Brief Information of the Compound and Protein
Compound Name
 Compound Info 
8-[[(3R,4R,5S)-3-[(4,4-difluorocyclohexyl)methoxy]-5-methoxypiperidin-4-yl]amino]-3-methyl-5-(5-methylpyridin-3-yl)-1H-1,7-naphthyridin-2-one
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 PubChem ID
CID: 121499171
Canonical SMILES
CO[C@H]1CNC[C@@H](OCC2CCC(F)(F)CC2)[C@@H]1Nc1ncc(-c2cncc(C)c2)c2cc(C)c(=O)[nH]c12
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Compound Formula C28H35F2N5O3
Compound Structure
Protein Name
 Protein Info 
ATPase family AAA domain-containing protein 2
Protein Classification
Epigenetic regulator
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Bromodomain
Uniprot ID
Q6PL18
Gene Name
ATAD2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 158.49 nM
   TI
   LI
   LO
   TS
2
IC50 = 199.53 nM
   TI
   LI
   LO
   TS
3
IC50 = 251.19 nM
   TI
   LI
   LO
   TS
4
IC50 = 630.96 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 8 nM