Brief Information of the Compound and Protein
Compound Name
 Compound Info 
6-[[4-[(4-aminocyclohexyl)amino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-2-methylisoquinolin-1-one
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Canonical SMILES
Cn1ccc2cc(Nc3ncc(c(N[C@@H]4CC[C@H](N)CC4)n3)C(F)(F)F)ccc2c1=O
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Compound Formula C21H23F3N6O
Compound Structure
Protein Name
 Protein Info 
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 3.56 nM
   TI
   LI
   LO
   TS
CL000091 MV4-11
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 < 1 nM
   TI
   LI
   LO
   TS
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 1.48 nM
   TI
   LI
   LO
   TS
2
IC50 = 2.87 nM
   TI
   LI
   LO
   TS