Brief Information of the Compound and Protein
Compound Name
5-[4-[(4-amino-1-bicyclo[2.2.2]octanyl)methoxy]-3-fluorophenyl]-7-methylpyrrolo[2,1-f][1,2,4]triazin-2-amine
    Show/Hide
Canonical SMILES
Cc1cc(-c2ccc(OCC34CCC(N)(CC3)CC4)c(F)c2)c2cnc(N)nn12
    Show/Hide
Compound Formula C22H26FN5O
Compound Structure
Protein Name
Toll-like receptor 8
Protein Classification
Membrane receptor
>
Toll-like and Il-1 receptors
Uniprot ID
Q9NR97
Gene Name
TLR8
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS