Brief Information of the Cell Line and Protein
Cell Line ID: CL000006 , HEK293
Synonyms
Hek293
HEK-293
HEK/293
HEK 293
HEK;293
293
293 HEK
293 Ad5
Graham 293
Graham-293
Human Embryonic Kidney 293
Category Transformed cell line
Organism
Homo sapiens (Human)
Cellosaurus ID
CVCL_0045
Protein ID: PT01121 , Motilin receptor
Gene Name MLNR
Organism Homo sapiens, Human
Protein Classification Membrane receptor
Uniprot ID O43193
Table of Molecular Bioactivities Related to the Cell Line and Protein
Cell Line ID: CL000006  Protein ID: PT01121
 
Compound ID Compound Name Compound Formula
CP0498201
[4-(3,4-difluoroanilino)piperidin-1-yl]-[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]methanone
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C30H35F2N5O
 1
1
EC50 = 1.995 nM
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CP0401369
[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone
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C31H37FN4O
 1
1
EC50 = 2.512 nM
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CP0471932
N-[[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-N-methyl-2-phenylsulfanylacetamide
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C29H35N3OS
 1
1
EC50 = 3.162 nM
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CP0498202
[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]-3-fluorophenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone
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C30H35F2N5O
 1
1
EC50 = 3.981 nM
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CP0230639
(4-anilinopiperidin-1-yl)-[2-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methanone
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C31H38N4O
 1
1
EC50 = 5.012 nM
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CP0538040
[3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]-3-methoxyphenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone
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C31H38FN5O2
 1
1
EC50 = 5.012 nM
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CP0505221
[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(3-fluoroanilino)piperidin-1-yl]methanone
   Show/Hide
C30H36FN5O
 1
1
EC50 = 6.31 nM
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CP0276373
4'-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-biphenyl-2-carboxylic acid ethyl-phenethyl-amide
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C30H37N3O
 1
1
EC50 = 7.943 nM
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CP0095130
[2-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]methanone
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C32H38FN3O
 1
1
EC50 = 10 nM
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CP0320332
[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-[(4-fluorophenyl)methyl]piperidin-1-yl]methanone
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C31H37FN4O
 1
1
EC50 = 10 nM
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CP0364569
2-Benzenesulfonyl-N-[4'-((3R,5S)-3,5-dimethyl-piperazin-1-ylmethyl)-biphenyl-2-ylmethyl]-N-methyl-acetamide
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C29H35N3O3S
 1
1
EC50 = 10 nM
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CP0547803
[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]-3-fluorophenyl]pyridin-2-yl]-[4-(3-fluoroanilino)piperidin-1-yl]methanone
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C30H35F2N5O
 1
1
EC50 = 10 nM
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CP0035879
[1-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]imidazol-2-yl]-[4-(3-fluoroanilino)piperidin-1-yl]methanone
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C28H35FN6O
 1
1
EC50 = 15.85 nM
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CP0035877
(3-(4-(((3R,5S)-3,5-dimethylpiperazin-1-yl)methyl)phenyl)pyridin-2-yl)(4-(4-fluorophenylamino)piperidin-1-yl)methanone
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C30H36FN5O
 1
1
EC50 = 19.95 nM
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CP0498200
3-[[1-[3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridine-2-carbonyl]piperidin-4-yl]amino]benzonitrile
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C31H36N6O
 1
1
EC50 = 19.95 nM
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CP0547802
N-[[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-N-methyl-2-[(4-methylphenyl)sulfonylamino]acetamide
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C30H38N4O3S
 1
1
EC50 = 19.95 nM
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CP0498974
N-[[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-2-(4-fluorophenoxy)-N-methylacetamide
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C29H34FN3O2
 1
1
EC50 = 31.62 nM
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CP0131787
3-Cyclohexyl-1-[4'-((3R,5S)-3,5-dimethyl-piperazin-1-ylmethyl)-biphenyl-2-ylmethyl]-1-[2-(3-methoxy-phenyl)-ethyl]-urea
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C36H48N4O2
 1
1
EC50 = 50.12 nM
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CP0167645
[4-(4-chloroanilino)piperidin-1-yl]-[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methanone
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C31H37ClN4O
 1
1
EC50 = 50.12 nM
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CP0511949
[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(2-fluoroanilino)piperidin-1-yl]methanone
   Show/Hide
C30H36FN5O
 1
1
EC50 = 50.12 nM
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CP0538039
N-[[2-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-2-(4-fluorophenyl)-N-methylacetamide
   Show/Hide
C29H34FN3O
 1
1
EC50 = 50.12 nM
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CP0136344
[1-[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]benzoyl]piperidin-4-yl]-(4-fluorophenyl)methanone
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C32H36FN3O2
 1
1
EC50 = 63.1 nM
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CP0230640
[2-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]-[4-(4-fluorophenoxy)piperidin-1-yl]methanone
   Show/Hide
C31H36FN3O2
 1
1
EC50 = 63.1 nM
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CP0035870
N-[[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-N-methyl-2-phenoxyacetamide
   Show/Hide
C29H35N3O2
 1
1
EC50 = 79.43 nM
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CP0320333
2-(3-Chloro-phenyl)-N-[4'-((3R,5S)-3,5-dimethyl-piperazin-1-ylmethyl)-biphenyl-2-ylmethyl]-N-methyl-acetamide
   Show/Hide
C29H34ClN3O
 1
1
EC50 = 79.43 nM
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CP0418599
3-cyclohexyl-1-[2-(3-methoxyphenyl)ethyl]-1-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]urea
   Show/Hide
C34H44N4O2
 1
1
EC50 = 100 nM
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CP0372334
N-[2-(3-methoxyphenyl)ethyl]-2-phenoxy-N-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]acetamide
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C35H39N3O3
 1
1
EC50 = 251.19 nM
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CP0471933
N-[[2-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-N,4-dimethylpentanamide
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C27H39N3O
 1
1
EC50 = 251.19 nM
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CP0496210
N-(3-methoxypropyl)-2-phenoxy-N-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]acetamide
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C30H37N3O3
 1
1
EC50 = 398.11 nM
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CP0517057
[2-[5-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]-1,3-thiazol-2-yl]phenyl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone
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C28H34FN5OS
 1
1
EC50 = 398.11 nM
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CP0515822
3-cyclohexyl-1-(3-methoxypropyl)-1-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]urea
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C29H42N4O2
 1
1
EC50 = 501.19 nM
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CP0494563
N-(3-methoxypropyl)-N-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]acetamide
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C24H33N3O2
 1
1
EC50 = 630.96 nM
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CP0510508
4-fluoro-N-(3-methoxypropyl)-N-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]benzenesulfonamide
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C28H34FN3O3S
 1
1
EC50 = 630.96 nM
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CP0055087
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
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C37H67NO13
 1
1
EC50 = 630.96 nM
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CP0498199
4-[[1-[3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridine-2-carbonyl]piperidin-4-yl]amino]benzonitrile
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C31H36N6O
 1
1
EC50 = 630.96 nM
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CP0522114
2-[[1-[3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridine-2-carbonyl]piperidin-4-yl]amino]benzonitrile
   Show/Hide
C31H36N6O
 1
1
EC50 = 794.33 nM
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CP0491298
N-[2-(3-methoxyphenyl)ethyl]-2-phenyl-N-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]acetamide
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C35H39N3O2
 1
1
EC50 = 1000 nM
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CP0095129
N-[[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-N-methyl-2-(3-methyl-1,2-oxazol-5-yl)acetamide
   Show/Hide
C27H34N4O2
 1
1
EC50 = 1000 nM
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CP0516040
[3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(4-methoxyanilino)piperidin-1-yl]methanone
   Show/Hide
C31H39N5O2
 1
1
EC50 = 1000 nM
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CP0504206
3-cyclohexyl-1-(2-phenylethyl)-1-[[2-[3-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]urea
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C33H42N4O
 1
1
EC50 = 1584.89 nM
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CP0479353
4-[[1-[3-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridine-2-carbonyl]piperidin-4-yl]amino]benzamide
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C31H38N6O2
 1
1
EC50 = 2511.89 nM
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CP0517058
[1-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyrrolidin-2-yl]-[4-(3-fluoroanilino)piperidin-1-yl]methanone
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C29H40FN5O
 1
1
EC50 = 2511.89 nM
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CP0522406
2-(3-methoxyphenyl)-N-[[2-[4-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]ethanamine
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C27H33N3O
 1
1
EC50 = 5011.87 nM
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CP0498198
N-[1-[2-[4-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]benzoyl]piperidin-4-yl]-4-fluorobenzamide
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C32H37FN4O2
 1
1
EC50 > 10000 nM
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CP0517056
[2-[5-[[(3R,5S)-3,5-dimethylpiperazin-1-yl]methyl]pyridin-2-yl]phenyl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone
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C30H36FN5O
 1
1
EC50 > 10000 nM
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CP0245273
4-fluoro-N-[[3-[(3-nitrophenyl)methyl-(2,2,2-trichloroacetyl)amino]cyclohexyl]methyl]-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide
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C35H38Cl3FN4O5
 1
1
IC50 = 52 nM
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CP0153657
N-[[3-[(3-chlorophenyl)methyl-(2,2,2-trichloroacetyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-piperidin-1-ylethoxy)phenyl]benzamide
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C36H40Cl4FN3O3
 1
1
IC50 = 228 nM
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CP0274921
N-[[3-[(3-chlorophenyl)methyl-(2,2,2-trichloroacetyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide
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C35H38Cl4FN3O3
 1
1
IC50 = 267 nM
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CP0153658
N-[[(1S,3R)-3-[benzyl(2,2-dimethylpropanoyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide
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C38H48FN3O3
 1
1
IC50 = 338 nM
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CP0288441
N-[[3-[benzyl(2,2-dimethylpropanoyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide
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C38H48FN3O3
 1
1
IC50 = 990 nM
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CP0131898
N-[[(1R,3S)-3-[benzyl(2,2-dimethylpropanoyl)amino]cyclohexyl]methyl]-4-fluoro-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]benzamide
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C38H48FN3O3
 1
1
IC50 = 2480 nM
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