Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide
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 PubChem ID
CID: 11364421
SID: 16456896
Canonical SMILES
CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O
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Compound Formula C28H39N7O3
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase PLK1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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Other protein kinase group
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Other protein kinase PLK family
Uniprot ID
P53350
Gene Name
PLK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 0.22 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.083 nM
2 IC50 = 0.8 nM
3 IC50 = 0.83 nM
4 IC50 < 2.6 nM
5 IC50 = 4 nM
6 IC50 = 8 nM
7 IC50 = 106 nM
8 Kd = 0.19 nM
9 Ki = 3 nM