Brief Information of the Compound and Protein
Compound Name
N-(2,6-diethylphenyl)-2-[4-(4-methylpiperazin-1-yl)-2-(prop-2-enoylamino)anilino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide
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PubChem ID
CID: 163196379
Canonical SMILES
CCc1cccc(CC)c1NC(=O)c1ccn-2c1CCc1cnc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)nc-21
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Compound Formula C35H40N8O2
Compound Structure
Protein Name
Dual specificity protein kinase TTK
Protein Classification
Enzyme
>
Kinase
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Protein Kinase
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Other protein kinase group
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Other protein kinase TTK family
Uniprot ID
P33981
Gene Name
TTK
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 22.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 13 nM
2 IC50 = 13.8 nM
3 IC50 = 20 nM
4 IC50 = 28.1 nM
5 IC50 = 40.2 nM
6 Ki = 0.83 nM
7 Ki = 14.2 nM