Brief Information of the Compound and Protein
Compound Name
(6R,12S)-17-amino-12-methyl-6,15-bis(trifluoromethyl)-13,19-dioxa-3,4,18-triazatricyclo[12.3.1.12,5]nonadeca-1(17),2,4,14(18),15-pentaen-6-ol
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Canonical SMILES
C[C@H]1CCCCC[C@@](O)(c2nnc(o2)-c2nc(O1)c(cc2N)C(F)(F)F)C(F)(F)F
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Compound Formula C17H18F6N4O3
Compound Structure
Protein Name
Cystic fibrosis transmembrane conductance regulator
Protein Classification
Ion channel
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Other ion channel
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Chloride channel
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Cystic fibrosis transmembrane conductance regulator
Uniprot ID
P13569
Gene Name
CFTR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000805 HBE1 Homo sapiens (Human)  1
1
EC50 < 500 nM
   TI
   LI
   LO
   TS