Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-[4-methyl-3-(trifluoromethyl)phenyl]-3-[3-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]propanamide
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 PubChem ID
CID: 165412733
Canonical SMILES
Cc1ccc(NC(=O)CCc2cccc(c2)-c2cnc3[nH]ccc3c2)cc1C(F)(F)F
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Compound Formula C24H20F3N3O
Compound Structure
Protein Name
 Protein Info 
Cyclin-dependent kinase 8
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
>
CMGC protein kinase CDK family
>
CMGC protein kinase CDK8 subfamily
Uniprot ID
P49336
Gene Name
CDK8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 24 nM
   TI
   LI
   LO
   TS
2
IC50 = 1500 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 46.5 nM