM
|
|
|
|
CP0381841
|
[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl 3,4-dihydro-1H-isoquinoline-2-carboxylate
Show/Hide
|
C25H24N4O4
|
1
|
| 1 |
Ki = 2.1 nM
|
|
|
|
CP0057624
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)-N-(4-iodophenyl)acetamide
Show/Hide
|
C25H26IN5O4
|
1
|
| 1 |
Ki = 2.13 nM
|
|
|
|
CP0397722
|
2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-(4-trifluoromethyl-phenyl)-acetamide
Show/Hide
|
C26H26F3N5O4
|
1
|
| 1 |
Ki = 2.14 nM
|
|
|
|
CP0083570
|
N-(4-bromophenyl)-2-[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetamide
Show/Hide
|
C26H27BrN4O4
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0474209
|
N-[6-(furan-2-yl)-5-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H14N4O2
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0512956
|
N-[6-(5-methylfuran-2-yl)-5-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C18H16N4O2
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0454791
|
1-propyl-8-[1-[3-[3-(trifluoromethyl)phenyl]prop-2-ynyl]pyrazol-4-yl]-3,7-dihydropurine-2,6-dione
Show/Hide
|
C21H17F3N6O2
|
1
|
| 1 |
Ki = 2.2 nM
|
|
|
|
CP0109688
|
2-(4-(2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy)-N-(4-fluorophenyl)acetamide
Show/Hide
|
C25H26FN5O4
|
1
|
| 1 |
Ki = 2.22 nM
|
|
|
|
CP0405375
|
6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C29H32N4O4
|
1
|
| 1 |
Ki = 2.291 nM
|
|
|
|
CP0469056
|
2-[4-(2,4-dioxo-3-propyl-1,5-dihydropyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]-N-(4-fluorophenyl)acetamide
Show/Hide
|
C23H21FN4O4
|
1
|
| 1 |
Ki = 2.344 nM
|
|
|
|
CP0161793
|
N-(4-bromophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C25H26BrN5O4
|
1
|
| 1 |
Ki = 2.35 nM
|
|
|
|
CP0273477
|
N-(4-chlorophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C25H26ClN5O4
|
1
|
| 1 |
Ki = 2.47 nM
|
|
|
|
CP0399317
|
6-(4-(2-(4-benzylpiperazin-1-yl)-2-oxoethoxy)phenyl)-7-hydroxy-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C31H37N5O5
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0406603
|
8-[1-[2-[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]ethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H30F3N7O3
|
1
|
| 1 |
Ki = 2.6 nM
|
|
|
|
CP0077961
|
N-(4-bromophenyl)-2-[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetamide
Show/Hide
|
C22H19BrN4O4
|
1
|
| 1 |
Ki = 2.63 nM
|
|
|
|
CP0397463
|
N-(2-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 2.74 nM
|
|
|
|
CP0387835
|
[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-phenylcarbamate
Show/Hide
|
C22H20N4O4
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0454806
|
1-propyl-8-[1-[3-[3-(trifluoromethoxy)phenyl]prop-2-ynyl]pyrazol-4-yl]-3,7-dihydropurine-2,6-dione
Show/Hide
|
C21H17F3N6O3
|
1
|
| 1 |
Ki = 2.8 nM
|
|
|
|
CP0373201
|
6-[4-[2-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H27ClN4O5
|
1
|
| 1 |
Ki = 2.884 nM
|
|
|
|
CP0397004
|
N-(4-bromophenyl)-2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]acetamide
Show/Hide
|
C25H26BrN5O5
|
1
|
| 1 |
Ki = 2.884 nM
|
|
|
|
CP0405152
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H17F3N6O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0499459
|
6-(furan-2-yl)-5-(pyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3(2H)-one
Show/Hide
|
C14H9N5O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0424167
|
N-[6-(furan-2-yl)-5-pyridin-4-ylpyrazin-2-yl]cyclobutanecarboxamide
Show/Hide
|
C18H16N4O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0406628
|
8-[6-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]pyridin-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C28H29F3N6O4
|
2
|
| 1 |
Ki = 3 nM
|
|
|
| 2 |
Ki = 71 nM
|
|
|
|
CP0413013
|
8-[1-[3-(3-fluorophenyl)prop-2-ynyl]pyrazol-4-yl]-1-propyl-3,7-dihydropurine-2,6-dione
Show/Hide
|
C20H17FN6O2
|
1
|
| 1 |
Ki = 3 nM
|
|
|
|
CP0372513
|
2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]-N-phenylacetamide
Show/Hide
|
C25H27N5O5
|
1
|
| 1 |
Ki = 3.02 nM
|
|
|
|
CP0491761
|
2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]-N-(4-fluorophenyl)acetamide
Show/Hide
|
C25H26FN5O5
|
1
|
| 1 |
Ki = 3.02 nM
|
|
|
|
CP0443443
|
[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-(furan-2-yl)carbamate
Show/Hide
|
C20H18N4O5
|
1
|
| 1 |
Ki = 3.2 nM
|
|
|
|
CP0482903
|
4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-N-methyl-benzamide (1.8CH2CL2)
Show/Hide
|
C27H30N6O5
|
1
|
| 1 |
Ki = 3.34 nM
|
|
|
|
CP0399706
|
6-[4-[2-[4-(4-chlorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C26H26ClN5O4
|
1
|
| 1 |
Ki = 3.388 nM
|
|
|
|
CP0058627
|
N-(4-bromophenyl)-2-[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-3-methoxyphenoxy]acetamide
Show/Hide
|
C23H21BrN4O5
|
1
|
| 1 |
Ki = 3.467 nM
|
|
|
|
CP0373449
|
6-[4-[2-[4-(4-bromophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C26H26BrN5O4
|
1
|
| 1 |
Ki = 3.467 nM
|
|
|
|
CP0384049
|
propan-2-yl 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H19N3O3
|
1
|
| 1 |
Ki = 3.49 nM
|
|
|
|
CP0469202
|
N-[6-(furan-2-yl)-5-pyridin-4-ylpyrazin-2-yl]propanamide
Show/Hide
|
C16H14N4O2
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0403600
|
8-[3-[(6-chloro-1H-benzimidazol-2-yl)methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C22H22ClN7O4
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0456611
|
ethyl 4-[3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoate
Show/Hide
|
C26H28N6O4
|
1
|
| 1 |
Ki = 3.5 nM
|
|
|
|
CP0400722
|
N-(4-bromophenyl)-2-[4-(2,4-dioxo-3-propyl-1,5-dihydropyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetamide
Show/Hide
|
C23H21BrN4O4
|
1
|
| 1 |
Ki = 3.548 nM
|
|
|
|
CP0397982
|
1,3-dipropyl-8-[1-[[1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C26H30F3N7O2
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0393453
|
1,3-dipropyl-8-[1-[3-[3-(trifluoromethoxy)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C24H23F3N6O3
|
2
|
| 1 |
Ki = 3.6 nM
|
|
|
| 2 |
Ki = 8.8 nM
|
|
|
|
CP0475990
|
N-[2,6-bis(4-methoxyphenyl)pyrimidin-4-yl]propanamide
Show/Hide
|
C21H21N3O3
|
1
|
| 1 |
Ki = 3.6 nM
|
|
|
|
CP0373291
|
6-[4-[2-[4-(5-chloro-1,3-benzothiazol-2-yl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H25ClN6O4S
|
1
|
| 1 |
Ki = 3.631 nM
|
|
|
|
CP0885574
|
N-(2-Acetyl-phenyl)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylamide
Show/Hide
|
C28H29N5O4
|
1
|
| 1 |
Ki = 3.65 nM
|
|
|
|
CP0437425
|
ethyl (4S)-2-methyl-4-(1,3-oxazol-4-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C17H16N4O3
|
1
|
| 1 |
Ki = 3.66 nM
|
|
|
|
CP0413015
|
3-[3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzonitrile
Show/Hide
|
C24H23N7O2
|
1
|
| 1 |
Ki = 3.7 nM
|
|
|
|
CP0535418
|
2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-(4-hydroxy-phenyl)-acetamide
Show/Hide
|
C25H27N5O5
|
1
|
| 1 |
Ki = 3.71 nM
|
|
|
|
CP0008892
|
Alloxazine
Show/Hide
|
C10H6N4O2
|
1
|
| 1 |
Ki = 3.8 nM
|
|
|
|
CP0443759
|
4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzoic acid methyl ester
Show/Hide
|
C27H29N5O6
|
1
|
| 1 |
Ki = 3.93 nM
|
|
|
|
CP0373725
|
N-[6-(furan-2-yl)-5-pyrimidin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H14N4O2
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0384317
|
N-[6-(4-fluorophenyl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C20H16FN3O
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0403597
|
8-(2-methyl-5-oxo-1H-pyrazol-3-yl)-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C15H20N6O3
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0378491
|
3-ethyl-8-[1-[[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C24H26FN7O3
|
2
|
| 1 |
Ki = 4 nM
|
|
|
| 2 |
Ki = 12 nM
|
|
|
|
CP0378495
|
8-[1-[[5-oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H28F3N7O4
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0432813
|
3-ethyl-8-[1-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C25H26F3N7O3
|
2
|
| 1 |
Ki = 4 nM
|
|
|
| 2 |
Ki = 8 nM
|
|
|
|
CP0447459
|
8-[6-[[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]methoxy]pyridin-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H29FN6O4
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0459922
|
8-[1-[1-[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]ethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C27H30F3N7O3
|
1
|
| 1 |
Ki = 4 nM
|
|
|
|
CP0391931
|
8-[3-[(6-bromo-1H-benzimidazol-2-yl)methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C22H22BrN7O4
|
1
|
| 1 |
Ki = 4.1 nM
|
|
|
|
CP0405398
|
6-[4-[2-oxo-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C31H34F3N5O4
|
1
|
| 1 |
Ki = 4.169 nM
|
|
|
|
CP0412428
|
1,3-dimethyl-6-[4-[2-oxo-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C27H26F3N5O4
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1
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| 1 |
Ki = 4.169 nM
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CP0433842
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3-methyl-6-[4-[2-methyl-1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]oxyphenyl]-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C30H35N5O4
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1
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| 1 |
Ki = 4.169 nM
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CP0373200
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6-[4-[2-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-2-oxoethoxy]phenyl]-3-methyl-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C27H28Cl2N6O4
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1
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| 1 |
Ki = 4.266 nM
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CP0469856
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3-ethyl-8-[1-[[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C25H26F3N7O3
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1
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| 1 |
Ki = 4.5 nM
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CP0413201
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8-[6-[[1-(3-fluorophenyl)-5-oxopyrrolidin-3-yl]methoxy]pyridin-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C27H29FN6O4
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1
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| 1 |
Ki = 4.6 nM
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CP0373450
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6-[4-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-1-oxopropan-2-yl]oxyphenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C30H34N4O4
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1
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| 1 |
Ki = 4.677 nM
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CP0432110
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6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C30H35N5O4
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1
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| 1 |
Ki = 4.786 nM
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CP0432108
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1,3-bis(2-methoxyethyl)-6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C30H35N5O6
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1
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| 1 |
Ki = 4.898 nM
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CP0413028
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1,3-dipropyl-8-[1-[3-[3-(trifluoromethyl)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C24H23F3N6O2
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1
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| 1 |
Ki = 4.9 nM
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CP0448990
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N-(3-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C27H29N5O5
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1
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| 1 |
Ki = 4.92 nM
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CP0457870
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8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C19H17FN6O2
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1
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| 1 |
Ki = 5 nM
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CP0293183
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2-(furan-2-yl)-8-phenethyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
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C18H15N7O
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1
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| 1 |
Ki = 5 nM
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CP0436497
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8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C19H19FN6O2
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1
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| 1 |
Ki = 5 nM
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CP0400406
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N-[6-(5-methylfuran-2-yl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
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C19H17N3O2
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1
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| 1 |
Ki = 5 nM
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CP0471520
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N-[5-(3-chloropyridin-4-yl)-6-(furan-2-yl)pyridin-2-yl]cyclopropanecarboxamide
Show/Hide
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C18H14ClN3O2
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1
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| 1 |
Ki = 5 nM
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CP0462139
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8-[5-[(6-chloro-1H-benzimidazol-2-yl)methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C23H25ClN8O3
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1
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| 1 |
Ki = 5 nM
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CP0413176
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8-[1-[2-[4-(4-methylphenyl)piperazin-1-yl]-2-oxoethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C27H34N8O3
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1
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| 1 |
Ki = 5 nM
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CP0413025
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8-[1-[3-(3-methylphenyl)prop-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C24H26N6O2
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1
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| 1 |
Ki = 5 nM
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CP0373202
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1,3-dimethyl-6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C26H27N5O4
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1
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| 1 |
Ki = 5.248 nM
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CP0447457
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8-[4-[[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]methoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C28H30FN5O4
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1
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| 1 |
Ki = 5.4 nM
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CP0470933
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2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-N-methyl-N-phenyl-acetamide
Show/Hide
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C26H29N5O4
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1
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| 1 |
Ki = 5.42 nM
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CP0099921
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N-(1,3-benzodioxol-5-yl)-2-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
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C24H27N7O6
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1
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| 1 |
Ki = 5.5 nM
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CP0387790
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8-[3-[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C22H21ClFN7O4
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1
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| 1 |
Ki = 5.5 nM
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CP0426389
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1,3-dipropyl-8-[1-[3-[4-(trifluoromethoxy)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C24H23F3N6O3
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1
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| 1 |
Ki = 5.5 nM
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CP0394403
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6-[4-[2-[4-(6-chloro-1,3-benzothiazol-2-yl)piperazin-1-yl]-2-oxoethoxy]phenyl]-3-methyl-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C29H29ClN6O4S
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1
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| 1 |
Ki = 5.754 nM
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CP0381844
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[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-(1H-pyrazol-5-yl)carbamate
Show/Hide
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C23H26N6O4
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1
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| 1 |
Ki = 5.9 nM
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CP0456613
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8-[1-[3-(4-fluorophenyl)prop-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C23H23FN6O2
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1
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| 1 |
Ki = 5.9 nM
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CP0372915
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1-ethyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C18H15F3N6O2
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1
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| 1 |
Ki = 6 nM
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CP0457597
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8-(1-benzyl-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C19H18N6O2
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1
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| 1 |
Ki = 6 nM
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CP0405203
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1-ethyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-7H-purine-2,6-dione
Show/Hide
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C18H17FN6O2
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1
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| 1 |
Ki = 6 nM
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CP0407886
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1-ethyl-3-methyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C19H17F3N6O2
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1
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| 1 |
Ki = 6 nM
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CP0375797
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5-(furan-2-yl)-6-(pyrimidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Show/Hide
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C14H9N5O2
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1
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| 1 |
Ki = 6 nM
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CP0441363
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N-[6-(furan-2-yl)-5-pyridin-4-ylpyrazin-2-yl]acetamide
Show/Hide
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C15H12N4O2
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1
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| 1 |
Ki = 6 nM
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CP0500467
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N-[5-(3-fluoropyridin-4-yl)-6-(1,3-oxazol-2-yl)pyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
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C16H12FN5O2
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1
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| 1 |
Ki = 6 nM
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CP0378476
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8-[1-[[2-oxo-1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H28F3N7O4
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2
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| 1 |
Ki = 6 nM
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| 2 |
Ki = 191 nM
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CP0406630
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8-[1-[[2-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H28F3N7O3
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1
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| 1 |
Ki = 6 nM
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CP0373461
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6-[4-[2-[4-(3-chlorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-3-methyl-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C28H30ClN5O4
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1
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| 1 |
Ki = 6.026 nM
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CP0388721
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6-(4-(2-(4-benzylpiperazin-1-yl)-2-oxoethoxy)phenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C31H37N5O4
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2
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| 1 |
Ki = 6.166 nM
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| 2 |
Ki = 6.2 nM
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CP0412432
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6-[4-[2-[4-(2-methoxyphenyl)piperidin-1-yl]-2-oxoethoxy]phenyl]-3-methyl-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C30H34N4O5
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1
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| 1 |
Ki = 6.166 nM
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CP0413021
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8-[1-[3-(3-methoxyphenyl)prop-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C24H26N6O3
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1
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| 1 |
Ki = 6.3 nM
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CP0373290
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6-[4-[2-[4-(2-chlorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C26H26ClN5O4
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1
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| 1 |
Ki = 6.31 nM
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CP0394406
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4-[4-[2-[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetyl]piperazin-1-yl]benzonitrile
Show/Hide
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C27H26N6O4
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1
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| 1 |
Ki = 6.31 nM
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CP0485487
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7-hydroxy-6-(4-(methylsulfonyl)phenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C19H23N3O5S
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1
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| 1 |
Ki = 6.5 nM
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CP0479844
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8-[1-[[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H28F3N7O3
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1
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| 1 |
Ki = 6.5 nM
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CP0426388
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8-[1-[3-(4-methylphenyl)prop-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C24H26N6O2
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1
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| 1 |
Ki = 6.5 nM
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CP0373455
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6-[4-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]oxyphenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C31H37N5O4
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1
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| 1 |
Ki = 6.607 nM
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CP0413027
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8-[1-[3-(3-fluorophenyl)prop-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C23H23FN6O2
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1
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| 1 |
Ki = 6.7 nM
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CP0455758
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[(2R)-1,1,1-trifluoropropan-2-yl] (4S)-4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C19H16F3N3O3
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1
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| 1 |
Ki = 6.91 nM
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CP0433836
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6-[4-[2-[4-(2-chlorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C30H34ClN5O4
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1
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| 1 |
Ki = 6.918 nM
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CP0457873
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8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C20H17ClN8O3
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1
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| 1 |
Ki = 7 nM
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CP0371891
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N-(4-chlorophenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]acetamide
Show/Hide
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C23H26ClN7O3
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1
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| 1 |
Ki = 7 nM
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CP0394506
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1-(cyclopropylmethyl)-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-7H-purine-2,6-dione
Show/Hide
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C20H19FN6O2
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1
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| 1 |
Ki = 7 nM
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CP0373969
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N-[6-(furan-2-yl)-5-pyridin-4-ylpyridin-2-yl]acetamide
Show/Hide
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C16H13N3O2
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1
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| 1 |
Ki = 7 nM
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CP0394407
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6-[4-[2-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C25H24Cl2N6O4
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1
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| 1 |
Ki = 7.079 nM
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CP0431173
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[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-phenylcarbamate
Show/Hide
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C26H28N4O4
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1
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| 1 |
Ki = 7.1 nM
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CP0454794
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3-ethyl-8-[1-[3-(4-fluorophenyl)prop-2-ynyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C22H21FN6O2
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1
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| 1 |
Ki = 7.3 nM
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CP0454807
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3-ethyl-8-[1-[3-(3-fluorophenyl)prop-2-ynyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C22H21FN6O2
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1
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| 1 |
Ki = 7.4 nM
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CP0505223
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3-(2-methylpropyl)-6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C31H37N5O4
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1
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| 1 |
Ki = 7.413 nM
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CP0374061
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1-ethyl-3-(furan-2-ylmethyl)-7-methyl-8-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
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C18H18N4O3S
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1
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| 1 |
Ki = 7.413 nM
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CP0403598
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6-(2-methyl-5-oxo-1H-pyrazol-3-yl)-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C16H21N5O3
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1
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| 1 |
Ki = 7.5 nM
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CP0413187
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8-[4-[[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C29H30F3N5O4
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1
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| 1 |
Ki = 7.5 nM
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CP0405391
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6-[4-[2-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C29H32Cl2N6O4
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1
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| 1 |
Ki = 7.586 nM
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CP0104008
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N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C21H28N6O4
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1
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| 1 |
Ki = 7.75 nM
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CP0395301
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4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzamide
Show/Hide
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C26H28N6O5
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1
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| 1 |
Ki = 7.75 nM
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CP0443441
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[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-pyrazin-2-ylcarbamate
Show/Hide
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C24H26N6O4
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1
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| 1 |
Ki = 7.8 nM
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CP0508365
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ethyl 2-[3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoate
Show/Hide
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C26H28N6O4
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1
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| 1 |
Ki = 7.8 nM
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CP0311323
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8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C19H17F3N6O2
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1
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| 1 |
Ki = 8 nM
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CP0501532
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6-(furan-2-yl)-5-(pyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-amine
Show/Hide
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C14H10N6O
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1
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| 1 |
Ki = 8 nM
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CP0472374
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8-[1-[[1-(4-methylphenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H31N7O3
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1
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| 1 |
Ki = 8 nM
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CP0454805
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3-ethyl-1-propyl-8-[1-[3-[3-(trifluoromethoxy)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C23H21F3N6O3
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2
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| 1 |
Ki = 8 nM
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| 2 |
Ki = 13 nM
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CP0403602
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8-[2-methyl-5-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methoxy]pyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C24H25F3N8O3
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1
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| 1 |
Ki = 8.1 nM
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CP0411022
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ethyl 2-methyl-4-(1,3-oxazol-4-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C17H16N4O3
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1
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| 1 |
Ki = 8.1 nM
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CP0409549
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6-[4-[1-[4-(4-bromophenyl)piperazin-1-yl]-1-oxopropan-2-yl]oxyphenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C27H28BrN5O4
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1
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| 1 |
Ki = 8.128 nM
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CP0174939
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3-ethyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
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C21H21F3N6O2
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2
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| 1 |
Ki = 8.3 nM
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| 2 |
Ki = 22 nM
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CP0406627
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8-[6-[[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]pyridin-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C28H29F3N6O4
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1
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| 1 |
Ki = 8.7 nM
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CP0373203
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6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C25H24N4O4
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1
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| 1 |
Ki = 8.71 nM
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CP0521426
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[(2S)-1,1,1-trifluoropropan-2-yl] (4S)-4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C19H16F3N3O3
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1
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| 1 |
Ki = 8.73 nM
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CP0494647
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6-(4-aminophenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C18H22N4O2
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1
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| 1 |
Ki = 8.9 nM
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CP0246556
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8-(4-Amino-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C17H21N5O2
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1
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| 1 |
Ki = 9 nM
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CP0529709
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1,3-Dipropyl-8-(1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C14H18N6O2
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1
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| 1 |
Ki = 9 nM
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CP0406602
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8-[1-[[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H31N7O4
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1
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| 1 |
Ki = 9 nM
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CP0413177
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8-[4-[[1-(3-fluorophenyl)-5-oxopyrrolidin-3-yl]methoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C28H30FN5O4
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1
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| 1 |
Ki = 9 nM
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CP0447455
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8-[1-[[5-oxo-1-[3-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H28F3N7O4
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1
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| 1 |
Ki = 9 nM
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CP0513722
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6-[4-[2-[4-(4-methoxyphenyl)piperidin-1-yl]-2-oxoethoxy]phenyl]-3-methyl-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C30H34N4O5
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1
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| 1 |
Ki = 9.12 nM
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CP0372541
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N-(4-cyanophenyl)-2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]acetamide
Show/Hide
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C26H26N6O5
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1
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| 1 |
Ki = 9.12 nM
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CP0496331
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8-[5-[[4-chloro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C24H24ClF3N8O3
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1
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| 1 |
Ki = 9.4 nM
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CP0381839
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[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-(4-fluorophenyl)carbamate
Show/Hide
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C22H19FN4O4
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1
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| 1 |
Ki = 9.5 nM
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CP0433834
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1,3-bis(cyclopropylmethyl)-6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C31H32N4O4
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1
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| 1 |
Ki = 9.55 nM
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CP0510600
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6-[4-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C26H26FN5O4
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1
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| 1 |
Ki = 9.55 nM
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CP0523135
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6-[4-[2-(4,4-diphenylpiperidin-1-yl)-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C33H32N4O4
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1
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| 1 |
Ki = 9.55 nM
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CP0397978
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8-[1-[[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C25H28FN7O3
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1
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| 1 |
Ki = 9.7 nM
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CP0453281
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(2,5-dioxopyrrolidin-1-yl) 2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetate
Show/Hide
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C23H25N5O7
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1
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| 1 |
Ki = 9.75 nM
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CP0044275
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9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-ylamine
Show/Hide
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C13H8ClN5O
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3
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| 1 |
Ki = 9.8 nM
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| 2 |
Ki = 16.4 nM
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| 3 |
Ki = 34.2 nM
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CP0403028
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N,N-dibenzyl-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C33H35N5O4
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1
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| 1 |
Ki = 9.88 nM
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CP0437148
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3-ethyl-1-propyl-8-[1-[3-[4-(trifluoromethoxy)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C23H21F3N6O3
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1
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| 1 |
Ki = 9.9 nM
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CP0374368
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[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-thiophen-2-ylcarbamate
Show/Hide
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C20H18N4O4S
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1
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| 1 |
Ki = 10 nM
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CP0463678
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N-(3,4-dimethylphenyl)-2-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
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C25H31N7O4
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1
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| 1 |
Ki = 10 nM
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CP0512960
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N-[6-(furan-2-yl)-5-pyridin-4-ylpyrazin-2-yl]-2-methylpropanamide
Show/Hide
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C17H16N4O2
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1
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| 1 |
Ki = 10 nM
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CP0437628
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1,3-dipropyl-8-[3-[[6-(trifluoromethyl)-1H-benzimidazol-2-yl]methoxy]-1,2-oxazol-5-yl]-7H-purine-2,6-dione
Show/Hide
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C23H22F3N7O4
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1
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| 1 |
Ki = 10 nM
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CP0418732
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8-[2-methyl-5-[(6-methyl-1H-benzimidazol-2-yl)methoxy]pyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C24H28N8O3
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1
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| 1 |
Ki = 10.2 nM
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CP0445509
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propan-2-yl 4-(furan-2-yl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C13H16N2O3S
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1
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| 1 |
Ki = 10.2 nM
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CP0146462
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2-Furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
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C12H11N7OS
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1
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| 1 |
Ki = 10.3 nM
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CP0433856
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6-[4-[2-[4-(6-chloro-1,3-benzothiazol-2-yl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C31H33ClN6O4S
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1
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| 1 |
Ki = 10.47 nM
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CP0378496
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8-[1-[2-[4-(2,4-difluorophenyl)piperazin-1-yl]-2-oxoethyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H30F2N8O3
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1
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| 1 |
Ki = 10.7 nM
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CP0517913
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8-[1-[[1-(3-methylphenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H31N7O3
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1
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| 1 |
Ki = 10.7 nM
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CP0405104
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8-(1-benzyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H24N6O2
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1
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| 1 |
Ki = 11 nM
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CP0457866
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8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C18H17FN6O2
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1
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| 1 |
Ki = 11 nM
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CP0434869
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6-(4-Hydroxy-phenyl)-7-hydroxy-1,3-dipropyl-1Hpyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C18H21N3O4
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1
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| 1 |
Ki = 11 nM
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CP0405202
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8-(1-benzylpyrazol-4-yl)-1-(cyclopropylmethyl)-3-methyl-7H-purine-2,6-dione
Show/Hide
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C20H20N6O2
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1
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| 1 |
Ki = 11 nM
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CP0407841
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3-ethyl-1-(2-methylpropyl)-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C22H23F3N6O2
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1
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| 1 |
Ki = 11 nM
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CP0505198
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1-butyl-3-methyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C21H21F3N6O2
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1
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| 1 |
Ki = 11 nM
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CP0452833
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5-(furan-2-yl)-1-methyl-6-(pyrimidin-4-yl)-1H-imidazo[4,5-b]pyridin-2(3H)-one
Show/Hide
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C15H11N5O2
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1
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| 1 |
Ki = 11 nM
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CP0441358
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N-(6-pyridin-2-yl-5-pyridin-4-ylpyrazin-2-yl)cyclopropanecarboxamide
Show/Hide
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C18H15N5O
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1
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| 1 |
Ki = 11 nM
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CP0505579
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N-[5-(3-fluoropyridin-4-yl)-6-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
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C18H14FN5O
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1
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| 1 |
Ki = 11 nM
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CP0412431
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6-[4-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C28H27FN4O5
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1
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| 1 |
Ki = 11.22 nM
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CP0384103
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2,2,2-trifluoroethyl (4S)-4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C18H14F3N3O3
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1
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| 1 |
Ki = 11.24 nM
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CP0387799
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6-[5-(1H-benzimidazol-2-ylmethoxy)-2-methylpyrazol-3-yl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C24H27N7O3
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1
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| 1 |
Ki = 11.4 nM
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CP0399310
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propan-2-yl 4-(furan-3-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C19H19N3O3
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1
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| 1 |
Ki = 11.4 nM
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CP0428533
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[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl 4-phenylpiperazine-1-carboxylate
Show/Hide
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C26H27N5O4
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1
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| 1 |
Ki = 11.5 nM
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CP0412425
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1,3-bis(cyclopropylmethyl)-6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C32H35N5O4
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1
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| 1 |
Ki = 11.75 nM
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CP0401005
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N-(4-acetylphenyl)-2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]acetamide
Show/Hide
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C27H29N5O6
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1
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| 1 |
Ki = 11.75 nM
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CP0860810
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2-Furan-2-yl-8-methyl-9-(4-methyl-piperazin-1-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine dihydrochloride
Show/Hide
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C16H21Cl2N9O
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1
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| 1 |
Ki = 12 nM
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CP0405151
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1-isobutyl-8-(1-((5-phenylisoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H21N7O3
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1
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| 1 |
Ki = 12 nM
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CP0399756
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2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-(4-methoxyphenyl)acetamide
Show/Hide
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C24H29N7O4
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1
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| 1 |
Ki = 12 nM
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CP0374742
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8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-ethoxy]-2H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C27H34N8O4
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2
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| 1 |
Ki = 12 nM
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| 2 |
Ki = 15 nM
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CP0374815
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N-(3,4-dimethoxyphenyl)-2-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
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C25H31N7O6
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1
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| 1 |
Ki = 12 nM
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CP0380156
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2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-N-(4-fluoro-phenyl)-acetamide
Show/Hide
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C23H26FN7O4
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1
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| 1 |
Ki = 12 nM
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CP0395865
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N-[2,6-bis(furan-2-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C14H11N3O3
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1
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| 1 |
Ki = 12 nM
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CP0424169
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2-Cyclopentyl-N-[6-(2-furyl)-5-pyridin-4-ylpyrazin-2-yl]acetamide
Show/Hide
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C20H20N4O2
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1
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| 1 |
Ki = 12 nM
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CP0391930
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ethyl 2-[[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxymethyl]-3H-benzimidazole-5-carboxylate
Show/Hide
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C26H30N8O5
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1
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| 1 |
Ki = 12 nM
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CP0428907
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8-[1-[[1-(4-methylphenyl)pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H33N7O2
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1
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| 1 |
Ki = 12 nM
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CP0393971
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3-ethyl-1-propyl-8-[1-[3-[4-(trifluoromethyl)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C23H21F3N6O2
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1
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| 1 |
Ki = 12 nM
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CP0413026
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methyl 2-[3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoate
Show/Hide
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C25H26N6O4
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1
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| 1 |
Ki = 12 nM
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CP0448662
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1,3-dipropyl-8-[1-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]but-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C29H33F3N8O2
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1
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| 1 |
Ki = 12 nM
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CP0384050
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ethyl 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C18H17N3O3
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1
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| 1 |
Ki = 12.03 nM
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CP0412430
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1,3-dimethyl-6-[4-[2-oxo-2-(4-phenylpiperidin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C27H28N4O4
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1
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| 1 |
Ki = 12.3 nM
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CP0432814
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8-[3-[[5-oxo-1-[4-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H27F3N6O5
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2
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| 1 |
Ki = 12.8 nM
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| 2 |
Ki = 540 nM
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CP0402303
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8-benzyl-1-ethyl-3-(furan-2-ylmethyl)-7-methylpurine-2,6-dione
Show/Hide
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C20H20N4O3
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1
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| 1 |
Ki = 12.88 nM
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CP0372911
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8-(1-benzyl-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C18H18N6O2
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1
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| 1 |
Ki = 13 nM
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CP0405103
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8-(1-benzyl-1H-pyrazol-4-yl)-1-isobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C19H20N6O2
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1
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| 1 |
Ki = 13 nM
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CP0405149
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1-(cyclopropylmethyl)-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H17F3N8O3
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1
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| 1 |
Ki = 13 nM
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CP0373148
|
8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-1-propyl-7H-purine-2,6-dione
Show/Hide
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C19H19FN6O2
|
1
|
| 1 |
Ki = 13 nM
|
|
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CP0471401
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki = 13 nM
|
|
|
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CP0375834
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-[4-[[2-(trifluoromethyl)phenyl]methoxy]phenyl]acetamide
Show/Hide
|
C31H32F3N7O4
|
1
|
| 1 |
Ki = 13 nM
|
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CP0373792
|
6-(furan-2-yl)-5-(pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridine
Show/Hide
|
C15H10N4O
|
1
|
| 1 |
Ki = 13 nM
|
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CP0490014
|
N-[6-(furan-2-yl)-5-pyridin-4-ylpyrazin-2-yl]cyclopentanecarboxamide
Show/Hide
|
C19H18N4O2
|
1
|
| 1 |
Ki = 13 nM
|
|
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CP0406632
|
8-[1-[[1-(4-methoxyphenyl)pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H33N7O3
|
1
|
| 1 |
Ki = 13 nM
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|
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CP0409542
|
2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-amine
Show/Hide
|
C13H9N5O
|
1
|
| 1 |
Ki = 13.18 nM
|
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CP0399717
|
1-methyl-6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-3-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C28H31N5O4
|
1
|
| 1 |
Ki = 13.18 nM
|
|
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CP0412433
|
6-[4-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 13.18 nM
|
|
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CP0387800
|
2-[5-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-1-methylpyrazol-3-yl]oxy-N-(4-fluorophenyl)acetamide
Show/Hide
|
C24H27FN6O4
|
1
|
| 1 |
Ki = 13.4 nM
|
|
|
|
CP0405376
|
6-[4-[2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-oxoethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C31H36N4O5
|
1
|
| 1 |
Ki = 13.49 nM
|
|
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CP0412436
|
1,3-dimethyl-6-[4-[2-oxo-2-(4-pyrimidin-2-ylpiperazin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C24H25N7O4
|
1
|
| 1 |
Ki = 13.49 nM
|
|
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CP0419241
|
8-[1-[[1-(3-methoxyphenyl)pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H33N7O3
|
1
|
| 1 |
Ki = 13.7 nM
|
|
|
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CP0384102
|
ethyl (4R)-4-(furan-3-yl)-2-(trifluoromethyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H14F3N3O3
|
1
|
| 1 |
Ki = 13.75 nM
|
|
|
|
CP0431175
|
[4-(1-methyl-2,4-dioxo-3-propyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-phenylcarbamate
Show/Hide
|
C24H24N4O4
|
1
|
| 1 |
Ki = 13.8 nM
|
|
|
|
CP0390389
|
1-ethyl-3,8-bis(furan-2-ylmethyl)-7-methylpurine-2,6-dione
Show/Hide
|
C18H18N4O4
|
1
|
| 1 |
Ki = 13.8 nM
|
|
|
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CP0372912
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H23F3N6O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
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CP0378789
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23FN6O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
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CP0405106
|
8-(1-((5-phenylisoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H25N7O3
|
1
|
| 1 |
Ki = 14 nM
|
|
|
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CP0444319
|
1-isobutyl-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H19F3N8O3
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0373435
|
2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-(4-fluorophenyl)acetamide
Show/Hide
|
C23H26FN7O3
|
1
|
| 1 |
Ki = 14 nM
|
|
|
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CP0436473
|
3-methyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0392196
|
4-(3-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1H-pyrazol-1-yl)methyl)-1,2,4-oxadiazol-5-yl)benzonitrile
Show/Hide
|
C24H23N9O3
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0373972
|
N-(5,6-dipyridin-4-ylpyridin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C19H16N4O
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0378475
|
3-ethyl-8-[1-[[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C25H29N7O4
|
2
|
| 1 |
Ki = 14 nM
|
|
|
| 2 |
Ki = 16 nM
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|
|
|
CP0462666
|
1,3-dipropyl-8-[1-[[1-[4-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C26H30F3N7O3
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0454804
|
4-[3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzonitrile
Show/Hide
|
C24H23N7O2
|
1
|
| 1 |
Ki = 14 nM
|
|
|
|
CP0437627
|
8-[2-methyl-5-[(4-methyl-1H-benzimidazol-2-yl)methoxy]pyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C24H28N8O3
|
1
|
| 1 |
Ki = 14.1 nM
|
|
|
|
CP0391929
|
8-[5-[(6-methoxy-1H-benzimidazol-2-yl)methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C24H28N8O4
|
1
|
| 1 |
Ki = 14.2 nM
|
|
|
|
CP0409531
|
6-[4-[2-[4-(2-chlorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-3-methyl-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C28H30ClN5O4
|
1
|
| 1 |
Ki = 14.79 nM
|
|
|
|
CP0407091
|
3-(furan-2-ylmethyl)-7-methyl-1-propyl-8-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
|
C19H20N4O3S
|
1
|
| 1 |
Ki = 14.79 nM
|
|
|
|
CP0462151
|
8-[2-methyl-5-[(6-nitro-1H-benzimidazol-2-yl)methoxy]pyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H25N9O5
|
1
|
| 1 |
Ki = 14.8 nM
|
|
|
|
CP0372914
|
1-propyl-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H17F3N8O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0457685
|
1-(cyclopropylmethyl)-8-(1-((5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H18F3N7O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0457889
|
8-(1-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H18N8O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0440938
|
2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-phenylacetamide
Show/Hide
|
C23H27N7O3
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0508364
|
8-[3-[3-(4-fluorophenyl)prop-2-ynoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H22FN5O4
|
1
|
| 1 |
Ki = 15 nM
|
|
|
|
CP0519618
|
propan-2-yl (4S)-2-(cyanoamino)-4-(furan-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C14H16N4O3
|
1
|
| 1 |
Ki = 15.1 nM
|
|
|
|
CP0373466
|
6-[4-[2-[4-(4-fluorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-3-methyl-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C28H30FN5O4
|
1
|
| 1 |
Ki = 15.14 nM
|
|
|
|
CP0482918
|
[(2S)-1,1,1-trifluoropropan-2-yl] 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H16F3N3O3
|
1
|
| 1 |
Ki = 15.14 nM
|
|
|
|
CP0488865
|
N-(2-aminoethyl)-2-[4-[[2-[4-(1,3-diethyl-2,6-dioxo-7H-purin-8-yl)phenoxy]acetyl]amino]phenyl]acetamide
Show/Hide
|
C27H31N7O5
|
1
|
| 1 |
Ki = 15.2 nM
|
|
|
|
CP0401006
|
2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]-N-(4-hydroxyphenyl)acetamide
Show/Hide
|
C25H27N5O6
|
1
|
| 1 |
Ki = 15.49 nM
|
|
|
|
CP0439338
|
2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]-N-pyridin-2-ylacetamide
Show/Hide
|
C24H26N6O5
|
1
|
| 1 |
Ki = 15.49 nM
|
|
|
|
CP0403606
|
8-[5-[(6-bromo-1H-benzimidazol-2-yl)methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H25BrN8O3
|
1
|
| 1 |
Ki = 15.9 nM
|
|
|
|
CP0461777
|
5-{[4'-(2-furyl)-4,5'-bipyrimidin-2'-yl]amino}pyridin-2(1H)-one
Show/Hide
|
C17H12N6O2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0373151
|
8-[1-[[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl]pyrazol-4-yl]-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C22H21ClN8O3
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0436501
|
1-(cyclopropylmethyl)-3-ethyl-8-[1-[6-(trifluoromethyl)pyridin-3-yl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C20H18F3N7O2
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0376494
|
N-(3,4-dichlorophenyl)-2-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
|
C23H25Cl2N7O4
|
1
|
| 1 |
Ki = 16 nM
|
|
|
|
CP0404077
|
4-{2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetylamino}-benzoic acid (0.60CH2CL2)
Show/Hide
|
C26H27N5O6
|
1
|
| 1 |
Ki = 16.1 nM
|
|
|
|
CP0381842
|
[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-benzylcarbamate
Show/Hide
|
C23H22N4O4
|
1
|
| 1 |
Ki = 16.2 nM
|
|
|
|
CP0083574
|
2-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide
Show/Hide
|
C19H23N5O4
|
1
|
| 1 |
Ki = 16.3 nM
|
|
|
|
CP0437405
|
N-[2,6-bis(furan-2-yl)pyrimidin-4-yl]butanamide
Show/Hide
|
C16H15N3O3
|
1
|
| 1 |
Ki = 16.4 nM
|
|
|
|
CP0856049
|
N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylamide
Show/Hide
|
C26H28N6O5
|
1
|
| 1 |
Ki = 16.7 nM
|
|
|
|
CP0394396
|
6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]phenyl]-1,3-bis(2-methoxyethyl)-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C29H32N4O6
|
1
|
| 1 |
Ki = 16.98 nM
|
|
|
|
CP0475549
|
[(2R)-1,1,1-trifluoropropan-2-yl] 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H16F3N3O3
|
1
|
| 1 |
Ki = 17.03 nM
|
|
|
|
CP0447456
|
3-ethyl-8-[1-[[5-oxo-1-[3-(trifluoromethoxy)phenyl]pyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C25H26F3N7O4
|
1
|
| 1 |
Ki = 17.5 nM
|
|
|
|
CP0454793
|
4-[3-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoic acid
Show/Hide
|
C24H24N6O4
|
1
|
| 1 |
Ki = 17.6 nM
|
|
|
|
CP0466884
|
9-Methyl-2-propyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C11H14N8
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0405154
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-butyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H19FN6O2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0394495
|
3-ethyl-1-propyl-8-[1-[6-(trifluoromethyl)pyridin-3-yl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C19H18F3N7O2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0382447
|
4-(5-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1H-pyrazol-1-yl)methyl)-1,2,4-oxadiazol-3-yl)benzonitrile
Show/Hide
|
C24H23N9O3
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0487097
|
2-Benzo[1,3]dioxol-5-yl-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-acetamide
Show/Hide
|
C24H27N7O5
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0378799
|
8-(1-(4-chlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23ClN6O2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0455088
|
8-(1-(3-chlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23ClN6O2
|
1
|
| 1 |
Ki = 18 nM
|
|
|
|
CP0106772
|
1,3-Dipropyl-8-phenylxanthine
Show/Hide
|
C17H20N4O2
|
1
|
| 1 |
Ki = 18.9 nM
|
|
|
|
CP0383390
|
6-(4-Amino-phenyl)-7-hydroxy-1,3-dipropyl-1H-pyrrolo-[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C18H22N4O3
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0407892
|
8-(1-benzylpyrazol-4-yl)-3-methyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0422176
|
8-(1-((3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0375425
|
2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-N-p-tolyl-acetamide
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0455086
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0391927
|
8-[5-[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H24ClFN8O3
|
1
|
| 1 |
Ki = 19 nM
|
|
|
|
CP0462667
|
8-[1-[[1-(2,4-difluorophenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C25H27F2N7O3
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1
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| 1 |
Ki = 19 nM
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CP0374062
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3,8-bis(furan-2-ylmethyl)-7-methyl-1-propylpurine-2,6-dione
Show/Hide
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C19H20N4O4
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1
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| 1 |
Ki = 19.05 nM
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CP0373433
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N-(4-chlorophenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]acetamide
Show/Hide
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C22H24ClN7O3
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1
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| 1 |
Ki = 20 nM
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CP0069170
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N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
Show/Hide
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C31H25N7O2
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1
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| 1 |
Ki = 20 nM
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CP0407893
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3-ethyl-1-(2-methylpropyl)-8-[1-[6-(trifluoromethyl)pyridin-3-yl]pyrazol-4-yl]-7H-purine-2,6-dione
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C20H20F3N7O2
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1
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| 1 |
Ki = 20 nM
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CP0430224
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N-(4-bromophenyl)-2-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
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C23H26BrN7O4
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1
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| 1 |
Ki = 20 nM
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CP0453740
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8-(1-(4-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H23F3N6O2
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1
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| 1 |
Ki = 20 nM
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CP0526986
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8-(1-(2-chlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H23ClN6O2
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1
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| 1 |
Ki = 20 nM
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CP0403599
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8-[5-(1H-benzo[f]benzimidazol-2-ylmethoxy)-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C27H28N8O3
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1
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| 1 |
Ki = 20 nM
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CP0451180
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N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]naphthalene-1-carboxamide
Show/Hide
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C30H23N7O2
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1
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| 1 |
Ki = 20 nM
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CP0513686
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phenyl 4-[2-[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetyl]piperazine-1-carboxylate
Show/Hide
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C31H35N5O6
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1
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| 1 |
Ki = 20.42 nM
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CP0516384
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1,3-dimethyl-6-[4-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]oxyphenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C27H29N5O4
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1
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| 1 |
Ki = 20.42 nM
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CP0487325
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N-[2,6-bis(furan-2-yl)pyrimidin-4-yl]propanamide
Show/Hide
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C15H13N3O3
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1
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| 1 |
Ki = 20.5 nM
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CP0384051
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ethyl 4-(furan-3-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C18H17N3O3
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1
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| 1 |
Ki = 20.6 nM
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CP0255221
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8-(2,4-Dihydroxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C17H20N4O4
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1
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| 1 |
Ki = 20.7 nM
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CP0399749
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6-[4-[2-oxo-2-(4-phenylpiperidin-1-yl)ethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C31H36N4O4
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1
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| 1 |
Ki = 20.89 nM
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CP0418138
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2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]-N-(1,2-oxazol-3-yl)acetamide
Show/Hide
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C22H24N6O6
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1
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| 1 |
Ki = 20.89 nM
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CP0288431
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5-Butyl-8-(4-propoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
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C19H22N6O
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1
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| 1 |
Ki = 21 nM
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CP0376124
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8-(1-((5-phenyl-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C23H24N8O3
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1
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| 1 |
Ki = 21 nM
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CP0373146
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1-(cyclopropylmethyl)-3-methyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C21H19F3N6O2
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1
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| 1 |
Ki = 21 nM
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CP0373147
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8-(1-benzylpyrazol-4-yl)-3-methyl-1-(2-methylpropyl)-7H-purine-2,6-dione
Show/Hide
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C20H22N6O2
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1
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| 1 |
Ki = 21 nM
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CP0382444
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1,3-dipropyl-8-(1-((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C24H23F3N8O3
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1
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| 1 |
Ki = 21 nM
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CP0392197
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8-(1-((3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C23H23ClN8O3
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1
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| 1 |
Ki = 21 nM
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CP0373794
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5-(furan-2-yl)-6-(pyrimidin-4-yl)-3H-imidazo[4,5-b]pyridine
Show/Hide
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C14H9N5O
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1
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| 1 |
Ki = 21 nM
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CP0399744
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6-[4-[2-(4,4-diphenylpiperidin-1-yl)-2-oxoethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C37H40N4O4
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1
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| 1 |
Ki = 21.38 nM
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CP0390390
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8-[(2,6-difluorophenyl)methyl]-3-(furan-2-ylmethyl)-7-methyl-1-prop-2-enylpurine-2,6-dione
Show/Hide
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C21H18F2N4O3
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1
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| 1 |
Ki = 21.38 nM
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CP0431101
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3-(furan-2-ylmethyl)-7-methyl-1-prop-2-enyl-8-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
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C19H18N4O3S
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1
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| 1 |
Ki = 21.38 nM
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CP0406629
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8-[1-[[1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C26H31N7O4
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1
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| 1 |
Ki = 21.6 nM
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CP0496170
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N-(4-bromophenyl)-2-[4-(2,4-dioxo-1-propyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetamide
Show/Hide
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C23H21BrN4O4
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1
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| 1 |
Ki = 21.88 nM
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CP0437409
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1-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-3-(4-methoxy-phenyl)-urea
Show/Hide
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C21H15ClN6O3
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1
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| 1 |
Ki = 22 nM
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CP0457872
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8-(1-((5-phenylisoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H19N7O3
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1
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| 1 |
Ki = 22 nM
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CP0397573
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N-[4-(furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenoxyacetamide
Show/Hide
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C26H21N7O3
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1
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| 1 |
Ki = 22 nM
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CP0407840
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3-ethyl-1-propyl-8-(1-((pyridin-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C18H19N7O2
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1
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| 1 |
Ki = 22 nM
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CP0437175
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1-(cyclopropylmethyl)-3-ethyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H21F3N6O2
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1
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| 1 |
Ki = 22 nM
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CP0485837
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N-(2-chlorophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]acetamide
Show/Hide
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C22H24ClN7O3
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1
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| 1 |
Ki = 22 nM
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CP0378798
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8-(1-(2-chloro-5-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H22ClF3N6O2
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1
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| 1 |
Ki = 22 nM
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CP0456959
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8-(1-(4-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H23FN6O2
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1
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| 1 |
Ki = 22 nM
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CP0403601
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8-[3-[[4-chloro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C23H21ClF3N7O4
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1
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| 1 |
Ki = 22 nM
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CP0437642
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8-[5-[(5,6-dimethyl-1H-benzimidazol-2-yl)methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C25H30N8O3
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1
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| 1 |
Ki = 22 nM
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CP0862927
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1-(9-Ethylamino-2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea hydrochloride
Show/Hide
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C21H22ClN9O3
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1
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| 1 |
Ki = 23 nM
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CP0372913
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1-butyl-8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H19ClN8O3
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1
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| 1 |
Ki = 23 nM
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CP0383388
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6-(furan-2-yl)-7-hydroxy-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C16H19N3O4
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1
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| 1 |
Ki = 23 nM
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CP0471459
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6-(furan-2-yl)-5-(pyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridine
Show/Hide
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C14H9N5O
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1
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| 1 |
Ki = 23 nM
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CP0437629
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8-[3-(1H-benzimidazol-2-ylmethoxy)-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C22H23N7O4
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1
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| 1 |
Ki = 23 nM
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CP0468057
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4-[4-[[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]methyl]-2-oxopyrrolidin-1-yl]benzonitrile
Show/Hide
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C26H28N8O3
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1
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| 1 |
Ki = 23 nM
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CP0394429
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4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methylcyclohexane-1-carboxamide
Show/Hide
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C20H27N3O4S
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2
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| 1 |
Ki = 23 nM
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| 2 |
Ki = 1000 nM
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CP0426390
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8-(1-but-2-ynylpyrazol-4-yl)-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C18H22N6O2
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1
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| 1 |
Ki = 23 nM
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CP0525436
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ethyl 2-methyl-4-(1,2-oxazol-4-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C17H16N4O3
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1
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| 1 |
Ki = 23.4 nM
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CP0407404
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ethyl 6-methyl-2-oxo-4-thiophen-3-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C12H14N2O3S
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1
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| 1 |
Ki = 23.6 nM
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CP0498105
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1-(2-Furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea
Show/Hide
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C20H18N8O3S
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1
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| 1 |
Ki = 24 nM
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CP0428532
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[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl 4-(3-chlorophenyl)piperazine-1-carboxylate
Show/Hide
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C30H34ClN5O4
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1
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| 1 |
Ki = 24 nM
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CP0457869
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8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-isobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C19H19FN6O2
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1
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| 1 |
Ki = 24 nM
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CP0388723
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7-hydroxy-6-(4-methoxyphenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C19H23N3O4
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1
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| 1 |
Ki = 24 nM
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CP0435580
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4'-(2-furyl)-N-pyrimidin-5-yl-4,5'-bipyrimidin-2'-amine
Show/Hide
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C16H11N7O
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1
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| 1 |
Ki = 24 nM
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CP0422081
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3-ethyl-1-propyl-8-[1-[[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C23H21F3N8O3
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1
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| 1 |
Ki = 24 nM
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CP0895197
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8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-ethoxy]-2H-pyrazol-3-yl}-1,3-bis-((E)-propenyl)-3,7-dihydro-purine-2,6-dione
Show/Hide
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C27H30N8O4
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1
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| 1 |
Ki = 24 nM
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CP0413106
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3-ethyl-8-[1-[[1-(3-fluorophenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C24H26FN7O3
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1
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| 1 |
Ki = 24 nM
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CP0446666
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propan-2-yl 2-(cyanoamino)-4-(furan-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C14H16N4O3
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1
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| 1 |
Ki = 24.3 nM
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CP0373199
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6-[4-[2-methyl-1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]oxyphenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C32H39N5O4
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1
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| 1 |
Ki = 24.55 nM
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CP0377526
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N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenoxyacetamide
Show/Hide
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C27H23N7O3
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1
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| 1 |
Ki = 25 nM
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CP0448140
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N-[4-(furan-2-yl)-11-(3-methylbutyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenoxyacetamide
Show/Hide
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C23H23N7O3
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1
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| 1 |
Ki = 25 nM
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CP0373150
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3-ethyl-1-propyl-8-[1-[[5-[4-(trifluoromethyl)phenyl]-1,2-oxazol-3-yl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
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C24H22F3N7O3
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1
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| 1 |
Ki = 25 nM
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CP0469203
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N-(6-pyridin-3-yl-5-pyridin-4-ylpyrazin-2-yl)cyclopropanecarboxamide
Show/Hide
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C18H15N5O
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1
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| 1 |
Ki = 25 nM
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CP0387791
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8-[5-[[4,6-bis(trifluoromethyl)-1H-benzimidazol-2-yl]methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C25H24F6N8O3
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1
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| 1 |
Ki = 25 nM
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CP0409546
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1,3-diethyl-6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C28H31N5O4
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1
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| 1 |
Ki = 25.7 nM
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CP0409554
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3-methyl-6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C28H31N5O4
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1
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| 1 |
Ki = 25.7 nM
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CP0405407
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1-[2-Furan-2-yl-8-methyl-9-(4-methyl-piperazin-1-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]-3-(4-methoxy-phenyl)-urea
Show/Hide
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C24H26N10O3
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1
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| 1 |
Ki = 26 nM
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CP0394511
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1-butyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-7H-purine-2,6-dione
Show/Hide
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C20H21FN6O2
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1
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| 1 |
Ki = 26 nM
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CP0441362
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N-[5-(3,5-difluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
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C18H13F2N5O
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1
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| 1 |
Ki = 26 nM
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CP0377525
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N-(3,4-dimethyl-2,5-dioxopyrrol-1-yl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
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C25H28N6O6
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1
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| 1 |
Ki = 26.6 nM
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CP0470940
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1-ethyl-8-(furan-2-ylmethyl)-7-methyl-3-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
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C18H18N4O3S
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1
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| 1 |
Ki = 26.92 nM
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CP0373142
|
8-(1-benzylpyrazol-4-yl)-1-(cyclopropylmethyl)-3-ethyl-7H-purine-2,6-dione
Show/Hide
|
C21H22N6O2
|
1
|
| 1 |
Ki = 27 nM
|
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|
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CP0378785
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C17H15FN6O2
|
1
|
| 1 |
Ki = 27 nM
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CP0482919
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2,2,2-trifluoroethyl 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H14F3N3O3
|
1
|
| 1 |
Ki = 27.03 nM
|
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CP0394405
|
6-[4-[2-[4-(4-hydroxyphenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C26H27N5O5
|
1
|
| 1 |
Ki = 27.54 nM
|
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CP0452607
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3-(furan-2-ylmethyl)-1-(2-methoxyethyl)-7-methyl-8-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
|
C19H20N4O4S
|
1
|
| 1 |
Ki = 27.54 nM
|
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CP0457867
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8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-isobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki = 28 nM
|
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CP0383577
|
5-{[4'-(2-furyl)-4,5'-bipyrimidin-2'-yl]amino}-1-methylpyridin-2(1H)-one
Show/Hide
|
C18H14N6O2
|
1
|
| 1 |
Ki = 28 nM
|
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CP0373439
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N-(3-chlorophenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]acetamide
Show/Hide
|
C23H26ClN7O3
|
1
|
| 1 |
Ki = 28 nM
|
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CP0373440
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2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-(4-iodophenyl)acetamide
Show/Hide
|
C23H26IN7O3
|
1
|
| 1 |
Ki = 28 nM
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|
|
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CP0453144
|
N-[4-(furan-2-yl)-11-(3-methylbutyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
Show/Hide
|
C27H25N7O2
|
1
|
| 1 |
Ki = 28 nM
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|
|
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CP0423138
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2-(4-Chloro-phenyl)-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-acetamide
Show/Hide
|
C23H26ClN7O3
|
1
|
| 1 |
Ki = 28 nM
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|
|
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CP0378791
|
8-(1-(2-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H23FN6O2
|
1
|
| 1 |
Ki = 28 nM
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CP0430317
|
N-[5-bromo-6-(furan-2-yl)pyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C13H11BrN2O2
|
1
|
| 1 |
Ki = 28 nM
|
|
|
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CP0053494
|
4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino}ethyl)phenol
Show/Hide
|
C16H15N7O2
|
2
|
| 1 |
Ki = 28 nM
|
|
|
| 2 |
Ki = 65.7 nM
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CP0464321
|
8-(1-(2,5-dichlorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1Hpurine-2,6(3H,7H)-dione
Show/Hide
|
C21H22Cl2N6O2
|
1
|
| 1 |
Ki = 29 nM
|
|
|
|
CP0441364
|
N-[6-(furan-2-yl)-5-pyrimidin-4-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C16H13N5O2
|
1
|
| 1 |
Ki = 29 nM
|
|
|
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CP0413017
|
1,3-dipropyl-8-[1-[3-[2-(trifluoromethyl)phenyl]prop-2-ynyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C24H23F3N6O2
|
1
|
| 1 |
Ki = 29 nM
|
|
|
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CP0391110
|
propan-2-yl 2-methyl-4-thiophen-3-yl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H19N3O2S
|
1
|
| 1 |
Ki = 29.34 nM
|
|
|
|
CP0417015
|
1,1,1-trifluoropropan-2-yl 4-(furan-2-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H16F3N3O3
|
1
|
| 1 |
Ki = 29.6 nM
|
|
|
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CP0437424
|
propan-2-yl 2-methyl-4-(1,2-oxazol-4-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O3
|
1
|
| 1 |
Ki = 29.6 nM
|
|
|
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CP0401658
|
ethyl 2-methyl-4-thiophen-3-yl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H17N3O2S
|
1
|
| 1 |
Ki = 29.71 nM
|
|
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CP0102758
|
1-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-3-(3-chloro-phenyl)-urea
Show/Hide
|
C20H12Cl2N6O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0420752
|
2-Benzo[1,3]dioxol-5-yl-N-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-acetamide
Show/Hide
|
C21H17N7O4S
|
1
|
| 1 |
Ki = 30 nM
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|
|
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CP0457683
|
8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1-butyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H19F3N6O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
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CP0454450
|
N-[4-(furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
Show/Hide
|
C30H23N7O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0485720
|
8-(1-benzylpyrazol-4-yl)-1-butyl-3-methyl-7H-purine-2,6-dione
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
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CP0429894
|
N-[6-(1,3-oxazol-5-yl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H14N4O2
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0471517
|
N-[6-(3-fluorophenyl)-5-pyridin-4-ylpyridin-2-yl]acetamide
Show/Hide
|
C18H14FN3O
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0437630
|
8-[5-[(6-fluoro-1H-benzimidazol-2-yl)methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H25FN8O3
|
1
|
| 1 |
Ki = 30 nM
|
|
|
|
CP0409544
|
6-[3-methoxy-4-[2-[4-(4-methoxyphenyl)piperidin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C29H32N4O6
|
1
|
| 1 |
Ki = 30.9 nM
|
|
|
|
CP0467476
|
2-[4-(1,5-dimethyl-2,4-dioxo-3-propylpyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]-N-(4-fluorophenyl)acetamide
Show/Hide
|
C25H25FN4O4
|
1
|
| 1 |
Ki = 30.9 nM
|
|
|
|
CP0079484
|
1-(3,4-Dichloro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H16Cl2N8O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0425843
|
2-Furan-2-yl-9-methylsulfanyl-8-(3-phenyl-propyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C20H19N7OS
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0392343
|
N-[4-(furan-2-yl)-11-(3-methylbutyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C23H23N7O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0407847
|
8-(1-benzylpyrazol-4-yl)-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0507906
|
3-ethyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-1-(2-methylpropyl)-7H-purine-2,6-dione
Show/Hide
|
C21H23FN6O2
|
1
|
| 1 |
Ki = 31 nM
|
|
|
|
CP0948371
|
(+/-)-Isopropyl 2-Methyl-4-(1H-pyrrol-2-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
|
C19H20N4O2
|
1
|
| 1 |
Ki = 31.3 nM
|
|
|
|
CP0373194
|
1,3-dimethyl-6-[4-[2-methyl-1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]oxyphenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C28H31N5O4
|
1
|
| 1 |
Ki = 31.62 nM
|
|
|
|
CP0438806
|
6-[4-[[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]methoxy]phenyl]-3-propyl-1,5-dihydropyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C24H20BrN5O4
|
1
|
| 1 |
Ki = 31.62 nM
|
|
|
|
CP0428285
|
8-(1-((3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0374684
|
4-{2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-acetylamino}-benzoic acid ethyl ester
Show/Hide
|
C26H31N7O6
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0459074
|
N-[6-(1,3-oxazol-2-yl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H14N4O2
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0469198
|
N-(5,6-dipyridin-4-ylpyrazin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C18H15N5O
|
1
|
| 1 |
Ki = 32 nM
|
|
|
|
CP0412435
|
6-[2-methoxy-4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 32.36 nM
|
|
|
|
CP0417841
|
3,8-bis(furan-2-ylmethyl)-1,7-dimethylpurine-2,6-dione
Show/Hide
|
C17H16N4O4
|
1
|
| 1 |
Ki = 32.36 nM
|
|
|
|
CP0461927
|
8-(1-(2-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0382881
|
N-(6-pyridin-3-yl-5-pyridin-4-ylpyridin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C19H16N4O
|
1
|
| 1 |
Ki = 33 nM
|
|
|
|
CP0535430
|
N-benzhydryl-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide
Show/Hide
|
C32H33N5O4
|
1
|
| 1 |
Ki = 33.7 nM
|
|
|
|
CP0401007
|
2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]-N-pyridin-3-ylacetamide
Show/Hide
|
C24H26N6O5
|
1
|
| 1 |
Ki = 33.88 nM
|
|
|
|
CP0150055
|
8-Cyclopentyl-1-propyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C13H18N4O2
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0079505
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3,4-dichloro-phenyl)-urea
Show/Hide
|
C21H18Cl2N8O2
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0471144
|
8-(1-benzyl-1H-pyrazol-4-yl)-1-butyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C19H20N6O2
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0439515
|
4'-(2-furyl)-N-(1-oxidopyridin-3-yl)-4,5'-bipyrimidin-2'-amine
Show/Hide
|
C17H12N6O2
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0429028
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-2-methylpyrazol-3-yl]-2-phenylacetamide
Show/Hide
|
C23H27N7O3
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0464323
|
8-(1-(3-methoxybenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O3
|
1
|
| 1 |
Ki = 34 nM
|
|
|
|
CP0405377
|
2-Furan-2-yl-8-methyl-9-(4-methyl-piperazin-1-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine; dihydrochloride
Show/Hide
|
C16H19N9O
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0399315
|
6-(2-Furyl)-2,4dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl hydrogen sulfate
Show/Hide
|
C16H19N3O7S
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0435133
|
N-(4-bromophenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]acetamide
Show/Hide
|
C23H26BrN7O3
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0395252
|
N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C27H23N7O2
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0431005
|
N-[4-(furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C26H21N7O2
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0373145
|
3-ethyl-8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C20H21FN6O2
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0429027
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-phenylacetamide
Show/Hide
|
C23H27N7O3
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0456957
|
8-(1-(3,4-difluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1Hpurine-2,6(3H,7H)-dione
Show/Hide
|
C21H22F2N6O2
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0387798
|
8-[3-[(6-methoxy-1H-benzimidazol-2-yl)methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H25N7O5
|
1
|
| 1 |
Ki = 35 nM
|
|
|
|
CP0407092
|
1-(cyclopropylmethyl)-3-(furan-2-ylmethyl)-7-methyl-8-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
|
C20H20N4O3S
|
1
|
| 1 |
Ki = 35.48 nM
|
|
|
|
CP0401994
|
1-ethyl-7-methyl-3,8-bis(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
|
C18H18N4O2S2
|
1
|
| 1 |
Ki = 35.48 nM
|
|
|
|
CP0869371
|
N*9*-Ethyl-2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5,9-diamine hydrochloride
Show/Hide
|
C13H15ClN8O
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0430510
|
4-{2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-acetylamino}-benzoic acid
Show/Hide
|
C24H27N7O6
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0464324
|
8-(1-(3-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 36 nM
|
|
|
|
CP0412151
|
N-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenyl]acetamide
Show/Hide
|
C19H23N5O3
|
1
|
| 1 |
Ki = 36.7 nM
|
|
|
|
CP0200052
|
1-Allyl-3-methyl-8-phenyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C15H14N4O2
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0409379
|
1-(9-Ethylamino-2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea
Show/Hide
|
C21H21N9O3
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0372916
|
8-(1-benzyl-1H-pyrazol-4-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C17H16N6O2
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0378800
|
8-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O3
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0455089
|
8-(1-(2-methoxybenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O3
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0532361
|
8-(1-(2-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H23F3N6O2
|
1
|
| 1 |
Ki = 37 nM
|
|
|
|
CP0384097
|
ethyl 4-(furan-3-yl)-2-(trifluoromethyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H14F3N3O3
|
1
|
| 1 |
Ki = 37.42 nM
|
|
|
|
CP0373438
|
2-(3,4-Dimethoxy-phenyl)-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-acetamide
Show/Hide
|
C25H31N7O5
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0391195
|
1-(cyclopropylmethyl)-3-ethyl-8-(1H-pyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C14H16N6O2
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0436646
|
8-(1-((5-(2-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 38 nM
|
|
|
|
CP0412426
|
benzyl 4-[2-[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]acetyl]piperazine-1-carboxylate
Show/Hide
|
C32H37N5O6
|
1
|
| 1 |
Ki = 38.9 nM
|
|
|
|
CP0431102
|
8-[(2,6-difluorophenyl)methyl]-3-(furan-2-ylmethyl)-1-(2-methoxyethyl)-7-methylpurine-2,6-dione
Show/Hide
|
C21H20F2N4O4
|
1
|
| 1 |
Ki = 38.9 nM
|
|
|
|
CP0435582
|
4'-(2-furyl)-N-(2-methoxypyrimidin-5-yl)-4,5'-bipyrimidin-2'-amine
Show/Hide
|
C17H13N7O2
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0436645
|
8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0451918
|
1-(3-Chloro-phenyl)-3-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-urea
Show/Hide
|
C22H25ClN8O3
|
1
|
| 1 |
Ki = 39 nM
|
|
|
|
CP0396196
|
ethyl 4-(furan-3-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C12H14N2O4
|
1
|
| 1 |
Ki = 39.6 nM
|
|
|
|
CP0057629
|
2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy)acetic acid
Show/Hide
|
C19H22N4O5
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0079482
|
1-(3,4-Dichloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H14Cl2N8O2
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0382371
|
N-(3,4-dichlorophenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]acetamide
Show/Hide
|
C23H25Cl2N7O3
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0453784
|
8-(1-(4-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 40 nM
|
|
|
|
CP0385545
|
6-[4-[[3-(4-bromophenyl)-1,2,4-oxadiazol-5-yl]methoxy]-2-methoxyphenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C24H20BrN5O5
|
1
|
| 1 |
Ki = 40.74 nM
|
|
|
|
CP0272889
|
propan-2-yl 4-(furan-2-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O4
|
1
|
| 1 |
Ki = 40.8 nM
|
|
|
|
CP0463661
|
2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-N-pyridin-4-yl-acetamide
Show/Hide
|
C22H26N8O4
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0433720
|
N-[5-cyano-6-(furan-2-yl)pyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C14H11N3O2
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0378494
|
8-[1-[[1-(3-fluorophenyl)-5-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C25H28FN7O3
|
1
|
| 1 |
Ki = 41 nM
|
|
|
|
CP0407888
|
8-[1-[[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl]pyrazol-4-yl]-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C23H22ClN7O3
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0407889
|
3-methyl-1-(2-methylpropyl)-8-(1H-pyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C13H16N6O2
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0376115
|
1,3-dipropyl-8-(1-((3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0433719
|
N-[5-pyridin-4-yl-6-(1,3-thiazol-2-yl)pyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H14N4OS
|
1
|
| 1 |
Ki = 42 nM
|
|
|
|
CP0384099
|
2,2,2-trifluoroethyl 4-(furan-3-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H14F3N3O3
|
1
|
| 1 |
Ki = 42.1 nM
|
|
|
|
CP0395863
|
N-(4,6-diphenylpyrimidin-2-yl)propanamide
Show/Hide
|
C19H17N3O
|
1
|
| 1 |
Ki = 42.5 nM
|
|
|
|
CP0428531
|
[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl 4-(4-fluorophenyl)piperazine-1-carboxylate
Show/Hide
|
C30H34FN5O4
|
1
|
| 1 |
Ki = 42.7 nM
|
|
|
|
CP0516510
|
N-[6-(1,3-oxazol-5-yl)-5-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C16H13N5O2
|
1
|
| 1 |
Ki = 43 nM
|
|
|
|
CP0468058
|
8-[1-[[1-(3-fluorophenyl)-2-oxopyrrolidin-3-yl]methyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C25H28FN7O3
|
1
|
| 1 |
Ki = 43 nM
|
|
|
|
CP0387772
|
ethyl 4-(furan-3-yl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C12H14N2O3S
|
1
|
| 1 |
Ki = 43.1 nM
|
|
|
|
CP0500462
|
8-[4-(2-Oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-4-yl)-phenyl]-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C27H35N5O8
|
1
|
| 1 |
Ki = 43.4 nM
|
|
|
|
CP0411033
|
propan-2-yl 2-methyl-4-(1,3-oxazol-4-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O3
|
1
|
| 1 |
Ki = 43.41 nM
|
|
|
|
CP0510605
|
6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]-2-methoxyphenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C26H26N4O5
|
1
|
| 1 |
Ki = 43.65 nM
|
|
|
|
CP0417901
|
8-benzyl-3-(furan-2-ylmethyl)-7-methyl-1-propylpurine-2,6-dione
Show/Hide
|
C21H22N4O3
|
1
|
| 1 |
Ki = 43.65 nM
|
|
|
|
CP0434868
|
6-(4-hydroxyphenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C18H21N3O3
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0378787
|
8-(1-(2-fluoro-3-methylbenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H25FN6O2
|
1
|
| 1 |
Ki = 44 nM
|
|
|
|
CP0460451
|
N-[4-(furan-2-yl)-11-methyl-12-methylsulfanyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-(4-methoxyphenyl)acetamide
Show/Hide
|
C21H19N7O3S
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0373080
|
3-ethyl-8-[1-(6-methylpyridin-3-yl)pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C19H21N7O2
|
1
|
| 1 |
Ki = 45 nM
|
|
|
|
CP0113085
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolylurea
Show/Hide
|
C21H20N8O2
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0529313
|
3-ethyl-1-propyl-8-(1-pyridin-2-ylpyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C18H19N7O2
|
1
|
| 1 |
Ki = 46 nM
|
|
|
|
CP0083663
|
8-(2-Hydroxy-4-methoxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C18H22N4O4
|
1
|
| 1 |
Ki = 46.5 nM
|
|
|
|
CP0463360
|
1-(cyclopropylmethyl)-8-[(2,6-difluorophenyl)methyl]-3-(furan-2-ylmethyl)-7-methylpurine-2,6-dione
Show/Hide
|
C22H20F2N4O3
|
1
|
| 1 |
Ki = 46.77 nM
|
|
|
|
CP0430550
|
N-(1,3-benzodioxol-5-yl)-2-[[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1,2-oxazol-3-yl]oxy]acetamide
Show/Hide
|
C23H24N6O7
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0433728
|
N-[6-(furan-2-yl)-5-pyrimidin-4-ylpyridin-2-yl]acetamide
Show/Hide
|
C15H12N4O2
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0527157
|
N-(6-pyridin-2-yl-5-pyridin-4-ylpyridin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C19H16N4O
|
1
|
| 1 |
Ki = 47 nM
|
|
|
|
CP0397632
|
2-[4-(1,3-dibutyl-2,6-dioxo-7H-purin-8-yl)phenoxy]acetic acid
Show/Hide
|
C21H26N4O5
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0079483
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(8-ethyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C20H16N8O4
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0444318
|
8-(1-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-(cyclopropylmethyl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H17ClN8O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0399759
|
N-(3,4-dimethylphenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]acetamide
Show/Hide
|
C25H31N7O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0376108
|
1,3-dipropyl-8-(1-((5-(4-(trifluoromethyl)phenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H24F3N7O3
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0426397
|
3-[3-[4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoic acid
Show/Hide
|
C21H18N6O4
|
1
|
| 1 |
Ki = 48 nM
|
|
|
|
CP0372517
|
N-(3,4-dihydro-1H-isoquinolin-2-yl)-2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]acetamide
Show/Hide
|
C28H32N6O5
|
1
|
| 1 |
Ki = 48.98 nM
|
|
|
|
CP0421960
|
3-ethyl-1-propyl-8-(1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C13H16N6O2
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0395868
|
N-[2,6-bis(furan-3-yl)pyrimidin-4-yl]propanamide
Show/Hide
|
C15H13N3O3
|
1
|
| 1 |
Ki = 49 nM
|
|
|
|
CP0477266
|
propan-2-yl 4-(furan-3-yl)-2-(trifluoromethyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H16F3N3O3
|
1
|
| 1 |
Ki = 49.2 nM
|
|
|
|
CP0895126
|
(+/-)-Ethyl 2-Methyl-4-(1H-pyrrol-2-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
|
C18H18N4O2
|
1
|
| 1 |
Ki = 49.6 nM
|
|
|
|
CP0079503
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenyl-urea
Show/Hide
|
C21H20N8O2
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0445287
|
7-hydroxy-6-(4-nitrophenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C18H20N4O5
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0402119
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(3-fluorophenyl)acetamide
Show/Hide
|
C23H26FN7O3
|
1
|
| 1 |
Ki = 50 nM
|
|
|
|
CP0454714
|
N-(3,4-dimethoxyphenyl)-2-[[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1,2-oxazol-3-yl]oxy]acetamide
Show/Hide
|
C24H28N6O7
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0058033
|
1,3-dipropyl-8-cyclopentylxanthine
Show/Hide
|
C16H24N4O2
|
5
|
| 1 |
Ki = 51 nM
|
|
|
| 2 |
Ki = 56 nM
|
|
|
| 3 |
Ki = 63.8 nM
|
|
|
| 4 |
Ki = 73.2 nM
|
|
|
| 5 |
Ki = 73.24 nM
|
|
|
|
CP0468841
|
ethyl 2-(cyanoamino)-6-methyl-4-thiophen-2-yl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C13H14N4O2S
|
1
|
| 1 |
Ki = 51 nM
|
|
|
|
CP0462071
|
N-(4,6-diphenylpyridin-2-yl)acetamide
Show/Hide
|
C19H16N2O
|
1
|
| 1 |
Ki = 51.2 nM
|
|
|
|
CP0409547
|
6-[4-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C37H41N5O4
|
1
|
| 1 |
Ki = 51.29 nM
|
|
|
|
CP0433855
|
6-[4-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 51.29 nM
|
|
|
|
CP0047383
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-nitro-phenyl)-urea
Show/Hide
|
C21H19N9O4
|
1
|
| 1 |
Ki = 52 nM
|
|
|
|
CP0417014
|
1,1,1-trifluoropropan-2-yl 4-(furan-3-yl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H16F3N3O3
|
1
|
| 1 |
Ki = 52.27 nM
|
|
|
|
CP0250680
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C21H18N8O4
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0420840
|
2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-isoxazol-3-yloxy]-N-(4-methoxy-phenyl)-acetamide
Show/Hide
|
C23H26N6O6
|
1
|
| 1 |
Ki = 53 nM
|
|
|
|
CP0714869
|
sodium 4-(2,6-dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonate
Show/Hide
|
C14H13N4NaO5S
|
1
|
| 1 |
Ki = 53.4 nM
|
|
|
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CP0409548
|
6-[4-[2-(4-benzylpiperazin-1-yl)-2-oxoethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H29N5O4
|
1
|
| 1 |
Ki = 53.7 nM
|
|
|
|
CP0445288
|
7-hydroxy-6-phenyl-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C18H21N3O3
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0422193
|
1,3-dipropyl-8-(1-((3-p-tolyl-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O3
|
1
|
| 1 |
Ki = 54 nM
|
|
|
|
CP0446658
|
1,3-dipropyl-8-(1-((3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0430570
|
8-(5-{2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-2-oxo-ethoxy}-2-methyl-2H-pyrazol-3-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C27H33FN8O4
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0571661
|
8-[3-[3-(3-fluorophenyl)prop-2-ynoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H22FN5O4
|
1
|
| 1 |
Ki = 55 nM
|
|
|
|
CP0403265
|
propan-2-yl 7-(furan-2-yl)-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate
Show/Hide
|
C14H16N4O3
|
1
|
| 1 |
Ki = 55.6 nM
|
|
|
|
CP0378549
|
2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-(4-methylphenyl)acetamide
Show/Hide
|
C24H29N7O3
|
1
|
| 1 |
Ki = 56 nM
|
|
|
|
CP0455691
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(4-phenylmethoxyphenyl)acetamide
Show/Hide
|
C30H33N7O4
|
1
|
| 1 |
Ki = 56 nM
|
|
|
|
CP0474216
|
N-[6-(1,3-oxazol-2-yl)-5-pyridin-4-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C16H13N5O2
|
1
|
| 1 |
Ki = 56 nM
|
|
|
|
CP0384057
|
propan-2-yl 6-methyl-2-oxo-4-thiophen-3-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O3S
|
2
|
| 1 |
Ki = 56.6 nM
|
|
|
| 2 |
Ki = 56.7 nM
|
|
|
|
CP0248931
|
1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]urea
Show/Hide
|
C20H17ClN8O2
|
1
|
| 1 |
Ki = 57 nM
|
|
|
|
CP0405394
|
6-[3-methoxy-4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H29N5O5
|
1
|
| 1 |
Ki = 57.54 nM
|
|
|
|
CP0373225
|
1-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-3-(3-methoxy-phenyl)-urea
Show/Hide
|
C25H28N6O4
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0430234
|
8-(5-Amino-1-methyl-1H-pyrazol-3-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C15H21N7O2
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0464322
|
8-(1-(3-chloro-2-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H22ClFN6O2
|
1
|
| 1 |
Ki = 58 nM
|
|
|
|
CP0399711
|
1,3-dimethyl-6-[4-[2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl)ethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C25H26N6O4
|
1
|
| 1 |
Ki = 58.88 nM
|
|
|
|
CP0532847
|
5-[2-amino-4-(furan-2-yl)pyrimidin-5-yl]-1-methylpyridin-2-one
Show/Hide
|
C14H12N4O2
|
1
|
| 1 |
Ki = 58.9 nM
|
|
|
|
CP0429029
|
1-(4-Dimethylamino-phenyl)-3-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-urea
Show/Hide
|
C24H31N9O3
|
1
|
| 1 |
Ki = 59 nM
|
|
|
|
CP0469664
|
propan-2-yl 2-(cyanoamino)-4-(furan-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C14H16N4O3
|
1
|
| 1 |
Ki = 59.4 nM
|
|
|
|
CP0281098
|
8-(3,5-Dihydroxy-4-methoxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C18H22N4O5
|
1
|
| 1 |
Ki = 59.5 nM
|
|
|
|
CP0040261
|
BW-A1433
Show/Hide
|
C20H22N4O4
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0435132
|
N-(3,4-dimethoxyphenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]acetamide
Show/Hide
|
C25H31N7O5
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0407882
|
8-[1-[(3-fluorophenyl)methyl]pyrazol-4-yl]-3-methyl-1-(2-methylpropyl)-7H-purine-2,6-dione
Show/Hide
|
C20H21FN6O2
|
1
|
| 1 |
Ki = 60 nM
|
|
|
|
CP0404009
|
8-(4-Hydroxy-phenyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C13H12N4O3
|
1
|
| 1 |
Ki = 60.7 nM
|
|
|
|
CP0333031
|
1-(2-Chloro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17ClN8O2
|
1
|
| 1 |
Ki = 61 nM
|
|
|
|
CP0418733
|
8-[5-[[5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl]methoxy]-2-methylpyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C25H28N8O5
|
1
|
| 1 |
Ki = 61 nM
|
|
|
|
CP0429845
|
8-benzyl-3-(furan-2-ylmethyl)-1-(2-methoxyethyl)-7-methylpurine-2,6-dione
Show/Hide
|
C21H22N4O4
|
1
|
| 1 |
Ki = 61.66 nM
|
|
|
|
CP0042332
|
1,3-Diethyl-8-phenyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C15H16N4O2
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0508368
|
1,3-dipropyl-8-(1-prop-2-ynylpyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C17H20N6O2
|
1
|
| 1 |
Ki = 62 nM
|
|
|
|
CP0467758
|
8-(1-((5-(4-methoxyphenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
Ki = 63 nM
|
|
|
|
CP0469199
|
4-Fluoro-N-[6-(2-furyl)-5-pyridin-4-ylpyrazin-2-yl]benzamide
Show/Hide
|
C20H13FN4O2
|
1
|
| 1 |
Ki = 63 nM
|
|
|
|
CP0456163
|
7-hydroxy-1-methyl-6-(4-(methylsulfonyl)phenyl)-3-propyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C17H19N3O5S
|
1
|
| 1 |
Ki = 64 nM
|
|
|
|
CP0436635
|
1,3-dipropyl-8-(1-((5-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki = 64 nM
|
|
|
|
CP0376058
|
2-Benzo[1,3]dioxol-5-yl-N-(9-ethylamino-2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-acetamide
Show/Hide
|
C22H20N8O4
|
1
|
| 1 |
Ki = 65 nM
|
|
|
|
CP0399758
|
2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-(3-methoxyphenyl)acetamide
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
Ki = 65 nM
|
|
|
|
CP0376495
|
2-[5-[1,3-bis(2-methylpropyl)-2,6-dioxo-7H-purin-8-yl]-2-methylpyrazol-3-yl]oxy-N-(4-bromophenyl)acetamide
Show/Hide
|
C25H30BrN7O4
|
1
|
| 1 |
Ki = 66 nM
|
|
|
|
CP0394306
|
1-[[2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-yl]amino]propan-2-ol
Show/Hide
|
C16H15N5O2
|
1
|
| 1 |
Ki = 67.61 nM
|
|
|
|
CP0388059
|
7-hydroxy-1,3-dimethyl-6-(4-(methylsulfonyl)phenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C15H15N3O5S
|
1
|
| 1 |
Ki = 68 nM
|
|
|
|
CP0423777
|
propan-2-yl 2-methyl-4-(1,3-thiazol-5-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O2S
|
1
|
| 1 |
Ki = 68.3 nM
|
|
|
|
CP0496284
|
2-(furan-2-yl)-8-methyl-9-(propylthio)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C14H15N7OS
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0437061
|
5-{[4'-(2-furyl)-4,5'-bipyrimidin-2'-yl]amino}nicotinonitrile
Show/Hide
|
C18H11N7O
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0378493
|
8-[3-[[5-oxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H27F3N6O5
|
1
|
| 1 |
Ki = 69 nM
|
|
|
|
CP0433858
|
6-[4-[2-[4-(2-chlorophenyl)piperazin-1-yl]-2-oxoethoxy]phenyl]-1-methyl-3-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C28H30ClN5O4
|
1
|
| 1 |
Ki = 69.18 nM
|
|
|
|
CP0092135
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-chloro-phenyl)-urea
Show/Hide
|
C21H19ClN8O2
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0451903
|
2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-isoxazol-3-yloxy]-N-(4-fluoro-phenyl)-acetamide
Show/Hide
|
C22H23FN6O5
|
1
|
| 1 |
Ki = 70 nM
|
|
|
|
CP0405392
|
6-[4-[1-[4-(2-chlorophenyl)piperazin-1-yl]-1-oxopropan-2-yl]oxyphenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H28ClN5O4
|
1
|
| 1 |
Ki = 70.79 nM
|
|
|
|
CP0429617
|
1-ethyl-3-(3-methoxypropyl)-8-(4-phenylphenyl)-7H-purine-2,6-dione
Show/Hide
|
C23H24N4O3
|
1
|
| 1 |
Ki = 70.79 nM
|
|
|
|
CP0396638
|
6-(4-acetylphenyl)-7-hydroxy-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C20H23N3O4
|
1
|
| 1 |
Ki = 71 nM
|
|
|
|
CP0430318
|
N-(6-pyrazol-1-yl-5-pyridin-4-ylpyridin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C17H15N5O
|
1
|
| 1 |
Ki = 72 nM
|
|
|
|
CP0372917
|
8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C17H15FN6O2
|
1
|
| 1 |
Ki = 73 nM
|
|
|
|
CP0490177
|
8-Cyclopentyl-1,3-diethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C14H20N4O2
|
1
|
| 1 |
Ki = 73.2 nM
|
|
|
|
CP0372447
|
1,3-dipropyl-8-(1-((3-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0430515
|
N-(4-butan-2-ylphenyl)-2-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
|
C27H35N7O4
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0525914
|
8-(1-phenethyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C22H26N6O2
|
1
|
| 1 |
Ki = 74 nM
|
|
|
|
CP0248930
|
1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17ClN8O2
|
1
|
| 1 |
Ki = 76 nM
|
|
|
|
CP0462138
|
8-[3-[[4,6-bis(trifluoromethyl)-1H-benzimidazol-2-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C24H21F6N7O4
|
1
|
| 1 |
Ki = 76 nM
|
|
|
|
CP0395969
|
N-(2,6-diphenylpyrimidin-4-yl)propanamide
Show/Hide
|
C19H17N3O
|
1
|
| 1 |
Ki = 76.6 nM
|
|
|
|
CP0397980
|
4-[4-[[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)pyrazol-1-yl]methyl]-2-oxopyrrolidin-1-yl]benzoic acid
Show/Hide
|
C26H29N7O5
|
1
|
| 1 |
Ki = 77 nM
|
|
|
|
CP0388037
|
N-cyclopentyl-2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]acetamide
Show/Hide
|
C24H31N5O5
|
1
|
| 1 |
Ki = 77.62 nM
|
|
|
|
CP0053427
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-chloro-phenyl)-urea
Show/Hide
|
C21H19ClN8O2
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0277666
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(8-butyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C22H20N8O4
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0380266
|
2-(3,4-Difluoro-phenyl)-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-acetamide
Show/Hide
|
C23H25F2N7O3
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0448526
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(4-nitrophenyl)acetamide
Show/Hide
|
C23H26N8O5
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0490970
|
N-[5-pyridin-4-yl-6-(1,3-thiazol-5-yl)pyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H14N4OS
|
1
|
| 1 |
Ki = 78 nM
|
|
|
|
CP0413030
|
8-[1-[3-(1-hydroxycyclopentyl)prop-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C22H28N6O3
|
1
|
| 1 |
Ki = 79 nM
|
|
|
|
CP0491019
|
6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]phenyl]-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C26H26N4O4
|
1
|
| 1 |
Ki = 79.43 nM
|
|
|
|
CP0456796
|
1,3-Dipropyl-8-pyrazin-2-yl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C15H18N6O2
|
1
|
| 1 |
Ki = 79.6 nM
|
|
|
|
CP0401647
|
12-N-ethyl-4-(furan-2-yl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaene-7,12-diamine
Show/Hide
|
C13H14N8O
|
1
|
| 1 |
Ki = 81 nM
|
|
|
|
CP0404316
|
1-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-3-(4-methoxy-phenyl)-urea
Show/Hide
|
C23H28N8O4
|
1
|
| 1 |
Ki = 81 nM
|
|
|
|
CP0443442
|
[4-(1,3-dimethyl-2,4-dioxo-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-pyridin-2-ylcarbamate
Show/Hide
|
C21H19N5O4
|
1
|
| 1 |
Ki = 81.3 nM
|
|
|
|
CP0376121
|
8-(1-((5-(4-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H24ClN7O3
|
1
|
| 1 |
Ki = 82 nM
|
|
|
|
CP0382445
|
8-(1-((3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 82 nM
|
|
|
|
CP0382446
|
8-(1-((3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 82 nM
|
|
|
|
CP0436674
|
8-(1-((5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 83 nM
|
|
|
|
CP0413022
|
8-[1-[4-(4-methylpiperazin-1-yl)but-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H32N8O2
|
1
|
| 1 |
Ki = 83 nM
|
|
|
|
CP0047376
|
1-(4-Chloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H15ClN8O2
|
1
|
| 1 |
Ki = 85 nM
|
|
|
|
CP0436670
|
8-{5-[2-(4-Benzyl-piperazin-1-yl)-2-oxo-ethoxy]-2-methyl-2H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C28H36N8O4
|
1
|
| 1 |
Ki = 85 nM
|
|
|
|
CP0469204
|
N-[5-(3-chloropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C18H14ClN5O
|
1
|
| 1 |
Ki = 85 nM
|
|
|
|
CP0427282
|
1-ethyl-3-(3-methoxypropyl)-8-(1H-pyrrol-2-yl)-7H-purine-2,6-dione
Show/Hide
|
C15H19N5O3
|
1
|
| 1 |
Ki = 85.11 nM
|
|
|
|
CP0398797
|
propan-2-yl 5-(furan-2-yl)-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate
Show/Hide
|
C15H17N3O3
|
1
|
| 1 |
Ki = 85.6 nM
|
|
|
|
CP0376493
|
N-(4-acetylphenyl)-2-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
|
C25H29N7O5
|
1
|
| 1 |
Ki = 86 nM
|
|
|
|
CP0392623
|
2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-N-(4-morpholin-4-yl-phenyl)-acetamide
Show/Hide
|
C27H34N8O5
|
1
|
| 1 |
Ki = 86 nM
|
|
|
|
CP0079507
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-chloro-phenyl)-urea
Show/Hide
|
C21H19ClN8O2
|
1
|
| 1 |
Ki = 87 nM
|
|
|
|
CP0437643
|
N-(1,3-benzodioxol-5-yl)-2-[5-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-1-methylpyrazol-3-yl]oxyacetamide
Show/Hide
|
C25H28N6O6
|
1
|
| 1 |
Ki = 87 nM
|
|
|
|
CP0348520
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenyl-urea
Show/Hide
|
C19H16N8O2
|
1
|
| 1 |
Ki = 88 nM
|
|
|
|
CP0375493
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(4-fluorophenyl)acetamide
Show/Hide
|
C23H26FN7O3
|
1
|
| 1 |
Ki = 88 nM
|
|
|
|
CP0403603
|
2-[[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]oxymethyl]-3H-benzimidazole-5-carboxylic acid
Show/Hide
|
C24H26N8O5
|
1
|
| 1 |
Ki = 88 nM
|
|
|
|
CP0373073
|
7-hydroxy-1,3-dipropyl-6-p-tolyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C19H23N3O3
|
1
|
| 1 |
Ki = 89 nM
|
|
|
|
CP0415069
|
8-[(2,6-difluorophenyl)methyl]-3-(furan-2-ylmethyl)-1-prop-2-ynyl-7H-purine-2,6-dione
Show/Hide
|
C20H14F2N4O3
|
1
|
| 1 |
Ki = 89.13 nM
|
|
|
|
CP0499322
|
1-(2-ethylsulfanylethyl)-3-(furan-2-ylmethyl)-7-methyl-8-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
|
C20H22N4O3S2
|
1
|
| 1 |
Ki = 89.13 nM
|
|
|
|
CP0499917
|
3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-propionic acid
Show/Hide
|
C22H32N4O4
|
1
|
| 1 |
Ki = 90 nM
|
|
|
|
CP0409273
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]acetamide
Show/Hide
|
C31H32F3N7O4
|
1
|
| 1 |
Ki = 90 nM
|
|
|
|
CP0430566
|
1-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-3-(3-methoxy-phenyl)-urea
Show/Hide
|
C23H28N8O4
|
1
|
| 1 |
Ki = 90 nM
|
|
|
|
CP0459923
|
8-[3-[[1-(3-fluorophenyl)-5-oxopyrrolidin-3-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C25H27FN6O5
|
1
|
| 1 |
Ki = 90 nM
|
|
|
|
CP0870601
|
(+/-)-Ethyl 2-Methyl-4-(1H-pyrazol-4-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
Ki = 92.6 nM
|
|
|
|
CP0860964
|
N-(4-Bromo-phenyl)-2-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-acetamide
Show/Hide
|
C23H26BrN7O4
|
1
|
| 1 |
Ki = 93 nM
|
|
|
|
CP0429618
|
N-(1H-benzimidazol-2-yl)-2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]acetamide
Show/Hide
|
C26H27N7O5
|
1
|
| 1 |
Ki = 93.33 nM
|
|
|
|
CP0407087
|
3-(furan-2-ylmethyl)-1-(2-methylsulfanylethyl)-8-(thiophen-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
|
C18H18N4O3S2
|
1
|
| 1 |
Ki = 93.33 nM
|
|
|
|
CP0380267
|
2-(3,4-Dimethoxy-phenyl)-N-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acetamide
Show/Hide
|
C27H31N5O5
|
1
|
| 1 |
Ki = 95 nM
|
|
|
|
CP0430569
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(3-methoxyphenyl)acetamide
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
Ki = 96 nM
|
|
|
|
CP0462072
|
N-[4,6-bis(3-methoxyphenyl)pyridin-2-yl]acetamide
Show/Hide
|
C21H20N2O3
|
1
|
| 1 |
Ki = 96.2 nM
|
|
|
|
CP0291713
|
1-(2-Chloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H15ClN8O2
|
1
|
| 1 |
Ki = 97 nM
|
|
|
|
CP0505846
|
6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]phenyl]-5-methyl-1,3-dipropylpyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C30H34N4O4
|
1
|
| 1 |
Ki = 97.72 nM
|
|
|
|
CP0535109
|
ethyl 2-methyl-4-(1,2-thiazol-5-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C17H16N4O2S
|
1
|
| 1 |
Ki = 98.7 nM
|
|
|
|
CP0386541
|
(E)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-acrylic acid
Show/Hide
|
C22H30N4O4
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0373198
|
6-[4-[2-oxo-2-(4-pyrazin-2-ylpiperazin-1-yl)ethoxy]phenyl]-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C28H33N7O4
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0505667
|
1,3-dipropyl-8-(1-((5-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H23F3N8O3
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0397484
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(4-methoxyphenyl)acetamide
Show/Hide
|
C24H29N7O4
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0461654
|
8-(1-(3-phenylpropyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0496171
|
2-[4-(2,4-dioxo-1-propyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]-N-(4-fluorophenyl)acetamide
Show/Hide
|
C23H21FN4O4
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0413023
|
8-[1-[3-(1-hydroxycyclohexyl)prop-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H30N6O3
|
1
|
| 1 |
Ki = 100 nM
|
|
|
|
CP0047373
|
1-(2-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13ClN8O2
|
1
|
| 1 |
Ki = 101 nM
|
|
|
|
CP0079509
|
N-[11-butyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C22H21N7O2
|
1
|
| 1 |
Ki = 101 nM
|
|
|
|
CP0472890
|
ethyl 2-(cyanoamino)-4-(furan-3-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C13H14N4O3
|
1
|
| 1 |
Ki = 102 nM
|
|
|
|
CP0455694
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(4-hydroxyphenyl)acetamide
Show/Hide
|
C23H27N7O4
|
1
|
| 1 |
Ki = 103 nM
|
|
|
|
CP0436633
|
8-(1-((3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 106 nM
|
|
|
|
CP0459866
|
2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-pyridin-2-yloxy]-N-(4-iodo-phenyl)-acetamide
Show/Hide
|
C24H25IN6O4
|
1
|
| 1 |
Ki = 108 nM
|
|
|
|
CP0403055
|
ethyl 5-(furan-2-yl)-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate
Show/Hide
|
C14H15N3O3
|
1
|
| 1 |
Ki = 108 nM
|
|
|
|
CP0451994
|
1-(3-Chloro-phenyl)-3-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-urea
Show/Hide
|
C24H25ClN6O3
|
1
|
| 1 |
Ki = 110 nM
|
|
|
|
CP0376110
|
8-(1-((5-(2-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H24ClN7O3
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0375424
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-[4-[(4-nitrophenyl)methoxy]phenyl]acetamide
Show/Hide
|
C30H32N8O6
|
1
|
| 1 |
Ki = 111 nM
|
|
|
|
CP0496172
|
6-[4-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]phenyl]-1-propyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C27H29N5O4
|
1
|
| 1 |
Ki = 114.82 nM
|
|
|
|
CP0440538
|
5-hydroxy-6-(4-hydroxyphenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C18H21N3O4
|
1
|
| 1 |
Ki = 115 nM
|
|
|
|
CP0422263
|
4'-(2-furyl)-N-(6-methoxypyridin-3-yl)-4,5'-bipyrimidin-2'-amine
Show/Hide
|
C18H14N6O2
|
1
|
| 1 |
Ki = 115 nM
|
|
|
|
CP0047372
|
1-(3,4-Dichloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H12Cl2N8O2
|
1
|
| 1 |
Ki = 116 nM
|
|
|
|
CP0436391
|
4'-(2-furyl)-N-pyrazin-2-yl-4,5'-bipyrimidin-2'-amine
Show/Hide
|
C16H11N7O
|
1
|
| 1 |
Ki = 116 nM
|
|
|
|
CP0431103
|
8-benzyl-3-(furan-2-ylmethyl)-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C20H20N4O3
|
1
|
| 1 |
Ki = 117.49 nM
|
|
|
|
CP0384098
|
ethyl 4-thiophen-3-yl-2-(trifluoromethyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H14F3N3O2S
|
1
|
| 1 |
Ki = 117.8 nM
|
|
|
|
CP0437059
|
1-(cyclopropylmethyl)-5-{[4'-(2-furyl)-4,5'-bipyrimidin-2'-yl]amino}pyridin-2(1H)-one
Show/Hide
|
C21H18N6O2
|
1
|
| 1 |
Ki = 119 nM
|
|
|
|
CP0407890
|
1-ethyl-3-methyl-8-(1H-pyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C11H12N6O2
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0558377
|
1,3-dipropyl-8-[1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C22H29N7O2
|
1
|
| 1 |
Ki = 120 nM
|
|
|
|
CP0463361
|
1-ethyl-3-(furan-2-ylmethyl)-8-(thiophen-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
|
C17H16N4O3S
|
1
|
| 1 |
Ki = 120.23 nM
|
|
|
|
CP0143977
|
1-(4-Bromo-phenyl)-3-(8-butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C21H19BrN8O2
|
1
|
| 1 |
Ki = 121 nM
|
|
|
|
CP0422167
|
1,3-dipropyl-8-(1-((5-(2-(trifluoromethyl)phenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H24F3N7O3
|
1
|
| 1 |
Ki = 121 nM
|
|
|
|
CP0394605
|
8-(1-((5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 123 nM
|
|
|
|
CP0394304
|
2-[[2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-yl]amino]ethanol
Show/Hide
|
C15H13N5O2
|
1
|
| 1 |
Ki = 123.03 nM
|
|
|
|
CP0277937
|
8-(2,3-Dihydroxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C17H20N4O4
|
1
|
| 1 |
Ki = 125 nM
|
|
|
|
CP0133191
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxy-phenyl)-urea
Show/Hide
|
C22H22N8O3
|
1
|
| 1 |
Ki = 125 nM
|
|
|
|
CP0427283
|
1-ethyl-3-(3-methoxypropyl)-8-thiophen-2-yl-7H-purine-2,6-dione
Show/Hide
|
C15H18N4O3S
|
1
|
| 1 |
Ki = 125.89 nM
|
|
|
|
CP0374066
|
1-ethyl-3,8-bis(furan-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
|
C17H16N4O4
|
1
|
| 1 |
Ki = 125.89 nM
|
|
|
|
CP0408620
|
4-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]oct-1-yl]-butyric acid
Show/Hide
|
C23H34N4O4
|
1
|
| 1 |
Ki = 127 nM
|
|
|
|
CP0210735
|
1-(4-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13ClN8O2
|
1
|
| 1 |
Ki = 128 nM
|
|
|
|
CP0372450
|
1,3-dipropyl-8-(1-((3-m-tolyl-1,2,4-oxadiazol-5-yl)methyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O3
|
1
|
| 1 |
Ki = 128 nM
|
|
|
|
CP0116391
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-trifluoromethyl-phenyl)-urea
Show/Hide
|
C22H19F3N8O2
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0395373
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-[4-(trifluoromethyl)phenyl]acetamide
Show/Hide
|
C24H26F3N7O3
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0413014
|
4-[3-[4-(3-ethyl-2,6-dioxo-1-propyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoic acid
Show/Hide
|
C23H22N6O4
|
1
|
| 1 |
Ki = 130 nM
|
|
|
|
CP0422188
|
8-(1-((5-(3-methoxyphenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
Ki = 131 nM
|
|
|
|
CP0047375
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolyl-urea
Show/Hide
|
C20H18N8O2
|
1
|
| 1 |
Ki = 132 nM
|
|
|
|
CP0392679
|
2-[5-[1,3-bis(2-methylpropyl)-2,6-dioxo-7H-purin-8-yl]-1-methylpyrazol-3-yl]oxy-N-(4-bromophenyl)acetamide
Show/Hide
|
C25H30BrN7O4
|
1
|
| 1 |
Ki = 132 nM
|
|
|
|
CP0382443
|
8-(1-((5-(3-chlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H23ClN8O3
|
1
|
| 1 |
Ki = 134 nM
|
|
|
|
CP0382900
|
N-[6-(1,3-oxazol-4-yl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H14N4O2
|
1
|
| 1 |
Ki = 134 nM
|
|
|
|
CP0489112
|
8-[(2,6-difluorophenyl)methyl]-1-ethyl-7-methyl-3-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
|
C20H18F2N4O2S
|
1
|
| 1 |
Ki = 134.9 nM
|
|
|
|
CP0277567
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-(trifluoromethyl)phenyl)urea
Show/Hide
|
C21H17F3N8O2
|
1
|
| 1 |
Ki = 136 nM
|
|
|
|
CP0290657
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-fluoro-phenyl)-urea
Show/Hide
|
C21H19FN8O2
|
1
|
| 1 |
Ki = 136 nM
|
|
|
|
CP0494603
|
8-(1-((5-(3-methoxyphenyl)-1,2,4-oxadiazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H26N8O4
|
1
|
| 1 |
Ki = 136 nM
|
|
|
|
CP0301653
|
8-(2,5-Dihydroxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C17H20N4O4
|
1
|
| 1 |
Ki = 138 nM
|
|
|
|
CP0397006
|
1-ethyl-8-(furan-2-yl)-3-(3-methoxypropyl)-7H-purine-2,6-dione
Show/Hide
|
C15H18N4O4
|
1
|
| 1 |
Ki = 138.04 nM
|
|
|
|
CP0470886
|
1-ethyl-3,8-bis(thiophen-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
|
C17H16N4O2S2
|
1
|
| 1 |
Ki = 138.04 nM
|
|
|
|
CP0483654
|
1,6-Dimethyl-2-[1,2,3]triazol-2-yl-1H-imidazo[4,5-c]pyridin-4-ylamine
Show/Hide
|
C10H11N7
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0426399
|
8-[1-(4-piperidin-1-ylbut-2-ynyl)pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C23H31N7O2
|
1
|
| 1 |
Ki = 140 nM
|
|
|
|
CP0448382
|
2-[4-[2,6-dioxo-1,3-bis(prop-2-enyl)-7H-purin-8-yl]phenoxy]acetic acid
Show/Hide
|
C19H18N4O5
|
1
|
| 1 |
Ki = 141 nM
|
|
|
|
CP0407843
|
3-ethyl-1-(2-methylpropyl)-8-(1H-pyrazol-4-yl)-7H-purine-2,6-dione
Show/Hide
|
C14H18N6O2
|
1
|
| 1 |
Ki = 141 nM
|
|
|
|
CP0348518
|
1-(benzo[d][1,3]dioxol-5-yl)-3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea
Show/Hide
|
C19H14N8O4
|
1
|
| 1 |
Ki = 142 nM
|
|
|
|
CP0053426
|
N-[4-(furan-2-yl)-11-propyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C21H19N7O2
|
1
|
| 1 |
Ki = 143 nM
|
|
|
|
CP0433743
|
2-(furan-2-yl)-4-(furan-3-ylmethoxy)-[1,2,4]triazolo[1,5-a]quinoxaline
Show/Hide
|
C18H12N4O3
|
1
|
| 1 |
Ki = 144.54 nM
|
|
|
|
CP0429616
|
3-(3-methoxypropyl)-1-propyl-8-(1H-pyrrol-2-yl)-7H-purine-2,6-dione
Show/Hide
|
C16H21N5O3
|
1
|
| 1 |
Ki = 147.91 nM
|
|
|
|
CP0187296
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxy-phenyl)-urea
Show/Hide
|
C22H22N8O3
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0187298
|
1-(4-Bromo-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17BrN8O2
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0222481
|
1-(3-Chloro-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C19H15ClN8O2
|
1
|
| 1 |
Ki = 150 nM
|
|
|
|
CP0015755
|
9-Methyl-2-pentyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C13H18N8
|
1
|
| 1 |
Ki = 153 nM
|
|
|
|
CP0456162
|
6-(4-Amino-phenyl)-5-hydroxy-1,3-dipropyl-1H-pyrrolo-[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C18H22N4O3
|
1
|
| 1 |
Ki = 155 nM
|
|
|
|
CP0384101
|
2,2,2-trifluoroethyl 4-(furan-2-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C12H11F3N2O4
|
1
|
| 1 |
Ki = 157 nM
|
|
|
|
CP0480744
|
2-(3-Chloro-phenyl)-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-acetamide
Show/Hide
|
C23H26ClN7O3
|
1
|
| 1 |
Ki = 160 nM
|
|
|
|
CP0047377
|
1-(4-Fluoro-phenyl)-3-(2-furan-2-yl-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C20H17FN8O2
|
1
|
| 1 |
Ki = 161 nM
|
|
|
|
CP0079506
|
1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolyl-urea
Show/Hide
|
C22H22N8O2
|
1
|
| 1 |
Ki = 161 nM
|
|
|
|
CP0258312
|
N-[11-ethyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C20H17N7O2
|
1
|
| 1 |
Ki = 161 nM
|
|
|
|
CP0417844
|
8-benzyl-1-ethyl-3-(furan-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
|
C19H18N4O3
|
1
|
| 1 |
Ki = 162.18 nM
|
|
|
|
CP0428286
|
8-(1-((5-(3-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C24H24ClN7O3
|
1
|
| 1 |
Ki = 163 nM
|
|
|
|
CP0465987
|
N-[2,6-di(thiophen-3-yl)pyrimidin-4-yl]propanamide
Show/Hide
|
C15H13N3OS2
|
1
|
| 1 |
Ki = 164.7 nM
|
|
|
|
CP0047382
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxyphenyl)urea
Show/Hide
|
C21H20N8O3
|
1
|
| 1 |
Ki = 165 nM
|
|
|
|
CP0258311
|
N-[4-(furan-2-yl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-phenylacetamide
Show/Hide
|
C19H15N7O2
|
1
|
| 1 |
Ki = 165 nM
|
|
|
|
CP0394400
|
6-[4-[2-(3,4-dihydro-1H-isoquinolin-2-yl)-2-oxoethoxy]-3-methoxyphenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C26H26N4O5
|
1
|
| 1 |
Ki = 169.82 nM
|
|
|
|
CP0457871
|
8-(1-((5-(4-chlorophenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1-propyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H18ClN7O3
|
1
|
| 1 |
Ki = 170 nM
|
|
|
|
CP0412427
|
1,3-dimethyl-6-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]phenyl]-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C21H25N5O4
|
1
|
| 1 |
Ki = 173.78 nM
|
|
|
|
CP0388036
|
N-[4-(dimethylamino)phenyl]-2-[4-[1-ethyl-3-(3-methoxypropyl)-2,6-dioxo-7H-purin-8-yl]phenoxy]acetamide
Show/Hide
|
C27H32N6O5
|
1
|
| 1 |
Ki = 173.78 nM
|
|
|
|
CP0237635
|
1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxyphenyl)urea
Show/Hide
|
C21H20N8O3
|
1
|
| 1 |
Ki = 175 nM
|
|
|
|
CP0430514
|
8-(5-Amino-1-methyl-1H-pyrazol-3-yl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C11H13N7O2
|
1
|
| 1 |
Ki = 175 nM
|
|
|
|
CP0460841
|
propan-2-yl 2-methyl-4-(1,2-thiazol-5-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O2S
|
1
|
| 1 |
Ki = 175 nM
|
|
|
|
CP0139902
|
1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-nitrophenyl)urea
Show/Hide
|
C18H13N9O4
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0401423
|
N-[4-(furan-2-yl)-11-methyl-12-methylsulfanyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-[4-(2-methylpropyl)phenyl]acetamide
Show/Hide
|
C24H25N7O2S
|
1
|
| 1 |
Ki = 180 nM
|
|
|
|
CP0116392
|
1-(4-Bromo-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13BrN8O2
|
1
|
| 1 |
Ki = 181 nM
|
|
|
|
CP0388722
|
1,3-Dimethyl-6-phenyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C14H13N3O2
|
1
|
| 1 |
Ki = 182 nM
|
|
|
|
CP0878146
|
2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-N-(4-fluoro-phenyl)-acetamide
Show/Hide
|
C23H26FN7O4
|
1
|
| 1 |
Ki = 185 nM
|
|
|
|
CP0292429
|
2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-3-hydroxyphenoxy]acetic acid
Show/Hide
|
C19H22N4O6
|
1
|
| 1 |
Ki = 188 nM
|
|
|
|
CP0413029
|
3-[3-[4-(3-ethyl-2,6-dioxo-1-propyl-7H-purin-8-yl)pyrazol-1-yl]prop-1-ynyl]benzoic acid
Show/Hide
|
C23H22N6O4
|
1
|
| 1 |
Ki = 190 nM
|
|
|
|
CP0506342
|
3-(2-ethylsulfanylethyl)-8-phenyl-1-propyl-7H-purine-2,6-dione
Show/Hide
|
C18H22N4O2S
|
1
|
| 1 |
Ki = 190.55 nM
|
|
|
|
CP0444200
|
propan-2-yl 4-(furan-3-yl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O3S
|
1
|
| 1 |
Ki = 194.2 nM
|
|
|
|
CP0376621
|
8-(1-((5-(2-methoxyphenyl)isoxazol-3-yl)methyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C25H27N7O4
|
1
|
| 1 |
Ki = 195 nM
|
|
|
|
CP0237628
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxy-phenyl)-urea
Show/Hide
|
C20H18N8O3
|
1
|
| 1 |
Ki = 196 nM
|
|
|
|
CP0894597
|
3-[4-(1,3-Bis-cyclohexylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylic acid
Show/Hide
|
C28H34N4O4
|
1
|
| 1 |
Ki = 199 nM
|
|
|
|
CP0494648
|
1,3-dipropyl-6-p-tolyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C19H23N3O2
|
1
|
| 1 |
Ki = 199 nM
|
|
|
|
CP0436468
|
3-methyl-1-(2-methylpropyl)-8-[1-[[3-(trifluoromethyl)phenyl]methyl]pyrazol-4-yl]-7H-purine-2,6-dione
Show/Hide
|
C21H21F3N6O2
|
1
|
| 1 |
Ki = 199 nM
|
|
|
|
CP0415070
|
8-[(2,6-difluorophenyl)methyl]-3-(furan-2-ylmethyl)-1-(2-methylsulfanylethyl)-7H-purine-2,6-dione
Show/Hide
|
C20H18F2N4O3S
|
1
|
| 1 |
Ki = 199.53 nM
|
|
|
|
CP0446063
|
8-(1-(4-chloro-3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H22ClF3N6O2
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0376341
|
1-(2-Furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-pyridin-4-yl-urea
Show/Hide
|
C17H13N9O2
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0426398
|
8-[1-[4-(diethylamino)but-2-ynyl]pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C22H31N7O2
|
1
|
| 1 |
Ki = 200 nM
|
|
|
|
CP0373951
|
N-[6-(1H-pyrazol-5-yl)-5-pyridin-4-ylpyridin-2-yl]cyclopropanecarboxamide
Show/Hide
|
C17H15N5O
|
1
|
| 1 |
Ki = 202 nM
|
|
|
|
CP0264646
|
1-(3-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
|
C18H13ClN8O2
|
1
|
| 1 |
Ki = 205 nM
|
|
|
|
CP0387848
|
propyl 4-(furan-2-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O4
|
1
|
| 1 |
Ki = 206.3 nM
|
|
|
|
CP0441857
|
CHEMBL424908
Show/Hide
|
C23H33N5O5
|
1
|
| 1 |
Ki = 207 nM
|
|
|
|
CP0430511
|
2-[5-(1,3-Diisobutyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-2-methyl-2H-pyrazol-3-yloxy]-N-(4-fluoro-phenyl)-acetamide
Show/Hide
|
C25H30FN7O4
|
1
|
| 1 |
Ki = 207 nM
|
|
|
|
CP0415562
|
N-(5-pyridin-4-yl-6-pyrimidin-4-ylpyridin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C18H15N5O
|
1
|
| 1 |
Ki = 208 nM
|
|
|
|
CP0378497
|
8-[3-[[1-(4-fluorophenyl)-5-oxopyrrolidin-3-yl]methoxy]-1,2-oxazol-5-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C25H27FN6O5
|
1
|
| 1 |
Ki = 210 nM
|
|
|
|
CP0291712
|
1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxy-phenyl)-urea
Show/Hide
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C20H18N8O3
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1
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| 1 |
Ki = 215 nM
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CP0521344
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ethyl 2-methyl-4-(1,3-thiazol-5-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C17H16N4O2S
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1
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| 1 |
Ki = 215 nM
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CP0273529
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1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenylurea
Show/Hide
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C18H14N8O2
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1
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| 1 |
Ki = 222 nM
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CP0373432
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2-[4-chloro-3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-(4-chlorophenyl)acetamide
Show/Hide
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C23H25Cl2N7O3
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1
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| 1 |
Ki = 222 nM
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CP0079480
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1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(2-methoxyphenyl)urea
Show/Hide
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C19H16N8O3
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1
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| 1 |
Ki = 223 nM
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CP0210714
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1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-nitro-phenyl)-urea
Show/Hide
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C19H15N9O4
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1
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| 1 |
Ki = 226 nM
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CP0133195
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1-(4-Fluoro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
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C18H13FN8O2
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1
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| 1 |
Ki = 226 nM
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CP0440534
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6-Phenyl-1,3-dipropyl-1,5-dihydro-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C18H21N3O2
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1
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| 1 |
Ki = 229 nM
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CP0259712
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N-[4-(3,5-dimethylphenyl)-5-pyridin-4-yl-1,3-thiazol-2-yl]pyridine-3-carboxamide
Show/Hide
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C22H18N4OS
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1
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| 1 |
Ki = 230 nM
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CP0384096
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1,1,1-trifluoropropan-2-yl 4-(furan-3-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C13H13F3N2O4
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1
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| 1 |
Ki = 234 nM
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CP0187299
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1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-trifluoromethyl-phenyl)-urea
Show/Hide
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C20H15F3N8O2
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1
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| 1 |
Ki = 235 nM
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CP0402118
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8-(5-Amino-2-methyl-2H-pyrazol-3-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C15H21N7O2
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1
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| 1 |
Ki = 235 nM
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CP0384094
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propan-2-yl 4-(furan-2-yl)-2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C13H13F3N2O4
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1
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| 1 |
Ki = 238 nM
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CP0455087
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8-(1-(2,3-difluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1Hpurine-2,6(3H,7H)-dione
Show/Hide
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C21H22F2N6O2
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1
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| 1 |
Ki = 240 nM
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CP0333052
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1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-phenylurea
Show/Hide
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C20H18N8O2
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1
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| 1 |
Ki = 241 nM
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CP0308558
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1-(8-ethyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea
Show/Hide
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C20H18N8O3
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1
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| 1 |
Ki = 245 nM
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CP0210713
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1-(8-Ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-fluoro-phenyl)-urea
Show/Hide
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C19H15FN8O2
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1
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| 1 |
Ki = 246 nM
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CP0373431
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2-[4-bromo-3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-(4-chlorophenyl)acetamide
Show/Hide
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C23H25BrClN7O3
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1
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| 1 |
Ki = 250 nM
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CP0133194
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1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(3-methoxyphenyl)urea
Show/Hide
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C19H16N8O3
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1
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| 1 |
Ki = 251 nM
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CP0394305
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N-[2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-yl]-2-phenylacetamide
Show/Hide
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C21H15N5O2
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1
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| 1 |
Ki = 251.19 nM
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CP0458038
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N-[2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-yl]acetamide
Show/Hide
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C15H11N5O2
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1
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| 1 |
Ki = 251.19 nM
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CP0467447
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ethyl 4-(furan-2-yl)-2-oxo-6-propyl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C14H18N2O4
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1
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| 1 |
Ki = 256.1 nM
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CP0225001
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4-(3,3-Dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide
Show/Hide
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C16H17F2N3O2S
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1
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| 1 |
Ki = 260 nM
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CP0282756
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1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxyphenyl)urea
Show/Hide
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C19H16N8O3
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1
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| 1 |
Ki = 261 nM
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CP0039348
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(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide
Show/Hide
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C12H16N6O4
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4
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| 1 |
Ki = 262 nM
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| 2 |
Ki = 570 nM
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| 3 |
Ki = 760 nM
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| 4 |
Ki = 884 nM
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CP0401592
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3-(furan-2-ylmethyl)-1-prop-2-ynyl-8-(thiophen-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
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C18H14N4O3S
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1
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| 1 |
Ki = 269.15 nM
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CP0411146
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1-(2-ethylsulfanylethyl)-3-(furan-2-ylmethyl)-8-(thiophen-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
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C19H20N4O3S2
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1
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| 1 |
Ki = 275.42 nM
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CP0380076
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propan-2-yl 5-(furan-3-yl)-7-methyl-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate
Show/Hide
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C15H17N3O3
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1
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| 1 |
Ki = 276.9 nM
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CP0420319
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propan-2-yl 2-methyl-4-(1,2-thiazol-4-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C18H18N4O2S
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1
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| 1 |
Ki = 278 nM
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CP0402055
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3-benzyl-1-ethyl-8-(furan-2-ylmethyl)-7-methylpurine-2,6-dione
Show/Hide
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C20H20N4O3
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1
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| 1 |
Ki = 281.84 nM
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CP0237626
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1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-(trifluoromethyl)phenyl)urea
Show/Hide
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C19H13F3N8O2
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1
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| 1 |
Ki = 286 nM
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CP0335602
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7-hydroxy-1,3-dimethyl-6-phenyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C14H13N3O3
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1
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| 1 |
Ki = 288 nM
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CP0534167
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8-(4-Dimethylamino-phenyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C15H17N5O2
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1
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| 1 |
Ki = 289 nM
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CP0258307
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1-(4-Bromo-phenyl)-3-(8-ethyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea
Show/Hide
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C19H15BrN8O2
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1
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| 1 |
Ki = 296 nM
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CP0386543
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3-noradamantyl-1,3-dipropylxanthine
Show/Hide
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C20H28N4O2
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1
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| 1 |
Ki = 296 nM
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CP0495993
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2-((4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)bicyclo[2.2.2]octan-1-yl)(methyl)amino)acetic acid
Show/Hide
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C24H35N5O5
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1
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| 1 |
Ki = 296 nM
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CP0378792
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8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-diisobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C24H27F3N6O2
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1
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| 1 |
Ki = 300 nM
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CP0333051
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1-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-p-tolylurea
Show/Hide
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C19H16N8O2
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1
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| 1 |
Ki = 302 nM
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CP0395867
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N-[2,6-bis(furan-3-yl)pyrimidin-4-yl]acetamide
Show/Hide
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C14H11N3O3
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1
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| 1 |
Ki = 302 nM
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CP0220980
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1-(8-Butyl-2-furan-2-yl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea
Show/Hide
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C22H22N8O3
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1
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| 1 |
Ki = 303 nM
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CP0448476
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2-[5-(1,3-Diisobutyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-N-(4-fluoro-phenyl)-acetamide
Show/Hide
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C25H30FN7O4
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1
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| 1 |
Ki = 303 nM
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CP0113084
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1-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-nitrophenyl)urea
Show/Hide
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C20H17N9O4
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1
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| 1 |
Ki = 305 nM
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CP0499553
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N-[4,6-bis(2-fluorophenyl)pyrimidin-2-yl]propanamide
Show/Hide
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C19H15F2N3O
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1
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| 1 |
Ki = 307 nM
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CP0375790
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8-(2,6-Difluoro-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C17H18F2N4O2
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1
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| 1 |
Ki = 310 nM
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CP0451869
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8-(1-phenyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
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C20H22N6O2
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1
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| 1 |
Ki = 310 nM
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CP0300612
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1-Allyl-7-(2-chloro-ethyl)-3-methyl-8-phenyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C17H17ClN4O2
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1
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| 1 |
Ki = 311 nM
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CP0477649
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3,8-bis(furan-2-ylmethyl)-1-methyl-7H-purine-2,6-dione
Show/Hide
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C16H14N4O4
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1
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| 1 |
Ki = 316.23 nM
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CP0378143
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2-imino-8-methoxychromene-3-carboxamide
Show/Hide
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C11H10N2O3
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1
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| 1 |
Ki = 316.23 nM
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CP0401008
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3-(3-methoxypropyl)-8-phenyl-1-propyl-7H-purine-2,6-dione
Show/Hide
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C18H22N4O3
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1
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| 1 |
Ki = 323.59 nM
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CP0454792
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8-[1-(4-morpholin-4-ylbut-2-ynyl)pyrazol-4-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
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C22H29N7O3
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1
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| 1 |
Ki = 330 nM
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CP0373144
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8-[1-[[5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl]methyl]pyrazol-4-yl]-3-ethyl-1-propyl-7H-purine-2,6-dione
Show/Hide
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C22H21ClN8O3
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1
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| 1 |
Ki = 335 nM
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CP0434871
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4-(7-hydroxy-2,4-dioxo-1,3-dipropyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)benzoic acid
Show/Hide
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C19H21N3O5
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1
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| 1 |
Ki = 338 nM
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CP0867471
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(+/-)-Isopropyl 2-Methyl-4-(1H-pyrazol-4-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
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C18H19N5O2
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1
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| 1 |
Ki = 340 nM
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CP0460823
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N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(4-hydroxy-3-methoxyphenyl)acetamide
Show/Hide
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C24H29N7O5
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1
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| 1 |
Ki = 342 nM
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CP0472887
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propan-2-yl 2-(cyanoamino)-6-methyl-4-thiophen-2-yl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C14H16N4O2S
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1
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| 1 |
Ki = 349.1 nM
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CP0378786
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8-(1-(3,5-bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C23H22F6N6O2
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1
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| 1 |
Ki = 350 nM
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CP0391112
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propan-2-yl 7-(furan-3-yl)-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate
Show/Hide
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C14H16N4O3
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1
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| 1 |
Ki = 350.5 nM
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CP0028721
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2-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
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C12H16N8
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1
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| 1 |
Ki = 352.3 nM
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CP0303870
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1-Propyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C8H10N4O2
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1
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| 1 |
Ki = 360 nM
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CP0514391
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8-(1-(3-chloro-2-fluoro-5-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C22H21ClF4N6O2
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1
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| 1 |
Ki = 360 nM
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CP0384053
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propan-2-yl 2-methyl-4-thiophen-2-yl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C19H19N3O2S
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1
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| 1 |
Ki = 371.2 nM
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CP0491172
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3-benzyl-1-ethyl-7-methyl-8-(thiophen-2-ylmethyl)purine-2,6-dione
Show/Hide
|
C20H20N4O2S
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1
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| 1 |
Ki = 371.54 nM
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CP0472416
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N-[4,6-bis(4-methylsulfanylphenyl)pyrimidin-2-yl]propanamide
Show/Hide
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C21H21N3OS2
|
1
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| 1 |
Ki = 374 nM
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CP0400402
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N-(6-chloro-5-pyridin-4-ylpyridin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C14H12ClN3O
|
1
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| 1 |
Ki = 380 nM
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CP0501856
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N-[4-(furan-2-yl)-5-pyrimidin-4-ylpyrimidin-2-yl]acetamide
Show/Hide
|
C14H11N5O2
|
1
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| 1 |
Ki = 380 nM
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CP0416059
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ethyl 2-methyl-4-(1,3-thiazol-2-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C17H16N4O2S
|
1
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| 1 |
Ki = 388 nM
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CP0528279
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8-(1-(2,6-difluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1Hpurine-2,6(3H,7H)-dione
Show/Hide
|
C21H22F2N6O2
|
1
|
| 1 |
Ki = 390 nM
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CP0082443
|
8-(4-Methoxy-phenyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C14H14N4O3
|
1
|
| 1 |
Ki = 394 nM
|
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CP0864282
|
(+/-)-Ethyl 4-(1H-Imidazol-2-yl)-2-methyl-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
Ki = 402 nM
|
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CP0299690
|
1-Phenethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C13H12N4O2
|
1
|
| 1 |
Ki = 408 nM
|
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CP0455090
|
8-(1-(3-(trifluoromethyl)-4-methoxybenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C23H25F3N6O3
|
1
|
| 1 |
Ki = 410 nM
|
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CP0059859
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1,3-Dimethyl-8-phenyl-3,9-dihydro-purine-2,6-dione
Show/Hide
|
C13H12N4O2
|
1
|
| 1 |
Ki = 415 nM
|
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CP0387851
|
propan-2-yl 6-methyl-2-sulfanylidene-4-thiophen-3-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O2S2
|
1
|
| 1 |
Ki = 415.7 nM
|
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CP0225943
|
1-Butyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C9H12N4O2
|
1
|
| 1 |
Ki = 421 nM
|
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CP0394301
|
2-(furan-2-yl)-N-(3-methoxypropyl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-amine
Show/Hide
|
C17H17N5O2
|
1
|
| 1 |
Ki = 426.58 nM
|
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CP0864280
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(+/-)-Ethyl 2-Methyl-4-(1H-pyrrol-3-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
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C18H18N4O2
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1
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| 1 |
Ki = 449.3 nM
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CP0497800
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1,3-dimethyl-6-p-tolyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C15H15N3O2
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1
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| 1 |
Ki = 457 nM
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CP0277227
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1-Allyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C8H8N4O2
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1
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| 1 |
Ki = 461 nM
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CP0430080
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ethyl 2-(cyanoamino)-6-methyl-4-thiophen-3-yl-1,4-dihydropyrimidine-5-carboxylate
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C13H14N4O2S
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1
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| 1 |
Ki = 461 nM
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CP0863266
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3-[4-(1,3-Dibenzyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenyl]-acrylic acid
Show/Hide
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C28H22N4O4
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1
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| 1 |
Ki = 469 nM
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CP0513685
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6-[4-[2-[4-(4-chlorophenyl)piperazin-1-yl]-2-oxoethoxy]-2-methoxyphenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
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C27H28ClN5O5
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1
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| 1 |
Ki = 478.63 nM
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CP0402056
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1-ethyl-3-(2-ethylsulfanylethyl)-8-phenyl-7H-purine-2,6-dione
Show/Hide
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C17H20N4O2S
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1
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| 1 |
Ki = 478.63 nM
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CP0399320
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5-hydroxy-6-(4-methoxyphenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C19H23N3O4
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1
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| 1 |
Ki = 479 nM
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CP0384100
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ethyl 2-methyl-4-thiophen-2-yl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C18H17N3O2S
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1
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| 1 |
Ki = 484.6 nM
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CP0506066
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1-(2-ethylsulfanylethyl)-8-(furan-2-yl)-3-(3-methoxypropyl)-7H-purine-2,6-dione
Show/Hide
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C17H22N4O4S
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1
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| 1 |
Ki = 489.78 nM
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CP0414876
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6-(4-methoxyphenyl)-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C19H23N3O3
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1
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| 1 |
Ki = 490 nM
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CP0190420
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4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1,4-dimethylcyclohexane-1-carboxamide
Show/Hide
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C21H29N3O4S
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2
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| 1 |
Ki = 500 nM
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| 2 |
Ki = 2000 nM
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CP0315512
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4-(diethylamino)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-1-methylcyclohexane-1-carboxamide
Show/Hide
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C24H36N4O3S
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2
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| 1 |
Ki = 500 nM
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| 2 |
Ki = 650 nM
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CP0431174
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[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-thiophen-3-ylcarbamate
Show/Hide
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C24H26N4O4S
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1
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| 1 |
Ki = 501 nM
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CP0409543
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N-[2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-yl]-3-phenylpropanamide
Show/Hide
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C22H17N5O2
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1
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| 1 |
Ki = 501.19 nM
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CP0428185
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3-{[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-bicyclo[2.2.2]octane-1-carbonyl]-amino}-propionic acid methy lester
Show/Hide
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C24H35N5O5
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1
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| 1 |
Ki = 505 nM
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CP0421972
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3-ethyl-8-[1-(1-oxidopyridin-1-ium-3-yl)pyrazol-4-yl]-1-propyl-7H-purine-2,6-dione
Show/Hide
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C18H19N7O3
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1
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| 1 |
Ki = 506 nM
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CP0525435
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ethyl 2-methyl-4-(1,3-oxazol-5-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C17H16N4O3
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1
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| 1 |
Ki = 508 nM
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CP0290021
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3-Methyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C9H8N4O2
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1
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| 1 |
Ki = 511 nM
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CP0456172
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7-hydroxy-1,3-dimethyl-6-p-tolyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C15H15N3O3
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1
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| 1 |
Ki = 513 nM
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CP0521937
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8-(4-Amino-phenyl)-7-methyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C18H23N5O2
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1
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| 1 |
Ki = 516 nM
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CP0895125
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(+/-)-Isopropyl 2-Methyl-4-(1H-pyrrol-3-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
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C19H20N4O2
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1
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| 1 |
Ki = 517.1 nM
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CP0490695
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1-Methyl-2-[1,2,3]triazol-2-yl-1H-imidazo[4,5-c]pyridin-4-ylamine
Show/Hide
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C9H9N7
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1
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| 1 |
Ki = 518 nM
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CP0477278
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ethyl 4-(furan-3-yl)-2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C12H11F3N2O4
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1
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| 1 |
Ki = 521 nM
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CP0373331
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3-(furan-2-ylmethyl)-1-prop-2-enyl-8-(thiophen-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
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C18H16N4O3S
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1
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| 1 |
Ki = 549.54 nM
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CP0447816
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1-Prop-2-ynyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C8H6N4O2
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1
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| 1 |
Ki = 552 nM
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CP0114093
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8-cyclopentyl-2-(2-methylpyridin-3-yl)oxy-1-propyl-7H-purin-6-one
Show/Hide
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C19H23N5O2
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1
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| 1 |
Ki = 560 nM
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CP0392722
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N-[5-(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-phenylacetamide
Show/Hide
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C19H19N7O3
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1
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| 1 |
Ki = 569 nM
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CP0490178
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ethyl 2-oxo-4-thiophen-3-yl-6-(trifluoromethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C12H11F3N2O3S
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1
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| 1 |
Ki = 575 nM
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CP0529470
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N-[4,6-bis(2,3-dimethoxyphenyl)pyridin-2-yl]acetamide
Show/Hide
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C23H24N2O5
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1
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| 1 |
Ki = 579 nM
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CP0195272
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ethyl 4-(furan-2-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C12H14N2O4
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2
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| 1 |
Ki = 585 nM
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| 2 |
Ki = 585.5 nM
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CP0475546
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2,2,2-trifluoroethyl 4-(furan-3-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C12H11F3N2O4
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1
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| 1 |
Ki = 588 nM
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CP0373560
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3-(2-ethylsulfinylethyl)-8-phenyl-1-propyl-7H-purine-2,6-dione
Show/Hide
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C18H22N4O3S
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1
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| 1 |
Ki = 588.84 nM
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CP0399314
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5-hydroxy-1,3-dipropyl-6-p-tolyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C19H23N3O3
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1
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| 1 |
Ki = 589 nM
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CP0374369
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[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenyl]methyl N-thiophen-2-ylcarbamate
Show/Hide
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C24H26N4O4S
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1
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| 1 |
Ki = 602 nM
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CP0380081
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ethyl 7-(furan-3-yl)-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate
Show/Hide
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C13H14N4O3
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1
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| 1 |
Ki = 602.4 nM
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CP0420683
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ethyl 4-(furan-2-yl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C12H14N2O3S
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1
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| 1 |
Ki = 608.4 nM
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CP0428069
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1,3-dipropyl-8-[2-(5,6-exo-epoxy-(1S,2S)-norborn-2-yl)]-xanthine
Show/Hide
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C18H24N4O3
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1
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| 1 |
Ki = 611 nM
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CP0391229
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(2R,3R,4S,5R)-2-{6-Amino-2-[(S)-1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethylamino]-purin-9-yl}-5-(2-ethyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol
Show/Hide
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C21H26N10O5
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1
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| 1 |
Ki = 624 nM
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CP0409436
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N-[2-(4-hydroxyphenyl)ethyl]-2-imino-8-methoxychromene-3-carboxamide
Show/Hide
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C19H18N2O4
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1
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| 1 |
Ki = 630.96 nM
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CP0455091
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8-(1-(4-fluoro-3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H22F4N6O2
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1
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| 1 |
Ki = 640 nM
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CP0384055
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1,1,1-trifluoropropan-2-yl 6-methyl-2-oxo-4-thiophen-3-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C13H13F3N2O3S
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1
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| 1 |
Ki = 643 nM
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CP0429843
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1-(2-ethylsulfanylethyl)-3,8-bis(furan-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
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C19H20N4O4S
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1
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| 1 |
Ki = 645.65 nM
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CP0300560
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3-Methyl-1-phenethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C14H14N4O2
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1
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| 1 |
Ki = 646 nM
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CP0396403
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propan-2-yl 2-(cyanoamino)-6-methyl-4-thiophen-3-yl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
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C14H16N4O2S
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1
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| 1 |
Ki = 647 nM
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CP0486451
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N-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenyl]-2-phenylacetamide
Show/Hide
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C25H27N5O3
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1
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| 1 |
Ki = 649 nM
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CP0378797
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8-(1-(2,4,6-trifluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H21F3N6O2
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1
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| 1 |
Ki = 650 nM
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CP0246514
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8-cyclopentyl-2-(3-methoxyphenyl)-1-propyl-7H-purin-6-one
Show/Hide
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C20H24N4O2
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2
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| 1 |
Ki = 650 nM
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| 2 |
Ki = 1100 nM
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CP0490176
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propan-2-yl 2-oxo-4-thiophen-3-yl-6-(trifluoromethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
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C13H13F3N2O3S
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1
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| 1 |
Ki = 651 nM
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CP0474525
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5-hydroxy-6-phenyl-1,3-dipropyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
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C18H21N3O3
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1
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| 1 |
Ki = 676 nM
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CP0869243
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2-[1-(R,S)-Methyl-2-phenylethylamino]-5'-(2-ethyl-2H-tetrazol-5-yl)adenosine
Show/Hide
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C21H26N10O3
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1
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| 1 |
Ki = 680 nM
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CP0367729
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7-(2-Chloro-ethyl)-8-phenyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C19H23ClN4O2
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1
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| 1 |
Ki = 691 nM
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CP0391111
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ethyl 5-methyl-7-thiophen-3-yl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate
Show/Hide
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C13H14N4O2S
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1
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| 1 |
Ki = 699.2 nM
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CP0378788
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8-(1-(2,4-difluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1Hpurine-2,6(3H,7H)-dione
Show/Hide
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C21H22F2N6O2
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1
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| 1 |
Ki = 700 nM
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CP0931233
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(+/-)-Ethyl 2-Methyl-4-(1H-pyrazol-3-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
|
C17H17N5O2
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1
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| 1 |
Ki = 707 nM
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CP0411023
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propan-2-yl 2-methyl-4-(1,3-oxazol-2-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O3
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1
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| 1 |
Ki = 708 nM
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CP0540755
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ethyl 2-methyl-4-(1,2-oxazol-5-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C17H16N4O3
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1
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| 1 |
Ki = 714 nM
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CP0469194
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ethyl 6-ethyl-4-(furan-2-yl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O4
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1
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| 1 |
Ki = 714.6 nM
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CP0416429
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propan-2-yl 2-methyl-4-(1,2-oxazol-3-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O3
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1
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| 1 |
Ki = 721 nM
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CP0407753
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propan-2-yl 7-methyl-5-thiophen-2-yl-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate
Show/Hide
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C15H17N3O2S
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1
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| 1 |
Ki = 728.1 nM
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CP0482920
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ethyl 4-(furan-2-yl)-2-(trifluoromethyl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
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C18H14F3N3O3
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1
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| 1 |
Ki = 731 nM
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CP0535108
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propan-2-yl 2-methyl-4-(1,3-thiazol-2-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O2S
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1
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| 1 |
Ki = 753 nM
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CP0416432
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ethyl 2-methyl-4-(1,3-oxazol-2-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C17H16N4O3
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1
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| 1 |
Ki = 769 nM
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CP0411021
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ethyl 2-methyl-4-(1,2-oxazol-3-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C17H16N4O3
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1
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| 1 |
Ki = 789 nM
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CP0499787
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propan-2-yl 5-methyl-7-thiophen-3-yl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate
Show/Hide
|
C14H16N4O2S
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1
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| 1 |
Ki = 816.7 nM
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CP0411127
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8-benzyl-1-(2-ethylsulfanylethyl)-3-(furan-2-ylmethyl)-7H-purine-2,6-dione
Show/Hide
|
C21H22N4O3S
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1
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| 1 |
Ki = 831.76 nM
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CP0037138
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5-Butyl-8-(4-ethoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
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C18H20N6O
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1
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| 1 |
Ki = 838 nM
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CP0420133
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propan-2-yl 7-methyl-5-thiophen-3-yl-5,8-dihydroimidazo[1,2-a]pyrimidine-6-carboxylate
Show/Hide
|
C15H17N3O2S
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1
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| 1 |
Ki = 847.3 nM
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CP0412424
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6-[2-methoxy-4-[2-oxo-2-(4-phenylpiperidin-1-yl)ethoxy]phenyl]-1,3-dimethyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-dione
Show/Hide
|
C28H30N4O5
|
1
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| 1 |
Ki = 891.25 nM
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CP0478242
|
ethyl 2-(cyanoamino)-4-(furan-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C13H14N4O3
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1
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| 1 |
Ki = 900 nM
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CP0312454
|
1-Cyclopentyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C10H12N4O2
|
1
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| 1 |
Ki = 965 nM
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CP0381985
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(2R,3R,4S,5R)-2-(6-amino-2-chloropurin-9-yl)-5-(2-ethyltetrazol-5-yl)oxolane-3,4-diol
Show/Hide
|
C12H14ClN9O3
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1
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| 1 |
Ki = 975 nM
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CP0378801
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8-(1-benzyl-1H-pyrazol-4-yl)-1,3-dibutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C23H28N6O2
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1
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| 1 |
Ki = 980 nM
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CP0503948
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8-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-diisobutyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C23H27FN6O2
|
1
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| 1 |
Ki = 990 nM
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CP0410144
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methyl (E)-2-cyano-3-(2-hydroxy-3-methoxyphenyl)prop-2-enoate
Show/Hide
|
C12H11NO4
|
1
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| 1 |
Ki = 1000 nM
|
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CP0416923
|
N-(2-hydroxy-2-phenylethyl)-2-imino-8-methoxychromene-3-carboxamide
Show/Hide
|
C19H18N2O4
|
1
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| 1 |
Ki = 1000 nM
|
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CP0430592
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2-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yloxy]-N-(3-methyl-1,4-dihydro-pyridin-4-yl)-acetamide
Show/Hide
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C23H28N8O4
|
1
|
| 1 |
Ki = 1012 nM
|
|
|
|
CP0106716
|
5-Butyl-8-(4-methoxy-phenyl)-3H-[1,2,4]triazolo[5,1-i]purine
Show/Hide
|
C17H18N6O
|
1
|
| 1 |
Ki = 1030 nM
|
|
|
|
CP0411044
|
propan-2-yl 2-methyl-4-(1,2-oxazol-5-yl)-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate
Show/Hide
|
C18H18N4O3
|
1
|
| 1 |
Ki = 1031 nM
|
|
|
|
CP0405717
|
2-[4-(2,4-dioxo-1-propyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)phenoxy]-N-phenylacetamide
Show/Hide
|
C23H22N4O4
|
1
|
| 1 |
Ki = 1047.13 nM
|
|
|
|
CP0529706
|
8-(1-phenyl-1H-pyrazol-5-yl)-1,3-dipropyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C20H22N6O2
|
1
|
| 1 |
Ki = 1100 nM
|
|
|
|
CP0429788
|
ethyl 6-methyl-2-sulfanylidene-4-thiophen-3-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C12H14N2O2S2
|
1
|
| 1 |
Ki = 1103 nM
|
|
|
|
CP0867319
|
(+/-)-Isopropyl 2-Methyl-4-(1H-pyrazol-3-yl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate
Show/Hide
|
C18H19N5O2
|
1
|
| 1 |
Ki = 1104 nM
|
|
|
|
CP0498672
|
1,3-Dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C11H16N4O2
|
1
|
| 1 |
Ki = 1110 nM
|
|
|
|
CP0406413
|
propan-2-yl 6-(furan-2-yl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
Show/Hide
|
C14H18N2O4
|
1
|
| 1 |
Ki = 1151 nM
|
|
|
|
CP0442213
|
(2R,3R,4S,5R)-2-{6-Amino-2-[(S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethylamino]-purin-9-yl}-5-(2-ethyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol
Show/Hide
|
C22H28N10O5
|
1
|
| 1 |
Ki = 1183 nM
|
|
|
|
CP0376069
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(3-nitrophenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H25N7O7
|
1
|
| 1 |
Ki = 1188 nM
|
|
|
|
CP0378793
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-diisobutyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C23H28N6O2
|
1
|
| 1 |
Ki = 1250 nM
|
|
|
|
CP0425964
|
N-(5-hydroxypentyl)-2-imino-8-methoxychromene-3-carboxamide
Show/Hide
|
C16H20N2O4
|
1
|
| 1 |
Ki = 1258.93 nM
|
|
|
|
CP0376070
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(3-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 1268 nM
|
|
|
|
CP0057366
|
(2R,3R,4S,5R)-2-(6-amino-2-((S)-1-hydroxy-3-phenylpropan-2-ylamino)-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydrofuran-3,4-diol
Show/Hide
|
C21H26N10O4
|
1
|
| 1 |
Ki = 1300 nM
|
|
|
|
CP0171808
|
4-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzenesulfonic acid
Show/Hide
|
C13H12N4O5S
|
1
|
| 1 |
Ki = 1330 nM
|
|
|
|
CP0511097
|
1,3-Diallyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C11H12N4O2
|
1
|
| 1 |
Ki = 1330 nM
|
|
|
|
CP0205725
|
N-(3,4-dihydroxyphenyl)-4-oxochromene-3-carboxamide
Show/Hide
|
C16H11NO5
|
1
|
| 1 |
Ki = 1350 nM
|
|
|
|
CP0405406
|
7-(2-Chloro-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C9H11ClN4O2
|
1
|
| 1 |
Ki = 1390 nM
|
|
|
|
CP0083160
|
2-(4-fluorophenoxy)-N-(7-methoxy-4-morpholin-4-yl-[1,3]thiazolo[5,4-c]pyridin-2-yl)-2-methylpropanamide
Show/Hide
|
C21H23FN4O4S
|
2
|
| 1 |
Ki = 1400 nM
|
|
|
| 2 |
Ki = 2000 nM
|
|
|
|
CP0407631
|
propan-2-yl 4-(furan-3-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O4
|
1
|
| 1 |
Ki = 1486 nM
|
|
|
|
CP0488532
|
8-(5-oxo-4-oxatricyclo[4.2.1.03,7]nonan-9-yl)-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C19H24N4O4
|
1
|
| 1 |
Ki = 1540 nM
|
|
|
|
CP0387845
|
propan-2-yl 6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O2S2
|
1
|
| 1 |
Ki = 1572 nM
|
|
|
|
CP0491756
|
5-[5-amino-2-(1,3-thiazol-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C14H11N7OS
|
1
|
| 1 |
Ki = 1586 nM
|
|
|
|
CP0150225
|
1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C8H10N4O2
|
1
|
| 1 |
Ki = 1620 nM
|
|
|
|
CP0395424
|
2-(4-Dimethylamino-phenyl)-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-acetamide
Show/Hide
|
C25H32N8O3
|
1
|
| 1 |
Ki = 1628 nM
|
|
|
|
CP0388718
|
5-hydroxy-1,3-dimethyl-6-phenyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C14H13N3O3
|
1
|
| 1 |
Ki = 1660 nM
|
|
|
|
CP0395862
|
N-[2,6-bis(1,3-benzodioxol-5-yl)pyrimidin-4-yl]propanamide
Show/Hide
|
C21H17N3O5
|
1
|
| 1 |
Ki = 1668 nM
|
|
|
|
CP0442961
|
1-Butyl-3-ethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C11H16N4O2
|
1
|
| 1 |
Ki = 1720 nM
|
|
|
|
CP0433742
|
2-(furan-2-yl)-N-(furan-2-ylmethyl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-amine
Show/Hide
|
C18H13N5O2
|
1
|
| 1 |
Ki = 1737.8 nM
|
|
|
|
CP0548502
|
2-[4-(1,3-dibenzyl-2,6-dioxo-7H-purin-8-yl)phenoxy]acetic acid
Show/Hide
|
C27H22N4O5
|
1
|
| 1 |
Ki = 1760 nM
|
|
|
|
CP0512321
|
1,3-Diethylxanthine
Show/Hide
|
C9H12N4O2
|
1
|
| 1 |
Ki = 1770 nM
|
|
|
|
CP0177665
|
propan-2-yl 3,4-dimethyl-2-oxo-6-thiophen-3-yl-1,6-dihydropyrimidine-5-carboxylate
Show/Hide
|
C14H18N2O3S
|
1
|
| 1 |
Ki = 1811 nM
|
|
|
|
CP0435534
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-phenylprop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H26N6O5
|
1
|
| 1 |
Ki = 1913 nM
|
|
|
|
CP0429600
|
1-(2-ethylsulfanylethyl)-8-(furan-2-ylmethyl)-3-(3-methoxypropyl)-7H-purine-2,6-dione
Show/Hide
|
C18H24N4O4S
|
1
|
| 1 |
Ki = 1995.26 nM
|
|
|
|
CP0018686
|
(2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylamino)-purin-9-yl]-tetrahydro-furan-2-carboxylic acid methylamide
Show/Hide
|
C18H19IN6O4
|
1
|
| 1 |
Ki = 2040 nM
|
|
|
|
CP0053428
|
1-[4-(furan-2-yl)-11-propyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-3-(4-methoxyphenyl)urea
Show/Hide
|
C21H20N8O3
|
2
|
| 1 |
Ki = 2056 nM
|
|
|
| 2 |
Ki = 2100 nM
|
|
|
|
CP0885838
|
4-Amino-N-[5-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-butyramide hydrochloride
Show/Hide
|
C19H29ClN8O3
|
1
|
| 1 |
Ki = 2065 nM
|
|
|
|
CP0467015
|
8-(1-ethyl-3-methyl-1H-pyrazol-5-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C17H24N6O2
|
1
|
| 1 |
Ki = 2100 nM
|
|
|
|
CP0461257
|
methyl 4-(furan-2-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C11H12N2O4
|
1
|
| 1 |
Ki = 2159 nM
|
|
|
|
CP0869224
|
2-[1-(R)-Methyl-2-phenylethylamino]-5'-(2-ethyl-2H-tetrazol-5-yl)adenosine
Show/Hide
|
C21H26N10O3
|
1
|
| 1 |
Ki = 2191 nM
|
|
|
|
CP0423216
|
5-hydroxy-1,3-dimethyl-6-p-tolyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione
Show/Hide
|
C15H15N3O3
|
1
|
| 1 |
Ki = 2239 nM
|
|
|
|
CP0391247
|
(2R,3R,4S,5R)-2-{6-Amino-2-[(S)-2-(4-bromo-phenyl)-1-hydroxymethyl-ethylamino]-purin-9-yl}-5-(2-ethyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol
Show/Hide
|
C21H25BrN10O4
|
1
|
| 1 |
Ki = 2261 nM
|
|
|
|
CP0378795
|
8-(1-benzyl-1H-pyrazol-4-yl)-1,3-dimethyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C17H16N6O2
|
1
|
| 1 |
Ki = 2300 nM
|
|
|
|
CP0099653
|
3-Methyl-1-(3-phenyl-propyl)-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C15H16N4O2
|
1
|
| 1 |
Ki = 2330 nM
|
|
|
|
CP0466883
|
9-Methyl-2-phenethyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine
Show/Hide
|
C16H16N8
|
1
|
| 1 |
Ki = 2330 nM
|
|
|
|
CP0394333
|
N,N-diethyl-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-amine
Show/Hide
|
C17H17N5O
|
1
|
| 1 |
Ki = 2398.83 nM
|
|
|
|
CP0451808
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(4-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 2481 nM
|
|
|
|
CP0394300
|
N-[2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]quinoxalin-4-yl]furan-2-carboxamide
Show/Hide
|
C18H11N5O3
|
1
|
| 1 |
Ki = 2511.89 nM
|
|
|
|
CP0401794
|
ethyl 4-(furan-2-yl)-6-methyl-2-oxo-3,4-dihydro-1H-pyridine-5-carboxylate
Show/Hide
|
C13H15NO4
|
1
|
| 1 |
Ki = 2536 nM
|
|
|
|
CP0372684
|
(2R,3R,4S,5R)-2-{6-Amino-2-[(S)-2-(4-chloro-phenyl)-1-hydroxymethyl-ethylamino]-purin-9-yl}-5-(2-ethyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol
Show/Hide
|
C21H25ClN10O4
|
1
|
| 1 |
Ki = 2715 nM
|
|
|
|
CP0871190
|
2-[1-(R)-Methyl-2-(4-methoxyphenyl)ethylamino]-5'-(2-ethyl-2H-tetrazol-5-yl)adenosine
Show/Hide
|
C22H28N10O4
|
1
|
| 1 |
Ki = 2780 nM
|
|
|
|
CP0231899
|
N-(4-hydroxyphenyl)-4-oxochromene-3-carboxamide
Show/Hide
|
C16H11NO4
|
1
|
| 1 |
Ki = 2890 nM
|
|
|
|
CP0406409
|
ethyl 3,4-dimethyl-2-oxo-6-thiophen-3-yl-1,6-dihydropyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O3S
|
1
|
| 1 |
Ki = 2968 nM
|
|
|
|
CP0387849
|
ethyl 3-acetyl-4-(furan-2-yl)-6-methyl-2-oxo-1,4-dihydropyrimidine-5-carboxylate
Show/Hide
|
C14H16N2O5
|
1
|
| 1 |
Ki = 3111 nM
|
|
|
|
CP0378855
|
N-[4,6-di(thiophen-3-yl)pyrimidin-2-yl]propanamide
Show/Hide
|
C15H13N3OS2
|
1
|
| 1 |
Ki = 3250 nM
|
|
|
|
CP0508572
|
1,3-Diallyl-7-methyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C12H14N4O2
|
1
|
| 1 |
Ki = 3390 nM
|
|
|
|
CP0467448
|
ethyl 4-(furan-2-yl)-6-methyl-2-oxo-1H-pyrimidine-5-carboxylate
Show/Hide
|
C12H12N2O4
|
1
|
| 1 |
Ki = 3428 nM
|
|
|
|
CP0037176
|
(2R,3R,4S,5R)-2-(6-(3-iodobenzylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
|
C17H18IN5O4
|
1
|
| 1 |
Ki = 3570 nM
|
|
|
|
CP0432866
|
(2R,3R,4S,5R)-2-{6-Amino-2-[(S)-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylamino]-purin-9-yl}-5-(2-ethyl-2H-tetrazol-5-yl)-tetrahydro-furan-3,4-diol
Show/Hide
|
C21H25N11O6
|
1
|
| 1 |
Ki = 3660 nM
|
|
|
|
CP0384311
|
N-(6-acetyl-5-pyridin-4-ylpyridin-2-yl)cyclopropanecarboxamide
Show/Hide
|
C16H15N3O2
|
1
|
| 1 |
Ki = 3668 nM
|
|
|
|
CP0446061
|
8-(1,3-dimethyl-1H-pyrazol-5-yl)-1,3-dipropyl-1H-purine-2,6-(3H,7H)-dione
Show/Hide
|
C16H22N6O2
|
1
|
| 1 |
Ki = 3700 nM
|
|
|
|
CP0436562
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(2-methoxyphenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C24H28N6O6
|
1
|
| 1 |
Ki = 3862 nM
|
|
|
|
CP0085146
|
3,7-Dimethyl-1-prop-2-ynyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C10H10N4O2
|
1
|
| 1 |
Ki = 4130 nM
|
|
|
|
CP0387852
|
ethyl 6-(furan-3-yl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O4
|
1
|
| 1 |
Ki = 4259 nM
|
|
|
|
CP0501289
|
3-Benzyl-1-methyl-9-thiophen-3-yl-pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-one
Show/Hide
|
C20H15N5OS
|
1
|
| 1 |
Ki = 4650 nM
|
|
|
|
CP0247766
|
3-Propyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C8H10N4O2
|
2
|
| 1 |
Ki = 4700 nM
|
|
|
| 2 |
Ki = 4730 nM
|
|
|
|
CP0378803
|
8-(1-(2-chloro-5-fluorobenzyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C21H22ClFN6O2
|
1
|
| 1 |
Ki = 4800 nM
|
|
|
|
CP0405677
|
3-Isopropyl-1-methyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C9H12N4O2
|
1
|
| 1 |
Ki = 4890 nM
|
|
|
|
CP0234129
|
A2A
Show/Hide
|
C19H26N4O4S
|
1
|
| 1 |
Ki = 5000 nM
|
|
|
|
CP0330093
|
2-(3,4-difluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H23F2N3O4S
|
1
|
| 1 |
Ki = 5000 nM
|
|
|
|
CP0237282
|
5-amino-3-[2-[4-[3-fluoro-4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-1-methyl-8-(1,3-thiazol-2-yl)-[1,2,4]triazolo[5,1-f]purin-2-one
Show/Hide
|
C25H29FN10O3S
|
1
|
| 1 |
Ki = 5000 nM
|
|
|
|
CP0102094
|
(2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
|
C17H17ClIN5O4
|
1
|
| 1 |
Ki = 5010 nM
|
|
|
|
CP0041221
|
1-(5-Oxohexyl)theobromine (pentoxifylline)
Show/Hide
|
C13H18N4O3
|
1
|
| 1 |
Ki = 5180 nM
|
|
|
|
CP0479961
|
3-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid
Show/Hide
|
C14H12N4O4
|
1
|
| 1 |
Ki = 5530 nM
|
|
|
|
CP0503048
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(1-hydroxycyclohexyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H30N6O5
|
1
|
| 1 |
Ki = 5533 nM
|
|
|
|
CP0404084
|
7-(3-Chloro-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C10H13ClN4O2
|
1
|
| 1 |
Ki = 5620 nM
|
|
|
|
CP0313187
|
N-(3-hydroxy-4-methoxyphenyl)-4-oxochromene-3-carboxamide
Show/Hide
|
C17H13NO5
|
1
|
| 1 |
Ki = 5820 nM
|
|
|
|
CP0457079
|
3-Isobutyl-1-(3-methyl-butyl)-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C14H22N4O2
|
1
|
| 1 |
Ki = 6240 nM
|
|
|
|
CP0429789
|
ethyl 6-methyl-2-sulfanylidene-4-thiophen-2-yl-3,4-dihydro-1H-pyrimidine-5-carboxylate
Show/Hide
|
C12H14N2O2S2
|
1
|
| 1 |
Ki = 6247 nM
|
|
|
|
CP0143008
|
N-(3,4-dimethoxyphenyl)-4-oxochromene-3-carboxamide
Show/Hide
|
C18H15NO5
|
1
|
| 1 |
Ki = 6390 nM
|
|
|
|
CP0136461
|
8-(4-Chloro-2-methoxy-phenyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C18H21ClN4O3
|
1
|
| 1 |
Ki = 6530 nM
|
|
|
|
CP0406416
|
ethyl 6-(furan-2-yl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate
Show/Hide
|
C13H16N2O4
|
1
|
| 1 |
Ki = 6544 nM
|
|
|
|
CP0311179
|
4-(5-butyl-1H-[1,2,4]triazolo[5,1-f]purin-8-yl)-N,N-dimethylaniline
Show/Hide
|
C18H21N7
|
1
|
| 1 |
Ki = 6660 nM
|
|
|
|
CP0527713
|
8-(4-Nitrophenyl)theophylline
Show/Hide
|
C13H11N5O4
|
1
|
| 1 |
Ki = 6940 nM
|
|
|
|
CP0110313
|
3-benzyl-1-methyl-9-phenylpyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-one
Show/Hide
|
C22H17N5O
|
1
|
| 1 |
Ki = 7560 nM
|
|
|
|
CP0375789
|
1,3-Dihexyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C17H28N4O2
|
1
|
| 1 |
Ki = 7580 nM
|
|
|
|
CP0424936
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((R,S)-3-hydroxy-3-(2-nitrophenyl)prop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H25N7O7
|
1
|
| 1 |
Ki = 7620 nM
|
|
|
|
CP0381594
|
(2S,3S,4R,5R)-5-(2-((R,S)-3-cyclopentyl-3-hydroxyprop-1-ynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H30N6O5
|
1
|
| 1 |
Ki = 7920 nM
|
|
|
|
CP0381502
|
(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((S)-3-hydroxyoct-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C22H32N6O5
|
1
|
| 1 |
Ki = 8473 nM
|
|
|
|
CP0292033
|
4-oxo-N-phenyl-4H-chromene-3-carboxamide
Show/Hide
|
C16H11NO3
|
1
|
| 1 |
Ki = 8510 nM
|
|
|
|
CP0525470
|
Acetic acid 2-(3,7-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-purin-1-yl)-ethyl ester
Show/Hide
|
C11H14N4O4
|
1
|
| 1 |
Ki = 8710 nM
|
|
|
|
CP0376071
|
(2S,3S,4R,5R)-5-(2-((R,S)-3-cyclohexyl-3-hydroxyprop-1-ynyl)-6-(ethylamino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
|
C23H32N6O5
|
1
|
| 1 |
Ki = 8970 nM
|
|
|
|
CP0042654
|
1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Show/Hide
|
C7H8N4O2
|
2
|
| 1 |
Ki = 9000 nM
|
|
|
| 2 |
Ki = 9070 nM
|
|
|
|
CP0502533
|
1,3-Dimethyl-7-prop-2-ynyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C10H10N4O2
|
1
|
| 1 |
Ki = 9460 nM
|
|
|
|
CP0512221
|
1,7-Dimethyl-3-prop-2-ynyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C10H10N4O2
|
1
|
| 1 |
Ki = 9480 nM
|
|
|
|
CP0456808
|
7-Allyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C10H12N4O2
|
1
|
| 1 |
Ki = 9490 nM
|
|
|
|
CP0403626
|
3-Isobutyl-1-(3-methyl-butyl)-8-phenyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C20H26N4O2
|
1
|
| 1 |
Ki = 9890 nM
|
|
|
|
CP0542569
|
5-[5-amino-2-(5-methyl-1,3-thiazol-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C15H13N7OS
|
1
|
| 1 |
Ki = 9919 nM
|
|
|
|
CP0294067
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)-N,N-bis(2-hydroxyethyl)benzenesulfonamide
Show/Hide
|
C22H24N8O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0375951
|
5-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-2-carboxylic acid ethyl ester
Show/Hide
|
C23H21N7O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0376218
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzonitrile
Show/Hide
|
C20H16N8O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0376596
|
5-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzo[d][1,3]dioxole-2,2-dicarboxylic acid
Show/Hide
|
C22H17N7O7
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0377048
|
7-(3-(4-(aminomethyl)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C20H20N8O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0383040
|
ethyl 2-[4-[2-[7-amino-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]phenoxy]acetate
Show/Hide
|
C22H21N7O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0383172
|
7-(3-(4-aminophenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H18N8O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0383255
|
N-[4-[2-[7-amino-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-10-yl]ethyl]phenyl]acetamide
Show/Hide
|
C20H18N8O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0383256
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)-N'-hydroxybenzimidamide
Show/Hide
|
C20H19N9O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0392763
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzenesulfonic acid
Show/Hide
|
C19H17N7O4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0393327
|
2-(furan-2-yl)-7-(3-phenylpropyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H17N7O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0404386
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)benzenesulfonamide
Show/Hide
|
C18H16N8O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0408894
|
4-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzoic acid ethyl ester
Show/Hide
|
C22H21N7O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0418184
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)-N,N-bis(2-chloroethyl)benzenesulfonamide
Show/Hide
|
C22H22Cl2N8O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0422125
|
5-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-2-carboxylic acid
Show/Hide
|
C21H17N7O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0422166
|
2-(furan-2-yl)-7-(4-(4-methylpiperazin-1-ylsulfonyl)phenethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C23H25N9O3S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0422758
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzoic acid
Show/Hide
|
C20H17N7O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0422849
|
4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzimidamide
Show/Hide
|
C20H19N9O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0430162
|
2-(4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)phenylsulfonamido)acetic acid
Show/Hide
|
C20H18N8O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0447324
|
2,2'-(4-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)phenylazanediyl)diethanol
Show/Hide
|
C23H26N8O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0460044
|
(5-(3-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)propyl)benzo[d][1,3]dioxole-2,2-diyl)dimethanol
Show/Hide
|
C22H21N7O5
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0462060
|
4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)benzenesulfonic acid
Show/Hide
|
C18H15N7O4S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0468028
|
7-(4-aminophenethyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C18H16N8O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0469720
|
2-(furan-2-yl)-7-(3-(4-nitrophenyl)propyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine
Show/Hide
|
C19H16N8O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0496241
|
2,2'-(4-(2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)ethyl)phenylazanediyl)diethanol
Show/Hide
|
C22H24N8O3
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0497710
|
6-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-5-sulfonic acid
Show/Hide
|
C20H17N7O6S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0847207
|
disodium 5-[3-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-propyl]-benzo[1,3]dioxole-2,2-dicarboxylic acid
Show/Hide
|
C22H15N7Na2O7
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0847208
|
N-{4-[2-(5-Amino-2-furan-2-yl-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-ethyl]-phenyl}-hydroxylamine
Show/Hide
|
C19H17N9O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0382067
|
4-(3-(2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C20H18N8O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0398582
|
4-(3-(8-butyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C21H20N8O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0401492
|
4-(3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C18H14N8O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0441668
|
4-(3-(8-ethyl-2-(furan-2-yl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)ureido)benzenesulfonic acid
Show/Hide
|
C19H16N8O5S
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0041258
|
(CGS21680) 3-(4-{2-[6-Amino-9-(5-ethylcarbamoylmethyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-ylamino]-ethyl}-phenyl)-propionic acid
Show/Hide
|
C23H29N7O6
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0409438
|
2-imino-N-[3-[(2-imino-8-methoxychromene-3-carbonyl)amino]propyl]-8-methoxychromene-3-carboxamide
Show/Hide
|
C25H24N4O6
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0439089
|
2-imino-N-[3-[4-[3-[(2-imino-8-methoxychromene-3-carbonyl)amino]propyl]piperazin-1-yl]propyl]-8-methoxychromene-3-carboxamide
Show/Hide
|
C32H38N6O6
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0323463
|
2-(4-fluorophenoxy)-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-2-methylpropanamide
Show/Hide
|
C22H24FN3O4S
|
1
|
| 1 |
Ki = 10000 nM
|
|
|
|
CP0130086
|
8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
|
C20H24N4O4
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0491757
|
5-[5-amino-2-(4-methyl-1,3-thiazol-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C15H13N7OS
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0498373
|
5-[5-amino-2-(5-methylfuran-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C16H14N6O2
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0533986
|
5-(5-amino-2-pyridin-2-yl-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl)-1-methylpyridin-2-one
Show/Hide
|
C16H13N7O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0571204
|
5-[5-amino-2-(6-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C17H15N7O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0571238
|
5-[5-amino-2-(2-methylpyrazol-3-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C15H14N8O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0575710
|
5-[5-amino-2-(1-methylpyrazol-3-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-8-yl]-1-methylpyridin-2-one
Show/Hide
|
C15H14N8O
|
1
|
| 1 |
Ki > 10000 nM
|
|
|
|
CP0094874
|
1-Benzyl-3-methyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C13H12N4O2
|
1
|
| 1 |
Ki = 10200 nM
|
|
|
|
CP0043620
|
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Show/Hide
|
C8H10N4O2
|
2
|
| 1 |
Ki = 10400 nM
|
|
|
| 2 |
Ki = 33800 nM
|
|
|
|
CP0420787
|
2-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzoic acid
Show/Hide
|
C14H12N4O4
|
1
|
| 1 |
Ki = 11100 nM
|
|
|
|
CP0210158
|
1-Allyl-3,7-dimethyl-8-phenyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C16H16N4O2
|
1
|
| 1 |
Ki = 11400 nM
|
|
|
|
CP0163656
|
(1R,2R,3S,4R,5S)-1-Hydroxymethyl-4-[6-(3-iodo-benzylamino)-purin-9-yl]-bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
|
C19H20IN5O3
|
1
|
| 1 |
Ki = 12100 nM
|
|
|
|
CP0503395
|
1-Methoxymethyl-3,7-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
|
C9H12N4O3
|
1
|
| 1 |
Ki = 14000 nM
|
|
|
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CP0502536
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(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetonitrile
Show/Hide
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C9H9N5O2
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1
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| 1 |
Ki = 14500 nM
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CP0193365
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7-(4-Chloro-butyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C11H15ClN4O2
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1
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| 1 |
Ki = 15000 nM
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CP0496975
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8-(2,4-Dinitro-phenyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C13H10N6O6
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1
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| 1 |
Ki = 15400 nM
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CP0420715
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7-(2-Hydroxy-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
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C9H12N4O3
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1
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| 1 |
Ki = 17300 nM
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CP0424122
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7-Benzyl-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C14H14N4O2
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1
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| 1 |
Ki = 19400 nM
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CP0399716
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N-cyclohexyl-2-imino-8-methoxychromene-3-carboxamide
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C17H20N2O3
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1
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| 1 |
Ki = 19952.62 nM
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CP0077413
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(2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Show/Hide
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C15H20ClN5O4
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1
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| 1 |
Ki = 20400 nM
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CP0453460
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3,7-Dimethyl-1-(2-oxo-propyl)-3,7-dihydro-purine-2,6-dione
Show/Hide
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C10H12N4O3
|
1
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| 1 |
Ki = 20800 nM
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CP0049200
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(2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Show/Hide
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C15H21N5O4
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1
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| 1 |
Ki = 21200 nM
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CP0381503
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(3-phenylprop-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C23H26N6O4
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1
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| 1 |
Ki = 21465 nM
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CP0512111
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(3,7-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-purin-1-yl)-acetonitrile
Show/Hide
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C9H9N5O2
|
1
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| 1 |
Ki = 21600 nM
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CP0420796
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Acetic acid 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-ethyl ester
Show/Hide
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C11H14N4O4
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1
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| 1 |
Ki = 23200 nM
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CP0512347
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7-(2-Amino-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Show/Hide
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C9H13N5O2
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1
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| 1 |
Ki = 23500 nM
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CP0534165
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(3,7-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-purin-1-yl)-acetic acid
Show/Hide
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C9H10N4O4
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1
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| 1 |
Ki = 23500 nM
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CP0376072
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-((S)-3-hydroxybut-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C18H24N6O5
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1
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| 1 |
Ki = 23800 nM
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CP0376044
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(5-phenylpent-1-ynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C25H30N6O4
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1
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| 1 |
Ki = 24057 nM
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CP0155498
|
2-CI Adenosine
Show/Hide
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C10H12ClN5O4
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1
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| 1 |
Ki = 25500 nM
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CP0453292
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(2S,3S,4R,5R)-N-ethyl-5-(6-(ethylamino)-2-(2-(1-hydroxycyclopentyl)ethynyl)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide
Show/Hide
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C21H28N6O5
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1
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| 1 |
Ki = 26466 nM
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CP0507079
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(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid
Show/Hide
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C9H10N4O4
|
1
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| 1 |
Ki = 27600 nM
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|
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CP0103764
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(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(3-iodo-benzylamino)-purin-9-yl]-1-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol
Show/Hide
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C19H19ClIN5O3
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1
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| 1 |
Ki = 41000 nM
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CP0082264
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(1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol
Show/Hide
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C11H15N5O3
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1
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| 1 |
Ki = 47300 nM
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CP0413019
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1,3-dipropyl-8-[3-[3-[3-(trifluoromethoxy)phenyl]prop-2-ynoxy]-1,2-oxazol-5-yl]-7H-purine-2,6-dione
Show/Hide
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C24H22F3N5O5
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1
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| 1 |
Ki > 600 nM
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CP0539293
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1,3-dipropyl-8-[3-[3-[3-(trifluoromethyl)phenyl]prop-2-ynoxy]-1,2-oxazol-5-yl]-7H-purine-2,6-dione
Show/Hide
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C24H22F3N5O4
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1
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| 1 |
Ki > 600 nM
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CP0567094
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1,3-dipropyl-8-[4-[3-[4-(trifluoromethoxy)phenyl]prop-2-ynoxy]phenyl]-7H-purine-2,6-dione
Show/Hide
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C27H25F3N4O4
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1
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| 1 |
Ki > 600 nM
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CP0376352
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2-(5-Morpholin-4-ylmethyl-furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
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C23H24N8O2
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1
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| 1 |
Ki > 1000 nM
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CP0376396
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8-Methyl-2-[5-(4-methyl-piperazin-1-ylmethyl)-furan-2-yl]-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
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C18H23N9OS
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1
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| 1 |
Ki > 1000 nM
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CP0384189
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4-(5-Amino-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-phenol
Show/Hide
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C20H17N7O
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1
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| 1 |
Ki > 1000 nM
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CP0394380
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4-(5-Amino-2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-9-ylamino)-phenol
Show/Hide
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C17H14N8O2
|
1
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| 1 |
Ki > 1000 nM
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CP0401422
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2-Furan-2-yl-N*9*-(4-methoxy-phenyl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5,9-diamine
Show/Hide
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C18H16N8O2
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1
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| 1 |
Ki > 1000 nM
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CP0409362
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2-[4-(5-Amino-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-phenoxy]-N-(4-iodo-phenyl)-acetamide
Show/Hide
|
C28H23IN8O2
|
1
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| 1 |
Ki > 1000 nM
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|
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CP0430285
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7-Phenethyl-2-phenyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C20H17N7
|
1
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| 1 |
Ki > 1000 nM
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CP0436749
|
ethyl 2-[4-[7-amino-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-4-yl]phenoxy]acetate
Show/Hide
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C24H23N7O3
|
1
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| 1 |
Ki > 1000 nM
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|
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CP0453036
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2-[4-[7-amino-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-4-yl]phenoxy]acetic acid
Show/Hide
|
C22H19N7O3
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1
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| 1 |
Ki > 1000 nM
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|
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CP0453430
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2-(4-Chloro-phenyl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C20H16ClN7
|
1
|
| 1 |
Ki > 1000 nM
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|
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CP0480975
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2-[5-(4-Methyl-piperazin-1-ylmethyl)-furan-2-yl]-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C24H27N9O
|
1
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| 1 |
Ki > 1000 nM
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CP0487506
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2-(2-Ethoxy-phenyl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
Show/Hide
|
C22H21N7O
|
1
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| 1 |
Ki > 1000 nM
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CP0371890
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2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-[4-(2-methylpropyl)phenyl]acetamide
Show/Hide
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C27H35N7O3
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1
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| 1 |
Ki > 1000 nM
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CP0373434
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N-(4-chlorophenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-ethylpyrazol-1-yl]acetamide
Show/Hide
|
C24H28ClN7O3
|
1
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| 1 |
Ki > 1000 nM
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CP0373436
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N-[4-(dimethylamino)phenyl]-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]acetamide
Show/Hide
|
C25H32N8O3
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1
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| 1 |
Ki > 1000 nM
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CP0440939
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2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-5-methylpyrazol-1-yl]-N-naphthalen-1-ylacetamide
Show/Hide
|
C27H29N7O3
|
1
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| 1 |
Ki > 1000 nM
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CP0459941
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N-(4-chlorophenyl)-2-[3-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-4-iodo-5-methylpyrazol-1-yl]acetamide
Show/Hide
|
C23H25ClIN7O3
|
1
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| 1 |
Ki > 1000 nM
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CP0376492
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4-[[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]amino]-4-oxobutanoic acid
Show/Hide
|
C19H25N7O5
|
1
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| 1 |
Ki > 1000 nM
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CP0380221
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(S)-N-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-2-phenyl-propionamide
Show/Hide
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C24H29N7O3
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1
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| 1 |
Ki > 1000 nM
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|
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CP0392677
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(R)-N-[5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol-3-yl]-2-phenyl-propionamide
Show/Hide
|
C24H29N7O3
|
1
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| 1 |
Ki > 1000 nM
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|
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CP0414779
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2-[6-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-pyridazin-3-yloxy]-N-(4-iodo-phenyl)-acetamide
Show/Hide
|
C23H24IN7O4
|
1
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| 1 |
Ki > 1000 nM
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|
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CP0426011
|
5-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-2-methyl-2H-pyrazole-3-carboxylic acid
Show/Hide
|
C16H20N6O4
|
1
|
| 1 |
Ki > 1000 nM
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|
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CP0426029
|
N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-(3,4,5-trimethoxyphenyl)acetamide
Show/Hide
|
C26H33N7O6
|
1
|
| 1 |
Ki > 1000 nM
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|
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CP0489978
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N-[5-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)-1-methylpyrazol-3-yl]-2-[4-(2-methylpropyl)phenyl]acetamide
Show/Hide
|
C27H35N7O3
|
1
|
| 1 |
Ki > 1000 nM
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CP0480462
|
8-[2-methyl-5-(7H-purin-8-ylmethoxy)pyrazol-3-yl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C21H24N10O3
|
1
|
| 1 |
Ki > 1000 nM
|
|
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CP0476581
|
8-[4-[3-(3-fluorophenyl)prop-2-ynoxy]phenyl]-1,3-dipropyl-7H-purine-2,6-dione
Show/Hide
|
C26H25FN4O3
|
1
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| 1 |
Ki > 1000 nM
|
|
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CP0134329
|
9-(3-chlorobenzyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimido[1,2-a]purine-2,4(1H,3H)-dione
Show/Hide
|
C17H18ClN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
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CP0360696
|
10-[(3-bromophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20BrN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
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CP0360697
|
10-[(4-chlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20ClN5O2
|
1
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| 1 |
Ki > 1000 nM
|
|
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CP0410873
|
10-[(2-bromophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20BrN5O2
|
1
|
| 1 |
Ki > 1000 nM
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|
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CP0410874
|
10-[(3-bromo-4-fluorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H19BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
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CP0410875
|
10-[(2-fluorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20FN5O2
|
1
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| 1 |
Ki > 1000 nM
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CP0410876
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10-[(2-methoxyphenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C19H23N5O3
|
1
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| 1 |
Ki > 1000 nM
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|
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CP0420992
|
6-[(3-bromophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H16BrN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
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CP0420993
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1,3-dimethyl-9-[(3,4,5-trifluorophenyl)methyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H16F3N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0420994
|
9-[(2-bromophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H18BrN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0420996
|
6-[(3,4-dichlorophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H15Cl2N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446832
|
1,3-dimethyl-9-[(2-methylphenyl)methyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H21N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446833
|
10-[(2-chlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H20ClN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446834
|
6-[(4-chlorophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H16ClN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446835
|
1,3-dimethyl-9-[(3-methylphenyl)methyl]-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H21N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446836
|
10-[(2,4-dichlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
Show/Hide
|
C18H19Cl2N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446837
|
6-[(2-bromophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H16BrN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446838
|
9-[(3-bromo-4-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446970
|
9-[(5-bromo-2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446972
|
9-[[4-chloro-3-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H17ClF3N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
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CP0446973
|
9-[(2-chloro-4-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C17H17ClFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446988
|
6-[(3-bromo-4-fluorophenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
Show/Hide
|
C16H15BrFN5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0446989
|
9-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
|
C18H17ClF3N5O2
|
1
|
| 1 |
Ki > 1000 nM
|
|
|
|
CP0460949
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9-[(4-chloro-2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C17H17ClFN5O2
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1
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| 1 |
Ki > 1000 nM
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CP0460950
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9-[(3-bromophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C17H18BrN5O2
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1
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| 1 |
Ki > 1000 nM
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CP0460951
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6-[(2-methoxyphenyl)methyl]-2,4-dimethyl-7,8-dihydropurino[7,8-a]imidazole-1,3-dione
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C17H19N5O3
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1
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| 1 |
Ki > 1000 nM
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CP0460952
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1,3-dimethyl-9-(2-pyridin-4-ylethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C17H20N6O2
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1
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| 1 |
Ki > 1000 nM
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CP0460953
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9-[(3-chloro-4-methoxyphenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C18H20ClN5O3
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1
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| 1 |
Ki > 1000 nM
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CP0460955
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1,3-dimethyl-9-(thiophen-2-ylmethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C15H17N5O2S
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1
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| 1 |
Ki > 1000 nM
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CP0460956
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9-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C17H17ClFN5O2
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1
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| 1 |
Ki > 1000 nM
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CP0460957
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1,3-dimethyl-9-(2-pyridin-3-ylethyl)-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C17H20N6O2
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1
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| 1 |
Ki > 1000 nM
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CP0463490
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9-[(4-bromo-2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C17H17BrFN5O2
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1
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| 1 |
Ki > 1000 nM
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CP0468800
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10-[(3,4-dichlorophenyl)methyl]-1,3-dimethyl-6,7,8,9-tetrahydropurino[7,8-a][1,3]diazepine-2,4-dione
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C18H19Cl2N5O2
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1
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| 1 |
Ki > 1000 nM
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CP0468836
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9-[(2-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
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C17H18FN5O2
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1
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| 1 |
Ki > 1000 nM
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CP0477295
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9-[(2,5-dichlorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C17H17Cl2N5O2
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1
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| 1 |
Ki > 1000 nM
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CP0482902
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9-[(6-chloro-2-fluoro-3-methoxyphenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
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C18H19ClFN5O3
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1
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| 1 |
Ki > 1000 nM
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CP0482946
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9-[(4-chloro-3-fluorophenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
Show/Hide
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C17H17ClFN5O2
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1
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| 1 |
Ki > 1000 nM
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CP0490278
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9-[(4-tert-butylphenyl)methyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
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C21H27N5O2
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1
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| 1 |
Ki > 1000 nM
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CP0453747
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8-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
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C21H24N6O2
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1
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| 1 |
Ki > 4100 nM
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CP0446060
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7-N-benzyl-1,3-dipropyl-8-(N-1-pyrazolyl)xanthine
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C21H24N6O2
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1
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| 1 |
Ki > 5800 nM
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CP0446062
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7-N-benzyl-1,3-dipropyl-8-[N-1-(4-iodo)pyrazolyl]xanthine
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C21H23IN6O2
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1
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| 1 |
Ki > 5800 nM
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CP0529707
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1,3-dipropyl-8-(N-1-pyrazolyl)xanthine
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C14H18N6O2
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1
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| 1 |
Ki > 5800 nM
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CP0372918
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8-(1-benzyl-1H-pyrazol-4-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione
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C16H14N6O2
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1
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| 1 |
Ki > 6000 nM
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CP0405105
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8-(1-benzyl-1H-pyrazol-4-yl)-3-isobutyl-1H-purine-2,6(3H,7H)-dione
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C19H20N6O2
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1
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| 1 |
Ki > 6000 nM
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CP0405153
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8-(1-benzyl-1H-pyrazol-4-yl)-3-ethyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C17H16N6O2
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1
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| 1 |
Ki > 6000 nM
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CP0457684
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8-(1-benzyl-1H-pyrazol-4-yl)-3-butyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C19H20N6O2
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1
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| 1 |
Ki > 6000 nM
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CP0457686
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1-benzyl-8-(1-benzyl-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H18N6O2
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1
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| 1 |
Ki > 6000 nM
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CP0457865
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8-(1-benzyl-1H-pyrazol-4-yl)-3-propyl-1H-purine-2,6(3H,7H)-dione
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C18H18N6O2
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1
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| 1 |
Ki > 6000 nM
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CP0525667
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3-benzyl-8-(1-benzyl-1H-pyrazol-4-yl)-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C22H18N6O2
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1
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| 1 |
Ki > 6000 nM
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CP0374794
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ethyl 1-[6-(cyclopentylamino)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
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C21H27N7O6
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1
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| 1 |
Ki > 6000 nM
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CP0374795
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1-(6-(p-toluidino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
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C23H26N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0374796
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2-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-9H-purin-6-ylamino)isonicotinic acid
Show/Hide
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C20H20N8O7
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1
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| 1 |
Ki > 6000 nM
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CP0374797
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1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxamide
Show/Hide
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C19H24N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0426958
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N-[(4-chlorophenyl)methyl]-1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carboxamide
Show/Hide
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C25H27ClN8O6
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1
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| 1 |
Ki > 6000 nM
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CP0426959
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N-benzyl-1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carboxamide
Show/Hide
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C25H28N8O6
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1
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| 1 |
Ki > 6000 nM
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CP0427011
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(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(pyrazin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
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C18H19N9O5
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1
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| 1 |
Ki > 6000 nM
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CP0427018
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(2R,3R,4S,5R)-2-(6-(cyclopentylamino)-2-(1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
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C18H23N7O4
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1
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| 1 |
Ki > 6000 nM
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CP0427023
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1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(quinolin-2-ylamino)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
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C25H25N9O5
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1
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| 1 |
Ki > 6000 nM
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CP0427026
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1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid
Show/Hide
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C19H23N7O6
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1
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| 1 |
Ki > 6000 nM
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CP0428481
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(2R,3R,4S,5R)-2-(6-(p-toluidino)-2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
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C21H23N7O5
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1
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| 1 |
Ki > 6000 nM
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CP0428515
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(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(pyridin-4-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
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C19H20N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0430041
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1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]-N-[(4-fluorophenyl)methyl]pyrazole-4-carboxamide
Show/Hide
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C25H27FN8O6
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1
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| 1 |
Ki > 6000 nM
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CP0433746
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1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C19H24N8O6
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1
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| 1 |
Ki > 6000 nM
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CP0435267
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ethyl 1-[6-(cyclohexylamino)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
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C22H29N7O6
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1
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| 1 |
Ki > 6000 nM
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CP0435268
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(2R,3R,4S,5R)-2-(6-(bicyclo[2.2.1]heptan-1-ylamino)-2-(1H-pyrazol-1-yl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol
Show/Hide
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C20H25N7O4
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1
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| 1 |
Ki > 6000 nM
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CP0435271
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1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid
Show/Hide
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C18H21N7O7
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1
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| 1 |
Ki > 6000 nM
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CP0435272
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1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
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C21H28N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0435273
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1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-N-propyl-1H-pyrazole-4-carboxamide
Show/Hide
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C21H28N8O6
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1
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| 1 |
Ki > 6000 nM
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CP0435274
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1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
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C20H26N8O6
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1
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| 1 |
Ki > 6000 nM
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CP0435639
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ethyl 1-[6-(1-bicyclo[2.2.1]heptanylamino)-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
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C23H29N7O6
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1
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| 1 |
Ki > 6000 nM
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CP0435640
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1-(6-(cyclohexylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C21H28N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0435642
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(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(quinazolin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
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C22H21N9O5
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1
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| 1 |
Ki > 6000 nM
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CP0437821
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1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-(pyridin-4-ylamino)-9H-purin-2-yl)-N-ethyl-1H-pyrazole-4-carboxamide
Show/Hide
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C21H23N9O5
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1
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| 1 |
Ki > 6000 nM
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CP0440380
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1-(6-(bicyclo[2.2.1]heptan-1-ylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-1H-pyrazole-4-carboxylic acid
Show/Hide
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C21H25N7O6
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1
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| 1 |
Ki > 6000 nM
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CP0445455
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(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(quinolin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
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C23H22N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0445456
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4-((1-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-6-((R)-tetrahydrofuran-2-ylamino)-9H-purin-2-yl)-1H-pyrazole-4-carboxamido)methyl)benzoic acid
Show/Hide
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C26H28N8O8
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1
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| 1 |
Ki > 6000 nM
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CP0449467
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ethyl 1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carboxylate
Show/Hide
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C20H25N7O7
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1
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| 1 |
Ki > 6000 nM
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CP0449772
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1-(6-(cyclopentylamino)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-9H-purin-2-yl)-N-methyl-1H-pyrazole-4-carboxamide
Show/Hide
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C20H26N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0449773
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(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(4-(trifluoromethyl)phenylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
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C21H20F3N7O5
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1
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| 1 |
Ki > 6000 nM
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CP0461923
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ethyl 4-[[[1-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-[[(2R)-oxolan-2-yl]amino]purin-2-yl]pyrazole-4-carbonyl]amino]methyl]benzoate
Show/Hide
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C28H32N8O8
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1
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| 1 |
Ki > 6000 nM
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CP0465225
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(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-(4-(hydroxymethyl)-1H-pyrazol-1-yl)-6-(pyridin-2-ylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol
Show/Hide
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C19H20N8O5
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1
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| 1 |
Ki > 6000 nM
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CP0464558
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8-(1-(4-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H20ClF3N6O2
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1
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| 1 |
Ki > 6600 nM
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CP0529704
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8-(5-(trifluoromethyl)-1-phenyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C21H21F3N6O2
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1
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| 1 |
Ki > 6600 nM
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CP0529705
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8-(1-phenyl-5-propyl-1H-pyrazol-4-yl)-1,3-dipropyl-1H-purine-2,6(3H,7H)-dione
Show/Hide
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C23H28N6O2
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1
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| 1 |
Ki > 6600 nM
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