Bioactivity Information | MolBiC

Brief Information of the Compound and Protein

Compound Name

Compound Info

[2-[(3-fluorobenzoyl)amino]-6-(4-methoxyphenyl)-3-thiophen-2-yl-1-benzofuran-4-yl] acetate

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Canonical SMILES	COc1ccc(cc1)-c1cc(OC(C)=O)c2c(c(NC(=O)c3cccc(F)c3)oc2c1)-c1cccs1 Show/Hide
Compound Formula	C28H20FNO5S

Compound Structure

Protein Name

Protein Info

ATP-dependent translocase ABCB1

Protein Classification

Transporter

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Primary active transporter

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ATP-binding cassette

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ABCB subfamily

Uniprot ID

P08183

Gene Name

ABCB1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000088	Flp-In-293 Cell Line Info	Homo sapiens (Human)	12
1	IC50 = 3.7 nM	TI LI LO TS
2	IC50 = 5.3 nM	TI LI LO TS
3	IC50 = 6.3 nM	TI LI LO TS
4	IC50 = 6.6 nM	TI LI LO TS
5	IC50 = 24.6 nM	TI LI LO TS
6	IC50 = 76.8 nM	TI LI LO TS
7	IC50 = 80.6 nM	TI LI LO TS
8	IC50 = 81.8 nM	TI LI LO TS
9	IC50 = 96.2 nM	TI LI LO TS
10	IC50 = 504 nM	TI LI LO TS
11	IC50 = 559 nM	TI LI LO TS
12	IC50 = 621 nM	TI LI LO TS
CL000162	HeLa S3 Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 4.72 nM	TI LI LO TS
2	IC50 = 5.37 nM	TI LI LO TS
3	IC50 = 10.8 nM	TI LI LO TS
4	IC50 = 11.5 nM	TI LI LO TS
5	IC50 = 86.6 nM	TI LI LO TS
6	IC50 = 93.3 nM	TI LI LO TS
CL000840	MDR-KB-VIN Cell Line Info	Homo sapiens (Human)	6
1	IC50 = 12 nM	TI LI LO TS
2	IC50 = 48.2 nM	TI LI LO TS
3	IC50 = 59.5 nM	TI LI LO TS
4	IC50 = 116 nM	TI LI LO TS
5	IC50 = 1397 nM	TI LI LO TS
6	IC50 = 2207 nM	TI LI LO TS