Brief Information of the Compound and Protein
Compound Name
 Compound Info 
GALUNISERTIB
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 PubChem ID
CID: 10090485
SID: 15077613
Canonical SMILES
Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O
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Compound Formula C22H19N5O
Compound Structure
Protein Name
 Protein Info 
TGF-beta receptor type-1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TKL protein kinase group
>
TKL protein kinase STKR family
>
TKL protein kinase STKR Type 1 subfamily
Uniprot ID
P36897
Gene Name
TGFBR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000150 HaCaT
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 > 100 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 126.6 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  5
1
IC50 = 4.1 nM
   TI
   LI
   LO
   TS
2
IC50 = 51 nM
   TI
   LI
   LO
   TS
3
IC50 = 69.4 nM
   TI
   LI
   LO
   TS
4
IC50 = 119 nM
   TI
   LI
   LO
   TS
5
IC50 = 129 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 56 nM
2 IC50 = 170 nM