Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
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 PubChem ID
CID: 91928414
Canonical SMILES
Cn1ncc2cc(ccc12)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1
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Compound Formula C21H22ClN5O
Compound Structure
Protein Name
 Protein Info 
Cyclin-dependent kinase 8
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase CDK family
>
CMGC protein kinase CDK8 subfamily
Uniprot ID
P49336
Gene Name
CDK8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 17.9 nM