Brief Information of the Compound and Protein
Compound Name
N-(3-chloro-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
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PubChem ID
CID: 138513849
Canonical SMILES
Fc1c(Cl)cccc1Nc1ncnc2cc3OCCOc3cc12
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Compound Formula C16H11ClFN3O2
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
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Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 3.91 nM
   TI
   LI
   LO
   TS
CL000102 U-87MG ATCC Homo sapiens (Human)  1
1
IC50 = 4.7 nM
   TI
   LI
   LO
   TS