Brief Information of the Compound and Protein
Compound Name
1-ethyl-3-[(2S)-1,1,1,5,5,5-hexafluoropentan-2-yl]-1-[2,2,2-trifluoro-1-[5-methoxy-4-(8-methoxyimidazo[1,2-b]pyridazin-6-yl)pyridin-2-yl]ethyl]urea
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Canonical SMILES
CCN(C(c1cc(c(OC)cn1)-c1cc(OC)c2nccn2n1)C(F)(F)F)C(=O)N[C@@H](CCC(F)(F)F)C(F)(F)F
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Compound Formula C23H23F9N6O3
Compound Structure
Protein Name
Orexin receptor type 2
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Orexin receptor
Uniprot ID
O43614
Gene Name
HCRTR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 = 4.7 nM
   TI
   LI
   LO
   TS