Brief Information of the Compound and Protein
Compound Name
[3-[[4-(aminomethyl)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carbonyl]amino]phenyl] N,N-dimethylcarbamate
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PubChem ID
CID: 56962369
SID: 136333479
Canonical SMILES
CN(C)C(=O)Oc1cccc(NC(=O)C2(CN)CCN(CC2)c2ncnc3[nH]cc(C)c23)c1
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Compound Formula C23H29N7O3
Compound Structure
Protein Name
LIM domain kinase 2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase LISK family
>
TKL protein kinase LIMK subfamily
Uniprot ID
P53671
Gene Name
LIMK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 6.761 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.6 nM
2 IC50 = 4.3 nM
3 IC50 = 7.5 nM
4 IC50 = 10.72 nM
5 IC50 = 309.03 nM
6 Kd < 1000 nM