Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
 Cell Line Info 
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01252 , Serine/threonine-protein kinase PLK1
 Protein Info 
Gene Name PLK1
Organism Homo sapiens, Human
Protein Classification Kinase
Uniprot ID P53350
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006
 Cell Line Info 
 Protein ID: PT01252
 Protein Info 
 
Compound ID Compound Name Compound Formula
CP0113988
 Compound Info 
CEP-32496
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C24H22F3N5O5
  1
1
Kd > 10000 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0044060
 Compound Info 
4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C28H39N7O3
  1
1
Ki = 0.22 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0148394
 Compound Info 
4-[[(7S)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C28H39N7O3
  1
1
Ki = 0.42 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0443651
 Compound Info 
4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C28H39N7O3
  1
1
Ki = 0.52 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0134906
 Compound Info 
4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-cyclopentyloxy-N-(1-methylpiperidin-4-yl)benzamide
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C32H45N7O3
  1
1
Ki = 0.84 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0201392
 Compound Info 
4-[[(7R)-8-cyclopentyl-5,7-diethyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C29H41N7O3
  1
1
Ki = 0.91 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0388691
 Compound Info 
4-[[(7R)-5,7-dibenzyl-8-cyclopentyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C39H45N7O3
  1
1
Ki = 4.2 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0443649
 Compound Info 
4-[[(7R)-8-[(3-bromophenyl)methyl]-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C30H36BrN7O3
  1
1
Ki = 5.8 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0463089
 Compound Info 
4-[[(7R)-7-ethyl-5-methyl-8-(2-methylpropyl)-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C27H39N7O3
  1
1
Ki = 6.95 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS
CP0201390
 Compound Info 
4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]oxy]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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C28H38N6O4
  1
1
Ki = 240 nM
 Bioactivity Info 
   TI
   LI
   LO
   TS