Brief Information of the Compound and Protein
Compound Name
6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-piperazin-1-ylanilino)pyrido[2,3-d]pyrimidin-7-one
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PubChem ID
CID: 68060125
Canonical SMILES
CCn1c2nc(Nc3ccc(N4CCNCC4)c(F)c3)ncc2cc(-c2ccc(Cl)cc2Cl)c1=O
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Compound Formula C25H23Cl2FN6O
Compound Structure
Protein Name
LIM domain kinase 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase LISK family
>
TKL protein kinase LIMK subfamily
Uniprot ID
P53671
Gene Name
LIMK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 38.9 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 13.49 nM
2 IC50 = 512.86 nM