Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

ENZALUTAMIDE

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PubChem ID

CID: 15951529

SID: 125299336

Canonical SMILES	CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F Show/Hide
Compound Formula	C21H16F4N4O2S

Compound Structure

Protein Name

Protein Info

Androgen receptor

Protein Classification

Transcription factor

Nuclear receptor

Nuclear hormone receptor subfamily 3

Nuclear hormone receptor subfamily 3 group C

Nuclear hormone receptor subfamily 3 group C member 4

Uniprot ID

P10275

Gene Name

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	5
1	IC50 = 112.3 nM	TI LI LO TS
2	IC50 = 216 nM	TI LI LO TS
3	IC50 = 450 nM	TI LI LO TS
4	IC50 = 492 nM	TI LI LO TS
5	IC50 = 646.9 nM	TI LI LO TS
CL000063	Hep-G2 Cell Line Info	Homo sapiens (Human)	1
1	EC50 = 61.8 nM	TI LI LO TS
CL000141	LNCaP Cell Line Info	Homo sapiens (Human)	12
1	EC50 = 180 nM	TI LI LO TS
2	IC50 = 14 nM	TI LI LO TS
3	IC50 = 36 nM	TI LI LO TS
4	IC50 = 38 nM	TI LI LO TS
5	IC50 = 50 nM	TI LI LO TS
6	IC50 = 70 nM	TI LI LO TS
7	IC50 = 75 nM	TI LI LO TS
8	IC50 = 90 nM	TI LI LO TS
9	IC50 = 117 nM	TI LI LO TS
10	IC50 = 480 nM	TI LI LO TS
11	IC50 > 100000 nM	TI LI LO TS
12	Ki = 17 nM	TI LI LO TS
CL001054	LNCap-ARR2PB-eGFP Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 25 nM	TI LI LO TS
CL000048	PC-3 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 1070 nM	TI LI LO TS
2	EC50 = 11390 nM	TI LI LO TS

Biochemical Assays