Brief Information of the Compound and Protein
Compound Name
1-ethyl-3-[(2S)-1,1,1,5,5,5-hexafluoropentan-2-yl]-1-[(1S)-2,2,2-trifluoro-1-[5-methoxy-4-(7-methoxy-3-methylbenzimidazol-5-yl)pyridin-2-yl]ethyl]urea
    Show/Hide
Canonical SMILES
CCN([C@@H](c1cc(c(OC)cn1)-c1cc(OC)c2ncn(C)c2c1)C(F)(F)F)C(=O)N[C@@H](CCC(F)(F)F)C(F)(F)F
    Show/Hide
Compound Formula C25H26F9N5O3
Compound Structure
Protein Name
Orexin receptor type 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Orexin receptor
Uniprot ID
O43614
Gene Name
HCRTR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 29.8 nM
   TI
   LI
   LO
   TS