Brief Information of the Compound and Protein
Compound Name
(1R,3R)-3-[[1-[3-(2-aminoethyl)-4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]-3-bromopyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide
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PubChem ID
CID: 151929313
Canonical SMILES
CNC(=O)[C@]1(C)CC[C@H](C1)Nc1ncc2c(Br)nn(-c3ccc(-c4nnc(C)s4)c(CCN)c3)c2n1
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Compound Formula C24H28BrN9OS
Compound Structure
Protein Name
eIF-2-alpha kinase GCN2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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Other protein kinase group
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Other protein kinase PEK family
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Other protein kinase GCN2 subfamily
Uniprot ID
Q9P2K8
Gene Name
EIF2AK4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000084 SK-OV-3 Homo sapiens (Human)  1
1
IC50 = 240 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 15 nM