Bioactivity Information | MolBiC

Brief Information of the Compound and Protein

Compound Name

Compound Info

[2-(diacetylamino)-6-(4-methoxyphenyl)-3-thiophen-2-yl-1-benzofuran-4-yl] acetate

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Canonical SMILES	COc1ccc(cc1)-c1cc(OC(C)=O)c2c(-c3cccs3)c(oc2c1)N(C(C)=O)C(C)=O Show/Hide
Compound Formula	C25H21NO6S

Compound Structure

Protein Name

Protein Info

ATP-dependent translocase ABCB1

Protein Classification

Transporter

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Primary active transporter

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ATP-binding cassette

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ABCB subfamily

Uniprot ID

P08183

Gene Name

ABCB1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000088	Flp-In-293 Cell Line Info	Homo sapiens (Human)	12
1	IC50 = 4 nM	TI LI LO TS
2	IC50 = 4.5 nM	TI LI LO TS
3	IC50 = 10 nM	TI LI LO TS
4	IC50 = 10.5 nM	TI LI LO TS
5	IC50 = 82.3 nM	TI LI LO TS
6	IC50 = 87.2 nM	TI LI LO TS
7	IC50 = 582 nM	TI LI LO TS
8	IC50 = 645 nM	TI LI LO TS
9	IC50 = 647 nM	TI LI LO TS
10	IC50 = 663 nM	TI LI LO TS
11	IC50 = 677 nM	TI LI LO TS
12	IC50 = 874 nM	TI LI LO TS
CL000162	HeLa S3 Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 5.16 nM	TI LI LO TS
2	IC50 = 5.68 nM	TI LI LO TS
3	IC50 = 13.6 nM	TI LI LO TS
4	IC50 = 14.3 nM	TI LI LO TS
5	IC50 = 102 nM	TI LI LO TS
6	IC50 = 105 nM	TI LI LO TS
CL000840	MDR-KB-VIN Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 314 nM	TI LI LO TS
2	IC50 = 501 nM	TI LI LO TS
3	IC50 = 597 nM	TI LI LO TS
4	IC50 = 652 nM	TI LI LO TS
5	IC50 = 1502 nM	TI LI LO TS
6	IC50 = 1742 nM	TI LI LO TS