Brief Information of the Compound and Protein
Compound Name
N-(2,6-diethylphenyl)-2-[4-(4-methylpiperazin-1-yl)-2-(propanoylamino)anilino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide
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Canonical SMILES
CCC(=O)Nc1cc(ccc1Nc1ncc2CCc3c(ccn3-c2n1)C(=O)Nc1c(CC)cccc1CC)N1CCN(C)CC1
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Compound Formula C35H42N8O2
Compound Structure
Protein Name
Dual specificity protein kinase TTK
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
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Other protein kinase group
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Other protein kinase TTK family
Uniprot ID
P33981
Gene Name
TTK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 32.7 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 9.06 nM