Bioactivity Information | MolBiC

Brief Information of the Compound and Protein

Compound Name

Compound Info

[2-[(2-chlorobenzoyl)amino]-6-(4-methoxyphenyl)-3-thiophen-2-yl-1-benzofuran-4-yl] acetate

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Canonical SMILES	COc1ccc(cc1)-c1cc(OC(C)=O)c2c(c(NC(=O)c3ccccc3Cl)oc2c1)-c1cccs1 Show/Hide
Compound Formula	C28H20ClNO5S

Compound Structure

Protein Name

Protein Info

ATP-dependent translocase ABCB1

Protein Classification

Transporter

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Primary active transporter

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ATP-binding cassette

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ABCB subfamily

Uniprot ID

P08183

Gene Name

ABCB1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000088	Flp-In-293 Cell Line Info	Homo sapiens (Human)	12
1	IC50 = 0.82 nM	TI LI LO TS
2	IC50 = 0.88 nM	TI LI LO TS
3	IC50 = 6.3 nM	TI LI LO TS
4	IC50 = 6.4 nM	TI LI LO TS
5	IC50 = 9.2 nM	TI LI LO TS
6	IC50 = 72.9 nM	TI LI LO TS
7	IC50 = 76.6 nM	TI LI LO TS
8	IC50 = 90.9 nM	TI LI LO TS
9	IC50 = 114 nM	TI LI LO TS
10	IC50 = 502 nM	TI LI LO TS
11	IC50 = 564 nM	TI LI LO TS
12	IC50 = 602 nM	TI LI LO TS
CL000162	HeLa S3 Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 2.24 nM	TI LI LO TS
2	IC50 = 3.91 nM	TI LI LO TS
3	IC50 = 8.81 nM	TI LI LO TS
4	IC50 = 9.58 nM	TI LI LO TS
5	IC50 = 85.7 nM	TI LI LO TS
6	IC50 = 111 nM	TI LI LO TS
CL000840	MDR-KB-VIN Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 7.59 nM	TI LI LO TS
2	IC50 = 21 nM	TI LI LO TS
3	IC50 = 36.82 nM	TI LI LO TS
4	IC50 = 79.5 nM	TI LI LO TS
5	IC50 = 102 nM	TI LI LO TS
6	IC50 = 1260 nM	TI LI LO TS