Brief Information of the Compound and Protein
Compound Name
N-(1H-indol-5-ylmethyl)-3-[[4-(trifluoromethyl)phenoxy]methyl]azetidine-1-carboxamide
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Canonical SMILES
FC(F)(F)c1ccc(OCC2CN(C2)C(=O)NCc2ccc3[nH]ccc3c2)cc1
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Compound Formula C21H20F3N3O2
Compound Structure
Protein Name
Neuronal acetylcholine receptor subunit alpha-7
Protein Classification
Ion channel
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Ligand-gated ion channel
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Nicotinic acetylcholine receptor
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Nicotinic acetylcholine receptor alpha subunit
Uniprot ID
P36544
Gene Name
CHRNA7
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000088 Flp-In-293 Homo sapiens (Human)  1
1
EC50 = 160 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 590 nM
   TI
   LI
   LO
   TS