Brief Information of the Compound and Protein
Compound Name
4-methyl-N-[6-[4-[(2S)-1,1,1-trifluoropropan-2-yl]-1,2,4-triazol-3-yl]pyridin-2-yl]-2,3-dihydro-1,4-benzoxazine-8-carboxamide
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Canonical SMILES
C[C@H](n1cnnc1-c1cccc(NC(=O)c2cccc3N(C)CCOc23)n1)C(F)(F)F
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Compound Formula C20H19F3N6O2
Compound Structure
Protein Name
Mitogen-activated protein kinase kinase kinase 5
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
STE protein kinase group
>
STE protein kinase STE11 family
Uniprot ID
Q99683
Gene Name
MAP3K5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  1
1
IC50 = 187 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 7 nM